BR0211665A - Composto, composição farmacêutica, método para a redução de glicose, método para a prevenção ou para tratamento de doenças, medicamento para a redução de glicose, medicamento para a prevenção ou para o tratamento de doenças, uso do composto, da composição farmacêutica e do medicamento e processo para a preparação do composto - Google Patents

Composto, composição farmacêutica, método para a redução de glicose, método para a prevenção ou para tratamento de doenças, medicamento para a redução de glicose, medicamento para a prevenção ou para o tratamento de doenças, uso do composto, da composição farmacêutica e do medicamento e processo para a preparação do composto

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Publication number
BR0211665A
BR0211665A BR0211665-0A BR0211665A BR0211665A BR 0211665 A BR0211665 A BR 0211665A BR 0211665 A BR0211665 A BR 0211665A BR 0211665 A BR0211665 A BR 0211665A
Authority
BR
Brazil
Prior art keywords
compound
medicament
pharmaceutically acceptable
pharmaceutical composition
preventing
Prior art date
Application number
BR0211665-0A
Other languages
English (en)
Other versions
BRPI0211665B8 (pt
BR0211665B1 (pt
Inventor
Braj Bhushan Lohray
Vidya Brushan Lohray
Vijay Kumar Barot
Saurin Khimshankar Raval
Sujay Basu
Preeti Saurin Raval
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of BR0211665A publication Critical patent/BR0211665A/pt
Publication of BR0211665B1 publication Critical patent/BR0211665B1/pt
Publication of BRPI0211665B8 publication Critical patent/BRPI0211665B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODO PARA A REDUçãO DE GLICOSE, MéTODO PARA A PREVENçãO OU PARA O TRATAMENTO DE DOENçAS, MEDICAMENTO PARA A REDUçãO DE GLICOSE, MEDICAMENTO PARA A PREVENçãO OU PARA O TRATAMENTO DE DOENçAS, USO DO COMPOSTO, DA COMPOSIçãO FARMACêUTICAS E DO MEDICAMENTO E PROCESSO PARA A PREPARAçãO DO COMPOSTO". A presente invenção refere-se a novos compostos de pirrol substituídos, seus derivados, seus análogos, suas formas tautoméricas, seus estereoisómeros, seus polimorfos, seus sais farmaceuticamente aceitáveis, seus solvatos farmaceuticamente aceitáveis e às composições farmaceuticamente aceitáveis contendo os mesmos. Mais particularmente, a presente invenção refere-se a novos compostos de pirrol substituídos tendo a fórmula geral (I) seus derivados, seus análogos, suas formas tautoméricas, seus estereoisómeros, seus polimorfos, seus sais farmaceuticamente aceitáveis, seus solvatos farmaceuticamente aceitáveis e às composições farmaceuticamente aceitáveis contendo os mesmos. A presente invenção também refere-se ao processo para o preparo de tal composto, a uma composição contendo o composto e ao uso deste composto e composição na medicina. Os compostos reduzem os níveis de triglicérides no sangue e podem ser úteis no tratamento de obesidade, hiperlipidêmia, hipercolesterêmia, síndrome X e diabete.
BRPI0211665A 2001-07-26 2002-07-25 "composto de pirrol substituído" BRPI0211665B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN711MU2001 2001-07-26
PCT/IN2002/000155 WO2003009841A1 (en) 2001-07-26 2002-07-25 Novel pyrroles having hypolipidemic hypocholesteremic activities, process for their preparation and pharmaceutical compositions containing them and their use in medicine

Publications (3)

Publication Number Publication Date
BR0211665A true BR0211665A (pt) 2005-01-11
BR0211665B1 BR0211665B1 (pt) 2017-10-31
BRPI0211665B8 BRPI0211665B8 (pt) 2021-05-25

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ID=11097270

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0211665A BRPI0211665B8 (pt) 2001-07-26 2002-07-25 "composto de pirrol substituído"

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US (6) US6987123B2 (pt)
EP (1) EP1414439B1 (pt)
JP (2) JP4313194B2 (pt)
KR (2) KR20060094545A (pt)
CN (1) CN100450477C (pt)
AP (1) AP1808A (pt)
AR (1) AR036347A1 (pt)
AT (1) ATE507828T1 (pt)
AU (1) AU2002355205B2 (pt)
BR (1) BRPI0211665B8 (pt)
CA (1) CA2454863C (pt)
CO (1) CO5390079A1 (pt)
CY (1) CY1111876T1 (pt)
DE (1) DE60239939D1 (pt)
DK (1) DK1414439T3 (pt)
EA (1) EA006858B1 (pt)
ES (1) ES2366279T3 (pt)
HR (1) HRP20040138B1 (pt)
IL (1) IL160042A (pt)
MX (1) MXPA04000758A (pt)
MY (1) MY140057A (pt)
NO (1) NO326698B1 (pt)
NZ (2) NZ550375A (pt)
OA (1) OA12702A (pt)
PL (1) PL224397B1 (pt)
PT (1) PT1414439E (pt)
RS (1) RS51837B (pt)
SI (1) SI1414439T1 (pt)
UA (1) UA76992C2 (pt)
WO (1) WO2003009841A1 (pt)
ZA (1) ZA200400563B (pt)

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