BR0208994A - Composição farmacêutica finamente auto-emulsificável - Google Patents

Composição farmacêutica finamente auto-emulsificável

Info

Publication number
BR0208994A
BR0208994A BR0208994-7A BR0208994A BR0208994A BR 0208994 A BR0208994 A BR 0208994A BR 0208994 A BR0208994 A BR 0208994A BR 0208994 A BR0208994 A BR 0208994A
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
self
drug
fatty acid
organic amine
Prior art date
Application number
BR0208994-7A
Other languages
English (en)
Inventor
Ping Gao
Aziz Karim
Fred Hassan
James C Forbes
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BR0208994A publication Critical patent/BR0208994A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSIçãO FARMACêUTICA FINAMENTE AUTO-EMULSIFICáVEL". A presente invenção refere-se a uma composição farmacêutica administrável por via oral, compreendendo uma droga de baixa solubilidade em água e um líquido solvente que compreende pelo menos um solvente farmaceuticamente aceitável, pelo menos um ácido graxo farmaceuticamente aceitável e pelo menos uma amina orgânica farmaceuticamente aceitável, onde (a) uma porção substancial, por exemplo pelo menos cerca de 15% em peso, da droga está dissolvida ou solubilizada no líquido solvente, e (b) o ácido graxo e a amina orgânica estão presentes em quantidades totais e relativas tais que a composição é finamente auto-emulsificável em fluido gástrico simulado.
BR0208994-7A 2001-04-17 2002-04-12 Composição farmacêutica finamente auto-emulsificável BR0208994A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28438101P 2001-04-17 2001-04-17
US32695201P 2001-10-04 2001-10-04
PCT/US2002/011689 WO2002083177A1 (en) 2001-04-17 2002-04-12 Orally deliverable pharmaceutical composition comprising a drug of low water solubility (cox-2 inhibitor), a solvent, a fatty acid and an organic amine

Publications (1)

Publication Number Publication Date
BR0208994A true BR0208994A (pt) 2004-04-27

Family

ID=26962574

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208994-7A BR0208994A (pt) 2001-04-17 2002-04-12 Composição farmacêutica finamente auto-emulsificável

Country Status (18)

