BR0005132A - Processo para a preparação de derivados de ácido (-) piridobenzoxazina carboxìlico - Google Patents

Processo para a preparação de derivados de ácido (-) piridobenzoxazina carboxìlico

Info

Publication number
BR0005132A
BR0005132A BR0005132-2A BR0005132A BR0005132A BR 0005132 A BR0005132 A BR 0005132A BR 0005132 A BR0005132 A BR 0005132A BR 0005132 A BR0005132 A BR 0005132A
Authority
BR
Brazil
Prior art keywords
preparation
carboxylic acid
pyridobenzoxazine carboxylic
acid derivatives
acid derivative
Prior art date
Application number
BR0005132-2A
Other languages
English (en)
Other versions
BR0005132B1 (pt
Inventor
Young-Jun Park
Ho-Seong Lee
Min-Hwan Kim
Kyung-Chul Kim
Original Assignee
Samsung Electronics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samsung Electronics Co Ltd filed Critical Samsung Electronics Co Ltd
Publication of BR0005132A publication Critical patent/BR0005132A/pt
Publication of BR0005132B1 publication Critical patent/BR0005132B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Patente de Invenção: <B>''PROCESSO PARA A PREPARAçãO DE DERIVADOS DE áCIDO (-) PIRIDOBENZOXAZINA CARBOXìLICO'' <D>. A presente invenção refere-se a um processo para a preparação de derivado de ácido (-) piridobenzoxazina carboxílico oticamente ativo e seu sal farmaceuticamente aceitável por emprego de um material de partida de (+) etil-2-(4-cloro-5-flúor-2-halo-3-nitrobenzoil)-3-[(1-hidroxipropóxi-2(S)-il) amino] acrilato. De acordo com a presente invenção, derivado de ácido (-) piridobenzoxazina carboxílico oticamente ativo pode ser fabricado a partir de derivado de ácido 4-cloro-5-fluorobenzóico de um modo simples e económico.
BRPI0005132-2A 1999-02-24 2000-02-23 processo para a preparação de derivados de ácido (-) piridobenzoxazina carboxìlico. BR0005132B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019990006093A KR100309871B1 (ko) 1999-02-24 1999-02-24 (-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
PCT/KR2000/000145 WO2000050428A1 (en) 1999-02-24 2000-02-23 Process for preparing (-)pyridobenzoxazine carboxylic acid derivatives

Publications (2)

Publication Number Publication Date
BR0005132A true BR0005132A (pt) 2001-01-02
BR0005132B1 BR0005132B1 (pt) 2010-06-15

Family

ID=19574927

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0005132-2A BR0005132B1 (pt) 1999-02-24 2000-02-23 processo para a preparação de derivados de ácido (-) piridobenzoxazina carboxìlico.

Country Status (9)

Country Link
US (1) US6316618B1 (pt)
EP (1) EP1073662B1 (pt)
JP (1) JP3530784B2 (pt)
KR (1) KR100309871B1 (pt)
CN (1) CN1125073C (pt)
BR (1) BR0005132B1 (pt)
DE (1) DE60009807T2 (pt)
ES (1) ES2215024T3 (pt)
WO (1) WO2000050428A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100494882B1 (ko) * 1999-08-21 2005-06-14 경동제약 주식회사 (-)-9-플루오로-2,3-디히드로-3(ｓ)-메틸-10-(4-메틸-1-피페라지닐)-7-옥소-7ｈ-피리도[1,2,3-데]-1,4-벤즈옥사진-6-카르복실산의 제조방법
SE0000933D0 (sv) 2000-03-21 2000-03-21 Independent Pharmaceutica Ab Method of producing 6-substituted (S)-nicotine derivatives and intermediate compounds
PT1451194E (pt) 2001-10-03 2007-01-31 Teva Pharma Preparação de hemi-hidrato de levofloxacina
US7425628B2 (en) * 2001-10-03 2008-09-16 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
WO2003045329A2 (en) * 2001-11-29 2003-06-05 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
KR100519158B1 (ko) * 2002-12-21 2005-10-06 주식회사유한양행 퀴놀론 카르복실레이트 유도체의 제조방법
KR100542600B1 (ko) * 2004-05-17 2006-01-11 주식회사 카이로켐 광학활성 (s)-피리도벤즈옥사진 카르복실산 반수화물 유도체의 제조 방법
KR100704641B1 (ko) * 2004-07-21 2007-04-06 주식회사유한양행 고순도의 레보플록사신 제조방법
CN1332962C (zh) * 2005-07-12 2007-08-22 武汉人福药业有限责任公司 一种合成甲磺酸帕珠沙星中间体的方法
CN102827075A (zh) * 2011-06-14 2012-12-19 四川科伦药物研究有限公司 一种西他沙星中间体的合成方法
CN113717100B (zh) * 2021-10-11 2023-03-17 郑州工业应用技术学院 一种培氟沙星醛缩4-芳基氨基硫脲类衍生物的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US477273A (en) * 1892-06-21 Norman f
JPS5746986A (en) 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
DK170473B1 (da) 1985-06-20 1995-09-11 Daiichi Seiyaku Co S(-)-pyridobenzoxazinforbindelser
DE3522406A1 (de) 1985-06-22 1987-01-02 Bayer Ag Verfahren zur herstellung von 1,8-verbrueckten 4-chinolon-3-carbonsaeuren
US5237060A (en) 1985-12-10 1993-08-17 Bayer Aktiengesellschaft Process of preparing enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids
US4777253A (en) 1986-04-25 1988-10-11 Abbott Laboratories Process for preparation of racemate and optically active ofloxacin and related derivatives
JPH0826029B2 (ja) * 1987-12-22 1996-03-13 第一製薬株式会社 魚類感染症の予防・治療剤
AU5404790A (en) * 1989-04-26 1990-11-16 Upjohn Company, The Antibacterial pyrido(1,2,3-de)-1,4-benzoxazinone agents
KR0142139B1 (ko) * 1994-03-22 1998-07-01 김은영 (+)2-벤조일-3-[(프로피-2(s)-일)아미노]아크릴레이트 유도체의 제조방법
KR0125115B1 (ko) * 1994-03-22 1997-12-05 김은영 (-)피페라진 벤즈옥사진 유도체의 제조방법
GB2301354A (en) 1995-04-04 1996-12-04 Resolution Chemicals Limited Preparation for intermediates for quinolone antibiotics

Also Published As

Publication number Publication date
EP1073662B1 (en) 2004-04-14
CN1125073C (zh) 2003-10-22
US6316618B1 (en) 2001-11-13
DE60009807D1 (de) 2004-05-19
KR100309871B1 (ko) 2001-10-29
BR0005132B1 (pt) 2010-06-15
JP3530784B2 (ja) 2004-05-24
EP1073662A1 (en) 2001-02-07
ES2215024T3 (es) 2004-10-01
KR20000056615A (ko) 2000-09-15
EP1073662A4 (en) 2002-04-17
CN1294592A (zh) 2001-05-09
JP2000247980A (ja) 2000-09-12
DE60009807T2 (de) 2005-04-28
WO2000050428A1 (en) 2000-08-31

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Legal Events

Date Code Title Description
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/06/2010, OBSERVADAS AS CONDICOES LEGAIS.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 15.06.2020