BG63970B1 - Метод за получаване на епросартан - Google Patents

Метод за получаване на епросартан Download PDF

Info

Publication number
BG63970B1
BG63970B1 BG103649A BG10364999A BG63970B1 BG 63970 B1 BG63970 B1 BG 63970B1 BG 103649 A BG103649 A BG 103649A BG 10364999 A BG10364999 A BG 10364999A BG 63970 B1 BG63970 B1 BG 63970B1
Authority
BG
Bulgaria
Prior art keywords
alkyl
formula
butyl
thienyl
reaction
Prior art date
Application number
BG103649A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG103649A (en
Inventor
Richard MATSUOKA
Peng Liu
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of BG103649A publication Critical patent/BG103649A/xx
Publication of BG63970B1 publication Critical patent/BG63970B1/bg

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG103649A 1997-02-14 1999-08-10 Метод за получаване на епросартан BG63970B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3819697P 1997-02-14 1997-02-14
PCT/US1998/002411 WO1998035962A1 (en) 1997-02-14 1998-02-13 Process for preparing eprosartan

Publications (2)

Publication Number Publication Date
BG103649A BG103649A (en) 2000-06-30
BG63970B1 true BG63970B1 (bg) 2003-08-29

Family

ID=21898590

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103649A BG63970B1 (bg) 1997-02-14 1999-08-10 Метод за получаване на епросартан

Country Status (41)

Country Link
US (2) US6294675B1 (de)
EP (1) EP0973769B1 (de)
JP (1) JP4227671B2 (de)
KR (1) KR100551667B1 (de)
CN (1) CN1093128C (de)
AP (1) AP1202A (de)
AR (1) AR011126A1 (de)
AT (1) ATE274511T1 (de)
AU (1) AU730162B2 (de)
BG (1) BG63970B1 (de)
BR (1) BRPI9808642B8 (de)
CA (1) CA2281471C (de)
CO (1) CO4950549A1 (de)
CY (1) CY2551B1 (de)
CZ (1) CZ296543B6 (de)
DE (1) DE69825880T2 (de)
DK (1) DK0973769T3 (de)
DZ (1) DZ2418A1 (de)
EA (1) EA001761B1 (de)
EG (1) EG23780A (de)
ES (1) ES2224358T3 (de)
HK (1) HK1026206A1 (de)
HU (1) HU228098B1 (de)
ID (1) ID23155A (de)
IL (4) IL143785A (de)
IN (1) IN188000B (de)
MA (1) MA24472A1 (de)
MY (1) MY120024A (de)
NO (1) NO317761B1 (de)
NZ (1) NZ337182A (de)
OA (1) OA11086A (de)
PE (1) PE59799A1 (de)
PL (1) PL192837B1 (de)
PT (1) PT973769E (de)
SA (1) SA98190146B1 (de)
SI (1) SI0973769T1 (de)
SK (1) SK285125B6 (de)
TR (1) TR199901935T2 (de)
UA (1) UA57060C2 (de)
WO (1) WO1998035962A1 (de)
ZA (1) ZA981208B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR011126A1 (es) * 1997-02-14 2000-08-02 Smithkline Beecham Corp Procedimiento para preparar eprosartano y compuestos intermediarios.
US6630498B2 (en) * 1997-08-06 2003-10-07 Smithkline Beecham Corporation Eprosartan arginyl charge-neutralization-complex and a process for its preparation and formulation
PL193673B1 (pl) * 1998-07-20 2007-03-30 Smithkline Beecham Corp Bezpostaciowa sól amonowa eprosartanu,jej granulat i biologicznie ulepszony preparat oraz sposoby ich wytwarzania i zastosowanie
US20060099230A1 (en) * 2004-11-10 2006-05-11 Chin-Chih Chiang Novel formulations of eprosartan with enhanced bioavailability
WO2008078330A1 (en) * 2006-12-27 2008-07-03 Hetero Drugs Limited Improved process for eprosartan
BRPI0817860A2 (pt) * 2007-10-22 2019-09-24 Orchid Res Laboratories Limited inibidores de histona deacetilase
CN101215284B (zh) * 2007-12-31 2010-10-13 浙江华海药业股份有限公司 一种改进的依普罗沙坦的制备方法
WO2011004384A2 (en) 2009-06-05 2011-01-13 Glochem Industries Limited Process for the preparation of eprosartan
CN102584709B (zh) * 2011-12-19 2016-08-17 浙江华海药业股份有限公司 一种改进的依普罗沙坦中间体芳基咪唑醛的制备工艺
CN103288742A (zh) * 2013-06-04 2013-09-11 四川百利药业有限责任公司 一种高纯度英加韦林原料的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185351A (en) * 1989-06-14 1993-02-09 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
US5418250A (en) * 1989-06-14 1995-05-23 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
EP0955294B1 (de) * 1989-06-14 2003-09-24 Smithkline Beecham Corporation Imidazoalkensäure
NZ239161A (en) * 1990-07-31 1994-01-26 Smithkline Beecham Corp Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
AU9137791A (en) * 1990-12-14 1992-07-08 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
AR011126A1 (es) * 1997-02-14 2000-08-02 Smithkline Beecham Corp Procedimiento para preparar eprosartano y compuestos intermediarios.

