BG108254A - ПРОИЗВОДНИ НА ДИХИДРО-БЕНЗО[b][1,4]ДИАЗЕПИН-2-ОН КАТО MGLUR2 АНТАГОНИСТИ II - Google Patents

ПРОИЗВОДНИ НА ДИХИДРО-БЕНЗО[b][1,4]ДИАЗЕПИН-2-ОН КАТО MGLUR2 АНТАГОНИСТИ II Download PDF

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Publication number
BG108254A
BG108254A BG108254A BG10825403A BG108254A BG 108254 A BG108254 A BG 108254A BG 108254 A BG108254 A BG 108254A BG 10825403 A BG10825403 A BG 10825403A BG 108254 A BG108254 A BG 108254A
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BG
Bulgaria
Prior art keywords
phenyl
methyl
amino
butyl ester
acid tert
Prior art date
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BG108254A
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Bulgarian (bg)
English (en)
Inventor
Geo Adam
Erwin Goetschi
Vincent Mutel
Juergen Wichmann
Johannes T. Woltering
Original Assignee
F. Hoffmann- La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann- La Roche Ag filed Critical F. Hoffmann- La Roche Ag
Publication of BG108254A publication Critical patent/BG108254A/bg

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BG108254A 2001-04-12 2003-10-10 ПРОИЗВОДНИ НА ДИХИДРО-БЕНЗО[b][1,4]ДИАЗЕПИН-2-ОН КАТО MGLUR2 АНТАГОНИСТИ II BG108254A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01109125 2001-04-12
PCT/EP2002/003644 WO2002083652A1 (en) 2001-04-12 2002-04-02 DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II

Publications (1)

Publication Number Publication Date
BG108254A true BG108254A (bg) 2004-09-30

Family

ID=8177126

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108254A BG108254A (bg) 2001-04-12 2003-10-10 ПРОИЗВОДНИ НА ДИХИДРО-БЕНЗО[b][1,4]ДИАЗЕПИН-2-ОН КАТО MGLUR2 АНТАГОНИСТИ II

Country Status (38)

Country Link
US (1) US6544985B2 (sh)
EP (1) EP1379511B1 (sh)
JP (1) JP4071115B2 (sh)
KR (1) KR100566171B1 (sh)
CN (1) CN1264825C (sh)
AR (1) AR035816A1 (sh)
AT (1) ATE299868T1 (sh)
AU (1) AU2002312788B2 (sh)
BG (1) BG108254A (sh)
BR (1) BR0208891A (sh)
CA (1) CA2442557C (sh)
CZ (1) CZ20033003A3 (sh)
DE (1) DE60205100T2 (sh)
DK (1) DK1379511T3 (sh)
EC (1) ECSP034797A (sh)
ES (1) ES2246012T3 (sh)
GT (1) GT200200073A (sh)
HK (1) HK1068888A1 (sh)
HR (1) HRP20030792A2 (sh)
HU (1) HUP0400851A3 (sh)
IL (2) IL157873A0 (sh)
JO (1) JO2285B1 (sh)
MA (1) MA27012A1 (sh)
MX (1) MXPA03009311A (sh)
MY (1) MY140271A (sh)
NO (1) NO20034576L (sh)
NZ (1) NZ528315A (sh)
PA (1) PA8543301A1 (sh)
PE (1) PE20021041A1 (sh)
PL (1) PL367064A1 (sh)
PT (1) PT1379511E (sh)
RU (1) RU2263112C2 (sh)
SI (1) SI1379511T1 (sh)
SK (1) SK13682003A3 (sh)
UY (1) UY27258A1 (sh)
WO (1) WO2002083652A1 (sh)
YU (1) YU79003A (sh)
ZA (1) ZA200307243B (sh)

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Also Published As

Publication number Publication date
JP4071115B2 (ja) 2008-04-02
UY27258A1 (es) 2002-10-31
EP1379511B1 (en) 2005-07-20
CN1264825C (zh) 2006-07-19
US20020193367A1 (en) 2002-12-19
HUP0400851A2 (hu) 2004-07-28
CA2442557C (en) 2008-12-23
KR20030087076A (ko) 2003-11-12
AU2002312788B2 (en) 2005-11-10
PL367064A1 (en) 2005-02-21
YU79003A (sh) 2006-05-25
EP1379511A1 (en) 2004-01-14
NZ528315A (en) 2005-04-29
RU2263112C2 (ru) 2005-10-27
GT200200073A (es) 2002-11-07
ZA200307243B (en) 2004-12-16
PT1379511E (pt) 2005-10-31
NO20034576L (no) 2003-11-12
CZ20033003A3 (cs) 2004-05-12
AR035816A1 (es) 2004-07-14
IL157873A (en) 2008-11-26
HRP20030792A2 (en) 2005-10-31
RU2003130637A (ru) 2005-04-10
HUP0400851A3 (en) 2010-03-29
MY140271A (en) 2009-12-31
BR0208891A (pt) 2004-04-20
SK13682003A3 (sk) 2004-07-07
DE60205100T2 (de) 2006-06-01
CN1535266A (zh) 2004-10-06
HK1068888A1 (en) 2005-05-06
JP2004529925A (ja) 2004-09-30
PA8543301A1 (es) 2003-01-24
DE60205100D1 (de) 2005-08-25
CA2442557A1 (en) 2002-10-24
DK1379511T3 (da) 2005-11-07
ES2246012T3 (es) 2006-02-01
KR100566171B1 (ko) 2006-03-29
PE20021041A1 (es) 2002-11-19
US6544985B2 (en) 2003-04-08
MA27012A1 (fr) 2004-12-20
IL157873A0 (en) 2004-03-28
ATE299868T1 (de) 2005-08-15
WO2002083652A1 (en) 2002-10-24
NO20034576D0 (no) 2003-10-10
MXPA03009311A (es) 2004-02-12
ECSP034797A (es) 2003-12-01
JO2285B1 (en) 2005-09-12
SI1379511T1 (en) 2005-10-31

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