BG60479B1 - N,о-сулфатирани хепарозани, метод за получаването им и фармацевтичните смеси, които ги съдържат - Google Patents

N,о-сулфатирани хепарозани, метод за получаването им и фармацевтичните смеси, които ги съдържат Download PDF

Info

Publication number
BG60479B1
BG60479B1 BG95567A BG9556791A BG60479B1 BG 60479 B1 BG60479 B1 BG 60479B1 BG 95567 A BG95567 A BG 95567A BG 9556791 A BG9556791 A BG 9556791A BG 60479 B1 BG60479 B1 BG 60479B1
Authority
BG
Bulgaria
Prior art keywords
sulfated
molecular weight
chains
acetylheparosan
heparosan
Prior art date
Application number
BG95567A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG95567A (en
Inventor
Jean-Claude Lormeau
Bruno Chevallier
Marc Salome
D'estais Guy Tenaille
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of BG95567A publication Critical patent/BG95567A/xx
Publication of BG60479B1 publication Critical patent/BG60479B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BG95567A 1990-12-03 1991-12-03 N,о-сулфатирани хепарозани, метод за получаването им и фармацевтичните смеси, които ги съдържат BG60479B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR909015114A FR2669932B1 (fr) 1990-12-03 1990-12-03 Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.

Publications (2)

Publication Number Publication Date
BG95567A BG95567A (en) 1994-03-31
BG60479B1 true BG60479B1 (bg) 1995-05-31

Family

ID=9402838

Family Applications (1)

Application Number Title Priority Date Filing Date
BG95567A BG60479B1 (bg) 1990-12-03 1991-12-03 N,о-сулфатирани хепарозани, метод за получаването им и фармацевтичните смеси, които ги съдържат

Country Status (32)

