MXPA04006029A - Derivados novedosos de benzofuranimidazolina y benzodifuranimidazolina y su uso para el tratamiento de glaucoma. - Google Patents
Derivados novedosos de benzofuranimidazolina y benzodifuranimidazolina y su uso para el tratamiento de glaucoma.Info
- Publication number
- MXPA04006029A MXPA04006029A MXPA04006029A MXPA04006029A MXPA04006029A MX PA04006029 A MXPA04006029 A MX PA04006029A MX PA04006029 A MXPA04006029 A MX PA04006029A MX PA04006029 A MXPA04006029 A MX PA04006029A MX PA04006029 A MXPA04006029 A MX PA04006029A
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives
- benzofuranimidazoline
- benzodifuranimidazoline
- glaucoma
- novel
- Prior art date
Links
- 208000010412 Glaucoma Diseases 0.000 title 1
- XZTDMGMENDDGMC-UHFFFAOYSA-N 1-benzofuran;4,5-dihydro-1h-imidazole Chemical class C1CN=CN1.C1=CC=C2OC=CC2=C1.C1=CC=C2OC=CC2=C1 XZTDMGMENDDGMC-UHFFFAOYSA-N 0.000 abstract 1
- ZGQQPCXSRVVQTG-UHFFFAOYSA-N 1-benzofuran;4,5-dihydro-1h-imidazole Chemical class C1CN=CN1.C1=CC=C2OC=CC2=C1 ZGQQPCXSRVVQTG-UHFFFAOYSA-N 0.000 abstract 1
- 230000004410 intraocular pressure Effects 0.000 abstract 1
- 230000004112 neuroprotection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34337801P | 2001-12-20 | 2001-12-20 | |
| PCT/US2002/039316 WO2003053436A1 (en) | 2001-12-20 | 2002-12-09 | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04006029A true MXPA04006029A (es) | 2004-09-27 |
Family
ID=23345873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04006029A MXPA04006029A (es) | 2001-12-20 | 2002-12-09 | Derivados novedosos de benzofuranimidazolina y benzodifuranimidazolina y su uso para el tratamiento de glaucoma. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7208512B2 (https=) |
| EP (1) | EP1455780A4 (https=) |
| JP (1) | JP2005513103A (https=) |
| KR (1) | KR20040068315A (https=) |
| CN (1) | CN1268334C (https=) |
| AR (1) | AR037880A1 (https=) |
| AU (1) | AU2002353088B2 (https=) |
| BR (1) | BR0215172A (https=) |
| CA (1) | CA2469904A1 (https=) |
| MX (1) | MXPA04006029A (https=) |
| TW (1) | TW593302B (https=) |
| WO (1) | WO2003053436A1 (https=) |
| ZA (1) | ZA200404473B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960579B1 (en) | 1998-05-19 | 2005-11-01 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
| TW593302B (en) | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
| BR0316775A (pt) | 2002-12-13 | 2005-11-01 | Alcon Inc | Novos análogos de benzopirano e seu uso para o tratamento de glaucoma |
| US7476687B2 (en) * | 2003-11-26 | 2009-01-13 | Alcon, Inc. | Substituted furo[2,3-g]indazoles for the treatment of glaucoma |
| US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
| TW200520760A (en) | 2003-12-15 | 2005-07-01 | Alcon Inc | Substituted [1,4] oxazino [2,3-g] indazoles for the treatment of glaucoma |
| US7129257B1 (en) | 2003-12-15 | 2006-10-31 | Alcon, Inc. | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma |
| US7425572B2 (en) | 2004-12-08 | 2008-09-16 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
| TW200744567A (en) * | 2005-09-23 | 2007-12-16 | Alcon Inc | Phenylethylamine analogs and their use for treating glaucoma |
| US20070293475A1 (en) * | 2006-06-20 | 2007-12-20 | Alcon Manufacturing Ltd. | Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES323985A1 (es) | 1966-02-26 | 1966-12-16 | Blade Pique Juan | Procedimiento para la obtenciën de derivados del imidazol |
