BG62401B1 - Пиридилтиосъединения, метод за тяхното получаване иприложението им за борба с бактерии от рода helicobacter - Google Patents
Пиридилтиосъединения, метод за тяхното получаване иприложението им за борба с бактерии от рода helicobacter Download PDFInfo
- Publication number
- BG62401B1 BG62401B1 BG101109A BG10110997A BG62401B1 BG 62401 B1 BG62401 B1 BG 62401B1 BG 101109 A BG101109 A BG 101109A BG 10110997 A BG10110997 A BG 10110997A BG 62401 B1 BG62401 B1 BG 62401B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- substituted
- residue
- group
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH230394 | 1994-07-20 | ||
| PCT/EP1995/002851 WO1996002505A1 (fr) | 1994-07-20 | 1995-07-19 | Composes de thiopyridyle utiles pour combattre des bacteries helicobacter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG101109A BG101109A (en) | 1997-08-29 |
| BG62401B1 true BG62401B1 (bg) | 1999-10-29 |
Family
ID=4230644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG101109A BG62401B1 (bg) | 1994-07-20 | 1997-01-06 | Пиридилтиосъединения, метод за тяхното получаване иприложението им за борба с бактерии от рода helicobacter |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6162809A (fr) |
| EP (1) | EP0772593B1 (fr) |
| JP (1) | JPH10502660A (fr) |
| KR (1) | KR970704688A (fr) |
| CN (1) | CN1157610A (fr) |
| AT (1) | ATE238990T1 (fr) |
| AU (1) | AU702609B2 (fr) |
| BG (1) | BG62401B1 (fr) |
| CA (1) | CA2195444A1 (fr) |
| CZ (1) | CZ288524B6 (fr) |
| DE (1) | DE59510667D1 (fr) |
| FI (1) | FI970203A0 (fr) |
| HU (1) | HUT76639A (fr) |
| NO (1) | NO307377B1 (fr) |
| NZ (1) | NZ290422A (fr) |
| PL (1) | PL318298A1 (fr) |
| RU (1) | RU2149872C1 (fr) |
| SK (1) | SK281683B6 (fr) |
| WO (1) | WO1996002505A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA56992C2 (uk) * | 1995-05-08 | 2003-06-16 | Фармація Енд Апджон Компані | <font face="Symbol">a</font>-ПІРИМІДИНТІОАЛКІЛЗАМІЩЕНІ ТА <font face="Symbol">a</font>-ПІРИМІДИНОКСОАЛКІЛЗАМІЩЕНІ СПОЛУКИ |
| US6362009B1 (en) | 1997-11-21 | 2002-03-26 | Merck & Co., Inc. | Solid phase synthesis of heterocycles |
| EP1086094A1 (fr) * | 1998-05-23 | 2001-03-28 | Byk Gulden Lomberg Chemische Fabrik GmbH | Derives de quinoleine-aminomethyle-pyridyle a activite anti-helicobacter |
| ES2234261T3 (es) | 1998-05-23 | 2005-06-16 | Altana Pharma Ag | Derivados de pirimidin-aminometil-piridina, su preparacion y su uso en el control de bacterias helicobacter. |
| US6904489B2 (en) * | 2001-10-23 | 2005-06-07 | Digi International Inc. | Methods and systems for remotely accessing universal serial bus devices |
| KR101389246B1 (ko) | 2004-07-15 | 2014-04-24 | 브리스톨-마이어스스퀴브컴파니 | 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
| KR101348643B1 (ko) * | 2006-03-10 | 2014-01-08 | 링크 제노믹스 가부시키가이샤 | 항 헬리코박터피로리 작용을 가지는 신규 피리딘 유도체 |
| PL2103608T3 (pl) * | 2006-12-18 | 2013-02-28 | Link Genomics Inc | Środek do eradykacji Helicobacter pylori mający działanie hamujące na sekrecję kwasu żołądkowego |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| CN101486706B (zh) * | 2009-03-09 | 2012-12-19 | 邓菊娟 | 一种奥美拉唑钠化合物及其合成方法 |
| EA020553B1 (ru) * | 2009-05-12 | 2014-12-30 | Олбани Молекьюлар Рисерч, Инк. | 7-([1,2,4]ТРИАЗОЛО[1,5-α]ПИРИДИН-6-ИЛ)-4-(3,4-ДИХЛОРФЕНИЛ)-1,2,3,4-ТЕТРАГИДРОИЗОХИНОЛИН, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ И СПОСОБЫ ЛЕЧЕНИЯ НЕВРОЛОГИЧЕСКИХ И ПСИХИЧЕСКИХ РАССТРОЙСТВ |