Country Link
US (1) US5550116A (el)
EP (1) EP0489647B1 (el)
JP (1) JPH051101A (el)
KR (1) KR100214752B1 (el)
AR (1) AR248429A1 (el)
AT (1) ATE150033T1 (el)
AU (1) AU646112B2 (el)
BG (1) BG60479B1 (el)
BR (1) BR9105239A (el)
CA (1) CA2056878A1 (el)
CZ (1) CZ279081B6 (el)
DE (1) DE69125109T2 (el)
DK (1) DK0489647T3 (el)
ES (1) ES2099145T3 (el)
FI (1) FI103050B1 (el)
FR (1) FR2669932B1 (el)
GR (1) GR3023541T3 (el)
HU (1) HU214986B (el)
IE (1) IE914197A1 (el)
IL (1) IL100229A (el)
MX (1) MX9102353A (el)
MY (1) MY109669A (el)
NO (1) NO300277B1 (el)
NZ (1) NZ240838A (el)
PL (1) PL167668B1 (el)
PT (1) PT99671B (el)
RU (1) RU2099353C1 (el)
SI (1) SI9111886B (el)
SK (1) SK280642B6 (el)
TW (1) TW216396B (el)
YU (1) YU48680B (el)
ZA (1) ZA919518B (el)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2286193A (en) * 1991-03-28 1995-08-09 Italfarmaco Spa Anticoagulants and processes for preparing such
FR2684385B1 (fr) * 1991-11-28 1997-08-01 Sanofi Elf Heparosanes-n,o-sulfates de haute masse moleculaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
FR2709132B1 (fr) * 1993-08-17 1995-11-17 Sanofi Elf Fragment d'ADN portant le gène codant pour l'enzyme de fragmentation du N-acétylhéparosane et les séquences adjacentes permettant son expression, enzyme recombinée et son utilisation.
IT1282994B1 (it) * 1996-05-10 1998-04-03 Inalco Spa Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
IT1289613B1 (it) * 1997-02-07 1998-10-15 Inalco Spa Polisaccaridi batterici o-solfatati
IT1290814B1 (it) * 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
US6329351B1 (en) * 1997-08-28 2001-12-11 Istituto Scientifico Di Chimica E Biochimica “G. Ronzoni” Semi-synthetic sulphaminoheparosansulphates having high anti-metastatic activity and reduced haemorrhagic risk
US6190875B1 (en) * 1997-09-02 2001-02-20 Insight Strategy & Marketing Ltd. Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe
US20030161823A1 (en) * 1998-08-31 2003-08-28 Neta Ilan Therapeutic and cosmetic uses of heparanases
US6699672B1 (en) * 1997-09-02 2004-03-02 Insight Biopharmaceuticals Ltd. Heparanase specific molecular probes and their use research and medical applications
US20020088019A1 (en) * 1997-09-02 2002-07-04 Oron Yacoby-Zeevi Methods of and pharmaceutical compositions for improving implantation of embryos
US20010006630A1 (en) * 1997-09-02 2001-07-05 Oron Yacoby-Zeevi Introducing a biological material into a patient
US20040213789A1 (en) * 1997-09-02 2004-10-28 Oron Yacoby-Zeevi Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies
US6177545B1 (en) * 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
US20030217375A1 (en) * 1998-08-31 2003-11-20 Eyal Zcharia Transgenic animals expressing heparanase and uses thereof
AU2878600A (en) * 1999-03-01 2000-09-21 Hadasit Medical Research Services & Development Company Ltd Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
ITMI991465A1 (it) * 1999-07-02 2001-01-02 Inalco Spa Processo per la preparazione dei polisaccaridi k4 e k5 da escherichiacoli
IT1318432B1 (it) * 2000-03-30 2003-08-25 Inalco Spa Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro
US20020062019A1 (en) * 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
US8227449B2 (en) * 2000-03-30 2012-07-24 Glycores 2000 S.R.L. Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
US20050027117A1 (en) * 2000-12-18 2005-02-03 Pasqua Oreste Anticoagulant and antithrombotic LMW-glycosaminoglycans derived from K5 polysaccharide and process for their preparation
US6671189B2 (en) * 2001-11-09 2003-12-30 Minebea Co., Ltd. Power converter having primary and secondary side switches
US8513407B2 (en) 2002-06-18 2013-08-20 Glycores 2000 S.R.L. Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
WO2003106504A1 (en) * 2002-06-18 2003-12-24 Pasqua Anna Oreste Epimerized derivatives of k5 polysaccharide with a very high degree of sulfation
WO2004108065A2 (en) * 2003-06-09 2004-12-16 Insight Biopharmaceuticals Ltd. Heparanase activity neutralizing anti- heparanase monoclonal antibody and other anti-heparanase antibodies
ITMI20031618A1 (it) * 2003-08-06 2005-02-07 Inalco Spa Derivati polisaccaridici dotati di alta attivita'
FR2874931B1 (fr) * 2004-09-08 2006-11-24 Aventis Pharma Sa Procede de production de polysaccharide k5
WO2011028668A2 (en) * 2009-09-01 2011-03-10 Zhenyu Wang K5 heparosan fermentation and purification
CN111725495B (zh) * 2020-06-04 2021-07-02 大连理工大学 一种含n、o原子的网状聚合物的自支撑锂硫正极材料及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3211616A (en) * 1961-12-17 1965-10-12 Yosizawa Zensakn N, o-sulfated neutral-mucopolysaccharide
FR2538404B1 (el) * 1982-12-28 1985-08-23 Anic Spa
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
EP0333243A3 (en) * 1988-03-10 1989-09-27 Akzo N.V. Sulphated k5 antigen and sulphated k5 antigen fragments
IT1217458B (it) * 1988-05-02 1990-03-22 Crinos Ind Farmacoriologica S Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche
FR2634485B1 (fr) * 1988-07-21 1992-02-28 Sanopi Glycosaminoglycanes selectivement o-acyles, leur preparation et compositions pharmaceutiques les contenant
NZ226835A (en) * 1988-11-04 1992-10-28 Andrew Boyle Weather proof lamp housing: adjustable angle retained by interengaging teeth

