BR0013306A - Processos úteis na sìntese de compostos antipicornavirais - Google Patents
Processos úteis na sìntese de compostos antipicornaviraisInfo
- Publication number
- BR0013306A BR0013306A BR0013306-0A BR0013306A BR0013306A BR 0013306 A BR0013306 A BR 0013306A BR 0013306 A BR0013306 A BR 0013306A BR 0013306 A BR0013306 A BR 0013306A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- synthesis
- processes useful
- useful
- formula
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/2415—Tubular reactors
- B01J19/2435—Loop-type reactors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/2475—Membrane reactors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
- B01J2219/00099—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor the reactor being immersed in the heat exchange medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00159—Controlling the temperature controlling multiple zones along the direction of flow, e.g. pre-heating and after-cooling
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15035899P | 1999-08-24 | 1999-08-24 | |
| PCT/US2000/023033 WO2001014329A1 (en) | 1999-08-24 | 2000-08-23 | Synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0013306A true BR0013306A (pt) | 2002-05-28 |
Family
ID=22534156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0013306-0A BR0013306A (pt) | 1999-08-24 | 2000-08-23 | Processos úteis na sìntese de compostos antipicornavirais |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1206450A1 (xx) |
| JP (1) | JP2003507453A (xx) |
| KR (1) | KR20020046283A (xx) |
| CN (1) | CN1168713C (xx) |
| AR (1) | AR025380A1 (xx) |
| AU (1) | AU770221B2 (xx) |
| BR (1) | BR0013306A (xx) |
| CA (1) | CA2376452A1 (xx) |
| CO (1) | CO5200782A1 (xx) |
| CZ (1) | CZ2002632A3 (xx) |
| HK (1) | HK1049336B (xx) |
| HU (1) | HUP0203365A3 (xx) |
| IL (1) | IL147674A0 (xx) |
| MX (1) | MXPA02001944A (xx) |
| PE (1) | PE20010517A1 (xx) |
| PL (1) | PL353997A1 (xx) |
| TW (1) | TWI245040B (xx) |
| UY (1) | UY26307A1 (xx) |
| WO (1) | WO2001014329A1 (xx) |
| ZA (1) | ZA200200504B (xx) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1198838C (zh) | 1998-04-30 | 2005-04-27 | 阿格罗尼制药公司 | 抗小rna病毒化合物及其制备方法和用途 |
| ES2230135T3 (es) | 1999-08-04 | 2005-05-01 | Agouron Pharmaceuticals, Inc. | Compuestos y composiciones anti-picornavirales; utilizaciones farmaceuticas y materiales utilizados para su sintesis. |
| PA8507801A1 (es) | 1999-12-03 | 2002-08-26 | Agouron Pharma | Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis |
| PE20011277A1 (es) | 2000-04-14 | 2002-01-07 | Agouron Pharma | Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis |
| PL365470A1 (en) | 2000-06-14 | 2005-01-10 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis |
| CN1309712C (zh) * | 2004-04-02 | 2007-04-11 | 中国科学院上海有机化学研究所 | Ag7088类化合物的关键中间体的前体及其合成方法 |
| US20230157998A1 (en) | 2020-03-06 | 2023-05-25 | Pfizer Inc. | Methods of Inhibiting SARS-CoV-2 Replication and Treating Corona Virus Disease 2019 |
| CN115260074B (zh) * | 2022-08-02 | 2024-06-21 | 爱斯特（成都）生物制药股份有限公司 | 一种口服抗病毒药物Paxlovid中间体的制备方法 |
| CN115322130B (zh) * | 2022-08-02 | 2024-05-14 | 南京正济医药研究有限公司 | 制备(s)-2-(boc-氨基)-3-[(s)-2-氧代-3-吡咯烷基]丙酸甲酯 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU722704B2 (en) * | 1996-05-14 | 2000-08-10 | Agouron Pharmaceuticals, Inc. | Inhibitors of picornavirus 3c proteases and methods for their use and preparation |
| CA2289541A1 (en) * | 1997-03-28 | 1998-10-08 | Peter S. Dragovich | Antipicornaviral compouds, compositions containing them, and methods for their use |
| US5962487A (en) * | 1997-12-16 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
| CN1198838C (zh) * | 1998-04-30 | 2005-04-27 | 阿格罗尼制药公司 | 抗小rna病毒化合物及其制备方法和用途 |
-
2000
- 2000-08-22 PE PE2000000854A patent/PE20010517A1/es not_active Application Discontinuation
- 2000-08-23 CZ CZ2002632A patent/CZ2002632A3/cs unknown
- 2000-08-23 HU HU0203365A patent/HUP0203365A3/hu unknown
- 2000-08-23 UY UY26307A patent/UY26307A1/es not_active Application Discontinuation
- 2000-08-23 JP JP2001518419A patent/JP2003507453A/ja active Pending
- 2000-08-23 WO PCT/US2000/023033 patent/WO2001014329A1/en not_active Application Discontinuation
- 2000-08-23 KR KR1020027002322A patent/KR20020046283A/ko not_active Application Discontinuation
- 2000-08-23 EP EP00955831A patent/EP1206450A1/en not_active Withdrawn
- 2000-08-23 CA CA002376452A patent/CA2376452A1/en not_active Abandoned
