BG104768A - Хипнотични бета-карболинови производни, метод за тяхното получаване и използването им като лекарствени средства - Google Patents

Хипнотични бета-карболинови производни, метод за тяхното получаване и използването им като лекарствени средства

Info

Publication number
BG104768A
BG104768A BG104768A BG10476800A BG104768A BG 104768 A BG104768 A BG 104768A BG 104768 A BG104768 A BG 104768A BG 10476800 A BG10476800 A BG 10476800A BG 104768 A BG104768 A BG 104768A
Authority
BG
Bulgaria
Prior art keywords
alkyl
optionally substituted
halo
groups
aryl
Prior art date
Application number
BG104768A
Other languages
English (en)
Other versions
BG63973B1 (bg
Inventor
Jean-Bernard Fourtillan
Marianne Fourtillan
Jean-Claude Jacquesy
Marie-Paule Jouannetaud
Bruno Violeau
Omar Karam
Original Assignee
Macef
Laboratoires Besins Iscovesco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/042,990 external-priority patent/US6048868A/en
Application filed by Macef, Laboratoires Besins Iscovesco filed Critical Macef
Publication of BG104768A publication Critical patent/BG104768A/bg
Publication of BG63973B1 publication Critical patent/BG63973B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Anesthesiology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Изобретението се отнася до производни с обща формула@@в която Х е двувалентен радикал с формула@@или@@R1, R2, R3 и R4 означават независимо един от друг водороден атом, хидроксилен радикал, низш алкилов, низш алкокси, арилокси-, хало- или нитрорадикал, или ненаситена алифатна верига, низша алкилкарбонилна, низша алкилкарбонилокси, карбоксилна, катотези групи се заместват по желание. R5 означава водороден атом, низш алкил, циклоалкил, арил, низш аралкил, низш алкокси, низш алкилкарбонил, хало(низш)алкилкарбонил, низш алкилоксикарбонил, амино,като тези групи се заместват по желание. R6, R7, R9, R10, R12, R13, R14 и R15 означават независимо един от друг водороден атом, низш алкил, низш циклоалкил, хало(низш)алкил, перхало(низш)алкил, арил,аралкил, низш алкокси, низш циклоалкокси, моно или полихалоалкокси, арилокси, аралкилокси, хидроксиалкил, алкилоксиалкил, низш алкилтио, низш циклоалкилтио като тези групи се заместват по избор. R8 означава низш алкил, низш циклоалкил, хидроксиалкил, алкилоксиалкил, хало(низш)алкил, перхало)низш)алкил, арил, като тези групи се заместват по избор. R11 означава кислороден или серен атом, заместени по избор.
BG104768A 1998-03-17 2000-09-14 Хипнотични бета-карболинови производни, метод за тяхното получаване и използването им като лекарствени средства BG63973B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/042,990 US6048868A (en) 1994-09-14 1998-03-17 Melatonin-antagonist β-carboline derivatives and analogues thereof containing naphthalenic structure, process for their preparation and their use as medicinal products
PCT/IB1999/000494 WO1999047521A1 (en) 1998-03-17 1999-03-17 HYPNOTIC β-CARBOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS

Publications (2)

Publication Number Publication Date
BG104768A true BG104768A (bg) 2001-05-31
BG63973B1 BG63973B1 (bg) 2003-08-29

Family

ID=21924862

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104768A BG63973B1 (bg) 1998-03-17 2000-09-14 Хипнотични бета-карболинови производни, метод за тяхното получаване и използването им като лекарствени средства

Country Status (24)

Country Link
EP (1) EP1064284B1 (bg)
JP (1) JP4333036B2 (bg)
CN (1) CN1115342C (bg)
AR (1) AR018767A1 (bg)
AT (1) ATE215087T1 (bg)
AU (1) AU752364B2 (bg)
BG (1) BG63973B1 (bg)
BR (1) BR9908833A (bg)
CA (1) CA2324270A1 (bg)
DE (1) DE69901098T2 (bg)
DK (1) DK1064284T3 (bg)
ES (1) ES2174632T3 (bg)
HU (1) HUP0101234A3 (bg)
IL (1) IL138442A (bg)
IS (1) IS2199B (bg)
NO (1) NO317296B1 (bg)
NZ (1) NZ506913A (bg)
PL (1) PL193450B1 (bg)
PT (1) PT1064284E (bg)
RU (1) RU2210571C2 (bg)
SK (1) SK284387B6 (bg)
TR (1) TR200003596T2 (bg)
UA (1) UA71911C2 (bg)
WO (1) WO1999047521A1 (bg)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2824829B1 (fr) * 2001-05-16 2005-06-03 Macef Nouveaux derives de dihydroimidazo [5,1-a]-beta-carboline, leur procede de preparation et leur application a titre de medicament
FR2904973A1 (fr) * 2006-08-18 2008-02-22 Fourtillan Snc Derives de 1-methylidene-pyrido[3,4-b]indole et leur utilisation en therapeutique.
FR2916200A1 (fr) * 2007-05-18 2008-11-21 Fourtillan Snc Nouveaux derives des 1,2,3,4,6,7,12,12a-octahydro pyrazino[1',2':1,6]pyrido[3,4-b]indoles, leur preparation et leur utilisation en therapeutique
EP2240481A1 (en) 2008-01-11 2010-10-20 Albany Molecular Research, Inc. (1-azinone) -substituted pyridoindoles as mch antagonists
US8629158B2 (en) 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003005A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
WO2012088124A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
FI130627B (en) * 2021-03-31 2023-12-18 Equinorm Ltd NEW HETEROCYCLIC COMPOUNDS AND THEIR USE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283343A (en) * 1987-08-17 1994-02-01 Whitby Research, Inc. 2-aryl substituted N-acetyltryptamines and process of preparing such
FR2724384B1 (fr) * 1994-09-14 1999-04-16 Cemaf Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament

Also Published As

Publication number Publication date
SK13852000A3 (sk) 2001-09-11
NO317296B1 (no) 2004-10-04
AU752364B2 (en) 2002-09-19
CN1299361A (zh) 2001-06-13
IL138442A0 (en) 2001-10-31
DE69901098D1 (de) 2002-05-02
UA71911C2 (en) 2005-01-17
NO20004638L (no) 2000-11-16
JP2002506867A (ja) 2002-03-05
IS5627A (is) 2000-09-12
AR018767A1 (es) 2001-12-12
NZ506913A (en) 2003-07-25
PT1064284E (pt) 2002-09-30
HUP0101234A3 (en) 2002-12-28
ES2174632T3 (es) 2002-11-01
NO20004638D0 (no) 2000-09-15
CN1115342C (zh) 2003-07-23
IS2199B (is) 2007-02-15
RU2210571C2 (ru) 2003-08-20
DK1064284T3 (da) 2002-07-22
EP1064284A1 (en) 2001-01-03
IL138442A (en) 2006-12-10
JP4333036B2 (ja) 2009-09-16
WO1999047521A1 (en) 1999-09-23
ATE215087T1 (de) 2002-04-15
EP1064284B1 (en) 2002-03-27
HUP0101234A2 (hu) 2001-12-28
SK284387B6 (sk) 2005-02-04
BG63973B1 (bg) 2003-08-29
AU3270799A (en) 1999-10-11
CA2324270A1 (en) 1999-09-23
DE69901098T2 (de) 2002-11-21
TR200003596T2 (tr) 2001-04-20
BR9908833A (pt) 2000-11-21
PL342929A1 (en) 2001-07-16
PL193450B1 (pl) 2007-02-28

Similar Documents

Publication Publication Date Title
BG104768A (bg) Хипнотични бета-карболинови производни, метод за тяхното получаване и използването им като лекарствени средства
NZ505362A (en) 4-hydroxyquinoline-3-carboxamides and -hydrazides useful as antiviral agents
ES8601902A1 (es) Procedimiento para la obtencion de 5-amino-1-fenil-pirazolessustituidos
MXPA02012425A (es) Compuestos nuevos.
DK0740674T3 (da) Polyurethanharpikser, fremgangsmåde til fremstilling deraf, samt anvendelse deraf i vandfortyndelige overtræksmidler
NZ240282A (en) Phenyl pyrazole derivatives; herbicidal compositions and use, and preparatory processes
TR199901765T2 (xx) S�lfomid-metalloproteaz inhibit�rleri
MY106400A (en) Substituted pyrroles.
NZ332990A (en) oral pharmaceutical composition containing a H+, K+-atpase inhibitor having a extended blood plasma profile
MY106065A (en) Antipicornaviral pyridazinamines.
CA2147807A1 (fr) Composes bicycliques-aromatiques, compositions pharmaceutiques et cosmetiques les contenant et utilisations
ZA941069B (en) Compounds preparation and use
ATE133939T1 (de) Indan-1,3-dion und indan-1,2,3-trionderivate, verfahren zu ihrer herstellung und ihrer therapeutische verwendung
MXPA02012426A (es) Compuestos nuevos.
JO1744B1 (en) N-herbicide cyanopyridazine
EP0551034A3 (en) Cephalosporins having in position 7 a benzyloxyimino radical substitute, process for their preparation and their use as medicaments
IL107335A0 (en) Picolinamide derivatives, their preparation and their use as herbicides
MY120617A (en) Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives.
BG103554A (bg) Заместени пиразол-3-илбензазоли
PL336237A1 (en) Sulphonyloxadiazolones
TW282458B (bg)
ZA939227B (en) Novel triazoloquinazolines,their preparation and use
MY117552A (en) Novel esters of 3-hydroxy-piperidinemethanol derivatives
AU7214398A (en) Sulfonyloxadiazolones and their use as microbicides
DK0750502T3 (da) Anvendelse af phosphorderivater af alkaloider til behandling af endokrinopatier