Also Published As

Publication number Publication date
DE69825880T2 (de) 2005-09-08
NO993912L (no) 1999-08-13
SK285125B6 (sk) 2006-06-01
IN188000B (de) 2002-08-03
IL143785A0 (en) 2002-04-21
EP0973769A4 (de) 2001-01-24
PL335074A1 (en) 2000-04-10
CN1247538A (zh) 2000-03-15
JP2001511808A (ja) 2001-08-14
IL143783A0 (en) 2002-04-21
DZ2418A1 (fr) 2003-06-26
KR20000071008A (ko) 2000-11-25
MY120024A (en) 2005-08-30
PT973769E (pt) 2004-11-30
IL131310A (en) 2003-02-12
ES2224358T3 (es) 2005-03-01
ID23155A (id) 2000-03-23
EP0973769B1 (de) 2004-08-25
CA2281471A1 (en) 1998-08-20
SI0973769T1 (en) 2004-12-31
EP0973769A1 (de) 2000-01-26
ATE274511T1 (de) 2004-09-15
JP4227671B2 (ja) 2009-02-18
OA11086A (en) 2003-03-13
CZ285199A3 (cs) 2000-02-16
NZ337182A (en) 2001-04-27
BR9808642A (pt) 2000-05-23
BR9808642B1 (pt) 2013-11-26
CA2281471C (en) 2007-04-24
EA001761B1 (ru) 2001-08-27
TR199901935T2 (xx) 1999-12-21
HUP0001813A2 (hu) 2001-06-28
AU730162B2 (en) 2001-03-01
WO1998035962A1 (en) 1998-08-20
CY2551B1 (en) 2008-07-02
US20020028951A1 (en) 2002-03-07
AP1202A (en) 2003-09-02
US6294675B1 (en) 2001-09-25
AU6273298A (en) 1998-09-08
MA24472A1 (fr) 1998-10-01
DK0973769T3 (da) 2004-12-13
CO4950549A1 (es) 2000-09-01
KR100551667B1 (ko) 2006-02-13
AR011126A1 (es) 2000-08-02
IL143784A (en) 2005-05-17
NO317761B1 (no) 2004-12-13
BG103649A (en) 2000-06-30
US6458963B1 (en) 2002-10-01
PE59799A1 (es) 1999-08-06
BRPI9808642B8 (pt) 2021-05-25
EG23780A (en) 2007-08-13
HK1026206A1 (en) 2000-12-08
IL143783A (en) 2005-05-17
IL143785A (en) 2004-12-15
ZA981208B (en) 1998-11-12
CN1093128C (zh) 2002-10-23
UA57060C2 (uk) 2003-06-16
CZ296543B6 (cs) 2006-04-12
DE69825880D1 (de) 2004-09-30
IL143784A0 (en) 2002-04-21
AP9901619A0 (en) 1999-09-30
HUP0001813A3 (en) 2001-07-30
SA98190146B1 (ar) 2006-08-20
HU228098B1 (en) 2012-10-29
PL192837B1 (pl) 2006-12-29
EA199900741A1 (ru) 2000-02-28
SK108699A3 (en) 2000-05-16
NO993912D0 (no) 1999-08-13
IL131310A0 (en) 2001-01-28

Similar Documents

Publication Publication Date Title
JP4048119B2 (ja) 2−(4−クロロベンゾイルアミノ)−3−[2(1h)−キノールリノン−4−イル]プロピオン酸の製造方法
US6294675B1 (en) Process for preparing eprosartan using regioselective protection of 2,4-disubstituted-imidazole intermediates
CA2281708C (en) Process for preparing eprosartan
JP4433365B2 (ja) 4−(2−メチル−1−イミダゾリル)−2,2−ジフェニルブタンアミドの製造方法
MXPA99007536A (en) Process for preparing eprosartan
SK62293A3 (en) Substituted (benzothiazolyl and quinaxalyl-methoxy) phenyl-acetic acid derivatives
JP2010013485A (ja) 4−(2−メチル−1−イミダゾリル)−2,2−ジフェニルブタンアミドの製造方法
CA2092886A1 (en) Cycloalkyl- and heterocyclyl-substituted imidazolylpropenoic acid derivatives