AR248429A1 - Procedimiento de preparacion de heparosanos-n, o-sulfatados; y heparosanos utilizados exclusivamente como intermediarios en dicho procedimiento. - Google Patents

Procedimiento de preparacion de heparosanos-n, o-sulfatados; y heparosanos utilizados exclusivamente como intermediarios en dicho procedimiento.

Info

Publication number
AR248429A1
AR248429A1 AR91321298A AR32129891A AR248429A1 AR 248429 A1 AR248429 A1 AR 248429A1 AR 91321298 A AR91321298 A AR 91321298A AR 32129891 A AR32129891 A AR 32129891A AR 248429 A1 AR248429 A1 AR 248429A1
Authority
AR
Argentina
Prior art keywords
partial
composition
total
stages
heparosanes
Prior art date
Application number
AR91321298A
Other languages
English (en)
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of AR248429A1 publication Critical patent/AR248429A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE UNA COMPOSICION QUE CONTENGA 70% A 100% DE UN HEPAROSANO-N, O-SULFATADO, QUE COMPRENDE LA SECUENCIA DE LAS ETAPAS: A) CULTIVO DE ESCHERICHIS COLI (K5); B) AISLAMIENTO Y PURIFICACION - PRECEDIDO O NO DE UNA PURIFICACION PRELIMINAR - DEL N-ACETILHEPAROSANO FORMADO PARA OBTENER UNA COMPOSICION QUE CONTENGA 70% A 100% DE UN N-ACETILHEPAROSANO CONSTITUIDO POR CADENAS O POR UNA MEZCLA DE CADENAS DE MASA MOLECULAR ENTRE 1.500 Y 15.000 DA, QUE TIENE UNA ESTRUCTURA DISACARIDICA REPETIDA DE FORMULA (II); C) DESACETILACION PARCIAL DE ESTA COMPOSICION; D) SEA N, O- SULFATACION PARCIAL DE ESTA COMPOSICION, SEA N, O-SULFATACION PARCIAL DE ESTA COMPOSICION, SEGUIDA DE UNA ETAPA DE N-SULFATACION TOTAL, SEA N, O- SULFATACION TOTAL O PARCIAL SEGUIDA DE UNA ETAPA DE O-SULFATACION TOTAL O PARCIAL, Y EVENTUALMENTE COMPORTA UNA O VARIAS ETAPAS DE FRACCIONAMIENTO DE LAS MASAS MOLECULARES EFECTUADAS AL FIN DE LAS ETAPAS A), B), C) O D).
AR91321298A 1990-12-03 1991-12-03 Procedimiento de preparacion de heparosanos-n, o-sulfatados; y heparosanos utilizados exclusivamente como intermediarios en dicho procedimiento. AR248429A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR909015114A FR2669932B1 (fr) 1990-12-03 1990-12-03 Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.

Publications (1)

Publication Number Publication Date
AR248429A1 true AR248429A1 (es) 1995-08-18

Family

ID=9402838

Family Applications (1)

Application Number Title Priority Date Filing Date
AR91321298A AR248429A1 (es) 1990-12-03 1991-12-03 Procedimiento de preparacion de heparosanos-n, o-sulfatados; y heparosanos utilizados exclusivamente como intermediarios en dicho procedimiento.

Country Status (32)

Country Link
US (1) US5550116A (es)
EP (1) EP0489647B1 (es)
JP (1) JPH051101A (es)
KR (1) KR100214752B1 (es)
AR (1) AR248429A1 (es)
AT (1) ATE150033T1 (es)
AU (1) AU646112B2 (es)
BG (1) BG60479B1 (es)
BR (1) BR9105239A (es)
CA (1) CA2056878A1 (es)
CZ (1) CZ279081B6 (es)
DE (1) DE69125109T2 (es)
DK (1) DK0489647T3 (es)
ES (1) ES2099145T3 (es)
FI (1) FI103050B1 (es)
FR (1) FR2669932B1 (es)
GR (1) GR3023541T3 (es)
HU (1) HU214986B (es)
IE (1) IE914197A1 (es)
IL (1) IL100229A (es)
MX (1) MX9102353A (es)
MY (1) MY109669A (es)
NO (1) NO300277B1 (es)
NZ (1) NZ240838A (es)
PL (1) PL167668B1 (es)
PT (1) PT99671B (es)
RU (1) RU2099353C1 (es)
SI (1) SI9111886B (es)
SK (1) SK280642B6 (es)
TW (1) TW216396B (es)
YU (1) YU48680B (es)
ZA (1) ZA919518B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2254083A (en) * 1991-03-28 1992-09-30 Italfarmaco Spa Anticoagulants from e.coli saccharide
FR2684385B1 (fr) * 1991-11-28 1997-08-01 Sanofi Elf Heparosanes-n,o-sulfates de haute masse moleculaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
FR2709132B1 (fr) * 1993-08-17 1995-11-17 Sanofi Elf Fragment d'ADN portant le gène codant pour l'enzyme de fragmentation du N-acétylhéparosane et les séquences adjacentes permettant son expression, enzyme recombinée et son utilisation.
IT1282994B1 (it) * 1996-05-10 1998-04-03 Inalco Spa Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
IT1289613B1 (it) * 1997-02-07 1998-10-15 Inalco Spa Polisaccaridi batterici o-solfatati
IT1290814B1 (it) * 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
US6329351B1 (en) * 1997-08-28 2001-12-11 Istituto Scientifico Di Chimica E Biochimica “G. Ronzoni” Semi-synthetic sulphaminoheparosansulphates having high anti-metastatic activity and reduced haemorrhagic risk
US6177545B1 (en) * 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
US6190875B1 (en) * 1997-09-02 2001-02-20 Insight Strategy & Marketing Ltd. Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe
US20020088019A1 (en) * 1997-09-02 2002-07-04 Oron Yacoby-Zeevi Methods of and pharmaceutical compositions for improving implantation of embryos
US20030161823A1 (en) * 1998-08-31 2003-08-28 Neta Ilan Therapeutic and cosmetic uses of heparanases
US6699672B1 (en) 1997-09-02 2004-03-02 Insight Biopharmaceuticals Ltd. Heparanase specific molecular probes and their use research and medical applications
US20010006630A1 (en) * 1997-09-02 2001-07-05 Oron Yacoby-Zeevi Introducing a biological material into a patient
US20040213789A1 (en) * 1997-09-02 2004-10-28 Oron Yacoby-Zeevi Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies
US20030217375A1 (en) * 1998-08-31 2003-11-20 Eyal Zcharia Transgenic animals expressing heparanase and uses thereof
WO2000052178A1 (en) * 1999-03-01 2000-09-08 Insight Strategy & Marketing Ltd. Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
ITMI991465A1 (it) * 1999-07-02 2001-01-02 Inalco Spa Processo per la preparazione dei polisaccaridi k4 e k5 da escherichiacoli
US8227449B2 (en) * 2000-03-30 2012-07-24 Glycores 2000 S.R.L. Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
IT1318432B1 (it) * 2000-03-30 2003-08-25 Inalco Spa Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro
US20020062019A1 (en) * 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
US20050027117A1 (en) * 2000-12-18 2005-02-03 Pasqua Oreste Anticoagulant and antithrombotic LMW-glycosaminoglycans derived from K5 polysaccharide and process for their preparation
US6671189B2 (en) * 2001-11-09 2003-12-30 Minebea Co., Ltd. Power converter having primary and secondary side switches
US8513407B2 (en) 2002-06-18 2013-08-20 Glycores 2000 S.R.L. Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
CN1671744A (zh) * 2002-06-18 2005-09-21 格利考斯2000有限公司 低分子量过硫酸化多糖
US20060269552A1 (en) * 2003-06-09 2006-11-30 Oron Yacoby-Zeevi Heparanase activity neutralizing anti-heparanase monclonal antibody and other anti-heparanase antibodies
ITMI20031618A1 (it) * 2003-08-06 2005-02-07 Inalco Spa Derivati polisaccaridici dotati di alta attivita'
FR2874931B1 (fr) * 2004-09-08 2006-11-24 Aventis Pharma Sa Procede de production de polysaccharide k5
CN102712942B (zh) * 2009-09-01 2014-05-14 伦斯勒理工学院 K5肝素前体的发酵和纯化
CN111725495B (zh) * 2020-06-04 2021-07-02 大连理工大学 一种含n、o原子的网状聚合物的自支撑锂硫正极材料及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3211616A (en) * 1961-12-17 1965-10-12 Yosizawa Zensakn N, o-sulfated neutral-mucopolysaccharide
FR2538404B1 (es) * 1982-12-28 1985-08-23 Anic Spa
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
EP0333243A3 (en) * 1988-03-10 1989-09-27 Akzo N.V. Sulphated k5 antigen and sulphated k5 antigen fragments
IT1217458B (it) * 1988-05-02 1990-03-22 Crinos Ind Farmacoriologica S Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche
FR2634485B1 (fr) * 1988-07-21 1992-02-28 Sanopi Glycosaminoglycanes selectivement o-acyles, leur preparation et compositions pharmaceutiques les contenant
NZ226835A (en) * 1988-11-04 1992-10-28 Andrew Boyle Weather proof lamp housing: adjustable angle retained by interengaging teeth

Also Published As

Publication number Publication date
RU2099353C1 (ru) 1997-12-20
EP0489647A2 (fr) 1992-06-10
EP0489647A3 (en) 1992-09-23
SI9111886B (sl) 1999-12-31
HU214986B (hu) 1998-08-28
TW216396B (es) 1993-11-21
NO914751D0 (no) 1991-12-03
NO300277B1 (no) 1997-05-05
PT99671B (pt) 1999-05-31
PT99671A (pt) 1992-10-30
KR920012103A (ko) 1992-07-25
IL100229A0 (en) 1992-09-06
ES2099145T3 (es) 1997-05-16
FI915697A0 (fi) 1991-12-03
BG95567A (en) 1994-03-31
JPH051101A (ja) 1993-01-08
EP0489647B1 (fr) 1997-03-12
CZ279081B6 (en) 1994-12-15
YU48680B (sh) 1999-06-15
IE914197A1 (en) 1992-06-03
FI103050B (fi) 1999-04-15
BG60479B1 (bg) 1995-05-31
HU913776D0 (en) 1992-02-28
MX9102353A (es) 1992-06-01
CA2056878A1 (en) 1992-06-04
FR2669932A1 (fr) 1992-06-05
MY109669A (en) 1997-03-31
HUT60784A (en) 1992-10-28
PL167668B1 (pl) 1995-10-31
NZ240838A (en) 1993-11-25
AU8836191A (en) 1992-06-04
ATE150033T1 (de) 1997-03-15
SI9111886A (sl) 1998-02-28
US5550116A (en) 1996-08-27
SK280642B6 (sk) 2000-05-16
DE69125109D1 (de) 1997-04-17
CS366891A3 (en) 1992-09-16
DK0489647T3 (da) 1997-09-08
BR9105239A (pt) 1992-08-18
GR3023541T3 (en) 1997-08-29
FR2669932B1 (fr) 1994-07-01
FI915697A (fi) 1992-06-04
NO914751L (no) 1992-06-04
ZA919518B (en) 1992-08-26
YU188691A (sh) 1994-05-10
AU646112B2 (en) 1994-02-10
IL100229A (en) 1998-01-04
KR100214752B1 (ko) 1999-08-02
DE69125109T2 (de) 1997-08-28
FI103050B1 (fi) 1999-04-15
PL292624A1 (en) 1993-03-08

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