MXPA05006528A - Proceso para preparar formulaciones farmaceuticas en combinacion utilizando fluidos supercriticos. - Google Patents

Proceso para preparar formulaciones farmaceuticas en combinacion utilizando fluidos supercriticos.

Info

Publication number
MXPA05006528A
MXPA05006528A MXPA05006528A MXPA05006528A MXPA05006528A MX PA05006528 A MXPA05006528 A MX PA05006528A MX PA05006528 A MXPA05006528 A MX PA05006528A MX PA05006528 A MXPA05006528 A MX PA05006528A MX PA05006528 A MXPA05006528 A MX PA05006528A
Authority
MX
Mexico
Prior art keywords
solution
ingredients
pharmaceutical formulations
preparing
active
Prior art date
Application number
MXPA05006528A
Other languages
English (en)
Inventor
Lalit Chordia
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Publication of MXPA05006528A publication Critical patent/MXPA05006528A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invencion se dirige a un proceso para preparar una formulacion farmaceutica que contiene dos o mas ingredientes farmaceuticos activos, que comprende: (a) contactar dos o mas ingredientes farmaceuticos activos con un fluido supercritico para formar una solucion de fluido supercritico; y (b) separar los ingredientes activos de la solucion supercritica para producir un precipitado en polvo. Preferentemente, la formulacion farmaceutica preparada de acuerdo a la invencion contiene una combinacion de dos agentes anti-infecciosos o dos agentes anti-cancer. La invencion esta mas dirigida a un proceso para preparar una formulacion farmaceutica que contiene dos a mas ingredientes farmaceuticos activos, que comprende: (a) combinar dos o mas ingredientes activos con un cosolvente para formar una solucion; (b) contactar la solucion con un fluido supercritico; y (c) recuperar el precipitado en una forma en polvo.
MXPA05006528A 2002-12-19 2003-12-19 Proceso para preparar formulaciones farmaceuticas en combinacion utilizando fluidos supercriticos. MXPA05006528A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43505402P 2002-12-19 2002-12-19
PCT/US2003/040608 WO2004056342A1 (en) 2002-12-19 2003-12-19 Process for preparing combination pharmaceutical formulations using supercritical fluids

Publications (1)

Publication Number Publication Date
MXPA05006528A true MXPA05006528A (es) 2006-05-25

Family

ID=32682148

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05006528A MXPA05006528A (es) 2002-12-19 2003-12-19 Proceso para preparar formulaciones farmaceuticas en combinacion utilizando fluidos supercriticos.

Country Status (9)

Country Link
US (2) US20040197412A1 (es)
EP (1) EP1572156A1 (es)
JP (1) JP2006516958A (es)
CN (1) CN1726010A (es)
AU (2) AU2003297367A1 (es)
BR (1) BR0317523A (es)
CA (1) CA2510019A1 (es)
MX (1) MXPA05006528A (es)
WO (2) WO2004056342A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050107252A1 (en) * 2003-11-17 2005-05-19 Gaffney Anne M. Process for preparing mixed metal oxide catalyst
CN100336816C (zh) * 2005-12-14 2007-09-12 广州大学 一种舒巴坦制备方法
CN100464750C (zh) * 2006-02-23 2009-03-04 珠海联邦制药股份有限公司 一种制备含阿莫西林钠和克拉维酸钾的药物混合物的方法
US8993814B2 (en) * 2009-08-05 2015-03-31 Yamaguchi University Method for producing alcohol compound
CN104224719A (zh) * 2013-06-06 2014-12-24 南京亿华药业有限公司 一种头孢地尼干混悬剂及其制备方法
US20160244547A1 (en) * 2013-10-10 2016-08-25 New York University Efficient collection of nanoparticles
CN105030683B (zh) * 2015-07-06 2018-08-10 中国药科大学 一种超临界流体技术制备依托泊苷超细微粒的方法
CN106265542A (zh) * 2016-09-22 2017-01-04 北京化工大学 一种阿霉素纳米药物颗粒的制备方法
CN107714697B (zh) * 2017-11-08 2018-08-07 海南通用三洋药业有限公司 负载有替卡西林钠克拉维酸钾药物组合物的生物活性植骨材料及其制备方法
CN108409821A (zh) * 2018-03-19 2018-08-17 青岛国海生物制药有限公司 一种醋酸甲地孕酮纳米结晶的制备方法及醋酸甲地孕酮
CN111000732A (zh) * 2020-01-02 2020-04-14 上海创元化妆品有限公司 一种片状或热浇注产品的制备方法
CN111973613B (zh) * 2020-07-30 2022-04-08 瑞普（天津）生物药业有限公司 一种复方大观霉素粉针及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3744329A1 (de) * 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
GB9313650D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
US5757348A (en) * 1994-12-22 1998-05-26 Displaytech, Inc. Active matrix liquid crystal image generator with hybrid writing scheme
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
GB9810559D0 (en) * 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
SE9804001D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New process
GB9915975D0 (en) * 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
US6620351B2 (en) * 2000-05-24 2003-09-16 Auburn University Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer
GB0027357D0 (en) * 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
GB0102075D0 (en) * 2001-01-26 2001-03-14 Astrazeneca Ab Process
US20030157031A1 (en) * 2002-02-08 2003-08-21 Lalit Chordia Method of and apparatus for forming and administering fine particles
US20030150085A1 (en) * 2002-02-08 2003-08-14 Lalit Chordia Manipulation of solvent properties for particle formation

Also Published As

Publication number Publication date
WO2004056342A1 (en) 2004-07-08
US20040197412A1 (en) 2004-10-07
CA2510019A1 (en) 2004-07-08
AU2003297391B2 (en) 2010-02-25
WO2004056341A1 (en) 2004-07-08
AU2003297367A1 (en) 2004-07-14
CN1726010A (zh) 2006-01-25
BR0317523A (pt) 2005-11-16
AU2003297391A1 (en) 2004-07-14
EP1572156A1 (en) 2005-09-14
US20040202681A1 (en) 2004-10-14
JP2006516958A (ja) 2006-07-13

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