BG101139A - Heteroatoms-containing cyclopentanopyridyloxazolidinons - Google Patents
Heteroatoms-containing cyclopentanopyridyloxazolidinonsInfo
- Publication number
- BG101139A BG101139A BG101139A BG10113997A BG101139A BG 101139 A BG101139 A BG 101139A BG 101139 A BG101139 A BG 101139A BG 10113997 A BG10113997 A BG 10113997A BG 101139 A BG101139 A BG 101139A
- Authority
- BG
- Bulgaria
- Prior art keywords
- heteroatoms
- cyclopentanopyridyloxazolidinons
- particularas
- containingcyclopentanopyridyloxazolidinons
- antibacerial
- Prior art date
Links
- 125000005842 heteroatom Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19601627A DE19601627A1 (de) | 1996-01-18 | 1996-01-18 | Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone |
Publications (1)
Publication Number | Publication Date |
---|---|
BG101139A true BG101139A (en) | 1998-04-30 |
Family
ID=7783042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG101139A BG101139A (en) | 1996-01-18 | 1997-01-16 | Heteroatoms-containing cyclopentanopyridyloxazolidinons |
Country Status (21)
Country | Link |
---|---|
US (1) | US5869659A (hu) |
EP (1) | EP0785201A1 (hu) |
JP (1) | JPH09202787A (hu) |
KR (1) | KR970059170A (hu) |
AU (1) | AU1012397A (hu) |
BG (1) | BG101139A (hu) |
BR (1) | BR9700716A (hu) |
CA (1) | CA2195177A1 (hu) |
CZ (1) | CZ15897A3 (hu) |
DE (1) | DE19601627A1 (hu) |
EE (1) | EE9700020A (hu) |
HU (1) | HU9700152D0 (hu) |
IL (1) | IL120016A0 (hu) |
MA (1) | MA24062A1 (hu) |
NO (1) | NO970210L (hu) |
PL (1) | PL317985A1 (hu) |
SG (1) | SG50001A1 (hu) |
SK (1) | SK6997A3 (hu) |
TN (1) | TNSN97010A1 (hu) |
TR (1) | TR199700039A2 (hu) |
ZA (1) | ZA97393B (hu) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6562844B2 (en) | 1998-01-23 | 2003-05-13 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
AU764184B2 (en) | 1998-01-23 | 2003-08-14 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
US7002020B1 (en) | 1998-01-23 | 2006-02-21 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
PL345162A1 (en) | 1998-06-05 | 2001-12-03 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
CN1367780A (zh) * | 1999-07-28 | 2002-09-04 | 法玛西雅厄普约翰美国公司 | 噁唑烷酮类化合物、其制备方法及其应用 |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
US6514529B2 (en) | 2000-03-22 | 2003-02-04 | Pharmacia & Upjohn Company | Oxazolidinone tablet formulation |
MY127336A (en) | 2000-03-22 | 2006-11-30 | Upjohn Co | Container for linezolid iv solution |
GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
DK1301207T3 (da) | 2000-06-30 | 2005-10-10 | Pharmacia & Upjohn Co Llc | Sammensætninger til behandling af bakterieinfektioner indeholdende en oxazolidinonforbindelse, sulbactam og ampicillin |
US6423844B1 (en) | 2001-06-06 | 2002-07-23 | The United States Of America As Represented By The Secretary Of The Navy | Process for making 1,2,4-triazolo[4,3-a][1,3,5]triazine-3,5,7-triamine |
AR038536A1 (es) * | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
US7141588B2 (en) * | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
US7094900B2 (en) * | 2002-08-12 | 2006-08-22 | Pharmacia & Upjohn Company Llc | N-Aryl-2-oxazolidinones and their derivatives |
AU2003280143A1 (en) * | 2002-11-21 | 2004-06-15 | Pharmacia & Upjohn Company Llc | N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents |
MXPA05007937A (es) * | 2003-02-07 | 2005-09-30 | Warner Lambert Co | Agentes antibacterianos. |
