BR0009943A - 8a- e 9a lactamas de 15 elementos - Google Patents

8a- e 9a lactamas de 15 elementos

Info

Publication number
BR0009943A
BR0009943A BR0009943-0A BR0009943A BR0009943A BR 0009943 A BR0009943 A BR 0009943A BR 0009943 A BR0009943 A BR 0009943A BR 0009943 A BR0009943 A BR 0009943A
Authority
BR
Brazil
Prior art keywords
group
elements
lactams
formula
alkyl
Prior art date
Application number
BR0009943-0A
Other languages
English (en)
Inventor
Gorjana Lazarevski
Sulejman Alihodzic
Gabrijela Kobrehel
Stjepan Mutak
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Publication of BR0009943A publication Critical patent/BR0009943A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Patente de Invenção: "8A- E 9A LACTAMAS DE 15 ELEMENTOS". A invenção refere-se a novas 8a- e 9a-lactamas de 15 elementos da classe da 6-O-metil-eritromicina da fórmula geral (I) seus sais de adição farmaceuticamente aceitáveis com ácidos inorgânicos ou orgânicos e seus hidratos, onde A representa o grupo NH e B representa simultaneamente o grupo C=O, ou A representa o grupo C=O e B representa simultaneamente o grupo NH, R^ 1^ representa o grupo OH, o grupo L-cladinosila de fórmula (II) ou R^ 1^ representa um grupo de fórmula (III) onde Y representa hidrogênio, C~ 1~-C~ 6~ alquila, um grupo C~ 1~-C~ 6~ alquila
BR0009943-0A 1999-04-20 2000-04-19 8a- e 9a lactamas de 15 elementos BR0009943A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR990116A HRP990116B1 (en) 1999-04-20 1999-04-20 NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
PCT/HR2000/000009 WO2000063223A1 (en) 1999-04-20 2000-04-19 Novel 8a- and 9a-15-membered lactams

Publications (1)

Publication Number Publication Date
BR0009943A true BR0009943A (pt) 2002-01-08

Family

ID=10946907

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009943-0A BR0009943A (pt) 1999-04-20 2000-04-19 8a- e 9a lactamas de 15 elementos

Country Status (33)

Country Link
US (1) US6593360B1 (pt)
EP (1) EP1181298B1 (pt)
JP (1) JP2002542254A (pt)
KR (1) KR20020007379A (pt)
CN (1) CN1246327C (pt)
AR (1) AR028823A1 (pt)
AT (1) ATE333461T1 (pt)
AU (1) AU772272B2 (pt)
BG (1) BG65281B1 (pt)
BR (1) BR0009943A (pt)
CA (1) CA2370273A1 (pt)
CZ (1) CZ20013730A3 (pt)
DE (1) DE60029439T2 (pt)
DK (1) DK1181298T3 (pt)
EA (1) EA003928B1 (pt)
EE (1) EE04553B1 (pt)
ES (1) ES2267519T3 (pt)
GE (1) GEP20032929B (pt)
HK (1) HK1049842B (pt)
HR (1) HRP990116B1 (pt)
HU (1) HUP0200868A3 (pt)
IL (1) IL145990A0 (pt)
IS (1) IS6110A (pt)
MX (1) MXPA01010627A (pt)
NO (1) NO320704B1 (pt)
NZ (1) NZ515279A (pt)
PL (1) PL351523A1 (pt)
PT (1) PT1181298E (pt)
SK (1) SK14942001A3 (pt)
TR (1) TR200103019T2 (pt)
UA (1) UA72246C2 (pt)
WO (1) WO2000063223A1 (pt)
ZA (1) ZA200108481B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0025688D0 (en) * 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
EP1879903A1 (en) 2005-05-10 2008-01-23 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Ether linked macrolides useful for the treatment of microbial infections
US9982005B2 (en) * 2013-04-04 2018-05-29 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
WO2016057798A1 (en) 2014-10-08 2016-04-14 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
CN107530365A (zh) 2015-03-25 2018-01-02 哈佛大学的校长及成员们 具有修饰的脱氧糖胺糖的大环内酯及其用途
GB201608236D0 (en) 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
SI9011409A (en) * 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
AU2340797A (en) * 1996-05-07 1997-11-26 Abbott Laboratories 6-o-substituted erythromycins and method for making them
WO1999019331A1 (en) * 1997-10-16 1999-04-22 Merck & Co., Inc. 8a-azalides, compositions containing such compounds and methods of treatment
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides

Also Published As

Publication number Publication date
NO20015068L (no) 2001-12-13
NO320704B1 (no) 2006-01-16
SK14942001A3 (sk) 2002-08-06
EP1181298A1 (en) 2002-02-27
PT1181298E (pt) 2006-11-30
US6593360B1 (en) 2003-07-15
IL145990A0 (en) 2002-07-25
HUP0200868A2 (hu) 2002-07-29
AR028823A1 (es) 2003-05-28
EP1181298B1 (en) 2006-07-19
HK1049842A1 (en) 2003-05-30
DE60029439T2 (de) 2007-02-01
UA72246C2 (uk) 2005-02-15
CN1362964A (zh) 2002-08-07
EE200100544A (et) 2003-02-17
HK1049842B (zh) 2006-09-22
ES2267519T3 (es) 2007-03-16
EA200101103A1 (ru) 2002-04-25
KR20020007379A (ko) 2002-01-26
CZ20013730A3 (cs) 2002-04-17
DE60029439D1 (de) 2006-08-31
CN1246327C (zh) 2006-03-22
HRP990116B1 (en) 2007-10-31
DK1181298T3 (da) 2006-11-13
IS6110A (is) 2001-10-16
NO20015068D0 (no) 2001-10-18
TR200103019T2 (tr) 2002-01-21
ZA200108481B (en) 2003-03-26
EA003928B1 (ru) 2003-10-30
PL351523A1 (en) 2003-05-05
BG65281B1 (bg) 2007-11-30
AU772272B2 (en) 2004-04-22
CA2370273A1 (en) 2000-10-26
JP2002542254A (ja) 2002-12-10
HUP0200868A3 (en) 2003-03-28
EE04553B1 (et) 2005-10-17
ATE333461T1 (de) 2006-08-15
WO2000063223A1 (en) 2000-10-26
NZ515279A (en) 2003-04-29
HRP990116A2 (en) 2001-10-31
GEP20032929B (en) 2003-03-25
BG106117A (en) 2002-07-31
AU4134700A (en) 2000-11-02
MXPA01010627A (es) 2002-06-04

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A E 11A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011.