Also Published As

Publication number Publication date
NZ240838A (en) 1993-11-25
CS366891A3 (en) 1992-09-16
CA2056878A1 (en) 1992-06-04
MX9102353A (es) 1992-06-01
FI915697A0 (fi) 1991-12-03
AU646112B2 (en) 1994-02-10
US5550116A (en) 1996-08-27
GR3023541T3 (en) 1997-08-29
PT99671B (pt) 1999-05-31
FR2669932A1 (fr) 1992-06-05
BR9105239A (pt) 1992-08-18
KR100214752B1 (ko) 1999-08-02
TW216396B (el) 1993-11-21
EP0489647B1 (fr) 1997-03-12
BG95567A (en) 1994-03-31
FI915697A (fi) 1992-06-04
ES2099145T3 (es) 1997-05-16
HUT60784A (en) 1992-10-28
YU188691A (sh) 1994-05-10
KR920012103A (ko) 1992-07-25
FR2669932B1 (fr) 1994-07-01
HU214986B (hu) 1998-08-28
CZ279081B6 (en) 1994-12-15
PL292624A1 (en) 1993-03-08
FI103050B (fi) 1999-04-15
AR248429A1 (es) 1995-08-18
SI9111886A (sl) 1998-02-28
SK280642B6 (sk) 2000-05-16
FI103050B1 (fi) 1999-04-15
JPH051101A (ja) 1993-01-08
DE69125109D1 (de) 1997-04-17
AU8836191A (en) 1992-06-04
IL100229A0 (en) 1992-09-06
ATE150033T1 (de) 1997-03-15
PT99671A (pt) 1992-10-30
EP0489647A3 (en) 1992-09-23
MY109669A (en) 1997-03-31
YU48680B (sh) 1999-06-15
SI9111886B (sl) 1999-12-31
ZA919518B (en) 1992-08-26
NO300277B1 (no) 1997-05-05
IL100229A (en) 1998-01-04
DE69125109T2 (de) 1997-08-28
IE914197A1 (en) 1992-06-03
NO914751D0 (no) 1991-12-03
HU913776D0 (en) 1992-02-28
DK0489647T3 (da) 1997-09-08
PL167668B1 (pl) 1995-10-31
RU2099353C1 (ru) 1997-12-20
EP0489647A2 (fr) 1992-06-10
NO914751L (no) 1992-06-04

Similar Documents

Publication Publication Date Title
BG60479B1 (bg) N,о-сулфатирани хепарозани, метод за получаването им и фармацевтичните смеси, които ги съдържат
US5384398A (en) High molecular mass N,O-sulphated heparosans, process for their preparation and the pharmaceutical compositions which contain them
US5013724A (en) Process for the sulfation of glycosaminoglycans, the sulfated glycosaminoglycans and their biological applications
RU2361881C2 (ru) Производные полисахаридов с высокой антитромботической активностью в плазме
TW200846014A (en) Low molecular weight heparins comprising at least one covalent bond with biotin or a biotin derivative, preparation process therefor and use thereof
Guezennec et al. Sulfation and depolymerization of a bacterial exopolysaccharide of hydrothermal origin
JP4267916B2 (ja) 多糖体ｋ５から誘導された高度のアンチトロンビン活性を有するグリコサミノグリカン及びその製法
JP5053512B2 (ja) 非常に大きい硫酸化度を持つｋ５多糖体のエピマー化誘導体
EP1268559A1 (en) Glycosaminoglycans derived from the k5 polysaccharide having high anticoagulant and antithrombotic activity and process for their preparation
EP1694714B1 (en) Low molecular weight polysaccharides having antithrombotic activity
WO1994029352A1 (en) Polysaccharides having high antithrombotic and anticoagulant activity
RU2333222C2 (ru) Эпимеризованные производные полисахарида к5 с высокой степенью сульфатирования
HRP920795A2 (en) Heparosan-n, o-sulfates, the process for obtaining them and pharmaceutical preparations containing the same