| US5011846A (en) | 1988-02-23 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof |
| EP0445073A1 (de) | 1990-02-27 | 1991-09-04 | Ciba-Geigy Ag | Benzofurane |
| EP0536223B1 (en) | 1990-06-26 | 2004-09-15 | AorTech Biomaterials Pty Ltd | Polyurethane or polyurethane-urea elastomeric compositions |
| US5578612A (en) | 1990-10-15 | 1996-11-26 | Pfizer Inc. | Indole derivatives |
| EP0593513B1 (en) | 1991-06-21 | 1998-10-28 | Smithkline Beecham Plc | Tryptamine analogues, their synthesis and their use as 5-ht1-like receptors or 5-ht2 receptor agonistes |
| GB9216380D0 (en) | 1992-07-31 | 1992-09-16 | Glaxo Group Ltd | Medicaments |
| US5290781A (en) | 1993-01-05 | 1994-03-01 | Iolab Corporation | Ketaneserinol as an agent to reduce intraocular pressure |
| US5891131A (en) | 1993-02-01 | 1999-04-06 | Arizona Board Of Regents | Method and apparatus for automated simulation and design of corneal refractive procedures |
| TW334423B (en) | 1993-10-22 | 1998-06-21 | Hoffmann La Roche | Tricyclic 1-aminoethylpyrrole-derivatives |
| TW270114B (https=) | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
| US5538974A (en) | 1994-01-27 | 1996-07-23 | Senju Pharamceutical Co., Ltd. | Ophthalmic composition for lowering intraocular pressure |
| ATE166227T1 (de) | 1994-03-18 | 1998-06-15 | Senju Pharma Co | Sarpogrelat enthaltende opthalmologische zubereitungen zur senkung des intraokularen druckes |
| US5874477A (en) | 1994-08-12 | 1999-02-23 | The University Of Hawaii | Method of treatment for malaria utilizing serotonin receptor ligands |
| TW403738B (en) | 1994-08-12 | 2000-09-01 | Hoffmann La Roche | Tricyclic pyrazole derivatives |
| US5998467A (en) | 1995-10-25 | 1999-12-07 | Mitsubishi Chemical Corporation | Medicine for oculopathy |
| AU2340997A (en) | 1996-03-27 | 1997-10-17 | Merck & Co., Inc. | A method for inhibiting clot formation |
| US5902815A (en) | 1996-09-03 | 1999-05-11 | Washington University | Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction |
| WO1998018458A1 (en) | 1996-10-31 | 1998-05-07 | Alcon Laboratories, Inc. | Opthalmological compositions containing serotonin 5-ht1a receptor agonist and their use in the treatment of glaucoma |
| GB9700899D0 (en) | 1997-01-17 | 1997-03-05 | Smithkline Beecham Plc | Novel treatment |
| MXPA00010060A (es) | 1998-04-14 | 2004-04-23 | Arena Pharm Inc | Receptores de serotonina humana constitutivamente activados, no endogenos y moduladores de molecula pequenos de los mismos. |
| CN1301161A (zh) | 1998-05-19 | 2001-06-27 | 艾尔科实验室公司 | 用于治疗眼睛和中枢神经系统障碍的血清素激活的5ht7受体化合物 |
| GB9819033D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds VI |
| GB9819035D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Res Ltd | Chemical compounds VII |
| CN1269484C (zh) | 1998-09-18 | 2006-08-16 | 艾尔科实验室公司 | 用于治疗青光眼的5－羟色胺激活性激动剂 |
| CA2351385A1 (en) | 1998-12-17 | 2000-06-22 | American Home Products Corporation | 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists |
| GB9902047D0 (en) | 1999-01-29 | 1999-03-17 | Cerebrus Ltd | Chemical compounds XI |
| WO2001040183A1 (en) | 1999-12-03 | 2001-06-07 | Alcon Universal Ltd. | 1-aminoalkyl-1h-indoles for treating glaucoma |
| BR0109193A (pt) | 2000-03-17 | 2003-05-27 | Alcon Inc | Compostos com atividade agonista 5-ht2 e 5-ht1a para tratamento do glaucoma |
| AU2001219185A1 (en) | 2000-03-17 | 2001-10-03 | Alcon, Inc. | 2-acylaminobenzimidazole derivatives for treating glaucoma |
