BG101582A - Пиперазинови производни, съдържащите ги лекарствени форми, приложението им и метод за тяхното получаване - Google Patents
Пиперазинови производни, съдържащите ги лекарствени форми, приложението им и метод за тяхното получаванеInfo
- Publication number
- BG101582A BG101582A BG101582A BG10158297A BG101582A BG 101582 A BG101582 A BG 101582A BG 101582 A BG101582 A BG 101582A BG 10158297 A BG10158297 A BG 10158297A BG 101582 A BG101582 A BG 101582A
- Authority
- BG
- Bulgaria
- Prior art keywords
- piperazine derivatives
- receiving
- application
- containing medicinal
- medicinal forms
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19944446301 DE4446301A1 (de) | 1994-12-23 | 1994-12-23 | Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE19526678A DE19526678A1 (de) | 1994-12-23 | 1995-07-21 | Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE1995133639 DE19533639A1 (de) | 1994-12-23 | 1995-09-12 | Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| PCT/EP1995/005031 WO1996020173A1 (de) | 1994-12-23 | 1995-12-19 | Piperazinderivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG101582A true BG101582A (bg) | 1998-01-30 |
Family
ID=27207101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG101582A BG101582A (bg) | 1994-12-23 | 1997-06-06 | Пиперазинови производни, съдържащите ги лекарствени форми, приложението им и метод за тяхното получаване |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5922717A (cs) |
| EP (1) | EP0799202A1 (cs) |
| JP (1) | JPH10511374A (cs) |
| CN (1) | CN1183770A (cs) |
| AR (1) | AR002950A1 (cs) |
| AU (1) | AU4432496A (cs) |
| BG (1) | BG101582A (cs) |
| BR (1) | BR9510360A (cs) |
| CA (1) | CA2207618A1 (cs) |
| CZ (1) | CZ189197A3 (cs) |
| EE (1) | EE9700141A (cs) |
| FI (1) | FI972646L (cs) |
| HR (1) | HRP950609A2 (cs) |
| IL (1) | IL116517A0 (cs) |
| MX (1) | MX9704745A (cs) |
| NO (1) | NO972881D0 (cs) |
| PL (1) | PL321003A1 (cs) |
| SK (1) | SK79797A3 (cs) |
| TR (1) | TR199501634A2 (cs) |
| WO (1) | WO1996020173A1 (cs) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037343A (en) * | 1994-12-22 | 2000-03-14 | Smithkline Beecham Corporation | Fibrinogen receptor antagonists |
| US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
| EP0858457A1 (de) * | 1995-10-20 | 1998-08-19 | Dr. Karl Thomae GmbH | 5-gliedrige heterocyclen, diese verbindungen enthaltende arzneimittel und deren verwendung sowie verfahren zu ihrer herstellung |
| UY25225A1 (es) | 1997-10-29 | 2000-12-29 | Smithkline Beecham Plc | Derivados de pleuromutilina utiles como agentes antimicrobianos |
| US6472397B1 (en) | 1998-04-09 | 2002-10-29 | Meiji Seika Kaisha, Ltd. | Nitrogen-containing heterocyclic compounds having antiplatelet aggregation effect and medicinal use thereof |
| NZ511997A (en) | 1999-09-29 | 2004-12-24 | Ortho Mcneil Pharm Inc | Isonipecotamides for the treatment of integrin-mediated disorders |
| EP1533310A1 (en) * | 1999-09-29 | 2005-05-25 | Ortho-McNeil Pharmaceutical, Inc. | Isonipecotamides for the treatment of integrin-mediated disorders |
| USRE39921E1 (en) | 1999-10-07 | 2007-11-13 | Smithkline Beecham Corporation | Chemical compounds |
