BR0317523A - Processo para a preparação de formulações farmacêuticas de combinação utilizando fluidos supercrìticos - Google Patents
Processo para a preparação de formulações farmacêuticas de combinação utilizando fluidos supercrìticosInfo
- Publication number
- BR0317523A BR0317523A BR0317523-5A BR0317523A BR0317523A BR 0317523 A BR0317523 A BR 0317523A BR 0317523 A BR0317523 A BR 0317523A BR 0317523 A BR0317523 A BR 0317523A
- Authority
- BR
- Brazil
- Prior art keywords
- solution
- preparation
- ingredients
- active
- pharmaceutical formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
"PROCESSO PARA A PREPARAçãO DE FORMULAçõES FARMACêUTICAS DE COMBINAçãO UTILIZANDO FLUIDOS SUPERCRìTICOS". A invenção é direcionada a um processo para a preparação de uma formulação farmacêutica contendo dois ou mais ingredientes farmacêuticos ativos compreendendo: (a) contatar dois ou mais ingredientes farmacêuticos ativos com um fluido supercrítico para formar uma solução em fluido supercrítico; e (b) separar os ingredientes ativos da solução supercrítica para produzir um precipitado em pó. Preferivelmente, a formulação farmacêutica preparada de acordo com a invenção contém uma combinação de dois agentes antiinfecciosos ou dois agentes anticancerígenos. A invenção é direcionada adicionalmente a um processo para preparar uma formulação farmacêutica contendo dois ou mais ingredientes farmacêuticas ativos compreendendo: (a) combinar dois ou mais ingredientes farmacêuticas ativos com um cossolvente para formar uma solução; (b) contatar a solução com um fluido supercrítico; e (c) recuperar o precipitado numa forma de pó.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43505402P | 2002-12-19 | 2002-12-19 | |
PCT/US2003/040608 WO2004056342A1 (en) | 2002-12-19 | 2003-12-19 | Process for preparing combination pharmaceutical formulations using supercritical fluids |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0317523A true BR0317523A (pt) | 2005-11-16 |
Family
ID=32682148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0317523-5A BR0317523A (pt) | 2002-12-19 | 2003-12-19 | Processo para a preparação de formulações farmacêuticas de combinação utilizando fluidos supercrìticos |
Country Status (9)
Country | Link |
---|---|
US (2) | US20040197412A1 (pt) |
EP (1) | EP1572156A1 (pt) |
JP (1) | JP2006516958A (pt) |
CN (1) | CN1726010A (pt) |
AU (2) | AU2003297391B2 (pt) |
BR (1) | BR0317523A (pt) |
CA (1) | CA2510019A1 (pt) |
MX (1) | MXPA05006528A (pt) |
WO (2) | WO2004056341A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050107252A1 (en) * | 2003-11-17 | 2005-05-19 | Gaffney Anne M. | Process for preparing mixed metal oxide catalyst |
CN100336816C (zh) * | 2005-12-14 | 2007-09-12 | 广州大学 | 一种舒巴坦制备方法 |
CN100464750C (zh) * | 2006-02-23 | 2009-03-04 | 珠海联邦制药股份有限公司 | 一种制备含阿莫西林钠和克拉维酸钾的药物混合物的方法 |
WO2011016409A1 (ja) * | 2009-08-05 | 2011-02-10 | 国立大学法人山口大学 | アルコール化合物の製造方法 |
CN104224719A (zh) * | 2013-06-06 | 2014-12-24 | 南京亿华药业有限公司 | 一种头孢地尼干混悬剂及其制备方法 |
WO2015053857A2 (en) * | 2013-10-10 | 2015-04-16 | New York University | Efficient collection of nanoparticles |
CN105030683B (zh) * | 2015-07-06 | 2018-08-10 | 中国药科大学 | 一种超临界流体技术制备依托泊苷超细微粒的方法 |