MXPA05007724A (es) * | 2003-02-07 | 2005-09-30 | Warner Lambert Co | Agentes antibacterianos. |
US7012088B2 (en) * | 2003-02-24 | 2006-03-14 | Pharmacia & Upjohn Company | Indolone oxazolidinones and derivatives thereof |
US20040204463A1 (en) * | 2003-04-01 | 2004-10-14 | Harris Christina Renee | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
WO2005082900A2 (en) * | 2004-01-28 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Oxazolidinone amidoximes as antibacterial agents |
US20080262056A1 (en) * | 2004-08-06 | 2008-10-23 | Pfizer Inc | Oxindole Oxazolidinones as Antibacterial Agents |
KR101504669B1 (ko) * | 2006-10-19 | 2015-03-20 | 시그날 파마소티칼 엘엘씨 | 헤테로아릴 화합물, 이들의 조성물 그리고 단백질 키나아제 억제제로서의 이들의 용도 |
US8110578B2 (en) | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
ES2613664T3 (es) | 2009-10-26 | 2017-05-25 | Signal Pharmaceuticals, Llc | Procedimientos de síntesis y purificación de compuestos de heteroarilo |
BR112014009755B1 (pt) | 2011-10-19 | 2022-09-13 | Signal Pharmaceuticals, Llc | Tratamento de câncer com inibidores de quinase tor |
CA3125862A1 (en) | 2011-12-02 | 2013-06-06 | Signal Pharmaceuticals, Llc | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use |
BR112014020786A2 (pt) | 2012-02-24 | 2020-10-27 | Signal Pharmaceuticals, Llc | método para tratamento de câncer de pulmão, método para alcançar um critério de avaliação de resposta em tumores sólidos, método para aumento da sobrevivência |
AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
CN105188704B (zh) | 2013-01-16 | 2017-09-19 | 西格诺药品有限公司 | 被取代的吡咯并嘧啶化合物、其组合物和使用其的治疗方法 |
TW201521725A (zh) | 2013-04-17 | 2015-06-16 | Signal Pharm Llc | 使用tor激酶抑制劑組合療法以治療癌症之方法 |
EP2986321A1 (en) | 2013-04-17 | 2016-02-24 | Signal Pharmaceuticals, LLC | Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer |
JP6382946B2 (ja) | 2013-04-17 | 2018-08-29 | シグナル ファーマシューティカルズ,エルエルシー | ジヒドロピラジノ−ピラジンによる癌治療 |
PE20160041A1 (es) | 2013-04-17 | 2016-01-28 | Signal Pharm Llc | FORMULACIONES FARMACEUTICAS, PROCESO, FORMAS SOLIDAS Y METODOS DE USO RELACIONADOS CON 1-ETIL-7-(2-METIL-6-(1H-1,2,4-TRIAZOL-3-IL)PIRIDIN-3-IL)-3,4-DIHIDROPIRAZINO[2,3-b]PIRAZIN-2(1H)-ONA |
TWI631950B (zh) | 2013-04-17 | 2018-08-11 | 標誌製藥公司 | 藉二氫吡𠯤并吡𠯤治療癌症 |
CA2908957C (en) | 2013-04-17 | 2021-05-18 | Signal Pharmaceuticals, Llc | Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer |
CA2909625C (en) | 2013-04-17 | 2021-06-01 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer |
JP6401250B2 (ja) | 2013-05-29 | 2018-10-10 | シグナル ファーマシューティカルズ,エルエルシー | 7−(6−(2−ヒドロキシプロパン−2−イル)ピリジン−3−イル)−1−((trans)−4−メトキシシクロヘキシル)−3,4−ジヒドロピラジノ[2,3−b]ピラジン−2(1H)−オン、その固体形態の医薬組成物、及びその使用方法 |
US9718824B2 (en) | 2014-04-16 | 2017-08-01 | Signal Pharmaceuticals, Llc | Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof |
WO2015160868A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | Methods for treating cancer using tor kinase inhibitor combination therapy |
WO2015160880A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
EA201790189A1 (ru) | 2014-07-14 | 2017-11-30 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Способы лечения злокачественного новообразования с использованием замещенных пирролопиримидиновых соединений, композиции на их основе |
NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
