BG60798B2 - Нови морфолинови производни,метод за тяхното получаване, фармацевтични средства,съдържащи тези производни,и използването им като антимикотици - Google Patents
Нови морфолинови производни,метод за тяхното получаване, фармацевтични средства,съдържащи тези производни,и използването им като антимикотици Download PDFInfo
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- BG60798B2 BG60798B2 BG098580A BG9858094A BG60798B2 BG 60798 B2 BG60798 B2 BG 60798B2 BG 098580 A BG098580 A BG 098580A BG 9858094 A BG9858094 A BG 9858094A BG 60798 B2 BG60798 B2 BG 60798B2
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- compound
- compounds
- phenyl
- cis
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- 238000000034 method Methods 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims description 9
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- 150000003839 salts Chemical class 0.000 claims abstract description 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 11
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- 239000012456 homogeneous solution Substances 0.000 description 1
- 238000003898 horticulture Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 229910000040 hydrogen fluoride Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical class CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 125000006178 methyl benzyl group Chemical group 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 150000002763 monocarboxylic acids Chemical class 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 239000010970 precious metal Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 210000005000 reproductive tract Anatomy 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- CRNIHJHMEQZAAS-UHFFFAOYSA-N tert-amyl chloride Chemical compound CCC(C)(C)Cl CRNIHJHMEQZAAS-UHFFFAOYSA-N 0.000 description 1
- 150000003509 tertiary alcohols Chemical class 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH756079A CH644113A5 (en) | 1979-08-17 | 1979-08-17 | N-substituted 2,6-dimethylmorpholine compounds |
| CH418780 | 1980-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG60798B2 true BG60798B2 (bg) | 1996-03-29 |
Family
ID=25694874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG098580A BG60798B2 (bg) | 1979-08-17 | 1994-02-25 | Нови морфолинови производни,метод за тяхното получаване, фармацевтични средства,съдържащи тези производни,и използването им като антимикотици |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP0024334B1 (fi) |
| AR (1) | AR225318A1 (fi) |
| AT (1) | ATE4206T1 (fi) |
| AU (1) | AU530398B2 (fi) |
| BG (1) | BG60798B2 (fi) |
| CA (1) | CA1128943A (fi) |
| CS (1) | CS402091A3 (fi) |
| CU (1) | CU35298A (fi) |
| DE (3) | DE3029966A1 (fi) |
| DK (1) | DK150509C (fi) |
| ES (2) | ES8200355A1 (fi) |
| FI (1) | FI69455C (fi) |
| FR (1) | FR2463767B1 (fi) |
| GB (1) | GB2056454B (fi) |
| HR (1) | HRP930340B1 (fi) |
| HU (1) | HU182189B (fi) |
| IE (1) | IE52642B1 (fi) |
| IL (1) | IL60813A (fi) |
| IT (1) | IT1220970B (fi) |
| LU (1) | LU82713A1 (fi) |
| MC (1) | MC1345A1 (fi) |
| MY (1) | MY8500272A (fi) |
| NL (1) | NL8004537A (fi) |
| NO (1) | NO153176C (fi) |
| NZ (1) | NZ194628A (fi) |
| PH (1) | PH15480A (fi) |
| PT (1) | PT71708B (fi) |
| SE (1) | SE447730B (fi) |
| SI (1) | SI8011754A8 (fi) |
| YU (1) | YU43475B (fi) |
| ZW (1) | ZW15780A1 (fi) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3421810A1 (de) * | 1984-06-12 | 1985-12-12 | Basf Ag, 6700 Ludwigshafen | Phenylalkylamine - bioregulatoren |
| CA2008775C (en) * | 1989-02-24 | 1998-12-22 | Alberto Ferro | Nail lacquer |
| EP0446585A1 (en) * | 1990-03-12 | 1991-09-18 | F. Hoffmann-La Roche Ag | Control of fungal infections in aquaculture |
| EP1749825A1 (en) * | 2005-07-28 | 2007-02-07 | Galderma S.A. | Process of producing amorolfine |
| EP1749826A1 (en) | 2005-07-28 | 2007-02-07 | Galderma S.A. | Process of producing bepromoline |
| EP1842848A1 (en) * | 2006-04-03 | 2007-10-10 | Galderma S.A. | Process for producing 3-[4-(1,1-dimethyl-propyl)-phenyl]2-methyl-propionaldehyde and cis-4{3-[4-(1,1-dimethyl-propyl)-phenyl]2-methyl-propyl}-2,6-dimethyl-morpholine (amorolfine) |
| EP1935889A1 (en) * | 2006-12-21 | 2008-06-25 | Galderma S.A. | Process of producing amorolfine |
| ITFI20090032A1 (it) | 2009-02-20 | 2010-08-21 | Synteco S P A Prodotti Di Sintesi Per L Ind | Processo di produzione industriale dell'amorolfina cloridrato |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT354187B (de) * | 1976-11-22 | 1979-12-27 | Hoffmann La Roche | Fungizides mittel |
| DE2656747C2 (de) * | 1976-12-15 | 1984-07-05 | Basf Ag, 6700 Ludwigshafen | Morpholinderivate |
| ZA792242B (en) * | 1978-05-16 | 1980-05-28 | Hoffmann La Roche | Heterocyclic compounds |
| DE2830127A1 (de) * | 1978-07-08 | 1980-01-17 | Basf Ag | N-arylpropyl-substituierte cyclische amine |
| DE2830999A1 (de) * | 1978-07-14 | 1980-01-31 | Basf Ag | Verfahren zur herstellung von stereoisomeren n-aralkyl-2,6-dimethylmorpholinen |
| DE2965247D1 (en) * | 1978-08-08 | 1983-05-26 | Hoffmann La Roche | Synthesis of phenyl-propyl morpholine and piperidine derivatives |
| DE2907614A1 (de) * | 1979-02-27 | 1980-09-04 | Basf Ag | Optische aktive formen des 1- eckige klammer auf 3-(p-tert.-buthylphenyl)-2- methylpropyl eckige klammer zu -cis-3,5- dimethylmorpholins |
-
1980
- 1980-07-07 IT IT23283/80A patent/IT1220970B/it active
- 1980-07-07 ZW ZW157/80A patent/ZW15780A1/xx unknown
- 1980-07-08 SI SI8011754A patent/SI8011754A8/sl unknown
- 1980-07-08 YU YU1754/80A patent/YU43475B/xx unknown
- 1980-07-11 CA CA356,038A patent/CA1128943A/en not_active Expired
- 1980-07-25 AR AR281915A patent/AR225318A1/es active
- 1980-07-30 CU CU8035298A patent/CU35298A/es unknown
- 1980-08-01 FI FI802418A patent/FI69455C/fi not_active IP Right Cessation
- 1980-08-05 PH PH24406A patent/PH15480A/en unknown
- 1980-08-07 DE DE19803029966 patent/DE3029966A1/de not_active Withdrawn
- 1980-08-07 DE DE1993175077 patent/DE19375077I2/de active Active
- 1980-08-07 EP EP80104656A patent/EP0024334B1/de not_active Expired
- 1980-08-07 AT AT80104656T patent/ATE4206T1/de active
- 1980-08-07 DE DE8080104656T patent/DE3064267D1/de not_active Expired
- 1980-08-08 NL NL8004537A patent/NL8004537A/nl not_active Application Discontinuation
- 1980-08-11 AU AU61321/80A patent/AU530398B2/en not_active Expired
- 1980-08-11 NZ NZ194628A patent/NZ194628A/en unknown
- 1980-08-11 IL IL60813A patent/IL60813A/xx unknown
- 1980-08-14 FR FR8017977A patent/FR2463767B1/fr not_active Expired
- 1980-08-14 LU LU82713A patent/LU82713A1/de unknown
- 1980-08-14 MC MC801466A patent/MC1345A1/xx unknown
- 1980-08-14 PT PT71708A patent/PT71708B/pt unknown
- 1980-08-15 DK DK355180A patent/DK150509C/da not_active IP Right Cessation
- 1980-08-15 HU HU802034A patent/HU182189B/hu unknown
- 1980-08-15 SE SE8005784A patent/SE447730B/sv not_active IP Right Cessation
- 1980-08-15 IE IE1729/80A patent/IE52642B1/en not_active IP Right Cessation
- 1980-08-15 NO NO802453A patent/NO153176C/no unknown
- 1980-08-15 GB GB8026709A patent/GB2056454B/en not_active Expired
- 1980-08-16 ES ES494314A patent/ES8200355A1/es not_active Expired
-
1981
- 1981-03-02 ES ES499957A patent/ES8201563A1/es not_active Expired
-
1985
- 1985-12-30 MY MY272/85A patent/MY8500272A/xx unknown
-
1991
- 1991-12-23 CS CS914020A patent/CS402091A3/cs unknown
-
1993
- 1993-03-12 HR HRP-1754/80A patent/HRP930340B1/xx not_active IP Right Cessation
-
1994
- 1994-02-25 BG BG098580A patent/BG60798B2/bg unknown
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