BG52073B2 - Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine - Google Patents

Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine

Info

Publication number
BG52073B2
BG52073B2 BG9100690A BG9100690A BG52073B2 BG 52073 B2 BG52073 B2 BG 52073B2 BG 9100690 A BG9100690 A BG 9100690A BG 9100690 A BG9100690 A BG 9100690A BG 52073 B2 BG52073 B2 BG 52073B2
Authority
BG
Bulgaria
Prior art keywords
interferon
preparation
recombinant human
noncystein
free
Prior art date
Application number
BG9100690A
Other languages
English (en)
Inventor
Ljuben N Marekov
Rositsa A Vasileva
Veselin P Ivanov
Adriana A Sarafova
Rumen G Tsanev
Ivan G Ivanov
Vesela S Ivanova
Original Assignee
Inst Molekuljarna Biolog
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Molekuljarna Biolog filed Critical Inst Molekuljarna Biolog
Priority to BG9100690A priority Critical patent/BG52073B2/xx
Priority to EP19910100777 priority patent/EP0446582B1/en
Priority to ES91100777T priority patent/ES2066237T3/es
Priority to DE1991606407 priority patent/DE69106407T2/de
Priority to JP707491A priority patent/JPH05176789A/ja
Priority to SU4894482 priority patent/RU2054044C1/ru
Publication of BG52073B2 publication Critical patent/BG52073B2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
BG9100690A 1990-01-24 1990-01-24 Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine BG52073B2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BG9100690A BG52073B2 (en) 1990-01-24 1990-01-24 Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine
EP19910100777 EP0446582B1 (en) 1990-01-24 1991-01-22 Method for producing of recombinant human cysteineless gamma-interferon free of methionine at n-terminal
ES91100777T ES2066237T3 (es) 1990-01-24 1991-01-22 Procedimiento para producir gamma-interferon humano recombinante sin cisteina carente de metionina en el extremo n-terminal.
DE1991606407 DE69106407T2 (de) 1990-01-24 1991-01-22 Verfahren zur Herstellung von rekombinantem menschlichem gamma-Interferon ohne Cystein und ohne Methionin am N-Terminal.
JP707491A JPH05176789A (ja) 1990-01-24 1991-01-24 Ｎ−末端にメチオニンを含有しない、遺伝子組換えによるヒト・システイン非含有γ− インターフェロンの製造方法
SU4894482 RU2054044C1 (ru) 1990-01-24 1991-01-24 Способ получения рекомбинантного человеческого свободного от метионина на n-конце гамма-интерферона

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BG9100690A BG52073B2 (en) 1990-01-24 1990-01-24 Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine

Publications (1)

Publication Number Publication Date
BG52073B2 true BG52073B2 (en) 1996-04-30

Family

ID=3922678

Family Applications (1)

Application Number Title Priority Date Filing Date
BG9100690A BG52073B2 (en) 1990-01-24 1990-01-24 Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine

Country Status (6)

Country Link
EP (1) EP0446582B1 (xx)
JP (1) JPH05176789A (xx)
BG (1) BG52073B2 (xx)
DE (1) DE69106407T2 (xx)
ES (1) ES2066237T3 (xx)
RU (1) RU2054044C1 (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK8292002A3 (en) 1999-11-12 2002-12-03 Maxygen Holdings Ltd A conjugate exhibiting interferon gamma activity, nucleotide sequence encoding for a polypeptide fraction of conjugate, an expression vector and a host cell containing nucleotide sequence, pharmaceutical composition comprising the same and use thereof
CN1309423C (zh) 1999-11-12 2007-04-11 马克西根控股公司 干扰素γ偶联物
AU2002227499A1 (en) * 2000-07-31 2002-02-13 Takeda Chemical Industries Ltd. Process for producing recombined protein
CN1257186C (zh) * 2001-04-06 2006-05-24 马克西根控股公司 干扰素γ多肽变体
US6958388B2 (en) 2001-04-06 2005-10-25 Maxygen, Aps Interferon gamma polypeptide variants
US7038015B2 (en) 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
EP1539814A2 (en) 2002-07-03 2005-06-15 Maxygen Holdings Ltd. c/o Close Brothers (Cayman) Limited Full-length interferon gamma polypeptide variants
BG66458B1 (bg) 2005-03-21 2014-10-31 Иван Иванов Средство за конкурентно инхибиране на ендогенен гама интерферон
BG66517B1 (bg) 2008-04-08 2016-02-29 Tigo Gmbh Супресор на ендогенния човешки гама - интерферон
US9359421B2 (en) 2008-04-08 2016-06-07 Tigo Gmbh Suppressor of the endogenous interferon-gamma
FR3052462A1 (fr) 2016-06-14 2017-12-15 Dna Script Variants d'une adn polymerase de la famille polx

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855238A (en) * 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
EP0168008A3 (en) * 1984-07-10 1986-12-30 Takeda Chemical Industries, Ltd. Stable composition of gamma-interferon
JPS63501471A (ja) * 1984-12-27 1988-06-09 サントリー株式会社 インタ−フェロンの精製方法
JPS61177996A (ja) * 1985-02-02 1986-08-09 Green Cross Corp:The インタ−フエロン−γの製造法
EP0315950A3 (en) * 1987-11-09 1990-05-23 Otsuka Pharmaceutical Co., Ltd. Method of incubating cells expressing a recombinant protein

Also Published As

Publication number Publication date
DE69106407D1 (de) 1995-02-16
EP0446582B1 (en) 1995-01-04
JPH05176789A (ja) 1993-07-20
ES2066237T3 (es) 1995-03-01
EP0446582A1 (en) 1991-09-18
DE69106407T2 (de) 1995-05-18
RU2054044C1 (ru) 1996-02-10

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