BR0002089A - Processo a sìntese de análogos de nucleosìdeos - Google Patents

Processo a sìntese de análogos de nucleosìdeos

Info

Publication number
BR0002089A
BR0002089A BR0002089-3A BR0002089A BR0002089A BR 0002089 A BR0002089 A BR 0002089A BR 0002089 A BR0002089 A BR 0002089A BR 0002089 A BR0002089 A BR 0002089A
Authority
BR
Brazil
Prior art keywords
synthesis
nucleoside analogues
protected
nucleosyde
analogs
Prior art date
Application number
BR0002089-3A
Other languages
English (en)
Inventor
Robert William Scott
Original Assignee
Pfizer Productus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Productus Inc filed Critical Pfizer Productus Inc
Publication of BR0002089A publication Critical patent/BR0002089A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA A SìNTESE DE ANáLOGOS DE NUCLEOSìDEOS"<D>. A presente invenção refere-se a um método aperfeiçoado para sintetizar nucleosídeos, com uma baixa razão anomérica <244>:<225>. O método compreende a junção de um halogeneto de furanosila protegido e de um heterociclo adequadamente protegido na presença de um solvente polar nucleofílico e de uma base forte.
BR0002089-3A 1999-05-11 2000-05-09 Processo a sìntese de análogos de nucleosìdeos BR0002089A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13365199P 1999-05-11 1999-05-11

Publications (1)

Publication Number Publication Date
BR0002089A true BR0002089A (pt) 2001-01-02

Family

ID=22459680

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0002089-3A BR0002089A (pt) 1999-05-11 2000-05-09 Processo a sìntese de análogos de nucleosìdeos

Country Status (22)

Country Link
US (1) US6271370B1 (pt)
EP (1) EP1052264B1 (pt)
JP (1) JP2001011092A (pt)
KR (1) KR100403900B1 (pt)
CN (1) CN1275575A (pt)
AR (1) AR028991A1 (pt)
AT (1) ATE291582T1 (pt)
AU (1) AU3401100A (pt)
BR (1) BR0002089A (pt)
CA (1) CA2307951A1 (pt)
CZ (1) CZ20001710A3 (pt)
DE (1) DE60018833D1 (pt)
HU (1) HUP0001843A3 (pt)
ID (1) ID25992A (pt)
IL (1) IL136027A0 (pt)
IN (1) IN186850B (pt)
MX (1) MXPA00004532A (pt)
PL (1) PL340109A1 (pt)
RU (1) RU2200738C2 (pt)
TR (1) TR200001340A2 (pt)
YU (1) YU25500A (pt)
ZA (1) ZA200002263B (pt)

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JP5808826B2 (ja) 2011-02-23 2015-11-10 インテリカイン， エルエルシー 複素環化合物およびその使用
AU2012220572A1 (en) 2011-02-25 2013-08-29 Irm Llc Compounds and compositions as trk inhibitors
US9062045B2 (en) 2011-09-15 2015-06-23 Novartis Ag Triazolopyridine compounds
JP6130391B2 (ja) 2011-11-23 2017-05-17 インテリカイン， エルエルシー Ｍｔｏｒ阻害剤を使用する強化された治療レジメン
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US9458154B2 (en) 2011-12-09 2016-10-04 Chiesi Farmaceutici S.P.A. Kinase inhibitors
CN110507654A (zh) 2012-04-03 2019-11-29 诺华有限公司 有酪氨酸激酶抑制剂的组合产品和其应用
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JP6873980B2 (ja) 2015-09-14 2021-05-19 ファイザー・インク ＬＲＲＫ２阻害薬としての新規のイミダゾ［４，５−ｃ］キノリンおよびイミダゾ［４，５−ｃ］［１，５］ナフチリジン誘導体
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AR107164A1 (es) 2015-12-23 2018-03-28 Chiesi Farm Spa INHIBIDORES DE QUINASA p38
WO2017108736A1 (en) 2015-12-23 2017-06-29 Chiesi Farmaceutici S.P.A. N-[3-(3-{4-[[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl} -ureido)-phenyl]-methanesulfonamide derivatives and their use as p38 mapk inhibitors
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PE20191236A1 (es) 2016-12-29 2019-09-11 Hoffmann La Roche Compuestos de pirazolopirimidina y metodos de uso de los mismos
JP2020510061A (ja) 2017-03-14 2020-04-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ピラゾロクロロフェニル化合物、組成物及びその使用方法
JP7228318B6 (ja) 2017-05-22 2023-03-10 エフ． ホフマン－ラ ロシュ アーゲー 処置用化合物及び組成物、並びにその使用方法
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Also Published As

Publication number Publication date
IL136027A0 (en) 2001-05-20
KR20010069193A (ko) 2001-07-23
MXPA00004532A (es) 2002-03-08
HUP0001843A2 (hu) 2001-06-28
EP1052264A3 (en) 2001-06-13
ZA200002263B (en) 2001-12-24
DE60018833D1 (de) 2005-04-28
JP2001011092A (ja) 2001-01-16
RU2200738C2 (ru) 2003-03-20
IN186850B (pt) 2001-11-24
CA2307951A1 (en) 2000-11-11
ID25992A (id) 2000-11-16
TR200001340A2 (tr) 2000-12-21
HU0001843D0 (en) 2000-07-28
EP1052264A2 (en) 2000-11-15
PL340109A1 (en) 2000-11-20
EP1052264B1 (en) 2005-03-23
YU25500A (sh) 2003-08-29
HUP0001843A3 (en) 2001-09-28
CN1275575A (zh) 2000-12-06
AU3401100A (en) 2000-11-16
AR028991A1 (es) 2003-06-04
CZ20001710A3 (cs) 2001-09-12
US6271370B1 (en) 2001-08-07
ATE291582T1 (de) 2005-04-15
KR100403900B1 (ko) 2003-11-01

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.