| US6806285B1 (en) | 2000-03-17 | 2004-10-19 | Alcon, Inc. | 5-Hydroxyl indole derivatives for treating glaucoma |
| WO2001070745A1 (en) | 2000-03-17 | 2001-09-27 | Alcon, Inc. | Pyranoindoles for treating glaucoma |
| BR0017157A (pt) | 2000-03-17 | 2002-11-26 | Alcon Inc | Derivados de 6-hidroxi-indazol para o tratamento de glaucoma |
| BR0017158A (pt) | 2000-03-17 | 2003-06-03 | Alcon Inc | Agonistas de 5ht2 para controlar a iop e tratar o glaucoma |
| WO2001070701A1 (en) | 2000-03-17 | 2001-09-27 | Alcon, Inc. | 5-hydroxy indazole derivatives for treating glaucoma |
| JP2004532887A (ja) | 2001-06-01 | 2004-10-28 | アルコン，インコーポレイテッド | 新規な融合インダゾールおよびインドールおよび緑内障治療へのこれらの使用 |
| JP2004534781A (ja) | 2001-06-01 | 2004-11-18 | アルコン，インコーポレイテッド | 新規なアリールアミノプロパン類似体および緑内障治療へのこれらの使用 |
| CA2447480A1 (en) | 2001-06-01 | 2002-12-12 | Alcon, Inc. | Pyranoindazoles and their use for the treatment of glaucoma |
| US6884816B2 (en) | 2001-08-31 | 2005-04-26 | Alcon, Inc. | Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma |
| WO2003051291A2 (en) | 2001-12-14 | 2003-06-26 | Alcon, Inc. | Substituted 5-hydroxy-indole compounds for the treatment of glaucoma |
| WO2003051352A1 (en) | 2001-12-14 | 2003-06-26 | Alcon, Inc. | Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma |
| TW593302B (en) | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
| JP2006501245A (ja) | 2002-08-30 | 2006-01-12 | アルコン，インコーポレイテッド | 置換された５−クロマン−５−イル−エチルアミン化合物および緑内障の治療のためのその使用 |
| CA2492468A1 (en) | 2002-09-24 | 2004-04-08 | Virginia Commonwealth University | .beta.-hydroxyphenylalkylamines and their use for treating glaucoma |
| BR0316775A (pt) | 2002-12-13 | 2005-11-01 | Alcon Inc | Novos análogos de benzopirano e seu uso para o tratamento de glaucoma |
| WO2004058725A1 (en) | 2002-12-23 | 2004-07-15 | Alcon, Inc. | 1-alkyl-3-aminoindazoles |
-
2002
- 2002-11-29 TW TW091134883A patent/TW593302B/zh not_active IP Right Cessation
- 2002-12-09 EP EP02790063A patent/EP1455780A4/en not_active Withdrawn
- 2002-12-09 WO PCT/US2002/039316 patent/WO2003053436A1/en not_active Ceased
- 2002-12-09 AU AU2002353088A patent/AU2002353088B2/en not_active Ceased
- 2002-12-09 JP JP2003554193A patent/JP2005513103A/ja active Pending
- 2002-12-09 CA CA002469904A patent/CA2469904A1/en not_active Abandoned
- 2002-12-09 US US10/525,410 patent/US7208512B2/en not_active Expired - Fee Related
- 2002-12-09 CN CNB028254643A patent/CN1268334C/zh not_active Expired - Fee Related
- 2002-12-09 KR KR10-2004-7009781A patent/KR20040068315A/ko not_active Withdrawn
- 2002-12-09 MX MXPA04006029A patent/MXPA04006029A/es active IP Right Grant
- 2002-12-09 BR BR0215172-3A patent/BR0215172A/pt not_active IP Right Cessation
- 2002-12-17 AR ARP020104911A patent/AR037880A1/es unknown
-
2004
- 2004-06-07 ZA ZA200404473A patent/ZA200404473B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003053436A1 (en) | 2003-07-03 |
| AU2002353088B2 (en) | 2006-09-21 |
| AR037880A1 (es) | 2004-12-09 |
| EP1455780A4 (en) | 2005-04-06 |
| BR0215172A (pt) | 2004-10-19 |
| CN1606441A (zh) | 2005-04-13 |
| US20060009503A1 (en) | 2006-01-12 |
| TW200301257A (en) | 2003-07-01 |
| CN1268334C (zh) | 2006-08-09 |
| JP2005513103A (ja) | 2005-05-12 |
| CA2469904A1 (en) | 2003-07-03 |
| ZA200404473B (en) | 2005-06-07 |
| EP1455780A1 (en) | 2004-09-15 |
| AU2002353088A1 (en) | 2003-07-09 |
| KR20040068315A (ko) | 2004-07-30 |
| US7208512B2 (en) | 2007-04-24 |
| TW593302B (en) | 2004-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |