BR0109453A - Processo de purificação de éster cìclico dimérico, composição de suspensão de cristais e composição de torta úmida - Google Patents
Processo de purificação de éster cìclico dimérico, composição de suspensão de cristais e composição de torta úmidaInfo
- Publication number
- BR0109453A BR0109453A BR0109453-0A BR0109453A BR0109453A BR 0109453 A BR0109453 A BR 0109453A BR 0109453 A BR0109453 A BR 0109453A BR 0109453 A BR0109453 A BR 0109453A
- Authority
- BR
- Brazil
- Prior art keywords
- lactide
- composition
- cyclic ester
- wet cake
- crystal suspension
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 239000000725 suspension Substances 0.000 title abstract 3
- -1 cyclic ester Chemical class 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 abstract 6
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 abstract 2
- 239000012535 impurity Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000007791 liquid phase Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 238000005204 segregation Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/12—1,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Polyesters Or Polycarbonates (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epoxy Compounds (AREA)
Abstract
"PROCESSO DE PURIFICAçãO DE éSTER CìCLICO DIMéRICO, COMPOSIçãO DE SUSPENSãO DE CRISTAIS E COMPOSIçãO DE TORTA úMIDA". Processo de purificação de éster cíclico dimérico de ácido láctico (ou glicólico) partindo de um lactídeo bruto (ou glicolídeo) compreendendo impurezas, o processo compreendendo: uma cristalização extrativa e controlada o lactídeo bruto, em meio aquoso, controlando a geometria dos cristais formados e provocando uma segregação de fases entre o lactídeo e as impurezas; uma separação da suspensão de cristais assim obtida, em uma fase líquida pobre em lactídeo e carregada de impurezas, e em uma torta úmida rica em cristais de lactídeo uma secagem da torta úmida assim obtida, e uma recristalização em meio em fusão do lactídeo impuro secado assim obtido e uma recuperação do lactídeo purificado.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00870052A EP1136480A1 (fr) | 2000-03-23 | 2000-03-23 | Procedé de purification d'esters cycliques |
| PCT/BE2001/000047 WO2001070721A1 (fr) | 2000-03-23 | 2001-03-22 | Procede de purificaction d'esters cycliques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0109453A true BR0109453A (pt) | 2003-06-24 |
Family
ID=8175721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0109453-0A BR0109453A (pt) | 2000-03-23 | 2001-03-22 | Processo de purificação de éster cìclico dimérico, composição de suspensão de cristais e composição de torta úmida |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6800767B2 (pt) |
| EP (2) | EP1136480A1 (pt) |
| JP (1) | JP4959899B2 (pt) |
| KR (1) | KR20030069792A (pt) |
| CN (1) | CN1257165C (pt) |
| AT (1) | ATE297388T1 (pt) |
| AU (1) | AU4212201A (pt) |
| BR (1) | BR0109453A (pt) |
| CA (1) | CA2403426A1 (pt) |
| CZ (1) | CZ20023060A3 (pt) |
| DE (1) | DE60111371T2 (pt) |
| ES (1) | ES2243463T3 (pt) |
| HU (1) | HUP0400853A2 (pt) |
| IL (1) | IL151676A0 (pt) |
| NO (1) | NO20024340L (pt) |
| PL (1) | PL359284A1 (pt) |
| SK (1) | SK13442002A3 (pt) |
| WO (1) | WO2001070721A1 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1015060A3 (fr) * | 2002-08-06 | 2004-09-07 | Brussels Biotech Nv Sa | Procede de production de polylactide au depart d'une solution d'acide lactique ou d'un de ses derives. |
| WO2008071776A2 (en) * | 2006-12-13 | 2008-06-19 | Solvay | Production of cyclic diesters of alpha-hydroxyacids |
| EP2031009A1 (de) | 2007-09-03 | 2009-03-04 | Uhde Inventa-Fischer GmbH | Reinigungsvorrichtung zur Abtrennung von Dilactid aus Stoffgemischen, Polymerisationsvorrichtung, Verfahren zur Abtrennung von Dilactid aus Stoffgemischen sowie Verwendung |
| AT506038B1 (de) * | 2007-11-14 | 2015-02-15 | Jungbunzlauer Austria Ag | Verfahren zur herstellung zyklischer diester von l-, d- und d,l-milchsäure |
