BR0108279A - Processo sintético para um intermediário para compostos de ecteinascidina e ftalascidina - Google Patents
Processo sintético para um intermediário para compostos de ecteinascidina e ftalascidinaInfo
- Publication number
- BR0108279A BR0108279A BR0108279-5A BR0108279A BR0108279A BR 0108279 A BR0108279 A BR 0108279A BR 0108279 A BR0108279 A BR 0108279A BR 0108279 A BR0108279 A BR 0108279A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- phthalascidine
- ecteinascidin
- synthetic process
- synthesis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 title abstract 2
- 229960000977 trabectedin Drugs 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"PROCESSO SINTéTICO PARA UM INTERMEDIáRIO PARA COMPOSTOS DE ECTEINASCIDINA E FTALASCIDINA". A invenção refere-se a um processo eficiente para a síntese de (5) um intermediário principal para a síntese da ecteinacidina 743 (1) e ftalacidina (2) de agentes antitumor, potentes a partir dos bloqueadores de construção facilmente disponíveis 3b e 4
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18179500P | 2000-02-11 | 2000-02-11 | |
| PCT/US2001/004376 WO2001058905A1 (en) | 2000-02-11 | 2001-02-09 | Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR0108279A true BR0108279A (pt) | 2002-11-05 |
| BRPI0108279B1 BRPI0108279B1 (pt) | 2016-04-26 |
Family
ID=22665840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0108279A BRPI0108279B1 (pt) | 2000-02-11 | 2001-02-09 | processos para preparação de intermediário de ecteinascidina e de ftalascidina e intermediários sintéticos dos referidos processos |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1255759B1 (pt) |
| JP (1) | JP5102925B2 (pt) |
| KR (1) | KR100768331B1 (pt) |
| CN (1) | CN1230437C (pt) |
| AT (1) | ATE368670T1 (pt) |
| AU (2) | AU3813501A (pt) |
| BR (1) | BRPI0108279B1 (pt) |
| CA (1) | CA2400614C (pt) |
| CY (1) | CY1107769T1 (pt) |
| CZ (1) | CZ300326B6 (pt) |
| DE (1) | DE60129669T2 (pt) |
| DK (1) | DK1255759T3 (pt) |
| ES (1) | ES2290114T3 (pt) |
| HU (1) | HU229511B1 (pt) |
| IL (2) | IL151168A0 (pt) |
| MX (1) | MXPA02007767A (pt) |
| NO (1) | NO328648B1 (pt) |
| NZ (1) | NZ520635A (pt) |
| PL (1) | PL209762B1 (pt) |
| PT (1) | PT1255759E (pt) |
| RU (1) | RU2267492C2 (pt) |
| WO (1) | WO2001058905A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107033164A (zh) | 2010-05-25 | 2017-08-11 | 法马马有限公司 | 制备海鞘素化合物的合成方法 |
| CN108101934B (zh) * | 2016-11-24 | 2022-02-08 | 江苏恒瑞医药股份有限公司 | 用于制备曲贝替定的方法及其中间体 |
| CN110092802B (zh) * | 2019-06-21 | 2022-01-07 | 爱斯特（成都）生物制药股份有限公司 | 一种制备曲贝替定中间体的方法 |
| CN112745327B (zh) * | 2019-10-30 | 2023-08-25 | 南通诺泰生物医药技术有限公司 | 一种曲贝替定中间体化合物的制备方法 |
| CN114621245A (zh) * | 2020-12-11 | 2022-06-14 | 江苏恒瑞医药股份有限公司 | 一种曲贝替定中间体的晶型及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5721362A (en) * | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
| US6124292A (en) * | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
-
2001
- 2001-02-09 CN CNB018070973A patent/CN1230437C/zh not_active Expired - Lifetime
- 2001-02-09 CA CA2400614A patent/CA2400614C/en not_active Expired - Lifetime
- 2001-02-09 ES ES01910540T patent/ES2290114T3/es not_active Expired - Lifetime
- 2001-02-09 PT PT01910540T patent/PT1255759E/pt unknown
- 2001-02-09 AU AU3813501A patent/AU3813501A/xx active Pending
- 2001-02-09 HU HU0204221A patent/HU229511B1/hu unknown
- 2001-02-09 NZ NZ520635A patent/NZ520635A/en not_active IP Right Cessation
- 2001-02-09 CZ CZ20022683A patent/CZ300326B6/cs not_active IP Right Cessation
- 2001-02-09 DE DE60129669T patent/DE60129669T2/de not_active Expired - Lifetime
- 2001-02-09 KR KR1020027010342A patent/KR100768331B1/ko active IP Right Grant
- 2001-02-09 EP EP01910540A patent/EP1255759B1/en not_active Expired - Lifetime
- 2001-02-09 BR BRPI0108279A patent/BRPI0108279B1/pt active IP Right Grant
- 2001-02-09 MX MXPA02007767A patent/MXPA02007767A/es active IP Right Grant
- 2001-02-09 AU AU2001238135A patent/AU2001238135B2/en not_active Expired
- 2001-02-09 RU RU2002124134/04A patent/RU2267492C2/ru active
- 2001-02-09 PL PL356392A patent/PL209762B1/pl unknown
- 2001-02-09 WO PCT/US2001/004376 patent/WO2001058905A1/en active IP Right Grant
- 2001-02-09 AT AT01910540T patent/ATE368670T1/de active
- 2001-02-09 IL IL15116801A patent/IL151168A0/xx unknown
- 2001-02-09 DK DK01910540T patent/DK1255759T3/da active
- 2001-02-09 JP JP2001558054A patent/JP5102925B2/ja not_active Expired - Lifetime
-
2002
- 2002-08-09 IL IL151168A patent/IL151168A/en active IP Right Grant
- 2002-08-09 NO NO20023769A patent/NO328648B1/no not_active IP Right Cessation
-
2007
- 2007-10-19 CY CY20071101347T patent/CY1107769T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: PARA INT.CL: C07D 498/18, C07D 491/18, A61P 35/00 Ipc: C07D 498/18 (2011.01), C07D 491/18 (2011.01), A61P |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI. |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07D 498/18 , C07D 491/18 , A61P 35/00 Ipc: C07D 498/18 (2006.01), C07D 491/18 (2006.01), A61P |
|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/04/2016, OBSERVADAS AS CONDICOES LEGAIS. |