BR0208457A - Sìntese enzimática de ésteres de n(alfa)-acil-l-arginina - Google Patents

Sìntese enzimática de ésteres de n(alfa)-acil-l-arginina

Info

Publication number
BR0208457A
BR0208457A BR0208457-0A BR0208457A BR0208457A BR 0208457 A BR0208457 A BR 0208457A BR 0208457 A BR0208457 A BR 0208457A BR 0208457 A BR0208457 A BR 0208457A
Authority
BR
Brazil
Prior art keywords
acyl
acid
alkyl chain
papain
protease
Prior art date
Application number
BR0208457-0A
Other languages
English (en)
Other versions
BRPI0208457B1 (pt
Inventor
Xavier Rocabayera Bonvila
Joan Seguer Bonaventura
Original Assignee
Miret Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miret Lab filed Critical Miret Lab
Publication of BR0208457A publication Critical patent/BR0208457A/pt
Publication of BRPI0208457B1 publication Critical patent/BRPI0208457B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/10—Citrulline; Arginine; Ornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"SìNTESE ENZIMáTICA DE éSTERES DE N^ ALFA^-ACIL-L-ARGININA". A invenção refere-se a um processo para a preparação de um éster de N^ <244>^-acil-L-arginina, derivado de ácidos graxos e aminoácidos dibásicos esterificados, de acordo com a seguinte fórmula: em que: X^ -^ é Br^ -^, CI^ -^ ou HSO~ 4~^ -^; R~ 1~: é uma cadeia de alquila linear de um ácído graxo saturado, ou hidroxiácido de 8 a 14 átomos de carbono, ligada ao grupo de <244>-aminoácido por meio de uma ligação amídica; R~ 2~ é uma cadeia de alquila linear ou ramificada de 1 a 18 átomos de carbono, ou aromática; R~ 3~: é em que n pode ser de 0 a 4, a partir do ácido orgânico e álcool adequados. O processo é catalisado por uma hidrolase, particularmente, uma protease, a protease papaína de "Carica papaya" sendo altamente adequada. Para que a reação de esterificação funcione adequadamente, o processo é conduzido em meio orgânico de baixo teor de água. Quando a papaína altamente solúvel de "Carica papaya" é usada, uma atividade de água entre 0,03 e 0,5 é selecionada.
BRPI0208457-0A 2002-02-01 2002-02-01 Processo para a preparação de um éster de n(alfa)-acil-l-arginina derivado de ácidos graxos e aminoácidos dibásicos esterificados BRPI0208457B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2002/001070 WO2003064669A1 (en) 2002-02-01 2002-02-01 ENZYMATIC SYNTHESIS OF Nα-ACYL-L-ARGININE ESTERS

Publications (2)

Publication Number Publication Date
BR0208457A true BR0208457A (pt) 2004-03-02
BRPI0208457B1 BRPI0208457B1 (pt) 2015-06-16

Family

ID=27635750

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0208457-0A BRPI0208457B1 (pt) 2002-02-01 2002-02-01 Processo para a preparação de um éster de n(alfa)-acil-l-arginina derivado de ácidos graxos e aminoácidos dibásicos esterificados

Country Status (11)

Country Link
US (1) US7399616B2 (pt)
EP (1) EP1470234B1 (pt)
AT (1) ATE408702T1 (pt)
BR (1) BRPI0208457B1 (pt)
CA (1) CA2471896C (pt)
DE (1) DE60229000D1 (pt)
DK (1) DK1470234T3 (pt)
ES (1) ES2314037T3 (pt)
MX (1) MXPA04007277A (pt)
PT (1) PT1470234E (pt)
WO (1) WO2003064669A1 (pt)

Families Citing this family (15)

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FR2856298B1 (fr) 2003-06-19 2007-08-17 Expanscience Lab Extrait de maca et composition cosmetique comprenant un tel extrait
US10130830B2 (en) 2005-08-01 2018-11-20 Laboratorios Miret, S.A. Preservative systems comprising cationic surfactants
US20100305055A1 (en) 2007-09-13 2010-12-02 Laboratorios Miret, S.A. Combinations of polyene fungicide with cationic surfactants
US8675573B2 (en) * 2008-05-05 2014-03-18 Qualcomm Incorporated Uplink resource management in a wireless communication system
WO2010000744A2 (en) 2008-07-02 2010-01-07 Laboratorios Miret, S.A. Use of cationic surfactants as sporicidal agents
WO2010084052A2 (en) 2009-01-22 2010-07-29 Laboratorios Miret, S. A. Use of cationic surfactants as acaricidal agents
US9284265B1 (en) 2009-12-02 2016-03-15 Vishwas Sadhu Ghare Preparation of organic acid salts of cationic surfactants
US8212061B1 (en) 2009-12-02 2012-07-03 Vishwas Sadhu Ghare Preparation of organic acid salts of cationic surfactants
US20130053422A1 (en) 2010-03-23 2013-02-28 Sarah L. Edmonds Antimicrobial Compositions
WO2012013577A1 (en) 2010-07-26 2012-02-02 Laboratorios Miret, S.A. Composition for coating medical devices containing lae and a polycationic amphoteric polymer
WO2012177433A1 (en) 2011-06-21 2012-12-27 Evologie Llc Topical compositions for the treatment of dermatological disorders
US10218483B2 (en) * 2015-09-25 2019-02-26 Qualcomm Incorporated Systems and methods for signaling and generating variable length block acknowledgment fields in a wireless network
US10652248B2 (en) * 2016-07-28 2020-05-12 Molecula Corp. Systems and methods of managing data rights and selective data sharing
CN107286059A (zh) * 2017-05-19 2017-10-24 武汉桀升生物科技有限公司 一种月桂酰精氨酸乙酯盐酸盐的制备方法
EP4114381A2 (en) 2020-12-08 2023-01-11 Laboratorios Miret, S.A. Cationic surfactants, in particular ethyl lauroyl arginate lae®, for treating or preventing infections and contaminations with coronavirus

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JPS5839651A (ja) 1981-09-04 1983-03-08 Ajinomoto Co Inc 新規ジアミノモノカルボン酸誘導体及びこれを活性成分とする界面活性剤
JPS59164704A (ja) 1983-03-09 1984-09-17 Lion Corp 防腐防カビ剤
US5336515A (en) 1989-06-15 1994-08-09 Kraft General Foods, Inc. Polysaccharide hydrocolloid-containing food products
JPH03291211A (ja) 1990-04-09 1991-12-20 Lion Corp 毛髪化粧料
JPH0684294B2 (ja) 1990-05-29 1994-10-26 サンスター株式会社 口腔用組成物
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Also Published As

Publication number Publication date
BRPI0208457B1 (pt) 2015-06-16
ES2314037T3 (es) 2009-03-16
DK1470234T3 (da) 2009-01-05
US20060003427A1 (en) 2006-01-05
MXPA04007277A (es) 2004-10-29
ATE408702T1 (de) 2008-10-15
WO2003064669A1 (en) 2003-08-07
CA2471896A1 (en) 2003-08-07
EP1470234B1 (en) 2008-09-17
EP1470234A1 (en) 2004-10-27
DE60229000D1 (de) 2008-10-30
PT1470234E (pt) 2008-11-10
US7399616B2 (en) 2008-07-15
CA2471896C (en) 2011-05-03

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C12P 13/04 , C12P 13/08 , C12P 13/10 , C12P 13/24

Ipc: C12P 13/04 (2006.01), C12P 13/08 (2006.01), C12P 1

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/06/2015, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2499 DE 27-11-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.