BR0110474A - Métodos para remover células neoplásticas mediadas por ras de uma composição celular, para preparar uma composição celular para transplante em um receptor e para reduzir um risco de recorrência de tumor, e, composição celular - Google Patents
Métodos para remover células neoplásticas mediadas por ras de uma composição celular, para preparar uma composição celular para transplante em um receptor e para reduzir um risco de recorrência de tumor, e, composição celularInfo
- Publication number
- BR0110474A BR0110474A BR0110474-8A BR0110474A BR0110474A BR 0110474 A BR0110474 A BR 0110474A BR 0110474 A BR0110474 A BR 0110474A BR 0110474 A BR0110474 A BR 0110474A
- Authority
- BR
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- Prior art keywords
- cell composition
- neoplastic cells
- recipient
- risk
- reducing
- Prior art date
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
- C12N5/0093—Purging against cancer cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/765—Reovirus; Rotavirus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N15/86—Viral vectors
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12211—Orthoreovirus, e.g. mammalian orthoreovirus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12211—Orthoreovirus, e.g. mammalian orthoreovirus
- C12N2720/12232—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12211—Orthoreovirus, e.g. mammalian orthoreovirus
- C12N2720/12241—Use of virus, viral particle or viral elements as a vector
- C12N2720/12243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
"MéTODOS PARA REMOVER CéLULAS NEOPLáSTICAS MEDIADAS POR RAS DE UMA COMPOSIçãO CELULAR, PARA PREPARAR UMA COMPOSIçãO CELULAR PARA TRANSPLANTE EM UM RECEPTOR E PARA REDUZIR UM RISCO DE RECORRêNCIA DE TUMOR, E, COMPOSIçãO CELULAR". O reovírus pode ser usado para remover seletivamente células neoplásticas mediadas por ras de uma composição celular. E de interesse particular purgar auto-enxertos que podem conter células neoplásticas com reovírus antes de transplantar os auto-enxertos de volta ao receptor, reduzindo deste modo o risco de introduzir ou reintroduzir células neoplásticas no receptor.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20199000P | 2000-05-03 | 2000-05-03 | |
US20538900P | 2000-05-19 | 2000-05-19 | |
US26805401P | 2001-02-13 | 2001-02-13 | |
PCT/CA2001/000620 WO2001083711A2 (en) | 2000-05-03 | 2001-05-02 | Clearance of ras-mediated neoplastic cells from mixed cellular compositions using reovirus |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0110474A true BR0110474A (pt) | 2003-04-01 |
Family
ID=27394375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0110474-8A BR0110474A (pt) | 2000-05-03 | 2001-05-02 | Métodos para remover células neoplásticas mediadas por ras de uma composição celular, para preparar uma composição celular para transplante em um receptor e para reduzir um risco de recorrência de tumor, e, composição celular |
Country Status (15)
Country | Link |
---|---|
US (5) | US6994858B2 (pt) |
EP (2) | EP2239321A1 (pt) |
JP (3) | JP2003531606A (pt) |
AR (1) | AR028039A1 (pt) |
AT (1) | ATE474040T1 (pt) |
AU (2) | AU5808601A (pt) |
BR (1) | BR0110474A (pt) |
CA (1) | CA2407894C (pt) |
DE (1) | DE60142559D1 (pt) |
DK (1) | DK1278824T3 (pt) |
ES (1) | ES2346182T3 (pt) |
IL (2) | IL152390A (pt) |
MX (1) | MXPA02010744A (pt) |
NZ (1) | NZ522179A (pt) |
WO (1) | WO2001083711A2 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6136307A (en) | 1997-08-13 | 2000-10-24 | Oncolytics Biotech Inc. | Reovirus for the treatment of cellular proliferative disorders |
US6110461A (en) * | 1997-08-13 | 2000-08-29 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
US7306902B2 (en) * | 2002-06-28 | 2007-12-11 | Oncolyties Biotech Inc. | Oncolytic viruses as phenotyping agents for neoplasms |
US8491884B2 (en) | 2000-05-03 | 2013-07-23 | Oncolytics Biotech Inc. | Virus clearance of neoplastic cells from mixed cellular compositions |
AR028040A1 (es) * | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | Remocion de virus de celulas neoplasticas a partir de composiciones celulares mixtas |
AR028039A1 (es) * | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | Remocion de reovirus de celulas neoplasticas intermediadas por ras a partir de composiciones celulares mixtas |
JP5208343B2 (ja) | 2000-06-26 | 2013-06-12 | ウェルスタット バイオロジクス コーポレイション | ウイルスを用いる細胞の浄化 |
TWI289158B (en) | 2000-08-10 | 2007-11-01 | Oncolytics Biotech Inc | Method of producing infectious reovirus |
US20050214266A1 (en) * | 2004-03-12 | 2005-09-29 | Oncolytics Biotech Inc. | Combination of transplantation and oncolytic virus treatment |
US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
WO2007099401A2 (en) | 2005-08-01 | 2007-09-07 | University Technologies International, Inc. | Oncolytic attenuated reoviruses for treatment of proliferative disorders |
US10369171B2 (en) * | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
US20160306006A1 (en) * | 2015-04-16 | 2016-10-20 | HGST, Inc. | Self-testing a storage device via system management bus interface |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1221307A (en) * | 1982-12-02 | 1987-05-05 | Nobutaka Tani | Adsorbent and process for preparing the same |
US5637677A (en) * | 1987-07-16 | 1997-06-10 | The Trustees Of The University Of Pennsylvania | Biologically active compounds and methods of constructing and using the same |
US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
AU2593192A (en) * | 1992-09-14 | 1994-04-12 | Oystein Fodstad | Detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations |
PT931830E (pt) | 1993-02-16 | 2001-08-30 | Onyx Pharma Inc | Virus citopaticos para terapia e profilaxia de neoplasia |
US5846945A (en) | 1993-02-16 | 1998-12-08 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
DK1486211T3 (da) | 1993-04-30 | 2009-01-19 | Wellstat Biologics Corp | Sammensætninger til behandling af cancer ved anvendelse af vira |
WO1995016464A1 (en) * | 1993-12-14 | 1995-06-22 | Johns Hopkins University School Of Medicine | Controlled release of pharmaceutically active substances for immunotherapy |
US5514340A (en) | 1994-01-24 | 1996-05-07 | Magnetix Biotechnology, Inc. | Device for separating magnetically labelled cells |
WO1995032300A1 (en) | 1994-05-23 | 1995-11-30 | University Of Medicine & Dentistry Of New Jersey | Selective biological destruction of tumor cells |
US5585096A (en) | 1994-06-23 | 1996-12-17 | Georgetown University | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
US5840502A (en) * | 1994-08-31 | 1998-11-24 | Activated Cell Therapy, Inc. | Methods for enriching specific cell-types by density gradient centrifugation |
US6110461A (en) | 1997-08-13 | 2000-08-29 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
US6136307A (en) | 1997-08-13 | 2000-10-24 | Oncolytics Biotech Inc. | Reovirus for the treatment of cellular proliferative disorders |
AU9603898A (en) | 1997-10-09 | 1999-05-03 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
US20030044384A1 (en) | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
US7780962B2 (en) | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
US6475481B2 (en) | 1997-11-18 | 2002-11-05 | Canji Inc | Purging of stem cell products |
EP1061806A4 (en) | 1998-03-12 | 2001-09-12 | Univ Pennsylvania | PRODUCTIVE CELLS FOR REPLICATION-SELECTIVE VIRUSES FOR TREATING Vicious DISEASES |