| AT506040B1 (de) * | 2007-11-14 | 2012-03-15 | Jungbunzlauer Austria Ag | Partikuläre katalysator- und katalysator/stabilisator-systeme zur herstellung hochmolekularer homo- und copolyester von l-, d- oder d,l-milchsäure |
| AT506768B1 (de) | 2008-04-16 | 2013-10-15 | Jungbunzlauer Austria Ag | Verfahren zur reinigung zyklischer diester der l- bzw. d-milchsäure |
| EP2133346A1 (fr) * | 2008-06-12 | 2009-12-16 | Ktanton Ltd | Procédé pour la fabrication d'un diester cyclique d'un acide alpha-hydroxylé |
| CN103145691A (zh) * | 2013-04-03 | 2013-06-12 | 天津科技大学 | 高纯l-丙交酯耦合精制方法 |
| KR101809663B1 (ko) | 2013-11-25 | 2017-12-15 | 한국화학연구원 | 알킬 프로피오네이트와 물 혼합용매를 이용한 광학순도가 향상된 락타이드의 제조방법 |
| CN103819690B (zh) * | 2014-02-18 | 2016-02-10 | 上海交通大学 | 降解消除法制备高结晶度聚乳酸的工艺 |
| EP3587409B8 (en) | 2014-05-30 | 2022-07-13 | Translate Bio, Inc. | Biodegradable lipids for delivery of nucleic acids |
| CN105646440B (zh) * | 2014-12-05 | 2018-06-15 | 中国石油化工股份有限公司 | 一种丙交酯的精制纯化方法 |
| CN105440011A (zh) * | 2015-12-17 | 2016-03-30 | 常州大学 | 一种快速提纯久置环酯的方法 |
| CN114507209A (zh) * | 2020-10-28 | 2022-05-17 | 中国石油化工股份有限公司 | 一种高收率高纯度丙交酯的提纯方法 |
| CN114478471B (zh) * | 2022-02-10 | 2024-01-09 | 普立思生物科技有限公司 | 一种丙交酯纯化系统及纯化工艺 |
| CN117903105A (zh) * | 2022-10-12 | 2024-04-19 | 中国石油化工股份有限公司 | 一种乙交酯的提纯方法、乙交酯及应用 |
| JP7499546B1 (ja) | 2023-09-28 | 2024-06-14 | 株式会社ラマシックス | ラクチド複合体の製造方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2115472C (en) * | 1993-02-17 | 2002-08-13 | William George O'brien | Melt crystallization purification of lactides |
| JPH07165753A (ja) * | 1993-12-08 | 1995-06-27 | Musashino Kagaku Kenkyusho:Kk | ラクチドの精製方法 |
| BE1011197A3 (fr) * | 1997-06-06 | 1999-06-01 | Brussels Biotech En Abrege Bb | Procede de purification d'acide lactique. |
-
2000
- 2000-03-23 EP EP00870052A patent/EP1136480A1/fr not_active Withdrawn
-
2001
- 2001-03-22 AU AU42122/01A patent/AU4212201A/en not_active Abandoned
- 2001-03-22 DE DE60111371T patent/DE60111371T2/de not_active Expired - Lifetime
- 2001-03-22 BR BR0109453-0A patent/BR0109453A/pt not_active Application Discontinuation
- 2001-03-22 EP EP01914850A patent/EP1276735B1/fr not_active Expired - Lifetime
- 2001-03-22 CA CA002403426A patent/CA2403426A1/fr not_active Abandoned
- 2001-03-22 ES ES01914850T patent/ES2243463T3/es not_active Expired - Lifetime
- 2001-03-22 WO PCT/BE2001/000047 patent/WO2001070721A1/fr active IP Right Grant
- 2001-03-22 JP JP2001568925A patent/JP4959899B2/ja not_active Expired - Fee Related
- 2001-03-22 CN CNB018151396A patent/CN1257165C/zh not_active Expired - Fee Related
- 2001-03-22 KR KR1020027012157A patent/KR20030069792A/ko not_active Application Discontinuation
- 2001-03-22 IL IL15167601A patent/IL151676A0/xx unknown
- 2001-03-22 CZ CZ20023060A patent/CZ20023060A3/cs unknown
- 2001-03-22 US US10/239,584 patent/US6800767B2/en not_active Expired - Fee Related
- 2001-03-22 HU HU0400853A patent/HUP0400853A2/hu unknown
- 2001-03-22 PL PL01359284A patent/PL359284A1/xx not_active Application Discontinuation
- 2001-03-22 SK SK1344-2002A patent/SK13442002A3/sk unknown
- 2001-03-22 AT AT01914850T patent/ATE297388T1/de not_active IP Right Cessation
-
2002
- 2002-09-11 NO NO20024340A patent/NO20024340L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003528094A (ja) | 2003-09-24 |
| CZ20023060A3 (cs) | 2003-02-12 |
| DE60111371D1 (de) | 2005-07-14 |
| PL359284A1 (en) | 2004-08-23 |
| EP1276735A1 (fr) | 2003-01-22 |
| NO20024340L (no) | 2002-10-20 |
| NO20024340D0 (no) | 2002-09-11 |
| US20040014991A1 (en) | 2004-01-22 |
| IL151676A0 (en) | 2003-04-10 |
| ES2243463T3 (es) | 2005-12-01 |
| KR20030069792A (ko) | 2003-08-27 |
| SK13442002A3 (sk) | 2003-03-04 |
| HUP0400853A2 (hu) | 2004-07-28 |
| JP4959899B2 (ja) | 2012-06-27 |
| CN1452618A (zh) | 2003-10-29 |
| AU4212201A (en) | 2001-10-03 |
| CA2403426A1 (fr) | 2001-09-27 |
| ATE297388T1 (de) | 2005-06-15 |
| EP1136480A1 (fr) | 2001-09-26 |
| WO2001070721A1 (fr) | 2001-09-27 |
| DE60111371T2 (de) | 2006-05-18 |
| CN1257165C (zh) | 2006-05-24 |
| EP1276735B1 (fr) | 2005-06-08 |
| US6800767B2 (en) | 2004-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |