BRPI0412457A - composição farmacêutica para aumento da solubilidade de drogas hidrofóbicas - Google Patents
composição farmacêutica para aumento da solubilidade de drogas hidrofóbicasInfo
- Publication number
- BRPI0412457A BRPI0412457A BRPI0412457-0A BRPI0412457A BRPI0412457A BR PI0412457 A BRPI0412457 A BR PI0412457A BR PI0412457 A BRPI0412457 A BR PI0412457A BR PI0412457 A BRPI0412457 A BR PI0412457A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- solubility
- increasing
- polyethylene glycol
- hydrophobic drugs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"COMPOSIçãO FARMACêUTICA PARA AUMENTO DA SOLUBILIDADE DE DROGAS HIDROFóBICAS". A presente invenção fornece uma composição farmacêutica contendo uma droga e polietileno glicol, na qual a razão em peso de polietileno glicol para a droga é de cerca de 0,2:1 a cerca de 10:1 e o polietileno glicol tem um ponto de fusão de pelo menos 37<198>C. As composições farmacêuticas da invenção exibem rápida dissolução em contato com solventes fisiológicos, tais como água, saliva ou fluidos gastrointestinais.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/618,545 US20050008704A1 (en) | 2003-07-11 | 2003-07-11 | Pharmaceutical composition for solubility enhancement of hydrophobic drugs |
PCT/EP2004/007585 WO2005004917A2 (en) | 2003-07-11 | 2004-07-09 | Pharmaceutical composition for solubility enhancement of hydrophobic drugs |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0412457A true BRPI0412457A (pt) | 2006-10-17 |
Family
ID=33565153
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0412457-0A BRPI0412457A (pt) | 2003-07-11 | 2004-07-09 | composição farmacêutica para aumento da solubilidade de drogas hidrofóbicas |
Country Status (10)
Country | Link |
---|---|
US (1) | US20050008704A1 (pt) |
EP (1) | EP1646403A2 (pt) |
CN (1) | CN1856297A (pt) |
AR (1) | AR045906A1 (pt) |
AU (1) | AU2004255459A1 (pt) |
BR (1) | BRPI0412457A (pt) |
CA (1) | CA2529606A1 (pt) |
MX (1) | MXPA06000445A (pt) |
RU (1) | RU2006104025A (pt) |
WO (1) | WO2005004917A2 (pt) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7259186B2 (en) * | 2002-12-17 | 2007-08-21 | Abbott Laboratories | Salts of fenofibric acid and pharmaceutical formulations thereof |
US20080051411A1 (en) * | 2002-12-17 | 2008-02-28 | Cink Russell D | Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof |
CN100473378C (zh) * | 2002-12-17 | 2009-04-01 | 阿伯特有限及两合公司 | 包含非诺贝酸、其生理可接受的盐或衍生物的制剂 |
US20040253308A1 (en) * | 2003-04-29 | 2004-12-16 | Barr Laboratories, Inc. | Surface-treated modafinil particles |
CA2540984C (en) | 2003-10-10 | 2011-02-08 | Lifecycle Pharma A/S | A solid dosage form comprising a fibrate |
US20080152714A1 (en) * | 2005-04-08 | 2008-06-26 | Yi Gao | Pharmaceutical Formulations |
EA015155B1 (ru) | 2005-05-26 | 2011-06-30 | Тева Вуменс Хелс, Инк. | Дозированные формы для перорального применения, содержащие прогестерон, и способы их изготовления и использования |
AU2007272501A1 (en) * | 2006-07-12 | 2008-01-17 | Elan Pharma International Limited | Nanoparticulate formulations of modafinil |
EP2051696A2 (en) * | 2006-08-18 | 2009-04-29 | Morton Grove Pharmaceuticals, Inc. | Stable liquid levetiracetam compositions and methods |
US7607596B1 (en) | 2007-03-07 | 2009-10-27 | Exxpharma, LLC | Process for enhancing the solubility of poorly soluble drugs |
US8173169B2 (en) | 2007-07-11 | 2012-05-08 | Hikma Pharmaceuticals | Formulation and process for the preparation of modafinil |
ITMI20071616A1 (it) | 2007-08-03 | 2009-02-04 | Cosmo Spa | Processo enzimatico per l'ottenimento di 17-alfa monoesteri del cortexolone e/o suoi 9,11-deidroderivati. |
EP2200613B1 (en) | 2007-09-21 | 2018-09-05 | The Johns Hopkins University | Phenazine derivatives and uses thereof |
US20090155325A1 (en) * | 2007-12-14 | 2009-06-18 | Kimberly-Clark Worldwide, Inc. | Formulation and products for promoting skin cleanliness and health |
AT10562U3 (de) * | 2008-12-05 | 2010-01-15 | Aop Orphan Pharmaceuticals Ag | Neuartige zusammensetzung zur behandlung einer essenziellen thrombozytämie |
DE102011010437A1 (de) * | 2011-02-04 | 2012-08-09 | J. Rettenmaier & Söhne Gmbh + Co. Kg | Tablettierhilfsmittel |
CN102321048A (zh) * | 2011-06-13 | 2012-01-18 | 中国药科大学 | 糖精瑞格列奈无定形物 |
FR2987265B1 (fr) | 2012-02-28 | 2014-02-28 | Debregeas Et Associes Pharma | Composition pharmaceutique sous forme de sirop a base de modafinil, son procede de fabrication et son application |
EP2897590A4 (en) * | 2012-09-20 | 2016-05-04 | Ipca Lab Ltd | PHARMACEUTICAL COMPOSITION |
CN103006570B (zh) * | 2012-10-08 | 2013-12-25 | 孙维会 | 一种阿佐昔芬速释微丸及其制备方法 |
ES2549106T3 (es) * | 2014-03-07 | 2021-12-21 | Galenicum Health S L U | Composiciones farmacéuticas que comprenden anagrelida |
CN103830197A (zh) * | 2014-03-14 | 2014-06-04 | 崔书豪 | 一种盐酸雷洛昔芬分散片及其制备方法 |
EP3307248A1 (en) * | 2015-06-10 | 2018-04-18 | Disphar International B.V. | Improved pharmaceutical formulation |
EP3108879A1 (en) | 2015-06-25 | 2016-12-28 | Cassiopea S.p.A. | High concentration formulation |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
CA3020153A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
EP3576718B1 (en) * | 2017-02-01 | 2021-07-14 | Johnson & Johnson Consumer Inc. | A lozenge |
TWI661841B (zh) * | 2017-04-19 | 2019-06-11 | 三凡生技研發股份有限公司 | 用於分散疏水性植物萃取物之載劑 |
KR20230035601A (ko) * | 2020-07-07 | 2023-03-14 | 에이티엑스에이 테라퓨틱스 리미티드 | 트롬복산 수용체 길항제 제제 |
CN114306253B (zh) * | 2021-11-16 | 2023-08-22 | 扬子江药业集团广州海瑞药业有限公司 | 格列美脲片剂及其制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5811120A (en) * | 1994-03-02 | 1998-09-22 | Eli Lilly And Company | Solid orally administerable raloxifene hydrochloride pharmaceutical formulation |
CA2143263C (en) * | 1994-03-02 | 2002-01-08 | Kerry John Hartauer | Orally administrable raloxifene formulations |
NZ333839A (en) * | 1996-08-28 | 2001-06-29 | Lilly Co Eli | Amorphous benzothiophenes |
US6395300B1 (en) * | 1999-05-27 | 2002-05-28 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
US6919378B2 (en) * | 2000-10-11 | 2005-07-19 | Cephalon, Inc. | Pharmaceutical solutions of modafinil compounds |
-
2003
- 2003-07-11 US US10/618,545 patent/US20050008704A1/en not_active Abandoned
-
2004
- 2004-07-09 CN CNA2004800193032A patent/CN1856297A/zh active Pending
- 2004-07-09 WO PCT/EP2004/007585 patent/WO2005004917A2/en not_active Application Discontinuation
- 2004-07-09 BR BRPI0412457-0A patent/BRPI0412457A/pt not_active Application Discontinuation
- 2004-07-09 AU AU2004255459A patent/AU2004255459A1/en not_active Abandoned
- 2004-07-09 CA CA002529606A patent/CA2529606A1/en not_active Abandoned
- 2004-07-09 MX MXPA06000445A patent/MXPA06000445A/es not_active Application Discontinuation
- 2004-07-09 EP EP04740864A patent/EP1646403A2/en not_active Withdrawn
- 2004-07-09 RU RU2006104025/15A patent/RU2006104025A/ru unknown
- 2004-07-12 AR ARP040102452A patent/AR045906A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AR045906A1 (es) | 2005-11-16 |
CN1856297A (zh) | 2006-11-01 |
RU2006104025A (ru) | 2007-08-27 |
WO2005004917A3 (en) | 2006-03-16 |
US20050008704A1 (en) | 2005-01-13 |
MXPA06000445A (es) | 2006-04-05 |
WO2005004917A2 (en) | 2005-01-20 |
EP1646403A2 (en) | 2006-04-19 |
CA2529606A1 (en) | 2005-01-20 |
AU2004255459A1 (en) | 2005-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |