BG40813A3 - Method for preparing bifunctional ester derivatives of 4- desacetyl indol- dihydroindol alkaloids - Google Patents

Method for preparing bifunctional ester derivatives of 4- desacetyl indol- dihydroindol alkaloids

Info

Publication number
BG40813A3
BG40813A3 BG064892A BG6489284A BG40813A3 BG 40813 A3 BG40813 A3 BG 40813A3 BG 064892 A BG064892 A BG 064892A BG 6489284 A BG6489284 A BG 6489284A BG 40813 A3 BG40813 A3 BG 40813A3
Authority
BG
Bulgaria
Prior art keywords
alkaloids
desacetyl
dihydroindol
indol
ester derivatives
Prior art date
Application number
BG064892A
Other languages
Bulgarian (bg)
English (en)
Inventor
George Cullinan
Original Assignee
Lilly Industries Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Limited filed Critical Lilly Industries Limited
Publication of BG40813A3 publication Critical patent/BG40813A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y10S530/816—Attached to the carrier via a bridging agent

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG064892A 1983-03-30 1984-03-29 Method for preparing bifunctional ester derivatives of 4- desacetyl indol- dihydroindol alkaloids BG40813A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8308856 1983-03-30

Publications (1)

Publication Number Publication Date
BG40813A3 true BG40813A3 (en) 1987-02-16

Family

ID=10540515

Family Applications (1)

Application Number Title Priority Date Filing Date
BG064892A BG40813A3 (en) 1983-03-30 1984-03-29 Method for preparing bifunctional ester derivatives of 4- desacetyl indol- dihydroindol alkaloids

Country Status (24)

Country Link
US (1) US4596676A (sk)
EP (1) EP0123441B1 (sk)
JP (1) JPS59184189A (sk)
KR (1) KR900001165B1 (sk)
AR (1) AR241594A1 (sk)
AT (1) ATE57187T1 (sk)
AU (1) AU560423B2 (sk)
BG (1) BG40813A3 (sk)
CA (1) CA1225395A (sk)
DE (1) DE3483336D1 (sk)
DK (1) DK167984A (sk)
EG (1) EG16223A (sk)
ES (1) ES531080A0 (sk)
FI (1) FI82939C (sk)
GR (1) GR79898B (sk)
HU (1) HU193283B (sk)
IL (1) IL71365A (sk)
NZ (1) NZ207674A (sk)
PH (1) PH20036A (sk)
PL (2) PL142818B1 (sk)
PT (1) PT78321B (sk)
RU (1) RU1774941C (sk)
SU (2) SU1326196A3 (sk)
ZA (1) ZA842348B (sk)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476659A (en) * 1982-11-09 1995-12-19 The Scripps Research Institute Cancerous B cell treatment using substituted nucleoside derivatives
GR79899B (sk) * 1983-03-30 1984-10-31 Lilly Industries Ltd
GR81790B (sk) * 1983-04-29 1984-12-12 Omnichem Sa
US4522750A (en) * 1984-02-21 1985-06-11 Eli Lilly And Company Cytotoxic compositions of transferrin coupled to vinca alkaloids
JPS62502684A (ja) * 1985-03-12 1987-10-15 ザ・ユニバ−シテイ・オブ・バ−モント・アンド・ステイト・アグリカルチユラル・カレツジ ビンブラスチン及びビンクリスチン型化合物の合成
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
EP0232693A3 (fr) * 1985-12-16 1988-04-06 La Region Wallonne Conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques les contenant
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
PT86377B (pt) * 1986-12-24 1990-11-20 Lilly Co Eli Processo para a preparacao de conjugados de imunoglobulinas com um difluoronucleosideo acilado
CA1339775C (en) * 1988-06-10 1998-03-24 Shuzo Matsushita Antibody 0.5b to hiv-i gp 120 modified with toxic substance
US5095109A (en) * 1989-06-08 1992-03-10 University Of Vermont Novel alkaloids
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
JP3100014B2 (ja) * 1991-12-10 2000-10-16 キヤノン株式会社 強誘電性液晶素子及び該素子の製造方法
AU5845594A (en) * 1992-11-13 1994-06-08 Scripps Research Institute, The Cancerous b cell treatment using substituted nucleoside derivatives
IL121789A (en) * 1996-10-03 2001-06-14 Rohm & Haas A medicinal product for inhibiting mammalian cell tumors
US20130178618A1 (en) 2012-01-10 2013-07-11 William Allen Boulanger Novel pharmaceutical intermediates and methods for preparing the same
US12116372B1 (en) 2023-12-14 2024-10-15 William Allen Boulanger Process for preparing methyl 3-bromo-2-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)propanoate

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
GB1541435A (en) * 1975-02-04 1979-02-28 Searle & Co Immunological materials
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4075214A (en) * 1976-05-17 1978-02-21 Eli Lilly And Company Preparation of leurosidine and novel leurosidine 4'-ethers and esters
US4087429A (en) * 1976-10-20 1978-05-02 Eli Lilly And Company 5' Acetoxy vinblastine 4' bis-sulfite
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4122082A (en) * 1977-11-07 1978-10-24 Eli Lilly And Company 4-Desacetoxy-4-oxovinblastine
US4195022A (en) * 1978-03-27 1980-03-25 Eli Lilly And Company 4-Desacetoxy-4α-hydroxyvinblastine and related compounds
US4166810A (en) * 1978-04-20 1979-09-04 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
FI820020L (fi) * 1981-01-12 1982-07-13 Lilly Industries Ltd Immunoglobulinkonjugater
GR81790B (sk) * 1983-04-29 1984-12-12 Omnichem Sa
US4522750A (en) * 1984-02-21 1985-06-11 Eli Lilly And Company Cytotoxic compositions of transferrin coupled to vinca alkaloids

Also Published As

Publication number Publication date
FI82939C (fi) 1991-05-10
RU1774941C (ru) 1992-11-07
EG16223A (en) 1990-12-30
NZ207674A (en) 1987-11-27
CA1225395A (en) 1987-08-11
US4596676A (en) 1986-06-24
SU1326196A3 (ru) 1987-07-23
PL142818B1 (en) 1987-12-31
IL71365A (en) 1988-05-31
EP0123441B1 (en) 1990-10-03
PT78321B (en) 1986-08-08
FI82939B (fi) 1991-01-31
AR241594A1 (es) 1992-09-30
KR840008161A (ko) 1984-12-13
PL246932A1 (en) 1985-12-03
AU560423B2 (en) 1987-04-09
PH20036A (en) 1986-09-04
PL142754B1 (en) 1987-11-30
AU2614484A (en) 1984-10-04
DE3483336D1 (de) 1990-11-08
DK167984A (da) 1984-10-01
ZA842348B (en) 1985-06-26
DK167984D0 (da) 1984-03-26
PT78321A (en) 1984-04-01
KR900001165B1 (ko) 1990-02-27
ES8506733A1 (es) 1985-07-16
IL71365A0 (en) 1984-06-29
ES531080A0 (es) 1985-07-16
JPS59184189A (ja) 1984-10-19
ATE57187T1 (de) 1990-10-15
SU1491341A3 (ru) 1989-06-30
FI841259A (fi) 1984-10-01
GR79898B (sk) 1984-10-31
HU193283B (en) 1987-09-28
FI841259A0 (fi) 1984-03-29
EP0123441A1 (en) 1984-10-31
PL254899A1 (en) 1986-06-17

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