BG85941A - Лекарствена форма с контролирано освобождаване и метод за получаването й - Google Patents
Лекарствена форма с контролирано освобождаване и метод за получаването йInfo
- Publication number
- BG85941A BG85941A BG085941A BG8594188A BG85941A BG 85941 A BG85941 A BG 85941A BG 085941 A BG085941 A BG 085941A BG 8594188 A BG8594188 A BG 8594188A BG 85941 A BG85941 A BG 85941A
- Authority
- BG
- Bulgaria
- Prior art keywords
- obtaining
- controlled
- release pharmaceutical
- pharmaceutical form
- substance
- Prior art date
Links
- 238000013270 controlled release Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 abstract 2
- 229960004166 diltiazem Drugs 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 1
- 239000001856 Ethyl cellulose Substances 0.000 abstract 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940088679 drug related substance Drugs 0.000 abstract 1
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 1
- 229920001249 ethyl cellulose Polymers 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Лекарствената форма се състои от водоразтворимо ядро, включващо веществото дилтиазем или дилтиаземхлорид, вътрешен обвиващ слой от етилцелулоза и хидрофобно вещество и външен обвиващ слой, съдържащ лекарственото вещество. Тази форма осигурява бързо повишаване на концентрацията на медикамента в кръвта, като поддържането й на високо ниво е за по-продължителен период от време. 9 претенции, 4 фигури
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP28118987 | 1987-11-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
BG85941A true BG85941A (bg) | 1993-12-24 |
BG60638B1 BG60638B1 (bg) | 1995-11-30 |
Family
ID=17635585
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG85941A BG60638B1 (bg) | 1987-11-06 | 1988-11-03 | Лекарствена форма с контролирано освобождаване иметод за получаването й |
Country Status (24)
Country | Link |
---|---|
US (1) | US4963365A (bg) |
EP (1) | EP0315414B1 (bg) |
KR (1) | KR940002655B1 (bg) |
CN (1) | CN1035099C (bg) |
AT (1) | ATE68343T1 (bg) |
AU (1) | AU610275B2 (bg) |
BG (1) | BG60638B1 (bg) |
CA (1) | CA1331565C (bg) |
DE (1) | DE3865631D1 (bg) |
DK (1) | DK175249B1 (bg) |
ES (1) | ES2027013T3 (bg) |
FI (1) | FI96273C (bg) |
FR (1) | FR2622799B1 (bg) |
GR (1) | GR3002915T3 (bg) |
HK (1) | HK44593A (bg) |
HU (1) | HU201468B (bg) |
IE (1) | IE60785B1 (bg) |
IL (1) | IL88083A (bg) |
NO (1) | NO176233C (bg) |
PH (1) | PH25905A (bg) |
PT (1) | PT88945B (bg) |
RU (1) | RU1816213C (bg) |
SG (1) | SG15493G (bg) |
ZA (1) | ZA888147B (bg) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5268182A (en) * | 1988-06-24 | 1993-12-07 | Abbott Laboratories | Sustained-release drug dosage units of terazosin |
US5169642A (en) * | 1988-06-24 | 1992-12-08 | Abbott Laboratories | Sustained-release drug dosage units |
DK0386440T3 (da) * | 1989-02-11 | 1992-09-14 | Bayer Ag | Lægemidler med kontrolleret afgivelse af virksomt stof |
US5258186A (en) * | 1989-03-10 | 1993-11-02 | Yamanouchi Pharmaceutical Co., Ltd. | Drug release controlling coating material for long acting formulations |
US5886012A (en) * | 1989-03-22 | 1999-03-23 | Peter K. T. Pang | Method of treatment for disease associated with excessive PHF using combination therapy involving exogenous calcium and calcium channel blockers |
EP0416094B1 (en) * | 1989-03-22 | 1996-10-23 | PANG, Peter K. T. | Parathyroid hypertensive factor |
US5122384A (en) * | 1989-05-05 | 1992-06-16 | Kv Pharmaceutical Company | Oral once-per-day organic nitrate formulation which does not induce tolerance |
US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
JP2558396B2 (ja) * | 1990-06-28 | 1996-11-27 | 田辺製薬株式会社 | 放出制御型製剤 |
US5286497A (en) * | 1991-05-20 | 1994-02-15 | Carderm Capital L.P. | Diltiazem formulation |
ES2073301T3 (es) * | 1991-05-20 | 1995-08-01 | Marion Laboratories Inc | Composicion multi-capa de liberacion controlada. |
ZA923474B (en) * | 1991-05-20 | 1993-01-27 | Marion Merrell Dow Inc | Diltiazem formulation |
