BG44206A3 - Method for preparation of sorbinil - Google Patents

Method for preparation of sorbinil

Info

Publication number
BG44206A3
BG44206A3 BG062988A BG6298883A BG44206A3 BG 44206 A3 BG44206 A3 BG 44206A3 BG 062988 A BG062988 A BG 062988A BG 6298883 A BG6298883 A BG 6298883A BG 44206 A3 BG44206 A3 BG 44206A3
Authority
BG
Bulgaria
Prior art keywords
sorbinil
preparation
hydantone
aminopinane
sorbinyl
Prior art date
Application number
BG062988A
Other languages
Bulgarian (bg)
Inventor
Barkeley Cuejun
Philip Hammen
Stephen MASSETT
Bernard Moore
Robert Sysko
Original Assignee
Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/440,641 external-priority patent/US4435578A/en
Priority claimed from US06/440,657 external-priority patent/US4431828A/en
Application filed by Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware filed Critical Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware
Publication of BG44206A3 publication Critical patent/BG44206A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Сорбинилът е високо потенциален алдозен редук тивен инхибитор с особена стойност при ефикасен контрол на хронични усложнения при диабетичен мелитус. Методът е лесноизпълним и с него се избягва използването на силно токсични разтворители. Той се състои в кристализация на (-)-3-аминопинанова сол на сорбинила из разтвор, за предпочитане в нисш алкохол или смес от нисши алкохоли, на рацемичен хидантони със следната формула.Sorbinil is a highly potent aldose reductive inhibitor of particular value in the efficient control of chronic complications in diabetes mellitus. The method is easy to perform and it avoids the use of highly toxic solvents. It consists in the crystallization of the (-)-3-aminopinane salt of sorbinyl from a solution, preferably in a lower alcohol or a mixture of lower alcohols, of a racemic hydantone of the following formula.

BG062988A 1982-11-10 1983-11-09 Method for preparation of sorbinil BG44206A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44068682A 1982-11-10 1982-11-10
US06/440,641 US4435578A (en) 1982-11-10 1982-11-10 Sorbinil by optical resolution of precursor 6-fluoro-4-ureidochroman-4-carboxylic acid
US06/440,657 US4431828A (en) 1982-11-10 1982-11-10 Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil

Publications (1)

Publication Number Publication Date
BG44206A3 true BG44206A3 (en) 1988-10-14

Family

ID=27412063

Family Applications (1)

Application Number Title Priority Date Filing Date
BG062988A BG44206A3 (en) 1982-11-10 1983-11-09 Method for preparation of sorbinil

Country Status (16)

Country Link
KR (1) KR870000867B1 (en)
AU (1) AU540399B2 (en)
BG (1) BG44206A3 (en)
CS (1) CS266560B2 (en)
DD (1) DD213924A5 (en)
DK (1) DK512683A (en)
ES (3) ES8506040A1 (en)
FI (1) FI77247C (en)
GR (1) GR79017B (en)
IL (2) IL70165A (en)
NO (1) NO161916C (en)
NZ (1) NZ206189A (en)
PL (1) PL139713B1 (en)
PT (1) PT77617B (en)
SU (1) SU1209030A3 (en)
YU (2) YU44867B (en)

Also Published As

Publication number Publication date
SU1209030A3 (en) 1986-01-30
KR870000867B1 (en) 1987-04-30
YU43883B (en) 1989-12-31
YU44867B (en) 1991-04-30
FI834088A0 (en) 1983-11-08
NZ206189A (en) 1987-06-30
YU140985A (en) 1986-04-30
NO161916B (en) 1989-07-03
FI77247C (en) 1989-02-10
GR79017B (en) 1984-10-02
FI77247B (en) 1988-10-31
PL244460A1 (en) 1985-03-26
AU2110583A (en) 1984-05-17
YU220383A (en) 1988-02-29
NO161916C (en) 1989-10-11
CS827183A2 (en) 1989-04-14
PT77617B (en) 1986-05-12
DK512683A (en) 1984-05-11
NO834086L (en) 1984-05-11
KR840006806A (en) 1984-12-03
AU540399B2 (en) 1984-11-15
ES534920A0 (en) 1985-09-16
PL139713B1 (en) 1987-02-28
ES527118A0 (en) 1985-06-16
IL70165A0 (en) 1984-02-29
ES534921A0 (en) 1985-06-16
ES8505988A1 (en) 1985-06-16
ES8600269A1 (en) 1985-09-16
DD213924A5 (en) 1984-09-26
IL81648A0 (en) 1987-09-16
PT77617A (en) 1983-12-01
FI834088A (en) 1984-05-11
DK512683D0 (en) 1983-11-09
IL70165A (en) 1987-12-20
CS266560B2 (en) 1990-01-12
ES8506040A1 (en) 1985-06-16

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