BE899564A - Composition pharmaceutique pour l'administration parenterale a base de nimodipin et procede pour sa preparation. - Google Patents

Composition pharmaceutique pour l'administration parenterale a base de nimodipin et procede pour sa preparation.

Info

Publication number
BE899564A
BE899564A BE0/212864A BE212864A BE899564A BE 899564 A BE899564 A BE 899564A BE 0/212864 A BE0/212864 A BE 0/212864A BE 212864 A BE212864 A BE 212864A BE 899564 A BE899564 A BE 899564A
Authority
BE
Belgium
Prior art keywords
nimodipin
weight
parenteral administration
preparation
pharmaceutical composition
Prior art date
Application number
BE0/212864A
Other languages
English (en)
French (fr)
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of BE899564A publication Critical patent/BE899564A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
BE0/212864A 1983-05-06 1984-05-03 Composition pharmaceutique pour l'administration parenterale a base de nimodipin et procede pour sa preparation. BE899564A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833316510 DE3316510A1 (de) 1983-05-06 1983-05-06 Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen

Publications (1)

Publication Number Publication Date
BE899564A true BE899564A (fr) 1984-11-05

Family

ID=6198265

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/212864A BE899564A (fr) 1983-05-06 1984-05-03 Composition pharmaceutique pour l'administration parenterale a base de nimodipin et procede pour sa preparation.

Country Status (19)

Country Link
US (1) US5114956A (enExample)
EP (1) EP0126315B1 (enExample)
JP (1) JPS59206305A (enExample)
KR (1) KR920000306B1 (enExample)
AT (1) ATE24835T1 (enExample)
AU (1) AU562293B2 (enExample)
BE (1) BE899564A (enExample)
CA (1) CA1220424A (enExample)
DE (2) DE3316510A1 (enExample)
DK (1) DK164148C (enExample)
ES (1) ES8505542A1 (enExample)
FR (1) FR2545354B1 (enExample)
GR (1) GR81609B (enExample)
HK (1) HK75889A (enExample)
IL (1) IL71744A (enExample)
IT (1) IT1181804B (enExample)
PT (1) PT78542B (enExample)
SG (1) SG44489G (enExample)
ZA (1) ZA843352B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60246313A (ja) * 1984-05-22 1985-12-06 Yamanouchi Pharmaceut Co Ltd 塩酸ニカルジピンの注射剤およびその製法
FR2585574B1 (fr) * 1985-07-31 1988-09-09 Corbiere Jerome Nouvelles compositions pharmaceutiques anti-glaucomateuses a base de 1,4-dihydropyridines et leur procede d'obtention
DE3544692A1 (de) * 1985-12-18 1987-06-19 Bayer Ag Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung
AT387518B (de) * 1985-12-18 1989-02-10 Bayer Ag Verfahren zur herstellung von fluessigen spruehpraeparaten von dihydropyridinen
DE3702105A1 (de) * 1987-01-24 1988-08-04 Bayer Ag Parenterale loesung
GB2228412B (en) * 1989-02-28 1993-04-14 Syntex Inc Nicardipine pharmaceutical composition for parenteral administration
RU1804845C (ru) * 1991-02-15 1993-03-30 Институт Органического Синтеза Латвийской Ан Ноотропное вещество
JPH10510540A (ja) 1994-12-12 1998-10-13 オメロス メディカル システムズ，インコーポレーテッド 灌注用溶液並びに疼痛、炎症及びけいれんの抑制法
KR100517210B1 (ko) * 1994-12-12 2006-06-07 오메로스 코포레이션 통증,염증및경련억제용관주용액
ES2377126T3 (es) * 1994-12-12 2012-03-22 Omeros Corporation Solución de irrigación y utilización de la misma para la inhibición perioperatoria del dolor, la inflamación y/o los espasmos en una estructura vascular
US6492332B1 (en) 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
US6413961B1 (en) 1995-12-12 2002-07-02 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
US6136799A (en) * 1998-04-08 2000-10-24 Abbott Laboratories Cosolvent formulations
DE10142416A1 (de) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re Verfahren zur Herstellung von Lösungen
DE10142417A1 (de) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re Arzneimittel
US8034762B2 (en) 2004-09-02 2011-10-11 Cognosci, Inc. Treatment of subarachnoid hemorrhage with Apo E analogs
WO2007047406A2 (en) * 2005-10-14 2007-04-26 Transform Pharmaceuticals, Inc. Liquid pharmaceutical compositions of nimodipine
WO2007125028A1 (de) * 2006-04-28 2007-11-08 Basf Se Verfahren zur solubilisierung von hydrophoben wirkstoffen in wässrigem medium
CN102741327B (zh) 2010-02-05 2014-11-05 巴斯夫欧洲公司 在水溶液中加溶疏水性活性成分的方法
US8728504B2 (en) 2010-02-05 2014-05-20 Basf Se Process for solubilizing hydrophobic active ingredients in aqueous medium
US9364433B2 (en) 2011-04-28 2016-06-14 Borje S. Andersson Parenteral formulations of lipophilic pharmaceutical agents and methods for preparing and using the same
PT3442586T (pt) * 2016-04-13 2022-09-28 Acasti Pharma U S Inc Formulação parentérica estável de nimodipina
US10092553B2 (en) 2016-04-13 2018-10-09 Nortic Holdings Inc. Stable nimodipine parenteral formulation
US20190255033A1 (en) 2018-02-22 2019-08-22 Nortic Holdings Inc. Stable Nimodipine Parenteral Formulation
CN119300828A (zh) 2022-05-16 2025-01-10 美国阿卡斯蒂制药股份有限公司 尼莫地平肠胃外给药

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US4154839A (en) * 1975-11-05 1979-05-15 Bayer Aktiengesellschaft 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
DE2650013C3 (de) * 1976-10-30 1981-04-02 Bayer Ag, 5090 Leverkusen 1.4-Dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsäureisopropyl-(2-propoxy-äthyl)-ester, Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel
DE2815578C2 (de) * 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen Neue pharmazeutische Verwendung von Nimodipin
DE2841667A1 (de) * 1978-09-25 1980-04-10 Bayer Ag Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
DE3316510A1 (de) 1984-11-08
SG44489G (en) 1989-11-17
ATE24835T1 (de) 1987-01-15
KR840009031A (ko) 1984-12-24
FR2545354B1 (fr) 1986-09-26
DK164148C (da) 1992-10-26
IT1181804B (it) 1987-09-30
GR81609B (enExample) 1984-12-11
ZA843352B (en) 1984-12-24
CA1220424A (en) 1987-04-14
DE3461988D1 (en) 1987-02-19
IL71744A (en) 1988-04-29
ES531995A0 (es) 1985-06-01
US5114956A (en) 1992-05-19
JPH0422888B2 (enExample) 1992-04-20
ES8505542A1 (es) 1985-06-01
FR2545354A1 (fr) 1984-11-09
HK75889A (en) 1989-09-29
KR920000306B1 (ko) 1992-01-11
EP0126315B1 (de) 1987-01-14
IT8448139A1 (it) 1985-11-04
DK224184A (da) 1984-11-07
AU562293B2 (en) 1987-06-04
AU2758384A (en) 1984-11-08
IL71744A0 (en) 1984-09-30
DK164148B (da) 1992-05-18
PT78542B (en) 1986-07-14
EP0126315A1 (de) 1984-11-28
IT8448139A0 (it) 1984-05-04
PT78542A (en) 1984-06-01
DK224184D0 (da) 1984-05-04
JPS59206305A (ja) 1984-11-22

Similar Documents

Publication Publication Date Title
BE899564A (fr) Composition pharmaceutique pour l'administration parenterale a base de nimodipin et procede pour sa preparation.
FI821598L (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 1-alkyl-2-aminotetralinderivat
ES8603870A1 (es) Un procedimiento para la preparacion de derivados de 2,2'-iminobisetanol.
BE901224A (fr) Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation.
FR2397403A1 (fr) Nouveaux derives de 1-acyl 2-cyano-aziridine, procede pour leur preparation et compositions pharmaceutiques contenant ces composes
FR2554346B1 (fr) Ensemble et procede pour l'administration de gangliosides et de leurs derives par inhalation et compositions pharmaceutiques les contenant
BE902528A (fr) 1,24-dihydroxy-delta 22-vitamines d3 et procede pour les preparer.
FR2505185B1 (fr) Procede de preparation d'un polysulfate de chondroitine injectable, produit obtenu par ce procede et compositions pharmaceutiques le contenant
IL97796A0 (en) Pharmaceutical compositions containing n-alkylated 1,4-dihydropyridine-dicarboxylic acid esters,certain such compounds and their preparation
TNSN92017A1 (fr) Procede de preparation, d'un derive de benzothiazole, et d'une composition pharmaceutique le contenant et procede de traitement en comportant application
BE901266A (fr) Nouveaux derives de 3-benzylidene camphre, leur procede de preparation et leur utilisation en tant qu'agents de protection contre les rayons uv et produits ainsi obtenus.
SE9302333D0 (sv) New compounds
FR2446829A1 (fr) Derives de polymethylene disubstitues en alpha, omega, procede pour leur preparation et compositions pharmaceutiques les contenant
BE903693A (fr) Derives de flavolignanes, procedes pour leur preparation et medicaments contenant ces composes.
FR2401132A1 (fr) Nouveaux derives de triphenylbutene-1, leur procede de production et composition pharmaceutique les contenant
BE1000719A4 (fr) Derives de 3-(hydroxymethyl)-isoquinoleine, procede pour les preparer et compositions pharmaceutiques les contenant.
FR2387035A1 (fr) Nouveau medicament destine notamment au traitement des troubles fonctionnels cerebraux
FR2515516B1 (fr) Composition pharmaceutique pour le traitement de la lithiase renale infectee contenant de l'acide propionohydroxamique ou ses sels acceptables en pharmacie
BE901879A (fr) Produits analogues de la 1alpha-hydroxyvitamine d2, leur procede de preparation et compositions pharmaceutiques les renfermant.
ES8307711A1 (es) "procedimiento para la preparacion de un nuevo derivado de alquilenodiamina".
FR2374035A1 (fr) Nouvelle composition pharmaceutique pour le traitement de troubles cardio-vasculaires
FR2415637A1 (fr) Nouveaux carbamates de 8b-(hydroxyethyl)ergolines, utiles notamment pour le traitement des affections des systemes circulatoire, respiratoire et nerveux central, et leur procede de preparation
FR2409990A1 (fr) Derives de 1-(naphtylethyl)imidazoles et application a titre de medicament
FR2444036A1 (fr) 2-phenylamino-imidazolines-(2) substituees, possedant des proprietes therapeutiques particulieres, procede pour leur preparation et composition pharmaceutiques les contenant
BE899402A (fr) Procede pour la preparation d'eburnamonines par voie electrochimique.

Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *BAYER HEALTHCARE A.G.

Effective date: 20040503