US5252337A (en) * | 1991-06-25 | 1993-10-12 | Eurand America, Inc. | Controlled release calcium channel blocker microcapsules |
GB9117361D0 (en) * | 1991-08-12 | 1991-09-25 | Euro Celtique Sa | Oral dosage form |
KR100221695B1 (ko) * | 1991-08-12 | 1999-09-15 | 그린 마틴, 브라이언 쥐 테슬리 | 약학적 구상 제형 |
US5492700A (en) * | 1991-11-26 | 1996-02-20 | Warner-Lambert Company | Process and composition for the development of controlled release gemfibrozil dosage form |
EP0571973B1 (en) * | 1992-05-29 | 2000-02-02 | Nikken Chemicals Co., Ltd. | Slow-release sodium valproate tablets |
DE4342091A1 (de) * | 1993-12-09 | 1995-06-14 | Asta Medica Ag | Erzeugnisse zur Anwendung von initial hohen Dosen von Cetrorelix und Herstellung einer Kombinationspackung zur Verwendung bei Therapie von Krankheiten |
US5447729A (en) * | 1994-04-07 | 1995-09-05 | Pharmavene, Inc. | Multilamellar drug delivery systems |
US5567441A (en) * | 1995-03-24 | 1996-10-22 | Andrx Pharmaceuticals Inc. | Diltiazem controlled release formulation |
US5830503A (en) * | 1996-06-21 | 1998-11-03 | Andrx Pharmaceuticals, Inc. | Enteric coated diltiazem once-a-day formulation |
AU4219497A (en) * | 1996-09-13 | 1998-04-02 | Shionogi & Co., Ltd. | Sustained-release preparation utilizing thermal change and process for the production thereof |
US6524620B2 (en) | 1998-07-20 | 2003-02-25 | Andrx Pharmaceuticals, Inc. | Diltiazem controlled release formulation and method of manufacture |
WO2000009133A1 (en) * | 1998-08-10 | 2000-02-24 | Asahi Kasei Kogyo Kabushiki Kaisha | Sustained release oral preparations of fasudil hydrochloride |
US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
US6245913B1 (en) | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
US6635277B2 (en) | 2000-04-12 | 2003-10-21 | Wockhardt Limited | Composition for pulsatile delivery of diltiazem and process of manufacture |
EP1385486A4 (en) * | 2001-04-18 | 2006-05-17 | Nostrum Pharmaceuticals Inc | NEW COATING OF SLOW RELEASE PHARMACEUTICAL COMPOSITION |
US20040029959A1 (en) * | 2002-08-08 | 2004-02-12 | John Devane | Isosorbide mononitrate compositions and methods of their use |
US9107804B2 (en) * | 2002-12-10 | 2015-08-18 | Nortec Development Associates, Inc. | Method of preparing biologically active formulations |
US8802139B2 (en) | 2003-06-26 | 2014-08-12 | Intellipharmaceutics Corp. | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
CN1296046C (zh) * | 2003-12-23 | 2007-01-24 | 广州市医药工业研究所 | 盐酸地尔硫䓬控释胶囊剂及其制备方法 |
US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
US8088414B2 (en) | 2006-02-07 | 2012-01-03 | Fmc Corporation | Latex or pseudolatex compositions, coatings and coating processes |
WO2007112581A1 (en) | 2006-04-03 | 2007-10-11 | Isa Odidi | Controlled release delivery device comprising an organosol coat |
US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
US10905652B2 (en) | 2011-03-23 | 2021-02-02 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US9498447B2 (en) | 2011-03-23 | 2016-11-22 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US9283214B2 (en) | 2011-03-23 | 2016-03-15 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US9603809B2 (en) | 2011-03-23 | 2017-03-28 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
US8916588B2 (en) * | 2011-03-23 | 2014-12-23 | Ironshore Pharmaceuticals & Development, Inc. | Methods for treatment of attention deficit hyperactivity disorder |
US10292937B2 (en) * | 2011-03-23 | 2019-05-21 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
US11241391B2 (en) | 2011-03-23 | 2022-02-08 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US8927010B2 (en) * | 2011-03-23 | 2015-01-06 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US9119809B2 (en) | 2011-03-23 | 2015-09-01 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US20120308662A1 (en) * | 2011-06-01 | 2012-12-06 | Nitto Denko Corporation | Particulate preparation and method for producing the same |
FR2996418B1 (fr) * | 2012-10-09 | 2015-05-29 | Seppic Sa | Compositions alimentaires comprenant des capsules obtenues par coacervation ne mettant pas en œuvre de reticulant toxique |