DE69929986T2 (de) | 1998-08-31 | 2006-10-19 | Ambrus, Julian L. | Verfahren zur entfernung von hiv und anderen viren aus blut |
CA2720361A1 (en) | 1999-11-12 | 2001-05-25 | Oncolytics Biotech, Inc. | Viruses for the treatment of cellular proliferative disorders |
AR028040A1 (es) | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | Remocion de virus de celulas neoplasticas a partir de composiciones celulares mixtas |
AR028039A1 (es) * | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | Remocion de reovirus de celulas neoplasticas intermediadas por ras a partir de composiciones celulares mixtas |
JP5208343B2 (ja) | 2000-06-26 | 2013-06-12 | ウェルスタット バイオロジクス コーポレイション | ウイルスを用いる細胞の浄化 |
-
2001
- 2001-04-25 AR ARP010101936A patent/AR028039A1/es unknown
- 2001-05-02 IL IL152390A patent/IL152390A/en active IP Right Grant
- 2001-05-02 DE DE60142559T patent/DE60142559D1/de not_active Expired - Lifetime
- 2001-05-02 CA CA002407894A patent/CA2407894C/en not_active Expired - Lifetime
- 2001-05-02 BR BR0110474-8A patent/BR0110474A/pt not_active Application Discontinuation
- 2001-05-02 EP EP10007121A patent/EP2239321A1/en not_active Withdrawn
- 2001-05-02 AU AU5808601A patent/AU5808601A/xx active Pending
- 2001-05-02 NZ NZ522179A patent/NZ522179A/en unknown
- 2001-05-02 JP JP2001580320A patent/JP2003531606A/ja active Pending
- 2001-05-02 WO PCT/CA2001/000620 patent/WO2001083711A2/en active Application Filing
- 2001-05-02 EP EP01931251A patent/EP1278824B1/en not_active Expired - Lifetime
- 2001-05-02 AT AT01931251T patent/ATE474040T1/de not_active IP Right Cessation
- 2001-05-02 AU AU2001258086A patent/AU2001258086B2/en not_active Expired
- 2001-05-02 DK DK01931251.1T patent/DK1278824T3/da active
- 2001-05-02 MX MXPA02010744A patent/MXPA02010744A/es active IP Right Grant
- 2001-05-02 ES ES01931251T patent/ES2346182T3/es not_active Expired - Lifetime
- 2001-05-03 US US09/847,356 patent/US6994858B2/en not_active Expired - Lifetime
-
2005
- 2005-09-26 US US11/236,059 patent/US7431932B2/en not_active Expired - Lifetime
-
2007
- 2007-05-30 US US11/807,930 patent/US7727534B2/en not_active Expired - Lifetime
-
2008
- 2008-07-23 JP JP2008190310A patent/JP2008278897A/ja active Pending
- 2008-08-25 IL IL193659A patent/IL193659A/en active IP Right Grant
-
2010
- 2010-03-17 US US12/726,002 patent/US8147845B2/en not_active Expired - Fee Related
- 2010-08-13 JP JP2010181396A patent/JP2010260875A/ja active Pending
-
2012
- 2012-02-29 US US13/408,478 patent/US8512712B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20080032279A1 (en) | 2008-02-07 |
WO2001083711A3 (en) | 2002-05-10 |
IL193659A (en) | 2012-04-30 |
US7727534B2 (en) | 2010-06-01 |
IL152390A (en) | 2009-02-11 |
NZ522179A (en) | 2004-11-26 |
DK1278824T3 (da) | 2010-08-23 |
CA2407894A1 (en) | 2001-11-08 |
US20060029598A1 (en) | 2006-02-09 |
AR028039A1 (es) | 2003-04-23 |
US7431932B2 (en) | 2008-10-07 |
EP1278824B1 (en) | 2010-07-14 |
IL193659A0 (en) | 2009-05-04 |
EP1278824A2 (en) | 2003-01-29 |
ES2346182T3 (es) | 2010-10-13 |
CA2407894C (en) | 2009-03-24 |
JP2008278897A (ja) | 2008-11-20 |
WO2001083711A2 (en) | 2001-11-08 |
US6994858B2 (en) | 2006-02-07 |
US20100248205A1 (en) | 2010-09-30 |
DE60142559D1 (de) | 2010-08-26 |
AU5808601A (en) | 2001-11-12 |
US20120225045A1 (en) | 2012-09-06 |
AU2001258086B2 (en) | 2006-08-24 |
ATE474040T1 (de) | 2010-07-15 |
IL152390A0 (en) | 2003-05-29 |
US8147845B2 (en) | 2012-04-03 |
JP2003531606A (ja) | 2003-10-28 |
US20020006398A1 (en) | 2002-01-17 |
EP2239321A1 (en) | 2010-10-13 |
US8512712B2 (en) | 2013-08-20 |
MXPA02010744A (es) | 2003-05-14 |
JP2010260875A (ja) | 2010-11-18 |
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