CN106265542A (zh) * | 2016-09-22 | 2017-01-04 | 北京化工大学 | 一种阿霉素纳米药物颗粒的制备方法 |
CN107714697B (zh) * | 2017-11-08 | 2018-08-07 | 海南通用三洋药业有限公司 | 负载有替卡西林钠克拉维酸钾药物组合物的生物活性植骨材料及其制备方法 |
CN108409821A (zh) * | 2018-03-19 | 2018-08-17 | 青岛国海生物制药有限公司 | 一种醋酸甲地孕酮纳米结晶的制备方法及醋酸甲地孕酮 |
CN111000732A (zh) * | 2020-01-02 | 2020-04-14 | 上海创元化妆品有限公司 | 一种片状或热浇注产品的制备方法 |
CN111973613B (zh) * | 2020-07-30 | 2022-04-08 | 瑞普(天津)生物药业有限公司 | 一种复方大观霉素粉针及其制备方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3744329A1 (de) * | 1987-12-28 | 1989-07-06 | Schwarz Pharma Gmbh | Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung |
US5639441A (en) * | 1992-03-06 | 1997-06-17 | Board Of Regents Of University Of Colorado | Methods for fine particle formation |
GB9313650D0 (en) * | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
GB9313642D0 (en) * | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
GB9413202D0 (en) * | 1994-06-30 | 1994-08-24 | Univ Bradford | Method and apparatus for the formation of particles |
US5757348A (en) * | 1994-12-22 | 1998-05-26 | Displaytech, Inc. | Active matrix liquid crystal image generator with hybrid writing scheme |
GB9703673D0 (en) * | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
GB9810559D0 (en) * | 1998-05-15 | 1998-07-15 | Bradford Particle Design Ltd | Method and apparatus for particle formation |
SE9804001D0 (sv) * | 1998-11-23 | 1998-11-23 | Astra Ab | New process |
GB9915975D0 (en) * | 1999-07-07 | 1999-09-08 | Bradford Particle Design Ltd | Method for the formation of particles |
US6620351B2 (en) * | 2000-05-24 | 2003-09-16 | Auburn University | Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer |
GB0027357D0 (en) * | 2000-11-09 | 2000-12-27 | Bradford Particle Design Plc | Particle formation methods and their products |
GB0102075D0 (en) * | 2001-01-26 | 2001-03-14 | Astrazeneca Ab | Process |
US20030150085A1 (en) * | 2002-02-08 | 2003-08-14 | Lalit Chordia | Manipulation of solvent properties for particle formation |
US20030157031A1 (en) * | 2002-02-08 | 2003-08-21 | Lalit Chordia | Method of and apparatus for forming and administering fine particles |
-
2003
- 2003-12-19 JP JP2004562314A patent/JP2006516958A/ja active Pending
- 2003-12-19 AU AU2003297391A patent/AU2003297391B2/en not_active Ceased
- 2003-12-19 WO PCT/US2003/040515 patent/WO2004056341A1/en not_active Application Discontinuation
- 2003-12-19 AU AU2003297367A patent/AU2003297367A1/en not_active Abandoned
- 2003-12-19 BR BR0317523-5A patent/BR0317523A/pt not_active IP Right Cessation
- 2003-12-19 US US10/743,448 patent/US20040197412A1/en not_active Abandoned
- 2003-12-19 CA CA002510019A patent/CA2510019A1/en not_active Abandoned
- 2003-12-19 CN CNA2003801065728A patent/CN1726010A/zh active Pending
- 2003-12-19 EP EP03813793A patent/EP1572156A1/en not_active Withdrawn
- 2003-12-19 WO PCT/US2003/040608 patent/WO2004056342A1/en active Application Filing
- 2003-12-19 MX MXPA05006528A patent/MXPA05006528A/es active IP Right Grant
- 2003-12-19 US US10/741,225 patent/US20040202681A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1726010A (zh) | 2006-01-25 |
AU2003297391A1 (en) | 2004-07-14 |
AU2003297391B2 (en) | 2010-02-25 |
CA2510019A1 (en) | 2004-07-08 |
WO2004056342A1 (en) | 2004-07-08 |
JP2006516958A (ja) | 2006-07-13 |
EP1572156A1 (en) | 2005-09-14 |
MXPA05006528A (es) | 2006-05-25 |
US20040202681A1 (en) | 2004-10-14 |
WO2004056341A1 (en) | 2004-07-08 |
AU2003297367A1 (en) | 2004-07-14 |
US20040197412A1 (en) | 2004-10-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6827092B2 (ja) | ルリコナゾール含有外用医薬組成物 | |
ES2539655T3 (es) | Composición cosmética líquida que comprende un monoalcohol | |
BR0317523A (pt) | Processo para a preparação de formulações farmacêuticas de combinação utilizando fluidos supercrìticos | |
NO20073059L (no) | 2,3,4,9-tetrahydro-1h-carbazole derivatives as crth2 receptor antagonists | |
BR9814818A (pt) | Métodos de tratamento de cápsulas e formulações farmacêuticas em pó secas | |
EA200900733A1 (ru) | ЗАМЕЩЁННЫЕ ПРОИЗВОДНЫЕ 2,3-ДИГИДРОИМИДАЗО[1,2-c]ХИНАЗОЛИНА, ПОЛЕЗНЫЕ ДЛЯ ЛЕЧЕНИЯ ГИПЕРПРОЛИФЕРАТИВНЫХ НАРУШЕНИЙ И БОЛЕЗНЕЙ, СВЯЗАННЫХ С АНГИОГЕНЕЗОМ | |
ES2187300A1 (es) | Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos. | |
DE60236541D1 (de) | Inhibitoren von 11-beta-hydroxysteroiddehydrogenase typ 1 | |
NO20064584L (no) | Tetrahydropyridoindolderivater | |
DE602005021770D1 (de) | Indol-1-yl-essigsäurederivate | |
BR0307802A (pt) | Formulações farmacêuticas de agentes antineoplásicos, em particular temozolomida, processos de produção e uso das mesmas | |
BR0214553A (pt) | Compostos, processo de preparação, em fase lìquida, dos compostos, e, composições farmacêuticas | |
TNSN07145A1 (fr) | Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique | |
PE20021017A1 (es) | Composicion parenteral reconstituible | |
BR9901782A (pt) | Forma para dosagem de nefazodona. | |
BRPI0417833A (pt) | novos derivados de benzofurano, os quais podem ser usados na profilaxia ou tratamento de distúrbios relacionados com o receptor 5-ht6 | |
BR0008713A (pt) | Processos para preparar formulações ecomposições farmacêuticas orais com ecb | |
NO20034863L (no) | Deutererte 3-piperidinopropiofenon så vel som legemidler som inneholder disse forbindelser | |
ATE549015T1 (de) | Pharmazeutische wirkstoffhaltige formulierung mit überzug | |
BR0109012A (pt) | Composição farmacêutica, forma de dosagem unitária, solução oral, método para o tratamento da dor, e, método para o tratamento de inflamações | |
MXPA04001328A (es) | Productos en combinacion de derivados de 1,4-benzotiepina-1,1-dioxido con otros ingredientes activos, y su uso. | |
FR2756561B1 (fr) | Composes heteroaryles, compositions pharmaceutiques et cosmetiques les contenant et utilisations | |
BR9916919A (pt) | Compósito de sulfonamida e seu uso | |
DK1268522T3 (da) | LH-RH-antagonister samt fremstilling deraf og anvendelse deraf som lægemidler | |
BR0212744A (pt) | Formulações de cisplatina de toxicidade reduzida e métodos para uso das mesmas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08L | Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 9A E 10A ANUIDADES. |
|
B08I | Publication cancelled [chapter 8.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2257 DE 08/04/2014 POR TER SIDO INDEVIDA. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 9A, 10A, 11A, 12A, 13A, 14A, 15A E 16A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |