BG20351A3 - Метод за получаване на асиметрични n-субституирани дихидропиридини - Google Patents

Метод за получаване на асиметрични n-субституирани дихидропиридини

Info

Publication number
BG20351A3
BG20351A3 BG024471A BG2447173A BG20351A3 BG 20351 A3 BG20351 A3 BG 20351A3 BG 024471 A BG024471 A BG 024471A BG 2447173 A BG2447173 A BG 2447173A BG 20351 A3 BG20351 A3 BG 20351A3
Authority
BG
Bulgaria
Prior art keywords
preparing asymmetric
substituted dihydropyridines
dihydropyridines
substituted
asymmetric
Prior art date
Application number
BG024471A
Other languages
Bulgarian (bg)
English (en)
Inventor
Horst Meyer
Friedrich Bossert
Wulf Vater
Kurt Stoepel
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of BG20351A3 publication Critical patent/BG20351A3/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG024471A 1972-03-06 1973-02-28 Метод за получаване на асиметрични n-субституирани дихидропиридини BG20351A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2210672A DE2210672C3 (de) 1972-03-06 1972-03-06 N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
BG20351A3 true BG20351A3 (bg) 1975-11-05

Family

ID=5838025

Family Applications (2)

Application Number Title Priority Date Filing Date
BG022856A BG22389A3 (bg) 1972-03-06 1973-02-28 Метод за получаване на асиметрични n- субституирани дихидропиридини
BG024471A BG20351A3 (bg) 1972-03-06 1973-02-28 Метод за получаване на асиметрични n-субституирани дихидропиридини

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BG022856A BG22389A3 (bg) 1972-03-06 1973-02-28 Метод за получаване на асиметрични n- субституирани дихидропиридини

Country Status (25)

Country Link
US (1) US3883540A (US07714131-20100511-C00001.png)
JP (1) JPS5626657B2 (US07714131-20100511-C00001.png)
KR (1) KR780000010B1 (US07714131-20100511-C00001.png)
AT (1) AT324335B (US07714131-20100511-C00001.png)
AU (1) AU468879B2 (US07714131-20100511-C00001.png)
BE (1) BE796274A (US07714131-20100511-C00001.png)
BG (2) BG22389A3 (US07714131-20100511-C00001.png)
CA (1) CA1045138A (US07714131-20100511-C00001.png)
CH (2) CH578530A5 (US07714131-20100511-C00001.png)
CS (2) CS173624B2 (US07714131-20100511-C00001.png)
DD (1) DD107456A5 (US07714131-20100511-C00001.png)
DE (1) DE2210672C3 (US07714131-20100511-C00001.png)
DK (1) DK136900C (US07714131-20100511-C00001.png)
ES (2) ES412319A1 (US07714131-20100511-C00001.png)
FR (1) FR2183674B1 (US07714131-20100511-C00001.png)
GB (1) GB1384031A (US07714131-20100511-C00001.png)
HU (1) HU164867B (US07714131-20100511-C00001.png)
IE (1) IE37366B1 (US07714131-20100511-C00001.png)
IL (1) IL41668A (US07714131-20100511-C00001.png)
LU (1) LU67146A1 (US07714131-20100511-C00001.png)
NL (1) NL7303135A (US07714131-20100511-C00001.png)
PL (2) PL92117B1 (US07714131-20100511-C00001.png)
RO (2) RO63067A (US07714131-20100511-C00001.png)
SU (6) SU464111A3 (US07714131-20100511-C00001.png)
ZA (1) ZA731500B (US07714131-20100511-C00001.png)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4031104A (en) * 1972-04-18 1977-06-21 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
US3974278A (en) * 1973-07-12 1976-08-10 Bayer Aktiengesellschaft 1,4-Dihydropyridine esters
CH607848A5 (US07714131-20100511-C00001.png) * 1974-06-04 1978-11-30 Bayer Ag
FR2320750A1 (fr) * 1975-08-12 1977-03-11 Hexachimie Dihydro-1,4 pyridines et leur application therapeutique
US4466972A (en) * 1977-06-20 1984-08-21 Sandoz Ltd. Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compositions containing them
SU798099A1 (ru) * 1978-03-06 1981-01-23 Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp 1-Бензил-2,6-диметил-4-о-или-M-НиТРОфЕНил-3,5-диэТОКСиКАРбОНил- 1,4-дигидРОпиРидиНы, пРО Вл ющиЕКОРОНАРОдилАТиРующую АКТиВНОСТь
SE429652B (sv) * 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4497808A (en) * 1981-12-30 1985-02-05 Ciba-Geigy Corporation N-Oxide compounds useful in the treatment of cardiovascular ailments
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
IL68604A0 (en) * 1982-05-21 1983-09-30 Haessle Ab Processes for preparing therapeutically active dihydropyridines and intermediates for the processes
DE3312283A1 (de) * 1983-04-05 1984-10-18 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von unsymmetrischen 1,4-dihydropyridincarbonsaeureestern
US5237089A (en) * 1986-02-07 1993-08-17 Basf Aktiengesellschaft Nitro or amino substituted phenylalkyl or phenylalkenyl carboxylic acid derivatives
DE3724399A1 (de) * 1987-07-23 1989-02-02 Basf Ag Phenylalkenylcarbonsaeuren und deren ester
US5216172A (en) * 1988-02-24 1993-06-01 Ajinomoto Co., Inc. 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells
EP0330470A3 (en) * 1988-02-24 1992-01-02 Ajinomoto Co., Inc. 1,4-dihydropyridine derivatives useful against tumour cells
DE4011695A1 (de) * 1990-04-11 1991-10-17 Bayer Ag Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung
DE4125271A1 (de) * 1991-07-31 1993-02-11 Bayer Ag Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester
DE4133257A1 (de) * 1991-10-08 1993-04-15 Bayer Ag N-methyl-nimodipin, verfahren zu seiner herstellung und seine verwendung als zerebraltherapeutikum
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
WO2010129819A2 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US10258498B2 (en) * 2011-11-24 2019-04-16 Richter Gedeon Nyrt. 1,4-dihydropyridine derivatives with Hsp modulating activity
JP7411994B2 (ja) 2020-03-19 2024-01-12 昌史 星野 腰枕および腰枕セット

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2359329A (en) * 1943-06-18 1944-10-03 Burroughs Wellcome Co Quinoline substituted dihydropyridines
DE2013431C3 (de) * 1970-03-20 1979-12-20 Bayer Ag, 5090 Leverkusen 4-Azidophenyl-l,4-dihydropyridin-3,5-dicarbonsäureester
DE1963186C3 (de) * 1969-12-17 1979-02-15 Bayer Ag, 5090 Leverkusen Schwefelhaltige 1,4-Dihydropyridin-33-dicarbonsäureester
DE2117572C3 (de) * 1971-04-10 1980-03-20 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
ES412319A1 (es) 1976-05-01
CS173649B2 (US07714131-20100511-C00001.png) 1977-02-28
SU457217A3 (ru) 1975-01-15
DK136900C (da) 1978-05-22
IL41668A0 (en) 1973-05-31
ES439487A1 (es) 1977-02-01
SU466656A3 (ru) 1975-04-05
ZA731500B (en) 1973-11-28
BG22389A3 (bg) 1977-02-20
AU468879B2 (en) 1975-03-27
CH578530A5 (US07714131-20100511-C00001.png) 1976-08-13
US3883540A (en) 1975-05-13
DD107456A5 (US07714131-20100511-C00001.png) 1974-08-05
IE37366B1 (en) 1977-07-06
CS173624B2 (US07714131-20100511-C00001.png) 1977-02-28
SU464111A3 (ru) 1975-03-15
AT324335B (de) 1975-08-25
DE2210672B2 (de) 1979-07-12
DE2210672C3 (de) 1980-03-20
NL7303135A (US07714131-20100511-C00001.png) 1973-09-10
LU67146A1 (US07714131-20100511-C00001.png) 1973-05-22
SU470958A3 (ru) 1975-05-15
DK136900B (da) 1977-12-12
RO62798A (fr) 1977-11-15
FR2183674A1 (US07714131-20100511-C00001.png) 1973-12-21
KR780000010B1 (en) 1978-03-04
FR2183674B1 (US07714131-20100511-C00001.png) 1976-10-22
AU5287673A (en) 1975-03-27
IL41668A (en) 1977-02-28
PL92117B1 (US07714131-20100511-C00001.png) 1977-03-31
JPS5626657B2 (US07714131-20100511-C00001.png) 1981-06-19
RO63067A (fr) 1978-05-15
CH579049A5 (US07714131-20100511-C00001.png) 1976-08-31
PL89257B1 (US07714131-20100511-C00001.png) 1976-11-30
GB1384031A (en) 1975-02-19
HU164867B (US07714131-20100511-C00001.png) 1974-05-28
DE2210672A1 (de) 1973-09-20
IE37366L (en) 1973-09-06
BE796274A (fr) 1973-09-05
JPS4899179A (US07714131-20100511-C00001.png) 1973-12-15
CA1045138A (en) 1978-12-26
SU468416A3 (ru) 1975-04-25
SU451241A3 (ru) 1974-11-25

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