BG102084A - Кондензирани тиазолови производни с афинитет към 5-нт рецептори - Google Patents

Кондензирани тиазолови производни с афинитет към 5-нт рецептори

Info

Publication number
BG102084A
BG102084A BG102084A BG10208497A BG102084A BG 102084 A BG102084 A BG 102084A BG 102084 A BG102084 A BG 102084A BG 10208497 A BG10208497 A BG 10208497A BG 102084 A BG102084 A BG 102084A
Authority
BG
Bulgaria
Prior art keywords
derivativs
receptors
affinity
disturbancies
condensed thiazole
Prior art date
Application number
BG102084A
Other languages
English (en)
Other versions
BG63206B1 (bg
Inventor
Frank Kerrigan
Sharon Cheetham
Roy Davies
Original Assignee
Knoll Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Gmbh filed Critical Knoll Gmbh
Publication of BG102084A publication Critical patent/BG102084A/bg
Publication of BG63206B1 publication Critical patent/BG63206B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Изобретението се отнася до съединения с формула, в която А е S(0)p или 0, р има стойност 0, 1 или 2, g - 0, 1, 2, 3 или 4, n - 2 или 3 и R1, R2, R3, R4 и R5 са в даден случай заместители. Тези съединения са полезни за лечение на депресия, безпокойство, психози, късна дискинезия, затлъстяване, лекарствена зависимост, злоупотреба с лекарства, смущения в познавателната способност, болестта на Алцхаймер, сенилна деменция, исхемия на мозъка, натрапчиво-компулсивно поведение, панически атаки, социофобия, смущения в храненето и анорексия, инсулинонезависим захарен диабет, хипергликемия и стрес.
BG102084A 1995-07-01 1997-11-28 Кондензирани тиазолови производни с афинитет към 5-нт рецептори BG63206B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9513467.2A GB9513467D0 (en) 1995-07-01 1995-07-01 Therapeutic agents
PCT/EP1996/002676 WO1997002269A1 (en) 1995-07-01 1996-06-20 Condensed thiazole derivatives, having 5-ht receptor affinity

Publications (2)

Publication Number Publication Date
BG102084A true BG102084A (bg) 1998-08-31
BG63206B1 BG63206B1 (bg) 2001-06-29

Family

ID=10777016

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102084A BG63206B1 (bg) 1995-07-01 1997-11-28 Кондензирани тиазолови производни с афинитет към 5-нт рецептори

Country Status (30)

Country Link
US (1) US5869492A (bg)
EP (1) EP0836606B1 (bg)
JP (1) JPH11508568A (bg)
KR (1) KR19990028619A (bg)
CN (1) CN1064966C (bg)
AR (1) AR003963A1 (bg)
AT (1) ATE195942T1 (bg)
AU (1) AU708789B2 (bg)
BG (1) BG63206B1 (bg)
BR (1) BR9609525A (bg)
CA (1) CA2222725A1 (bg)
CO (1) CO4700463A1 (bg)
CZ (1) CZ376297A3 (bg)
DE (1) DE69610104T2 (bg)
DK (1) DK0836606T3 (bg)
ES (1) ES2151175T3 (bg)
GB (1) GB9513467D0 (bg)
GR (1) GR3034397T3 (bg)
HR (1) HRP960306B1 (bg)
HU (1) HUP9901258A3 (bg)
IL (1) IL122158A (bg)
NO (1) NO310660B1 (bg)
NZ (1) NZ312130A (bg)
PL (1) PL324337A1 (bg)
PT (1) PT836606E (bg)
SK (1) SK179297A3 (bg)
TR (1) TR199701756T1 (bg)
TW (1) TW474939B (bg)
WO (1) WO1997002269A1 (bg)
ZA (1) ZA965494B (bg)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9705428D0 (en) 1997-03-15 1997-04-30 Knoll Ag Therapeutic agents
HUP0101728A3 (en) 1998-03-31 2002-04-29 Shionogi & Co 5-hydroxybenzo[b]thiophene-3-carboxylic acid and their derivatives and methods for producing them
DE19908536A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische Thiazol-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
GB9911881D0 (en) * 1999-05-21 1999-07-21 Knoll Ag Therapeutic agents
GB9911863D0 (en) * 1999-05-21 1999-07-21 Knoll Ag Therapeutic agents
GB0005789D0 (en) * 2000-03-11 2000-05-03 Knoll Ag Therapeutic agents
GB0023610D0 (en) * 2000-09-27 2000-11-08 Knoll Ag Therapeutic agents
DE10112197A1 (de) * 2001-03-14 2002-09-19 Gruenenthal Gmbh Substituierte Pyrazolo- und Thiazolopyrimidine
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002400A1 (fr) * 1977-11-24 1979-06-13 Synthelabo Dérivés de thiazole, leur préparation, intermédiaires et leur application en thérapeutique
PT672043E (pt) * 1992-07-13 2001-11-30 Janssen Pharmaceutica Nv Novos derivados de 4-(3-benzofuranil)piperidinilo e 4-(3-benzotienil)piperidinilo e composicoes farmaceuticas que os contem

Also Published As

Publication number Publication date
HRP960306B1 (en) 2001-08-31
PT836606E (pt) 2001-02-28
PL324337A1 (en) 1998-05-25
GB9513467D0 (en) 1995-09-06
KR19990028619A (ko) 1999-04-15
ES2151175T3 (es) 2000-12-16
GR3034397T3 (en) 2000-12-29
DE69610104T2 (de) 2001-01-18
BG63206B1 (bg) 2001-06-29
IL122158A (en) 2000-01-31
CO4700463A1 (es) 1998-12-29
BR9609525A (pt) 1999-02-23
AU708789B2 (en) 1999-08-12
EP0836606A1 (en) 1998-04-22
NZ312130A (en) 1999-08-30
TR199701756T1 (xx) 1998-04-21
US5869492A (en) 1999-02-09
TW474939B (en) 2002-02-01
IL122158A0 (en) 1998-04-05
CN1064966C (zh) 2001-04-25
NO976157D0 (no) 1997-12-30
EP0836606B1 (en) 2000-08-30
CN1189834A (zh) 1998-08-05
ATE195942T1 (de) 2000-09-15
AR003963A1 (es) 1998-09-30
CZ376297A3 (cs) 1998-06-17
CA2222725A1 (en) 1997-01-23
AU6358996A (en) 1997-02-05
HUP9901258A2 (hu) 1999-08-30
NO976157L (no) 1997-12-30
SK179297A3 (en) 1998-07-08
NO310660B1 (no) 2001-08-06
WO1997002269A1 (en) 1997-01-23
HUP9901258A3 (en) 2000-08-28
HRP960306A2 (en) 1998-04-30
JPH11508568A (ja) 1999-07-27
MX9709509A (es) 1998-03-29
DK0836606T3 (da) 2000-11-20
DE69610104D1 (de) 2000-10-05
ZA965494B (en) 1997-12-29

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