SG11201912403SA (en) | 2017-06-22 | 2020-01-30 | Celgene Corp | Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
US4985429A (en) * | 1987-10-09 | 1991-01-15 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4965268A (en) * | 1987-10-09 | 1990-10-23 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4921869A (en) * | 1987-10-09 | 1990-05-01 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4801600A (en) * | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4942183A (en) * | 1987-10-16 | 1990-07-17 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents |
US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
DE68918792T2 (de) | 1988-09-15 | 1995-03-30 | Upjohn Co | 5-Indolinyl-5-beta-amidomethyloxazolidin-2-one, 3-(substituierte kondensierte)phenyl-5-beta amidomethyloxazolidin-2-one und 3-(Nitrogen-substituierte)phenyl-5-beta-amidomethyloxazolidin-2-one. |
JP2679745B2 (ja) * | 1989-06-29 | 1997-11-19 | 明治製菓株式会社 | アゾール誘導体及びそれらを有効成分とする抗潰瘍剤 |
JP2669579B2 (ja) * | 1991-10-23 | 1997-10-29 | エーザイ株式会社 | オキサゾリドン誘導体 |
DE4332384A1 (de) * | 1993-09-23 | 1995-03-30 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten III |
TW286317B (hu) * | 1993-12-13 | 1996-09-21 | Hoffmann La Roche | |
DE4425612A1 (de) * | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
-
1996
- 1996-01-18 DE DE19601627A patent/DE19601627A1/de not_active Withdrawn
-
1997
- 1997-01-07 EP EP97100114A patent/EP0785201A1/de not_active Withdrawn
- 1997-01-10 AU AU10123/97A patent/AU1012397A/en not_active Abandoned
- 1997-01-13 US US08/785,145 patent/US5869659A/en not_active Expired - Fee Related
- 1997-01-14 MA MA24463A patent/MA24062A1/fr unknown
- 1997-01-15 CA CA002195177A patent/CA2195177A1/en not_active Abandoned
- 1997-01-15 TN TNTNSN97010A patent/TNSN97010A1/fr unknown
- 1997-01-15 SG SG1997000082A patent/SG50001A1/en unknown
- 1997-01-16 PL PL97317985A patent/PL317985A1/xx unknown
- 1997-01-16 EE EE9700020A patent/EE9700020A/xx unknown
- 1997-01-16 IL IL12001697A patent/IL120016A0/xx unknown
- 1997-01-16 BG BG101139A patent/BG101139A/xx unknown
- 1997-01-16 JP JP9017765A patent/JPH09202787A/ja active Pending
- 1997-01-17 HU HU9700152A patent/HU9700152D0/hu unknown
- 1997-01-17 NO NO970210A patent/NO970210L/no unknown
- 1997-01-17 SK SK69-97A patent/SK6997A3/sk unknown
- 1997-01-17 BR BR9700716A patent/BR9700716A/pt unknown
- 1997-01-17 KR KR1019970001266A patent/KR970059170A/ko not_active Application Discontinuation
- 1997-01-17 ZA ZA97393A patent/ZA97393B/xx unknown
- 1997-01-17 TR TR97/00039A patent/TR199700039A2/xx unknown
- 1997-01-17 CZ CZ97158A patent/CZ15897A3/cs unknown
Also Published As
Publication number | Publication date |
---|---|
DE19601627A1 (de) | 1997-07-24 |
NO970210D0 (no) | 1997-01-17 |
EE9700020A (et) | 1997-08-15 |
US5869659A (en) | 1999-02-09 |
SK6997A3 (en) | 1997-09-10 |
AU1012397A (en) | 1997-07-24 |
EP0785201A1 (de) | 1997-07-23 |
IL120016A0 (en) | 1997-04-15 |
TR199700039A2 (tr) | 1997-08-21 |
HU9700152D0 (en) | 1997-03-28 |
PL317985A1 (en) | 1997-07-21 |
CZ15897A3 (en) | 1997-08-13 |
CA2195177A1 (en) | 1997-07-19 |
KR970059170A (ko) | 1997-08-12 |
ZA97393B (en) | 1997-07-17 |
TNSN97010A1 (fr) | 2005-03-15 |
MX9700388A (es) | 1997-07-31 |
NO970210L (no) | 1997-07-21 |
SG50001A1 (en) | 1998-06-15 |
MA24062A1 (fr) | 1997-10-01 |
BR9700716A (pt) | 1998-10-06 |
JPH09202787A (ja) | 1997-08-05 |
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