EP2919903B1 (en) | 2012-11-14 | 2020-07-22 | W.R. Grace & CO. - CONN. | Compositions containing a biologically active material and a non-ordered inorganic oxide |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1172087A (fr) * | 1956-01-25 | 1959-02-05 | Bellon Labor Sa Roger | Perfectionnements concernant l'enrobage de préparations à effet retardé et à effet soutenu |
US2921883A (en) * | 1957-05-03 | 1960-01-19 | Smith Kline French Lab | Novel coating material for medicaments |
US2928770A (en) * | 1958-11-28 | 1960-03-15 | Frank M Bardani | Sustained action pill |
US3492397A (en) * | 1967-04-07 | 1970-01-27 | Warner Lambert Pharmaceutical | Sustained release dosage in the pellet form and process thereof |
IT1153487B (it) * | 1982-04-15 | 1987-01-14 | Prophin Lab Spa | Prodotti farmaceutici in forma-ritardo e procedimento per ottenerli |
US4390406A (en) * | 1982-07-23 | 1983-06-28 | Allied Corporation | Replaceable outer junction double junction reference electrode |
JPS604120A (ja) * | 1983-06-22 | 1985-01-10 | Shionogi & Co Ltd | 作用持続型ピナシジル製剤 |
IE56999B1 (en) * | 1983-12-22 | 1992-03-11 | Elan Corp Plc | Pharmaceutical formulation |
SE457505B (sv) * | 1984-01-10 | 1989-01-09 | Lejus Medical Ab | Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning |
DE3403329A1 (de) * | 1984-02-01 | 1985-08-01 | Horst Dr. 4019 Monheim Zerbe | Pharmazeutisches produkt in form von pellets mit kontinuierlicher, verzoegerter wirkstoffabgabe |
IT1206166B (it) * | 1984-07-26 | 1989-04-14 | Sigma Tau Ind Farmaceuti | Dispositivo per rilasciare una sostanza in un fluido di dissoluzione con cinetica di ordine zero e procedimento per la sua preparazione |
US4851228A (en) * | 1984-06-20 | 1989-07-25 | Merck & Co., Inc. | Multiparticulate controlled porosity osmotic |
US4600645A (en) * | 1985-01-31 | 1986-07-15 | Warner-Lambert Company | Process for treating dosage forms |
JPS62103012A (ja) * | 1985-10-23 | 1987-05-13 | Eisai Co Ltd | 多重顆粒 |
US4842867A (en) * | 1986-05-09 | 1989-06-27 | Alza Corporation | Pulsed drug delivery of doxylamine |
US4795644A (en) * | 1987-08-03 | 1989-01-03 | Merck & Co., Inc. | Device for pH independent release of drugs through the Donnan-like influence of charged insoluble resins |
-
1988
- 1988-10-19 IL IL88083A patent/IL88083A/xx not_active IP Right Cessation
- 1988-10-26 IE IE324688A patent/IE60785B1/en not_active IP Right Cessation
- 1988-10-31 ZA ZA888147A patent/ZA888147B/xx unknown
- 1988-11-01 AT AT88310271T patent/ATE68343T1/de not_active IP Right Cessation
- 1988-11-01 EP EP88310271A patent/EP0315414B1/en not_active Expired - Lifetime
- 1988-11-01 ES ES198888310271T patent/ES2027013T3/es not_active Expired - Lifetime
- 1988-11-01 DE DE8888310271T patent/DE3865631D1/de not_active Expired - Lifetime
- 1988-11-03 BG BG85941A patent/BG60638B1/bg unknown
- 1988-11-03 CA CA000582132A patent/CA1331565C/en not_active Expired - Lifetime
- 1988-11-04 DK DK198806180A patent/DK175249B1/da not_active IP Right Cessation
- 1988-11-04 PT PT88945A patent/PT88945B/pt not_active IP Right Cessation
- 1988-11-04 HU HU885710A patent/HU201468B/hu unknown
- 1988-11-04 US US07/267,085 patent/US4963365A/en not_active Expired - Lifetime
- 1988-11-04 RU SU884356826A patent/RU1816213C/ru active
- 1988-11-04 FR FR888814466A patent/FR2622799B1/fr not_active Expired - Lifetime
- 1988-11-04 PH PH3772A patent/PH25905A/en unknown
- 1988-11-04 FI FI885101A patent/FI96273C/fi not_active IP Right Cessation
- 1988-11-04 AU AU24727/88A patent/AU610275B2/en not_active Expired
- 1988-11-04 NO NO884947A patent/NO176233C/no not_active IP Right Cessation
- 1988-11-05 KR KR1019880014528A patent/KR940002655B1/ko not_active IP Right Cessation
- 1988-11-05 CN CN88107687A patent/CN1035099C/zh not_active Expired - Lifetime
-
1991
- 1991-10-17 GR GR91401439T patent/GR3002915T3/el unknown
-
1993
- 1993-02-11 SG SG154/93A patent/SG15493G/en unknown
- 1993-05-06 HK HK445/93A patent/HK44593A/xx not_active IP Right Cessation
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