BG45388A3 - Метод за получаване на сорбинил - Google Patents
Метод за получаване на сорбинилInfo
- Publication number
- BG45388A3 BG45388A3 BG076698A BG7669883A BG45388A3 BG 45388 A3 BG45388 A3 BG 45388A3 BG 076698 A BG076698 A BG 076698A BG 7669883 A BG7669883 A BG 7669883A BG 45388 A3 BG45388 A3 BG 45388A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- sorbinil
- salt
- ephedrine
- obtaining
- ncarbonylation
- Prior art date
Links
- LXANPKRCLVQAOG-NSHDSACASA-N sorbinil Chemical compound C12=CC(F)=CC=C2OCC[C@@]21NC(=O)NC2=O LXANPKRCLVQAOG-NSHDSACASA-N 0.000 title abstract 3
- 229950004311 sorbinil Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Chemical compound NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- PLFOGGJHQOVQAF-UHFFFAOYSA-N 4-(carbamoylamino)-6-fluoro-2,3-dihydrochromene-4-carboxylic acid Chemical compound C1=C(F)C=C2C(NC(=O)N)(C(O)=O)CCOC2=C1 PLFOGGJHQOVQAF-UHFFFAOYSA-N 0.000 abstract 1
- 102000016912 Aldehyde Reductase Human genes 0.000 abstract 1
- 108010053754 Aldehyde reductase Proteins 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 239000012362 glacial acetic acid Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229940117803 phenethylamine Drugs 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Engine Equipment That Uses Special Cycles (AREA)
- Control Of Turbines (AREA)
- Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/440,641 US4435578A (en) | 1982-11-10 | 1982-11-10 | Sorbinil by optical resolution of precursor 6-fluoro-4-ureidochroman-4-carboxylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG45388A3 true BG45388A3 (bg) | 1989-05-15 |
Family
ID=23749580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG076698A BG45388A3 (bg) | 1982-11-10 | 1983-11-09 | Метод за получаване на сорбинил |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4435578A (ja) |
| EP (1) | EP0109232B1 (ja) |
| JP (4) | JPS59101491A (ja) |
| AT (1) | ATE23044T1 (ja) |
| BG (1) | BG45388A3 (ja) |
| CA (1) | CA1202034A (ja) |
| DE (1) | DE3367099D1 (ja) |
| GT (1) | GT198303963A (ja) |
| HU (1) | HU191708B (ja) |
| IE (1) | IE56256B1 (ja) |
| PH (1) | PH18843A (ja) |
| PL (1) | PL143960B1 (ja) |
| SU (1) | SU1282816A3 (ja) |
| ZA (1) | ZA838336B (ja) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0172719B1 (en) * | 1984-08-20 | 1988-09-21 | Pfizer Inc. | Process for the production as asymmetric hydantoins |
| US4620019A (en) * | 1984-08-23 | 1986-10-28 | Pfizer Inc. | S-6-fluoro-4-aminochroman-4-carboxylic acid derivatives useful as intermediates for sorbinil |
| US4551542A (en) * | 1984-09-26 | 1985-11-05 | Pfizer Inc. | Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid |
| WO1986007353A1 (en) | 1985-06-14 | 1986-12-18 | Pfizer Inc. | Intermediate in the production of an asymmetric hydantoin |
| US4841079A (en) * | 1987-08-07 | 1989-06-20 | Pfizer, Inc. | Process for the production of asymmetric hydantoins |
| US5206367A (en) * | 1992-02-18 | 1993-04-27 | Pfizer Inc. | Preparation of optically active spiro-hydantoins |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4286098A (en) * | 1980-03-28 | 1981-08-25 | Pfizer Inc. | Process for the preparation of chiral hydantoins |
-
1982
- 1982-11-10 US US06/440,641 patent/US4435578A/en not_active Expired - Fee Related
-
1983
- 1983-11-03 DE DE8383306691T patent/DE3367099D1/de not_active Expired
- 1983-11-03 AT AT83306691T patent/ATE23044T1/de not_active IP Right Cessation
- 1983-11-03 EP EP83306691A patent/EP0109232B1/en not_active Expired
- 1983-11-07 GT GT198303963A patent/GT198303963A/es unknown
- 1983-11-08 PL PL1983250369A patent/PL143960B1/pl unknown
- 1983-11-08 CA CA000440665A patent/CA1202034A/en not_active Expired
- 1983-11-09 ZA ZA838336A patent/ZA838336B/xx unknown
- 1983-11-09 BG BG076698A patent/BG45388A3/xx unknown
- 1983-11-09 PH PH29804A patent/PH18843A/en unknown
- 1983-11-09 IE IE2619/83A patent/IE56256B1/en not_active IP Right Cessation
- 1983-11-09 HU HU832969A patent/HU191708B/hu not_active IP Right Cessation
- 1983-11-10 JP JP58211674A patent/JPS59101491A/ja active Granted
-
1984
- 1984-06-29 SU SU843754142A patent/SU1282816A3/ru active
-
1988
- 1988-01-27 JP JP63016774A patent/JPS63211282A/ja active Granted
- 1988-01-27 JP JP63016773A patent/JPS63211278A/ja active Granted
- 1988-01-27 JP JP63016772A patent/JPS63211281A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| PL143960B1 (en) | 1988-03-31 |
| PL250369A1 (en) | 1985-09-24 |
| US4435578A (en) | 1984-03-06 |
| ATE23044T1 (de) | 1986-11-15 |
| JPH032866B2 (ja) | 1991-01-17 |
| DE3367099D1 (en) | 1986-11-27 |
| IE832619L (en) | 1984-05-10 |
| EP0109232B1 (en) | 1986-10-22 |
| JPH0248555B2 (ja) | 1990-10-25 |
| GT198303963A (es) | 1985-04-30 |
| JPH0244832B2 (ja) | 1990-10-05 |
| CA1202034A (en) | 1986-03-18 |
| JPS59101491A (ja) | 1984-06-12 |
| HUT36124A (en) | 1985-08-28 |
| PH18843A (en) | 1985-10-10 |
| JPS63211282A (ja) | 1988-09-02 |
| IE56256B1 (en) | 1991-06-05 |
| HU191708B (en) | 1987-03-30 |
| ZA838336B (en) | 1985-06-26 |
| SU1282816A3 (ru) | 1987-01-07 |
| JPS63211281A (ja) | 1988-09-02 |
| EP0109232A1 (en) | 1984-05-23 |
| JPS63211278A (ja) | 1988-09-02 |
| JPS6344755B2 (ja) | 1988-09-06 |
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