BR0212333A - Liberação controlada de suspensões de peptìdeos microcristalino - Google Patents

Liberação controlada de suspensões de peptìdeos microcristalino

Info

Publication number
BR0212333A
BR0212333A BR0212333-9A BR0212333A BR0212333A BR 0212333 A BR0212333 A BR 0212333A BR 0212333 A BR0212333 A BR 0212333A BR 0212333 A BR0212333 A BR 0212333A
Authority
BR
Brazil
Prior art keywords
peptide
controlled release
formation
gel
microcrystalline
Prior art date
Application number
BR0212333-9A
Other languages
English (en)
Inventor
Romano Deghenghi
Francois Boutignon
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of BR0212333A publication Critical patent/BR0212333A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"LIBERAçãO CONTROLADA DE SUSPENSõES DE PEPTìDEO MICROCRISTALINO". A invenção refere-se a um processo para evitar a formação de gel de um peptídeo hidrófobo por contato do peptídeo hidrófobo com um íon indicador em uma quantidade e a uma razão molar suficiente para fornecer uma suspensão aquosa fluida, microcristalina leitosa de um peptídeo hidrófobo sem a formação de um gel. A invenção também se refere a uma suspensão aquosa fluida, microcristalina leitosa de um peptídeo hidrófobo e a um íon indicador em água, em que o peptídeo e o íon indicador estão presentes em quantidades e a uma razão molar suficiente, para formar, por misturação, a suspensão sem a formação de um gel.
BR0212333-9A 2001-09-06 2002-08-27 Liberação controlada de suspensões de peptìdeos microcristalino BR0212333A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31761601P 2001-09-06 2001-09-06
PCT/EP2002/009537 WO2003022243A2 (en) 2001-09-06 2002-08-27 Sustained release of microcrystalline peptide suspensions

Publications (1)

Publication Number Publication Date
BR0212333A true BR0212333A (pt) 2004-09-21

Family

ID=23234486

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0212333-9A BR0212333A (pt) 2001-09-06 2002-08-27 Liberação controlada de suspensões de peptìdeos microcristalino

Country Status (27)

Country Link
US (5) US7098305B2 (pt)
EP (2) EP1423150B1 (pt)
JP (3) JP2005504787A (pt)
KR (2) KR100818904B1 (pt)
CN (1) CN100386116C (pt)
AR (1) AR042592A1 (pt)
AT (1) ATE463258T1 (pt)
AU (1) AU2002337025B2 (pt)
BR (1) BR0212333A (pt)
CA (1) CA2459309C (pt)
CY (1) CY1118642T1 (pt)
DE (1) DE60235896D1 (pt)
DK (1) DK2198888T3 (pt)
ES (2) ES2362505T3 (pt)
HK (1) HK1062148A1 (pt)
HU (1) HUP0402099A2 (pt)
IL (1) IL160443A0 (pt)
MX (1) MXPA04002185A (pt)
NO (1) NO20040938L (pt)
NZ (1) NZ531734A (pt)
PL (1) PL368056A1 (pt)
PT (1) PT2198888T (pt)
RU (1) RU2311195C2 (pt)
TW (1) TWI249409B (pt)
UA (1) UA79435C2 (pt)
WO (1) WO2003022243A2 (pt)
ZA (1) ZA200401390B (pt)

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Also Published As

Publication number Publication date
CA2459309A1 (en) 2003-03-20
HK1062148A1 (en) 2004-10-21
EP2198888A2 (en) 2010-06-23
JP2013177449A (ja) 2013-09-09
CN100386116C (zh) 2008-05-07
JP5757686B2 (ja) 2015-07-29
HUP0402099A2 (hu) 2005-02-28
CA2459309C (en) 2012-04-03
WO2003022243A2 (en) 2003-03-20
JP2010095533A (ja) 2010-04-30
DE60235896D1 (de) 2010-05-20
NO20040938D0 (no) 2004-03-04
US20060228385A1 (en) 2006-10-12
ZA200401390B (en) 2004-08-27
JP2005504787A (ja) 2005-02-17
US20030044463A1 (en) 2003-03-06
MXPA04002185A (es) 2004-07-23
NO20040938L (no) 2004-06-04
US8415300B2 (en) 2013-04-09
US20060229238A1 (en) 2006-10-12
KR20070107161A (ko) 2007-11-06
EP2198888B1 (en) 2016-11-02
ES2362505T3 (es) 2011-07-06
US20110312889A1 (en) 2011-12-22
UA79435C2 (en) 2007-06-25
IL160443A0 (en) 2004-07-25
US20100239683A1 (en) 2010-09-23
ES2618777T3 (es) 2017-06-22
EP1423150B1 (en) 2010-04-07
EP1423150A2 (en) 2004-06-02
KR100818904B1 (ko) 2008-04-04
WO2003022243A3 (en) 2003-10-30
US7098305B2 (en) 2006-08-29
KR20040037077A (ko) 2004-05-04
PT2198888T (pt) 2017-02-10
TWI249409B (en) 2006-02-21
DK2198888T3 (en) 2017-02-13
RU2311195C2 (ru) 2007-11-27
AR042592A1 (es) 2005-06-29
CN1551785A (zh) 2004-12-01
CY1118642T1 (el) 2017-07-12
EP2198888A3 (en) 2011-08-31
PL368056A1 (en) 2005-03-21
RU2004110615A (ru) 2005-05-10
ATE463258T1 (de) 2010-04-15
NZ531734A (en) 2006-02-24
AU2002337025B2 (en) 2006-12-07

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