BG106117A - Нови 8а- и 9а-15-членни лактами - Google Patents

Нови 8а- и 9а-15-членни лактами

Info

Publication number
BG106117A
BG106117A BG106117A BG10611701A BG106117A BG 106117 A BG106117 A BG 106117A BG 106117 A BG106117 A BG 106117A BG 10611701 A BG10611701 A BG 10611701A BG 106117 A BG106117 A BG 106117A
Authority
BG
Bulgaria
Prior art keywords
group
novel
stands
membered lactams
lactams
Prior art date
Application number
BG106117A
Other languages
English (en)
Other versions
BG65281B1 (bg
Inventor
Gorjana Lazarevski
Sulejman Alihodzic
Gabrijela Kobrehel
Stjepan Mutak
Original Assignee
Pliva-Istrazivacki Institut D.O.O.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva-Istrazivacki Institut D.O.O. filed Critical Pliva-Istrazivacki Institut D.O.O.
Publication of BG106117A publication Critical patent/BG106117A/bg
Publication of BG65281B1 publication Critical patent/BG65281B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Abstract

Изобретението се отнася до нови 15-членни 8а- и 9а-лактами от класа на 6-О-метил-еритромицин А с обща формула, в която А се поставя на мястото на NH група и В едновременно се поставя на мястото на С=О група, или А се поставя на мястото на С=О група и В едновременно се поставя на мястото на NH група, и радикалите R1, R2, R3, R4, R5 и R6 имат значенията, посочени в описанието. Изобретението се отнася също до фармацевтично приемливи, допълнителни снеорганични или органични киселини соли на тези съединения и до техни хидрати.
BG106117A 1999-04-20 2001-11-20 8а- и 9а-15-членни лактами BG65281B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR990116A HRP990116B1 (en) 1999-04-20 1999-04-20 NOVEL 8a AND 9a- 15-MEMBERED LACTAMES

Publications (2)

Publication Number Publication Date
BG106117A true BG106117A (bg) 2002-07-31
BG65281B1 BG65281B1 (bg) 2007-11-30

Family

ID=10946907

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106117A BG65281B1 (bg) 1999-04-20 2001-11-20 8а- и 9а-15-членни лактами

Country Status (33)

Country Link
US (1) US6593360B1 (bg)
EP (1) EP1181298B1 (bg)
JP (1) JP2002542254A (bg)
KR (1) KR20020007379A (bg)
CN (1) CN1246327C (bg)
AR (1) AR028823A1 (bg)
AT (1) ATE333461T1 (bg)
AU (1) AU772272B2 (bg)
BG (1) BG65281B1 (bg)
BR (1) BR0009943A (bg)
CA (1) CA2370273A1 (bg)
CZ (1) CZ20013730A3 (bg)
DE (1) DE60029439T2 (bg)
DK (1) DK1181298T3 (bg)
EA (1) EA003928B1 (bg)
EE (1) EE04553B1 (bg)
ES (1) ES2267519T3 (bg)
GE (1) GEP20032929B (bg)
HK (1) HK1049842B (bg)
HR (1) HRP990116B1 (bg)
HU (1) HUP0200868A3 (bg)
IL (1) IL145990A0 (bg)
IS (1) IS6110A (bg)
MX (1) MXPA01010627A (bg)
NO (1) NO320704B1 (bg)
NZ (1) NZ515279A (bg)
PL (1) PL351523A1 (bg)
PT (1) PT1181298E (bg)
SK (1) SK14942001A3 (bg)
TR (1) TR200103019T2 (bg)
UA (1) UA72246C2 (bg)
WO (1) WO2000063223A1 (bg)
ZA (1) ZA200108481B (bg)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0025688D0 (en) * 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2006120541A1 (en) 2005-05-10 2006-11-16 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Ether linked macrolides useful for the treatment of microbial infections
CA3130061A1 (en) 2013-04-04 2014-10-09 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
JP2017531663A (ja) 2014-10-08 2017-10-26 プレジデント アンド フェローズ オブ ハーバード カレッジ １４員ケトライドならびにそれらの調製および使用の方法
CA2980315A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
GB201608236D0 (en) 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
SI9011409A (en) * 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
AU2340797A (en) * 1996-05-07 1997-11-26 Abbott Laboratories 6-o-substituted erythromycins and method for making them
AU1082599A (en) * 1997-10-16 1999-05-03 Merck & Co., Inc. 8a-azalides, compositions containing such compounds and methods of treatment
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides

Also Published As

Publication number Publication date
EP1181298B1 (en) 2006-07-19
EP1181298A1 (en) 2002-02-27
AU4134700A (en) 2000-11-02
HK1049842A1 (en) 2003-05-30
CN1362964A (zh) 2002-08-07
CA2370273A1 (en) 2000-10-26
NO20015068D0 (no) 2001-10-18
MXPA01010627A (es) 2002-06-04
ATE333461T1 (de) 2006-08-15
HUP0200868A2 (hu) 2002-07-29
KR20020007379A (ko) 2002-01-26
DK1181298T3 (da) 2006-11-13
HK1049842B (zh) 2006-09-22
ES2267519T3 (es) 2007-03-16
EA200101103A1 (ru) 2002-04-25
EE200100544A (et) 2003-02-17
NO320704B1 (no) 2006-01-16
AU772272B2 (en) 2004-04-22
HRP990116B1 (en) 2007-10-31
HUP0200868A3 (en) 2003-03-28
EA003928B1 (ru) 2003-10-30
EE04553B1 (et) 2005-10-17
ZA200108481B (en) 2003-03-26
UA72246C2 (uk) 2005-02-15
WO2000063223A1 (en) 2000-10-26
HRP990116A2 (en) 2001-10-31
BG65281B1 (bg) 2007-11-30
IL145990A0 (en) 2002-07-25
NO20015068L (no) 2001-12-13
CN1246327C (zh) 2006-03-22
CZ20013730A3 (cs) 2002-04-17
NZ515279A (en) 2003-04-29
JP2002542254A (ja) 2002-12-10
AR028823A1 (es) 2003-05-28
TR200103019T2 (tr) 2002-01-21
IS6110A (is) 2001-10-16
SK14942001A3 (sk) 2002-08-06
DE60029439T2 (de) 2007-02-01
PT1181298E (pt) 2006-11-30
DE60029439D1 (de) 2006-08-31
US6593360B1 (en) 2003-07-15
GEP20032929B (en) 2003-03-25
BR0009943A (pt) 2002-01-08
PL351523A1 (en) 2003-05-05

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