Country Link
US (1) US20030105141A1 (pt)
EP (1) EP1379279A1 (pt)
JP (1) JP2004530669A (pt)
KR (1) KR20040018355A (pt)
CN (1) CN1516601A (pt)
AR (1) AR033221A1 (pt)
AU (1) AU2002305175B2 (pt)
BR (1) BR0208994A (pt)
CA (1) CA2444220A1 (pt)
CZ (1) CZ20032792A3 (pt)
EA (1) EA008103B1 (pt)
IL (1) IL158201A0 (pt)
MX (1) MXPA03009411A (pt)
NO (1) NO20034629L (pt)
NZ (1) NZ528741A (pt)
PE (1) PE20021145A1 (pt)
PL (1) PL364524A1 (pt)
WO (1) WO2002083177A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
EP1344523A1 (en) * 2002-03-11 2003-09-17 Warner-Lambert Company Ibuprofen solution for hard gelatin capsules
IL164163A0 (en) * 2002-04-09 2005-12-18 Pharmacia Corp Process for preparing a finely self-emulsifiable pharmaceutical composition
US20060141470A1 (en) * 2003-02-14 2006-06-29 Kalayoglu Murat V Chlamydia pneumoniae associated chronic intraocular disorders and treatment thereof
LT2279729T (lt) * 2003-07-17 2016-10-10 Banner Life Sciences, LLC Kontroliuojamo atpalaidavimo preparatas
EP1510206A1 (en) * 2003-08-29 2005-03-02 Novagali Pharma SA Self-nanoemulsifying oily formulation for the administration of poorly water-soluble drugs
WO2005123043A2 (en) * 2004-06-10 2005-12-29 Duramed Pharmaceuticals, Inc. Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
MX2007009888A (es) * 2005-02-17 2007-10-16 Synta Pharmaceuticals Corp Compuestos para el tratamiento de trastornos proliferativos.
US8293270B2 (en) 2005-10-26 2012-10-23 Banner Pharmacaps, Inc. Lipophilic vehicle-based dual controlled release matrix system
CN101360485B (zh) * 2005-10-26 2013-04-17 班纳制药公司 作为胶囊填充物的基于亲水性载体的双重控释基质系统
US8999381B2 (en) * 2007-09-27 2015-04-07 Wockhardt Ltd. Self-emulsifying pharmaceutical compositions of rhein or diacerein
EA020354B1 (ru) * 2008-12-03 2014-10-30 Астеллас Дойчланд Гмбх Пероральные лекарственные формы бендамустина
US9717703B2 (en) 2009-10-16 2017-08-01 Glaxosmithkline Llc Emulsion and emulsion preconcentrate compositions comprising omega-3 fatty acids and uses thereof are disclosed
JO3659B1 (ar) 2010-06-02 2020-08-27 Astellas Deutschland Gmbh أشكال جرعات بينداموستين عن طريق الفم وإستخداماته العلاجية
EP2575784B1 (en) * 2010-06-02 2018-08-08 Astellas Deutschland GmbH Oral dosage forms of bendamustine
EP2392319A1 (en) * 2010-06-04 2011-12-07 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical compositions of co-crystals of tramadol and coxibs
US9119826B2 (en) 2011-02-16 2015-09-01 Pivotal Therapeutics, Inc. Omega 3 fatty acid for use as a prescription medical food and omega 3 fatty acid diagniostic assay for the dietary management of cardiovascular patients with cardiovascular disease (CVD) who are deficient in blood EPA and DHA levels
US8951514B2 (en) 2011-02-16 2015-02-10 Pivotal Therapeutics Inc. Statin and omega 3 fatty acids for reduction of apolipoprotein-B levels
US8952000B2 (en) 2011-02-16 2015-02-10 Pivotal Therapeutics Inc. Cholesterol absorption inhibitor and omega 3 fatty acids for the reduction of cholesterol and for the prevention or reduction of cardiovascular, cardiac and vascular events
ES2859676T3 (es) * 2011-10-18 2021-10-04 Askat Inc Composición medicinal
BR112015015858B1 (pt) * 2013-01-14 2023-02-28 Infirst Healthcare Limited Uso de uma composição farmacêutica de solução sólida no tratamento de uma inflamação crônica
WO2014117999A1 (en) * 2013-02-04 2014-08-07 Biocopea Limited Compositions and methods for treating chronic inflammation and inflammatory diseases
CN105491886B (zh) 2013-08-27 2019-01-29 V·沃道里斯 苯达莫司汀医药组合物
CN113750043A (zh) * 2021-09-18 2021-12-07 山东省药学科学院 一种塞来昔布自乳化口服液及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2193609T3 (es) * 1993-11-30 2003-11-01 Searle & Co Pirazolil-bencenosulfonamidas sustituidas y su uso como inhibidores de la ciclooxigenasa ii.
US5571536A (en) * 1995-02-06 1996-11-05 Nano Systems L.L.C. Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids
US5733909A (en) * 1996-02-01 1998-03-31 Merck Frosst Canada, Inc. Diphenyl stilbenes as prodrugs to COX-2 inhibitors
BR9812018A (pt) * 1997-08-27 2000-09-26 Hexal Ag Composições farmacêuticas de meloxicam com solubilidade e biodisponibilidade melhoradas
US6025353A (en) * 1997-11-19 2000-02-15 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents
SA99191255B1 (ar) * 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
AR035642A1 (es) * 2000-05-26 2004-06-23 Pharmacia Corp Uso de una composicion de celecoxib para el alivio rapido del dolor
WO2002005799A2 (en) * 2000-07-13 2002-01-24 Pharmacia Corporation Combination of a cox-2 inhibitor and a vasomodulator for treating pain and headache pain

