BG64167B1 - Използване на заместени аминометил-хромани за профилактика на невронална дегенерация и за стимулиране на невронална регенерация - Google Patents

Използване на заместени аминометил-хромани за профилактика на невронална дегенерация и за стимулиране на невронална регенерация Download PDF

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Publication number
BG64167B1
BG64167B1 BG104466A BG10446600A BG64167B1 BG 64167 B1 BG64167 B1 BG 64167B1 BG 104466 A BG104466 A BG 104466A BG 10446600 A BG10446600 A BG 10446600A BG 64167 B1 BG64167 B1 BG 64167B1
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BG
Bulgaria
Prior art keywords
formula
och
hydrogen
use according
radical
Prior art date
Application number
BG104466A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104466A (en
Inventor
Thomas Fahrig
Irene Gerlach
Ervin Horvath
Reinhard Jork
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of BG104466A publication Critical patent/BG104466A/xx
Publication of BG64167B1 publication Critical patent/BG64167B1/bg

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
BG104466A 1997-11-24 2000-05-22 Използване на заместени аминометил-хромани за профилактика на невронална дегенерация и за стимулиране на невронална регенерация BG64167B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19751949A DE19751949A1 (de) 1997-11-24 1997-11-24 Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
PCT/EP1998/007197 WO1999026621A1 (de) 1997-11-24 1998-11-11 Verwendung von substituierten aminomethyl-chromanen zur verhinderung der neuronalen degeneration und zur förderung der neuronalen regeneration

Publications (2)

Publication Number Publication Date
BG104466A BG104466A (en) 2001-02-28
BG64167B1 true BG64167B1 (bg) 2004-03-31

Family

ID=7849618

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104466A BG64167B1 (bg) 1997-11-24 2000-05-22 Използване на заместени аминометил-хромани за профилактика на невронална дегенерация и за стимулиране на невронална регенерация

Country Status (30)

Country Link
US (2) US6235774B1 (no)
EP (1) EP1051170B1 (no)
JP (1) JP2001523716A (no)
KR (1) KR20010032357A (no)
CN (1) CN1134256C (no)
AR (1) AR016973A1 (no)
AT (1) ATE206615T1 (no)
AU (1) AU745759B2 (no)
BG (1) BG64167B1 (no)
CA (1) CA2311126A1 (no)
DE (2) DE19751949A1 (no)
DK (1) DK1051170T3 (no)
ES (1) ES2164465T3 (no)
HN (1) HN1998000169A (no)
HU (1) HUP0004369A3 (no)
IL (1) IL135904A (no)
IS (1) IS5496A (no)
MY (1) MY118414A (no)
NO (1) NO20002638D0 (no)
NZ (1) NZ504656A (no)
PE (1) PE134999A1 (no)
PL (1) PL340674A1 (no)
PT (1) PT1051170E (no)
RU (1) RU2217140C2 (no)
SI (1) SI1051170T1 (no)
SV (1) SV1998000138A (no)
TR (1) TR200001471T2 (no)
TW (1) TW524690B (no)
WO (1) WO1999026621A1 (no)
ZA (1) ZA9810668B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
UA73981C2 (en) * 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
US20030207890A1 (en) 2001-02-23 2003-11-06 Collier Robert J Compounds with 5-ht1a activity useful for treating disorders of the outer retina
EP1263434A1 (en) * 2000-03-17 2002-12-11 Alcon, Inc Compounds with 5-ht 2 and 5-ht 1a agonist activity for treating glaucoma
DE10058119A1 (de) * 2000-11-22 2002-05-23 Bayer Ag Pepinotan-Kit
SE0004455D0 (sv) * 2000-12-01 2000-12-01 Milos Pekny Method for neuron regeneration in the central nervous system
DE10101917A1 (de) * 2001-01-16 2002-07-18 Bayer Ag Verwendung von Chromanen
DK1408964T3 (da) * 2001-07-26 2007-05-21 Merck Patent Gmbh Hidtil ukendt anvendelse af 2-5-(4-fluorphenyl)-3-pyridylmethylaminomethyl-chroman og fysiologisk acceptable salte deraf
EP1425008B1 (en) * 2001-09-12 2006-10-04 MERCK PATENT GmbH Use of substituted aminomethyl chromans in the treatment of side effects of neuroleptics
DE10155075A1 (de) * 2001-11-09 2003-05-22 Merck Patent Gmbh Cyclische Sulfonamide
ITTO20030140U1 (it) * 2003-09-16 2005-03-17 Interfila Srl Matita cosmetica
CA2583087C (en) * 2003-09-19 2012-07-10 Galileo Pharmaceuticals, Inc. Chroman derivatives
DE102004017627A1 (de) * 2004-04-10 2005-10-27 Bayer Healthcare Ag Verwendung von vollen 5-HT1A-Agonisten zur Hemmung der opiat/opioid-induzierten Atemdepression
SG11201900687VA (en) 2016-07-29 2019-02-27 Sunovion Pharmaceuticals Inc Compounds and compositions and uses thereof
UA125519C2 (uk) 2016-07-29 2022-04-13 Суновіон Фармасьютікалз Інк. Сполуки і композиції і їх застосування
RU2651756C1 (ru) * 2017-05-10 2018-04-23 Федеральное государственное бюджетное образовательное учреждение Высшего Образования Кубанский Государственный Медицинский Университет Министерства Здравоохранения Российской Федерации, КубГМУ Препарат для предотвращения образования глиальных рубцов
CA3070993A1 (en) * 2017-08-02 2019-02-07 Sunovion Pharmaceuticals Inc. Isochroman compounds and uses thereof
AU2020236225A1 (en) 2019-03-14 2021-09-16 Sunovion Pharmaceuticals Inc. Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300523A (en) 1988-07-28 1994-04-05 Bayer Aktiengesellschaft Substituted aminomethyltetralins and their heterocyclic analogues
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
DE4135474A1 (de) 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
DE19522088A1 (de) 1995-06-19 1997-01-02 Bayer Ag Benzisothiazolyl-substituierte Aminomethylchromane
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration

Also Published As

Publication number Publication date
HN1998000169A (es) 1999-11-03
US6235774B1 (en) 2001-05-22
ZA9810668B (en) 1999-05-26
NO20002638L (no) 2000-05-23
IL135904A0 (en) 2001-05-20
RU2217140C2 (ru) 2003-11-27
CA2311126A1 (en) 1999-06-03
HUP0004369A2 (hu) 2001-04-28
DE19751949A1 (de) 1999-05-27
AR016973A1 (es) 2001-08-01
IL135904A (en) 2003-07-06
WO1999026621A1 (de) 1999-06-03
AU1668599A (en) 1999-06-15
MY118414A (en) 2004-10-30
JP2001523716A (ja) 2001-11-27
SV1998000138A (es) 1999-05-25
AU745759B2 (en) 2002-03-28
CN1279604A (zh) 2001-01-10
EP1051170A1 (de) 2000-11-15
US20010018530A1 (en) 2001-08-30
SI1051170T1 (en) 2001-12-31
IS5496A (is) 2000-05-15
HUP0004369A3 (en) 2002-04-29
DK1051170T3 (da) 2001-12-27
US6331561B2 (en) 2001-12-18
ATE206615T1 (de) 2001-10-15
TR200001471T2 (tr) 2000-10-23
PL340674A1 (en) 2001-02-12
DE59801724D1 (de) 2001-11-15
NZ504656A (en) 2002-02-01
ES2164465T3 (es) 2002-02-16
BG104466A (en) 2001-02-28
PT1051170E (pt) 2002-02-28
NO20002638D0 (no) 2000-05-23
PE134999A1 (es) 2000-03-05
TW524690B (en) 2003-03-21
EP1051170B1 (de) 2001-10-10
KR20010032357A (ko) 2001-04-16
CN1134256C (zh) 2004-01-14

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