BG103852A - Цог-2 селективен карпрофен за лечение на болка и възпаление при кучета - Google Patents
Цог-2 селективен карпрофен за лечение на болка и възпаление при кучетаInfo
- Publication number
- BG103852A BG103852A BG103852A BG10385299A BG103852A BG 103852 A BG103852 A BG 103852A BG 103852 A BG103852 A BG 103852A BG 10385299 A BG10385299 A BG 10385299A BG 103852 A BG103852 A BG 103852A
- Authority
- BG
- Bulgaria
- Prior art keywords
- cog
- activity
- acids
- inhibition
- dogs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Изобретението се отнася до лечение или профилактика на възпалителни процеси и заболявания при кучета, свързано с активността на индуцираната циклооксигеназа-2 (ЦОГ-2). Намаляват се или се отстраняватнежеланите странични ефекти, предизвикани от едновременното инхибиране активността на съставната циклооксигеназа-1 (ЦОГ-1), чрез селективно инхибиране на ЦОГ-2 активността по отношение на ЦОГ-1 активността. Съотношението между селективност или ЦОГ-2:ЦОГ-1 активност на инхибиране е най-малко 3:1, основано на ex vivo нива на инхибиране, измерени в цялата кръв. Инхибиторът е избран от групата противовъзпалителни съединения, състоящи се в основата си от производни на салициловата киселина, на парааминофенол, индол и инден оцетни киселини, хетероарилоцетни киселини, арилпропионови киселини, антранилови киселини, енолови киселини и алканони. Инхибиторът по-специално се състои от (+)(S)-енантиомерна 6-хлор- -метил-9Н-карбазол-2-оцетна киселина.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4563597P | 1997-05-05 | 1997-05-05 | |
| PCT/IB1998/000662 WO1998050033A1 (en) | 1997-05-05 | 1998-05-01 | Cox-2 selective carprofen for treating pain and inflammation in dogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG103852A true BG103852A (bg) | 2000-06-30 |
Family
ID=21939053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG103852A BG103852A (bg) | 1997-05-05 | 1999-11-03 | Цог-2 селективен карпрофен за лечение на болка и възпаление при кучета |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP0988034A1 (bg) |
| JP (1) | JP2000513020A (bg) |
| KR (2) | KR20010012300A (bg) |
| CN (1) | CN1255059A (bg) |
| AP (1) | AP9801234A0 (bg) |
| AR (2) | AR011726A1 (bg) |
| AU (1) | AU6932198A (bg) |
| BG (1) | BG103852A (bg) |
| BR (1) | BR9808720A (bg) |
| CA (1) | CA2288759A1 (bg) |
| DZ (1) | DZ2479A1 (bg) |
| EA (1) | EA003696B1 (bg) |
| GT (1) | GT199800063A (bg) |
| HR (1) | HRP980244A2 (bg) |
| HU (1) | HUP0001286A3 (bg) |
| ID (1) | ID21311A (bg) |
| IL (1) | IL132570A0 (bg) |
| IS (1) | IS5220A (bg) |
| MA (1) | MA26491A1 (bg) |
| NO (1) | NO995389L (bg) |
| NZ (1) | NZ500183A (bg) |
| OA (1) | OA11213A (bg) |
| PA (1) | PA8450601A1 (bg) |
| PE (1) | PE72599A1 (bg) |
| PL (1) | PL337003A1 (bg) |
| SK (1) | SK148199A3 (bg) |
| TN (1) | TNSN98059A1 (bg) |
| TW (1) | TW590773B (bg) |
| UY (1) | UY24989A1 (bg) |
| WO (1) | WO1998050033A1 (bg) |
| YU (1) | YU55899A (bg) |
| ZA (1) | ZA983722B (bg) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6245797B1 (en) | 1997-10-22 | 2001-06-12 | Merck & Co., Inc. | Combination therapy for reducing the risks associated with cardio-and-cerebrovascular disease |
| AU2003204888B2 (en) * | 1998-05-22 | 2005-07-28 | Pfizer Products Inc. | Treating or Preventing the Early Stages of Degeneration of Articular Cartilage or Subchondral Bone in Mammals Using Carprofen and Derivatives |
| US6506785B2 (en) * | 1998-05-22 | 2003-01-14 | Pfizer, Inc. | Treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in mammals using carprofen and derivatives |
| EP1123091A1 (en) * | 1998-10-23 | 2001-08-16 | Merck Frosst Canada & Co. | Combination product comprising an e-type prostaglandin ligand and a cox-2 selective inhibitor and methods of use |
| EP1637137A3 (en) * | 1999-03-10 | 2006-07-05 | G.D. Searle LLC | Method and composition for administering a cyclooxygenase-2 inhibitor to animals |
| AU1592901A (en) * | 1999-11-11 | 2001-06-06 | Eli Lilly And Company | Oncolytic combinations for the treatment of cancer |
| AU2001259974A1 (en) * | 2000-05-15 | 2001-11-26 | Merck Frosst Canada & Co | Combination therapy using cox-2 selective inhibitor and thromboxane inhibitor and compositions therefor |
| EA200802070A1 (ru) | 2000-06-13 | 2009-06-30 | Вайет | Болеутоляющее и противовоспалительные составы, содержащие ингибиторы циклооксигеназы-2 |
| DE10032132A1 (de) * | 2000-07-01 | 2002-01-17 | Lohmann Therapie Syst Lts | Dermales Therapeutisches System enthaltend nichtsteroidale Antiphlogistika mit selektiver COX-2-Hemmung |