Also Published As

Publication number Publication date
JP2004530669A (ja) 2004-10-07
NO20034629L (no) 2003-12-10
NZ528741A (en) 2005-09-30
EA008103B1 (ru) 2007-04-27
CA2444220A1 (en) 2002-10-24
AR033221A1 (es) 2003-12-10
NO20034629D0 (no) 2003-10-16
EA200301019A1 (ru) 2004-06-24
MXPA03009411A (es) 2004-01-29
KR20040018355A (ko) 2004-03-03
PL364524A1 (en) 2004-12-13
CZ20032792A3 (cs) 2004-04-14
CN1516601A (zh) 2004-07-28
EP1379279A1 (en) 2004-01-14
US20030105141A1 (en) 2003-06-05
PE20021145A1 (es) 2003-01-16
WO2002083177A1 (en) 2002-10-24
AU2002305175B2 (en) 2007-07-12
IL158201A0 (en) 2004-05-12

Similar Documents

Publication Publication Date Title
BR0208994A (pt) Composição farmacêutica finamente auto-emulsificável
BR0309138A (pt) Processo para a preparação de uma composição farmacêutica finamente auto-emulsionável
BR0206580A (pt) Composição farmacêutica tendo tendência reduzida para cristalização de droga
BRPI0412457A (pt) composição farmacêutica para aumento da solubilidade de drogas hidrofóbicas
BR9814755A (pt) Composto, formulação farmacêutica, uso de um composto, e, processos para a preparação de um composto, para inibir a secreção do ácido gástrico, para o tratamento de doenças inflamatórias gastrointestinais, e para o tratamento ou profilaxia de condições que envolvam infecção por helicobacter pylori da mucosa gástrica humana
BR0313060A (pt) Composições farmacêuticas aquosas de 2,6-diisopropilfenol
MX9306303A (es) Derivados de acidos carboxilicos, medicamentos que contienen estos compuestos y procedimientos para su preparacion.
AR020662A1 (es) Compuestos dihidrotiazoles policiclicos, procedimientos para su preparacion, medicamento, procedimiento para la preparacion de dicho medicamento y lautilizacion de dichos compuestos para la preparacion de un medicamento.
CY1112523T1 (el) Υγρες συνθεσεις κανναβινοειδων για χορηγηση σε βλεννογονο
EP1362846A4 (en) AMINOETHANOLDERIVATE
BR0212864A (pt) Derivados de 1,6-naftiridina como antidiabéticos
MX9307781A (es) Derivados de acidos carboxilicos, medicamentos que contienen estos compuestos y procedimientos para su preparacion.
BR0214343A (pt) Inibidores de 11 - beta - hidroxi esteróide desidrogenase tipo 1
BR9810592A (pt) Composto, processos para preparar um composto, para tratar ou prevenir doenças do sistema endócrino e para a fabricação de um medicamento, composição farmacêutica, e, uso de um composto
BRPI0906348A2 (pt) composto representado pela fórmula (1), composição farmacêutica; inibidor pai-1 e medicamento para prevenção para prevenção e/ou tratamento terapêutico de doença causada pela manifestação de pai-1 ou pelo aumento da ação de pai-1
BR0215240A (pt) Derivados de calcona e seu uso no tratamento de doenças
BR9807457A (pt) Composto, sal de hidrocloreto, formulação farmacêutica, uso de um composto, e, processos para a preparação de um composto, para a inibição da secreção de ácido gástrico, para o tratamento de doenças inflamatórias gastrointestinais e para o tratamento ou profilaxia de condições que envolvem infecção por helicobacter pylori da mucosa gástrica humana.
NO20025629D0 (no) Formulering
FI20000172A (fi) Itse-emulgoituvan valmisteen muodossa oleva farmaseuttinen koostumus happamia lipoifiilisia yhdisteitä varten
BR0107958A (pt) Composição farmacêutica contendo pemetrexado juntamente com l-cisteìna monotrioglicerol ou ácido tioglicólico
BR0109012A (pt) Composição farmacêutica, forma de dosagem unitária, solução oral, método para o tratamento da dor, e, método para o tratamento de inflamações
MA29481B1 (fr) Derives d'azolopyridine-2-one en tant qu'inhibiteurs de lipase et de phospholipase
BR0317523A (pt) Processo para a preparação de formulações farmacêuticas de combinação utilizando fluidos supercrìticos
BR0008479A (pt) Agonistas de 5-ht 1f
ATE270T1 (de) Neue n1-benzoyl-n2-phenyl-1,3-diaminopropan-2-ole und ihre salze; verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel.

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A(S) 8A E 9A ANUIDADE(S)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011.