- 2000-08-23 CN CNB008118779A patent/CN1168713C/zh not_active Expired - Fee Related
- 2000-08-23 MX MXPA02001944A patent/MXPA02001944A/es active IP Right Grant
- 2000-08-23 PL PL00353997A patent/PL353997A1/xx not_active Application Discontinuation
- 2000-08-23 BR BR0013306-0A patent/BR0013306A/pt not_active IP Right Cessation
- 2000-08-23 AU AU67971/00A patent/AU770221B2/en not_active Ceased
- 2000-08-23 IL IL14767400A patent/IL147674A0/xx unknown
- 2000-08-24 CO CO00063457A patent/CO5200782A1/es not_active Application Discontinuation
- 2000-08-24 AR ARP000104401A patent/AR025380A1/es unknown
- 2000-10-24 TW TW089117083A patent/TWI245040B/zh active
-
2002
- 2002-01-21 ZA ZA200200504A patent/ZA200200504B/en unknown
-
2003
- 2003-02-27 HK HK03101461.5A patent/HK1049336B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ2002632A3 (cs) | 2003-04-16 |
| HUP0203365A2 (hu) | 2003-02-28 |
| UY26307A1 (es) | 2001-04-30 |
| CN1168713C (zh) | 2004-09-29 |
| HUP0203365A3 (en) | 2003-12-29 |
| EP1206450A1 (en) | 2002-05-22 |
| JP2003507453A (ja) | 2003-02-25 |
| AU770221B2 (en) | 2004-02-19 |
| IL147674A0 (en) | 2002-08-14 |
| CA2376452A1 (en) | 2001-03-01 |
| CN1374947A (zh) | 2002-10-16 |
| ZA200200504B (en) | 2003-03-26 |
| AU6797100A (en) | 2001-03-19 |
| PL353997A1 (en) | 2003-12-15 |
| WO2001014329A1 (en) | 2001-03-01 |
| AR025380A1 (es) | 2002-11-20 |
| HK1049336A1 (en) | 2003-05-09 |
| PE20010517A1 (es) | 2001-05-16 |
| KR20020046283A (ko) | 2002-06-20 |
| HK1049336B (zh) | 2005-05-20 |
| TWI245040B (en) | 2005-12-11 |
| CO5200782A1 (es) | 2002-09-27 |
| MXPA02001944A (es) | 2002-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0312729A (pt) | Novos derivados de indol-3-enxofre | |
| BR0312513A (pt) | Derivados de glicosìdeo de tiofeno, processos para a produção dos mesmos, medicamentos que contêm esses compostos e uso dos mesmos | |
| BRPI0418031A (pt) | inibidores de quinase fosfonato-substituìdos | |
| BR0210384A (pt) | Heteroarilas multicìclicas substituìdas por quinuclidinas para o tratamento de doença | |
| BR0209129A (pt) | Compostos, composições farmacêuticas, métodos para tratamento de dores, métodos para modulação de uma resposta farmacológica e usos de compostos | |
| BRPI0413452A (pt) | composto, composição farmacêutica, kit, artigo de fabricação, e, métodos de inibir dpp-iv, terapêutico e de tratar um estado de doença, cáncer, distúrbios autoimunes, uma condição einfecção por hiv | |
| DK1519724T3 (da) | Fredericamycin-derivater som lægemidler til behandling af tumorer | |
| BR0210711A (pt) | Uso de um composto, composição farmacêutica, composto, e, processo para a preparação de um composto | |
| BR0315296A (pt) | Derivados do ciclohexanol espirocìclicos | |
| ECSP034896A (es) | Derivados aromaticos de acidos dicarboxilicos | |
| UY27604A1 (es) | Compuestos químicos. | |
| BR9914451A (pt) | Composto de oxazol, processo para sua preparação, composição farmacêutica compreendendo dito composto, uso da composição e métodos de tratamento | |
| GT200100183A (es) | Derivados de quinolina y quinazolina. | |
| BR9910573A (pt) | Compostos antipicornavirais, preparação e uso dos mesmos | |
| IL169184A0 (en) | Aromatic compounds as anti-inflammatory, immunomdulatory and anti-proliferatory agents | |
| BR0007229A (pt) | Aminoazaciclos heterocìclicos substituìdos úteis como agentes de sistema nervoso central | |
| AR025052A1 (es) | Derivados de 2-dialquilaminoalquilbifenilo sustituidos, procedimiento para su preparacion, medicamentos que contienen estos compuestos y el uso de estoscompuestos para la preparacion de medicamentos. | |
| BR0109542A (pt) | Derivados de imidazopirina alquilados | |
| BR0209128A (pt) | Compostos, composições farmacêuticas, métodos para o tratamento de dores, métodos para a modulação de uma resposta farmacológica e usos de compostos | |
| BR0109483A (pt) | Pró-drogas de derivados de imidazopiridina | |
| BR0211826A (pt) | Imidazopiridinas tricìclicas | |
| BRPI0411092A (pt) | benzo[b]tiofenos substituìdos com 3-arilsulfanila e com 3-heteroarilsulfanila como agentes terapêuticos | |
| BR0013306A (pt) | Processos úteis na sìntese de compostos antipicornavirais | |
| AR029795A1 (es) | Derivados de acido 1,2,3,4-tetrahidroquinolin-2-carboxilico sustituidos, procedimientos para su preparacion, su uso para la preparacion de medicamentos y medicamentos que contienen estos compuestos | |
| BR9916807A (pt) | Antagonistas de 5ht1 para terapia antidepressiva |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009. |