| WO2002012549A1 (en) | 2000-08-07 | 2002-02-14 | Vanderbilt University | Compositions and methods for detecting and quantifying cox-2 activity and 2-arachidonylglycerol metabolites |
| AU2002354901A1 (en) * | 2001-07-16 | 2003-03-03 | Edward Hogestatt | Compounds with analgesic, antipyretic and/or anti-inflammatory activity |
| ATE342722T1 (de) | 2003-05-07 | 2006-11-15 | Osteologix As | Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen |
| KR100780983B1 (ko) * | 2003-07-31 | 2007-11-30 | 파마시아 앤드 업존 캄파니 엘엘씨 | 소염제의 분산성 제제 |
| EP1940380A2 (en) * | 2005-05-20 | 2008-07-09 | Pfizer Limited | Synergistic combinations of non-steroidal antiinflammatory drugs with alpha-2 delta-ligands |
| US9114071B2 (en) | 2007-04-04 | 2015-08-25 | Sigmoid Pharma Limited | Oral pharmaceutical composition |
| JP2010527285A (ja) | 2007-04-26 | 2010-08-12 | シグモイド・ファーマ・リミテッド | 複数のミニカプセルの製造 |
| ES2649112T3 (es) | 2009-05-18 | 2018-01-10 | Sigmoid Pharma Limited | Composición que comprende gotas de aceite |
| WO2011018504A2 (en) | 2009-08-12 | 2011-02-17 | Sigmoid Pharma Limited | Immunomodulatory compositions comprising a polymer matrix and an oil phase |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| WO2015134792A1 (en) | 2014-03-06 | 2015-09-11 | Aratana Therapeutics, Inc. | Compositions of grapiprant and methods for using the same |
| BR112017009510A2 (pt) | 2014-11-07 | 2017-12-19 | Sigmoid Pharma Ltd | composições compreendendo ciclosporina |
| CN107106536A (zh) * | 2015-01-09 | 2017-08-29 | 美洲豹动物健康公司 | 治疗伴侣动物的腹泻的方法 |
| US20230174485A1 (en) * | 2020-03-25 | 2023-06-08 | Sri International | Lipoxygenase inhibitors |
| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
| KR102404883B1 (ko) | 2020-11-30 | 2022-06-07 | (주)이노보테라퓨틱스 | 벤즈브로마론을 포함하는 켈로이드 또는 비대흉터 예방 또는 치료용 약학 조성물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3896145A (en) * | 1972-07-24 | 1975-07-22 | Hoffmann La Roche | Carbazoles |
| CA1319886C (en) * | 1987-02-03 | 1993-07-06 | Alberto Ferro | Mixed micelle solutions |
-
1998
- 1998-03-02 DZ DZ980089A patent/DZ2479A1/xx active
- 1998-04-30 TW TW087106689A patent/TW590773B/zh not_active IP Right Cessation
- 1998-05-01 CA CA002288759A patent/CA2288759A1/en not_active Abandoned
- 1998-05-01 NZ NZ500183A patent/NZ500183A/en unknown
- 1998-05-01 PL PL98337003A patent/PL337003A1/xx unknown
- 1998-05-01 WO PCT/IB1998/000662 patent/WO1998050033A1/en not_active Application Discontinuation
- 1998-05-01 HU HU0001286A patent/HUP0001286A3/hu unknown
- 1998-05-01 IL IL13257098A patent/IL132570A0/xx unknown
- 1998-05-01 EP EP98915041A patent/EP0988034A1/en not_active Withdrawn
- 1998-05-01 KR KR1019997010252A patent/KR20010012300A/ko not_active Application Discontinuation
- 1998-05-01 BR BR9808720-7A patent/BR9808720A/pt not_active IP Right Cessation
- 1998-05-01 JP JP10547869A patent/JP2000513020A/ja active Pending
- 1998-05-01 CN CN98804845A patent/CN1255059A/zh active Pending
- 1998-05-01 AU AU69321/98A patent/AU6932198A/en not_active Abandoned
- 1998-05-01 KR KR10-2003-7005258A patent/KR20040004406A/ko not_active Application Discontinuation
- 1998-05-01 ID IDP980651A patent/ID21311A/id unknown
- 1998-05-01 EA EA199900895A patent/EA003696B1/ru not_active IP Right Cessation
- 1998-05-01 SK SK1481-99A patent/SK148199A3/sk unknown
- 1998-05-01 YU YU55899A patent/YU55899A/sh unknown
- 1998-05-04 TN TNTNSN98059A patent/TNSN98059A1/fr unknown
- 1998-05-04 PE PE1998000335A patent/PE72599A1/es not_active Application Discontinuation
- 1998-05-04 ZA ZA9803722A patent/ZA983722B/xx unknown
- 1998-05-04 MA MA25059A patent/MA26491A1/fr unknown
- 1998-05-04 UY UY24989A patent/UY24989A1/es not_active Application Discontinuation
- 1998-05-04 AP APAP/P/1998/001234A patent/AP9801234A0/en unknown
- 1998-05-04 GT GT199800063A patent/GT199800063A/es unknown
- 1998-05-05 HR HR60/045,635A patent/HRP980244A2/hr not_active Application Discontinuation
- 1998-05-05 AR ARP980102089A patent/AR011726A1/es unknown
- 1998-05-05 PA PA19988450601A patent/PA8450601A1/es unknown
-
1999
- 1999-10-19 IS IS5220A patent/IS5220A/is unknown
- 1999-11-02 OA OA9900242A patent/OA11213A/en unknown
- 1999-11-03 BG BG103852A patent/BG103852A/bg unknown
- 1999-11-04 NO NO995389A patent/NO995389L/no not_active Application Discontinuation
-
2003
- 2003-04-09 AR ARP030101251A patent/AR039628A2/es unknown
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