WO2003001981A3 - Method of promoting engraftment of a donor transplant in a recipient host - Google Patents

Method of promoting engraftment of a donor transplant in a recipient host Download PDF

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Publication number
WO2003001981A3
WO2003001981A3 PCT/US2002/020550 US0220550W WO03001981A3 WO 2003001981 A3 WO2003001981 A3 WO 2003001981A3 US 0220550 W US0220550 W US 0220550W WO 03001981 A3 WO03001981 A3 WO 03001981A3
Authority
WO
WIPO (PCT)
Prior art keywords
recipient host
donor
donor transplant
transplant
engraftment
Prior art date
Application number
PCT/US2002/020550
Other languages
French (fr)
Other versions
WO2003001981A2 (en
Inventor
William J Murphy
Crystal Koh
Michael D Bennett
Francois Romagne
Original Assignee
Us Gov Health & Human Serv
William J Murphy
Crystal Koh
Michael D Bennett
Francois Romagne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, William J Murphy, Crystal Koh, Michael D Bennett, Francois Romagne filed Critical Us Gov Health & Human Serv
Priority to AU2002316448A priority Critical patent/AU2002316448A1/en
Publication of WO2003001981A2 publication Critical patent/WO2003001981A2/en
Publication of WO2003001981A3 publication Critical patent/WO2003001981A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4613—Natural-killer cells [NK or NK-T]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46434—Antigens related to induction of tolerance to non-self
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere

Abstract

A method of promoting engraftment of a donor transplant in a recipient host, comprising adoptive transfer to the recipient host donor natural killer (NK) cells, which have been treated ex vivo to interfere with the ability of inhibitory receptors on the donor NK cells to interact with major histocompatibility complex molecules in the recipient host, simultaneously with, or sequentially to, in either order, the donor transplant, whereupon the engraftment of the donor transplant in the recipient host is promoted.
PCT/US2002/020550 2001-06-29 2002-06-28 Method of promoting engraftment of a donor transplant in a recipient host WO2003001981A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002316448A AU2002316448A1 (en) 2001-06-29 2002-06-28 Method of promoting engraftment of a donor transplant in a recipient host

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30225801P 2001-06-29 2001-06-29
US60/302,258 2001-06-29

Publications (2)

Publication Number Publication Date
WO2003001981A2 WO2003001981A2 (en) 2003-01-09
WO2003001981A3 true WO2003001981A3 (en) 2003-11-27

Family

ID=23166967

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/020550 WO2003001981A2 (en) 2001-06-29 2002-06-28 Method of promoting engraftment of a donor transplant in a recipient host

Country Status (2)

Country Link
AU (1) AU2002316448A1 (en)
WO (1) WO2003001981A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9179319B2 (en) 2005-06-16 2015-11-03 Qualcomm Incorporated Adaptive sectorization in cellular systems
US9184870B2 (en) 2005-04-01 2015-11-10 Qualcomm Incorporated Systems and methods for control channel signaling
US9408220B2 (en) 2005-04-19 2016-08-02 Qualcomm Incorporated Channel quality reporting for adaptive sectorization

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US9130810B2 (en) 2000-09-13 2015-09-08 Qualcomm Incorporated OFDM communications methods and apparatus
US7295509B2 (en) 2000-09-13 2007-11-13 Qualcomm, Incorporated Signaling method in an OFDM multiple access system
US9137822B2 (en) 2004-07-21 2015-09-15 Qualcomm Incorporated Efficient signaling over access channel
US9246560B2 (en) 2005-03-10 2016-01-26 Qualcomm Incorporated Systems and methods for beamforming and rate control in a multi-input multi-output communication systems
US9154211B2 (en) 2005-03-11 2015-10-06 Qualcomm Incorporated Systems and methods for beamforming feedback in multi antenna communication systems
US8446892B2 (en) 2005-03-16 2013-05-21 Qualcomm Incorporated Channel structures for a quasi-orthogonal multiple-access communication system
US9143305B2 (en) 2005-03-17 2015-09-22 Qualcomm Incorporated Pilot signal transmission for an orthogonal frequency division wireless communication system
US9461859B2 (en) 2005-03-17 2016-10-04 Qualcomm Incorporated Pilot signal transmission for an orthogonal frequency division wireless communication system
US9520972B2 (en) 2005-03-17 2016-12-13 Qualcomm Incorporated Pilot signal transmission for an orthogonal frequency division wireless communication system
US9036538B2 (en) 2005-04-19 2015-05-19 Qualcomm Incorporated Frequency hopping design for single carrier FDMA systems
US8879511B2 (en) 2005-10-27 2014-11-04 Qualcomm Incorporated Assignment acknowledgement for a wireless communication system
US8565194B2 (en) 2005-10-27 2013-10-22 Qualcomm Incorporated Puncturing signaling channel for a wireless communication system
US8885628B2 (en) 2005-08-08 2014-11-11 Qualcomm Incorporated Code division multiplexing in a single-carrier frequency division multiple access system
US9209956B2 (en) 2005-08-22 2015-12-08 Qualcomm Incorporated Segment sensitive scheduling
US9136974B2 (en) 2005-08-30 2015-09-15 Qualcomm Incorporated Precoding and SDMA support
US9088384B2 (en) 2005-10-27 2015-07-21 Qualcomm Incorporated Pilot symbol transmission in wireless communication systems
US9225416B2 (en) 2005-10-27 2015-12-29 Qualcomm Incorporated Varied signaling channels for a reverse link in a wireless communication system
US9144060B2 (en) 2005-10-27 2015-09-22 Qualcomm Incorporated Resource allocation for shared signaling channels
US9225488B2 (en) 2005-10-27 2015-12-29 Qualcomm Incorporated Shared signaling channel
US8693405B2 (en) 2005-10-27 2014-04-08 Qualcomm Incorporated SDMA resource management
US9172453B2 (en) 2005-10-27 2015-10-27 Qualcomm Incorporated Method and apparatus for pre-coding frequency division duplexing system
US8477684B2 (en) 2005-10-27 2013-07-02 Qualcomm Incorporated Acknowledgement of control messages in a wireless communication system
US9210651B2 (en) 2005-10-27 2015-12-08 Qualcomm Incorporated Method and apparatus for bootstraping information in a communication system
US8582548B2 (en) 2005-11-18 2013-11-12 Qualcomm Incorporated Frequency division multiple access schemes for wireless communication

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038543A1 (en) * 1995-04-20 1996-12-05 Diacrin, Incorporated Modified cells and methods for inhibiting xenograft rejection
US5800539A (en) * 1995-11-08 1998-09-01 Emory University Method of allogeneic hematopoietic stem cell transplantation without graft failure or graft vs. host disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038543A1 (en) * 1995-04-20 1996-12-05 Diacrin, Incorporated Modified cells and methods for inhibiting xenograft rejection
US5800539A (en) * 1995-11-08 1998-09-01 Emory University Method of allogeneic hematopoietic stem cell transplantation without graft failure or graft vs. host disease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KOH C. ET AL.: "Adoptive cellular immunotherapy: NK cells and bone marrow transplantation", HISTOLOGY AND HISTOPATHOLOGY, vol. 15, 2000, pages 1201 - 1210, XP002959292 *
MURPHY W. ET AL.: "Immunobiology of natural killer cells and bone marrow transplantation: merging of basic and preclinical studies", IMMUNOLOGICAL REVIEWS, vol. 181, 2001, pages 279 - 289, XP002959291 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9184870B2 (en) 2005-04-01 2015-11-10 Qualcomm Incorporated Systems and methods for control channel signaling
US9408220B2 (en) 2005-04-19 2016-08-02 Qualcomm Incorporated Channel quality reporting for adaptive sectorization
US9179319B2 (en) 2005-06-16 2015-11-03 Qualcomm Incorporated Adaptive sectorization in cellular systems

Also Published As

Publication number Publication date
AU2002316448A1 (en) 2003-03-03
WO2003001981A2 (en) 2003-01-09

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