| WO2010132437A1 (fr) * | 2009-05-12 | 2010-11-18 | Albany Molecular Research, Inc. | Aryle, hétéroaryle et tétrahydroisoquinolines à hétérocycle substitué et leur utilisation |
| JP5739415B2 (ja) * | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用 |
| SG186885A1 (en) | 2010-06-04 | 2013-02-28 | Albany Molecular Res Inc | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| CN105622599B (zh) * | 2016-03-01 | 2018-08-31 | 浙江工业大学 | 一种2-取代苄硫基-5-(4,6-二甲基嘧啶-2-)硫甲基-1,3,4-噻二唑类化合物及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62209062A (ja) * | 1986-03-10 | 1987-09-14 | Yamanouchi Pharmaceut Co Ltd | ２−ピリジルメチルチオ−または２−ピリジルメチルスルフイニル−置換縮合環化合物 |
| AU5699594A (en) * | 1992-12-10 | 1994-07-04 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Use of alkylthiopyridines for controlling helicobacter bacteria |
-
1995
- 1995-07-19 HU HU9700023A patent/HUT76639A/hu unknown
- 1995-07-19 CN CN95195063A patent/CN1157610A/zh active Pending
- 1995-07-19 AT AT95926959T patent/ATE238990T1/de not_active IP Right Cessation
- 1995-07-19 KR KR1019970700444A patent/KR970704688A/ko not_active Application Discontinuation
- 1995-07-19 CZ CZ1997170A patent/CZ288524B6/cs not_active IP Right Cessation
- 1995-07-19 NZ NZ290422A patent/NZ290422A/xx unknown
- 1995-07-19 DE DE59510667T patent/DE59510667D1/de not_active Expired - Fee Related
- 1995-07-19 JP JP8504717A patent/JPH10502660A/ja active Pending
- 1995-07-19 US US08/776,047 patent/US6162809A/en not_active Expired - Fee Related
- 1995-07-19 SK SK1687-96A patent/SK281683B6/sk unknown
- 1995-07-19 RU RU97102557A patent/RU2149872C1/ru active
- 1995-07-19 PL PL95318298A patent/PL318298A1/xx unknown
- 1995-07-19 EP EP95926959A patent/EP0772593B1/fr not_active Expired - Lifetime
- 1995-07-19 CA CA002195444A patent/CA2195444A1/fr not_active Abandoned
- 1995-07-19 WO PCT/EP1995/002851 patent/WO1996002505A1/fr active IP Right Grant
- 1995-07-19 AU AU31155/95A patent/AU702609B2/en not_active Ceased
-
1997
- 1997-01-06 BG BG101109A patent/BG62401B1/bg unknown
- 1997-01-17 FI FI970203A patent/FI970203A0/fi unknown
- 1997-01-17 NO NO970225A patent/NO307377B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SK168796A3 (en) | 1997-09-10 |
| AU3115595A (en) | 1996-02-16 |
| AU702609B2 (en) | 1999-02-25 |
| EP0772593B1 (fr) | 2003-05-02 |
| EP0772593A1 (fr) | 1997-05-14 |
| CA2195444A1 (fr) | 1996-02-01 |
| JPH10502660A (ja) | 1998-03-10 |
| BG101109A (en) | 1997-08-29 |
| FI970203A (fi) | 1997-01-17 |
| MX9700524A (es) | 1998-05-31 |
| ATE238990T1 (de) | 2003-05-15 |
| DE59510667D1 (de) | 2003-06-05 |
| US6162809A (en) | 2000-12-19 |
| KR970704688A (ko) | 1997-09-06 |
| NO970225D0 (no) | 1997-01-17 |
| HU9700023D0 (en) | 1997-02-28 |
| CN1157610A (zh) | 1997-08-20 |
| PL318298A1 (en) | 1997-06-09 |
| CZ17097A3 (en) | 1997-09-17 |
| WO1996002505A1 (fr) | 1996-02-01 |
| NZ290422A (en) | 1999-02-25 |
| RU2149872C1 (ru) | 2000-05-27 |
| SK281683B6 (sk) | 2001-06-11 |
| NO970225L (no) | 1997-03-17 |
| CZ288524B6 (cs) | 2001-07-11 |
| HUT76639A (en) | 1997-10-28 |
| NO307377B1 (no) | 2000-03-27 |
| FI970203A0 (fi) | 1997-01-17 |
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| MXPA97000524A (en) | Compounds of piridiltium to combat bacteriasde helicobac | |
| WO1996000224A1 (fr) | 6-alkylpyridines a substitution n et 4-s utiles pour combattre des bacteries helicobacter | |
| CZ20004376A3 (cs) | Deriváty pyrimidin-aminomethyl-pyridinii |