| GB9923748D0 (en) | 1999-10-07 | 1999-12-08 | Glaxo Group Ltd | Chemical compounds |
| GB0025354D0 (en) | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
| US7081460B2 (en) * | 2001-04-09 | 2006-07-25 | Ortho-Mcneil Pharmaceutical, Inc. | Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders |
| ATE447955T1 (de) | 2001-08-24 | 2009-11-15 | Univ Yale | Piperazinon-verbindungen als antitumorale und krebsbekämpfende mittel |
| FR2829766A1 (fr) * | 2001-09-14 | 2003-03-21 | Lipha | Derives d'oxamates comportant un heterocycle azote diversement substitue |
| GB0203022D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
| GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
| JP2005522436A (ja) | 2002-02-08 | 2005-07-28 | グラクソ グループ リミテッド | ピペリジルカルボキシアミド誘導体またはそのタキキニン介在疾患の治療における使用 |
| EP1737809B1 (en) * | 2004-02-27 | 2013-09-18 | Amgen, Inc | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders |
| JP2009506987A (ja) * | 2005-08-02 | 2009-02-19 | ニューロゲン コーポレイション | ジピペラジニルケトンおよび関連する類似体 |
| US7947714B2 (en) | 2005-10-28 | 2011-05-24 | Merck, Sharp & Dohme Corp. | Piperidine glycine transporter inhibitors |
| HRP20140336T1 (hr) | 2006-06-28 | 2014-06-06 | Amgen Inc. | Inhibitori glicin transportera-1 |
| US9090604B2 (en) | 2006-07-27 | 2015-07-28 | E I Du Pont De Nemours And Company | Fungicidal azocyclic amides |
| WO2008013622A2 (en) * | 2006-07-27 | 2008-01-31 | E. I. Du Pont De Nemours And Company | Fungicidal azocyclic amides |
| KR101370434B1 (ko) * | 2007-01-16 | 2014-03-06 | 시오노기세이야쿠가부시키가이샤 | Ｏｒｌ-1 리간드로서의 헤테로시클릭-치환 피페리딘 |
| CN101878208B (zh) | 2007-08-31 | 2014-10-15 | 普渡制药公司 | 取代的喹喔啉型哌啶化合物及其用途 |
| WO2010081851A1 (en) | 2009-01-14 | 2010-07-22 | Genoscience Pharma | Piperidin-4-ylpiperazine compounds for the treatment of hcv infection |
| CA2839703A1 (en) | 2011-06-24 | 2012-12-27 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
| CA2839699A1 (en) | 2011-06-24 | 2012-12-27 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
| WO2013123511A1 (en) * | 2012-02-16 | 2013-08-22 | New York University | Control of hypoxia-inducible gene expression with oligooxopiperazine nonpeptidic helix mimetics |
| US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
| EP2945631A4 (en) | 2013-01-19 | 2016-06-29 | Univ New York | OLIGOOXOPIPERAZINE FOR THE REACTIVATION OF P53 |
| AU2015264201A1 (en) | 2014-05-21 | 2017-01-12 | New York University | Oxopiperazine helix mimetics for control of hypoxia-inducible gene expression |
| WO2023122481A2 (en) * | 2021-12-20 | 2023-06-29 | Sigma-Aldrich Co. Llc | Chemical linkers |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2926472A1 (de) * | 1979-06-30 | 1981-01-15 | Thomae Gmbh Dr K | Neue benzoylderivate, deren herstellung und deren verwendung als arzneimittel |
| ZA825719B (en) * | 1981-09-03 | 1983-06-29 | Recordati Chem Pharm | Alkanoylanilides |
| PH19166A (en) * | 1982-09-04 | 1986-01-16 | Pfizer | Dihydropyridined,pharmaceutical compositions and method of use |
| US4895846A (en) * | 1984-04-11 | 1990-01-23 | Bristol-Myers Company | Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moieties |
| US4778796A (en) * | 1985-07-19 | 1988-10-18 | Dainippon Pharmaceutical Co., Ltd. | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same |
| DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE4213919A1 (de) * | 1992-04-28 | 1993-11-04 | Thomae Gmbh Dr K | Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE4332168A1 (de) * | 1993-02-22 | 1995-03-23 | Thomae Gmbh Dr K | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| IL109145A0 (en) * | 1993-03-29 | 1994-06-24 | Zeneca Ltd | Heterocyclic compounds |
| PT825184E (pt) * | 1993-03-29 | 2001-11-30 | Astrazeneca Ab | Derivados heterociclicos como inibidores de agregacao de plaquetas |
| DE4324580A1 (de) * | 1993-07-22 | 1995-01-26 | Thomae Gmbh Dr K | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE4326344A1 (de) * | 1993-08-05 | 1995-02-09 | Thomae Gmbh Dr K | Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| CA2171850A1 (en) * | 1994-07-15 | 1996-02-01 | Kiyoaki Katano | Novel compound having platelet aggregation inhibitor effect |
| IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
-
1995
- 1995-12-19 WO PCT/EP1995/005031 patent/WO1996020173A1/de not_active Ceased
- 1995-12-19 EE EE9700141A patent/EE9700141A/xx unknown
- 1995-12-19 AU AU44324/96A patent/AU4432496A/en not_active Abandoned
- 1995-12-19 PL PL95321003A patent/PL321003A1/xx unknown
- 1995-12-19 EP EP95943168A patent/EP0799202A1/de not_active Withdrawn
- 1995-12-19 CA CA002207618A patent/CA2207618A1/en not_active Abandoned
- 1995-12-19 BR BR9510360A patent/BR9510360A/pt not_active Application Discontinuation
- 1995-12-19 SK SK797-97A patent/SK79797A3/sk unknown
- 1995-12-19 FI FI972646A patent/FI972646L/fi not_active Application Discontinuation
- 1995-12-19 MX MX9704745A patent/MX9704745A/es unknown
- 1995-12-19 CZ CZ971891A patent/CZ189197A3/cs unknown
- 1995-12-19 JP JP8520188A patent/JPH10511374A/ja active Pending
- 1995-12-19 CN CN95196854A patent/CN1183770A/zh active Pending
- 1995-12-20 HR HR19533639.9A patent/HRP950609A2/hr not_active Application Discontinuation
- 1995-12-21 TR TR95/01634A patent/TR199501634A2/xx unknown
- 1995-12-21 US US08/576,528 patent/US5922717A/en not_active Expired - Fee Related
- 1995-12-22 IL IL11651795A patent/IL116517A0/xx unknown
- 1995-12-22 AR ARP950100727A patent/AR002950A1/es unknown
-
1997
- 1997-06-06 BG BG101582A patent/BG101582A/xx unknown
- 1997-06-20 NO NO972881A patent/NO972881D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9510360A (pt) | 1997-12-23 |
| EE9700141A (et) | 1997-12-15 |
| NO972881L (no) | 1997-06-20 |
| HRP950609A2 (en) | 1997-10-31 |
| CN1183770A (zh) | 1998-06-03 |
| AR002950A1 (es) | 1998-05-27 |
| FI972646A7 (fi) | 1997-08-19 |
| IL116517A0 (en) | 1996-03-31 |
| TR199501634A2 (tr) | 1996-07-21 |
| PL321003A1 (en) | 1997-11-24 |
| FI972646A0 (fi) | 1997-06-19 |
| SK79797A3 (en) | 1997-11-05 |
| JPH10511374A (ja) | 1998-11-04 |
| CA2207618A1 (en) | 1996-07-04 |
| EP0799202A1 (de) | 1997-10-08 |
| WO1996020173A1 (de) | 1996-07-04 |
| NO972881D0 (no) | 1997-06-20 |
| AU4432496A (en) | 1996-07-19 |
| US5922717A (en) | 1999-07-13 |
| MX9704745A (es) | 1997-10-31 |
| CZ189197A3 (cs) | 1998-01-14 |
| FI972646L (fi) | 1997-08-19 |
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