BG98583A - Изостерни пептиди - Google Patents

Изостерни пептиди Download PDF

Info

Publication number
BG98583A
BG98583A BG98583A BG9858394A BG98583A BG 98583 A BG98583 A BG 98583A BG 98583 A BG98583 A BG 98583A BG 9858394 A BG9858394 A BG 9858394A BG 98583 A BG98583 A BG 98583A
Authority
BG
Bulgaria
Prior art keywords
dcha
larg
pro
hooc
nbu
Prior art date
Application number
BG98583A
Other languages
Bulgarian (bg)
English (en)
Inventor
Butrus Atrash
David Jones
Michael Szelke
Original Assignee
Aktiebolaget Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aktiebolaget Astra filed Critical Aktiebolaget Astra
Publication of BG98583A publication Critical patent/BG98583A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BG98583A 1991-08-28 1994-02-25 Изостерни пептиди BG98583A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9102462A SE9102462D0 (sv) 1991-08-28 1991-08-28 New isosteric peptides
PCT/SE1992/000584 WO1993005069A1 (fr) 1991-08-28 1992-08-25 Nouveaux peptides isosteriques

Publications (1)

Publication Number Publication Date
BG98583A true BG98583A (bg) 1994-09-30

Family

ID=20383557

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98583A BG98583A (bg) 1991-08-28 1994-02-25 Изостерни пептиди

Country Status (27)

Country Link
US (1) US5424291A (fr)
EP (2) EP0605462B1 (fr)
JP (1) JP3353297B2 (fr)
CN (1) CN1069736A (fr)
AP (1) AP313A (fr)
AT (1) ATE212643T1 (fr)
AU (1) AU2499092A (fr)
BG (1) BG98583A (fr)
CA (1) CA2116527A1 (fr)
CZ (1) CZ38094A3 (fr)
DE (1) DE69232394T2 (fr)
DZ (1) DZ1613A1 (fr)
FI (1) FI940945A0 (fr)
HU (1) HUT66060A (fr)
IL (1) IL102840A0 (fr)
IS (1) IS3906A (fr)
MA (1) MA22632A1 (fr)
MX (1) MX9204767A (fr)
NO (1) NO940669L (fr)
NZ (1) NZ243675A (fr)
SE (1) SE9102462D0 (fr)
SI (1) SI9200193A (fr)
SK (1) SK23394A3 (fr)
TN (1) TNSN92076A1 (fr)
TW (1) TW221816B (fr)
WO (1) WO1993005069A1 (fr)
ZA (1) ZA925737B (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ245039A (en) * 1991-11-12 1994-12-22 Lilly Co Eli N-phenylalanyl and n-phenylglycyl derivatives of the dipeptide of l-azetidine-2-carboxylic acid and l-arginine aldehyde; anti-blood clotting compositions
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
JPH06329627A (ja) * 1993-05-03 1994-11-29 Bristol Myers Squibb Co グアニジニル−またはアミジニル−置換ヘテロ環トロンビンインヒビター
US5783563A (en) * 1993-06-03 1998-07-21 Astra Aktiebolag Method for treatment or prophylaxis of venous thrombosis
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (fr) * 1994-03-04 1995-09-05 Kenneth D. Kurz Agents antithrombotiques
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
NZ302649A (en) * 1995-02-17 2000-01-28 Basf Ag Dipeptide amidine derivatives, preparation and pharmaceutical compositions thereof
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
AR005245A1 (es) * 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
US5840733A (en) 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
AU751111B2 (en) 1998-01-26 2002-08-08 Basf Aktiengesellschaft Thrombin inhibitors
JP2003529528A (ja) 1998-04-24 2003-10-07 ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド プロテアーゼインヒビターとしてのアミノ酸アミジノヒドラゾン、アルコキシグアニジン、およびアミノグアニジン
SE9802973D0 (sv) 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
CN1170842C (zh) 1999-01-13 2004-10-13 阿斯特拉曾尼卡有限公司 新的脒基苄基胺衍生物及其作为凝血酶抑制剂的用途
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
US6353032B1 (en) * 1999-11-09 2002-03-05 Alcon Universal Ltd. Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR035216A1 (es) 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
US7781424B2 (en) 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7795205B2 (en) 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
TW200827336A (en) 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
EP3204352B1 (fr) 2014-10-06 2020-07-01 Cortexyme, Inc. Inhibiteurs de lysine gingipaïne
EP3374352A4 (fr) 2015-11-09 2019-10-02 Cortexyme, Inc. Inhibiteurs d'arginine gingipaïne
WO2017156071A1 (fr) 2016-03-09 2017-09-14 Blade Therapeutics, Inc. Composés céto-amides cycliques utilisés en tant que modulateurs de la calpaïne, et leurs procédés de production et d'utilisation
EP3481835A4 (fr) 2016-07-05 2020-02-26 Blade Therapeutics, Inc. Modulateurs de calpain et leurs utilisations thérapeutiques
CA3036862A1 (fr) 2016-09-16 2018-03-22 Cortexyme, Inc. Inhibiteurs cetone de lysine gingipaine
CN110023304A (zh) 2016-09-28 2019-07-16 布莱德治疗公司 钙蛋白酶调节剂及其治疗用途
SG11202008750XA (en) * 2018-03-28 2020-10-29 Blade Therapeutics Inc Calpain modulators and therapeutic uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents

Also Published As

Publication number Publication date
ZA925737B (en) 1993-03-01
TW221816B (fr) 1994-03-21
ATE212643T1 (de) 2002-02-15
HU9400589D0 (en) 1994-05-30
CN1069736A (zh) 1993-03-10
HUT66060A (en) 1994-09-28
TNSN92076A1 (fr) 1993-06-08
EP0530167A1 (fr) 1993-03-03
SK23394A3 (en) 1994-08-10
JP3353297B2 (ja) 2002-12-03
MX9204767A (es) 1993-05-01
US5424291A (en) 1995-06-13
NZ243675A (en) 1994-06-27
NO940669D0 (no) 1994-02-25
WO1993005069A1 (fr) 1993-03-18
EP0605462A1 (fr) 1994-07-13
FI940945A (fi) 1994-02-28
AU2499092A (en) 1993-04-05
DE69232394T2 (de) 2002-08-22
DE69232394D1 (de) 2002-03-14
AP9200418A0 (en) 1992-10-31
SE9102462D0 (sv) 1991-08-28
FI940945A0 (fi) 1994-02-28
CA2116527A1 (fr) 1993-03-18
NO940669L (no) 1994-04-19
CZ38094A3 (en) 1994-08-17
DZ1613A1 (fr) 2002-02-17
AP313A (en) 1994-02-10
EP0605462B1 (fr) 2002-01-30
SI9200193A (en) 1993-06-30
IL102840A0 (en) 1993-01-31
IS3906A (is) 1993-03-01
JPH06510059A (ja) 1994-11-10
MA22632A1 (fr) 1993-04-01

Similar Documents

Publication Publication Date Title
EP0605462B1 (fr) Nouveaux peptides isosteriques
US5736521A (en) Method of treatment and prophylaxis of arterial thrombosis
US5723444A (en) Starting materials in the synthesis of thrombin and kinogenase inhibitors
US5523308A (en) Peptidyl heterocycles useful in the treatment of thrombin related disorders
US5783563A (en) Method for treatment or prophylaxis of venous thrombosis
US5827866A (en) Peptidyl heterocycles useful in the treatment of thrombin related disorders
US5827860A (en) Peptidyl heterocycles useful in the treatment of thrombin related disorders
CZ277998A3 (cs) Inhibitory serinproteázy a farmaceutický prostředek
CA2246246A1 (fr) Inhibiteur de la serine-protease
US6984627B1 (en) Peptide derivatives
US5648338A (en) Inhibitors and substrates of thrombin
HU221310B1 (en) Acylated enol di and tripeptide derivatives, their use and pharmaceutical compositions comprising thereof
AU684086C (en) New peptide derivatives