DK164148C - Parenteralt praeparat af nimodipin og fremgangsmaade til dets fremstilling - Google Patents

Parenteralt praeparat af nimodipin og fremgangsmaade til dets fremstilling

Info

Publication number
DK164148C
DK164148C DK224184A DK224184A DK164148C DK 164148 C DK164148 C DK 164148C DK 224184 A DK224184 A DK 224184A DK 224184 A DK224184 A DK 224184A DK 164148 C DK164148 C DK 164148C
Authority
DK
Denmark
Prior art keywords
weight
preparation
per cent
nimodipin
procedure
Prior art date
Application number
DK224184A
Other languages
Danish (da)
English (en)
Other versions
DK224184A (da
DK164148B (da
DK224184D0 (da
Inventor
Dieter Hoff
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DK224184D0 publication Critical patent/DK224184D0/da
Publication of DK224184A publication Critical patent/DK224184A/da
Publication of DK164148B publication Critical patent/DK164148B/da
Application granted granted Critical
Publication of DK164148C publication Critical patent/DK164148C/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
DK224184A 1983-05-06 1984-05-04 Parenteralt praeparat af nimodipin og fremgangsmaade til dets fremstilling DK164148C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833316510 DE3316510A1 (de) 1983-05-06 1983-05-06 Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen
DE3316510 1983-05-06

Publications (4)

Publication Number Publication Date
DK224184D0 DK224184D0 (da) 1984-05-04
DK224184A DK224184A (da) 1984-11-07
DK164148B DK164148B (da) 1992-05-18
DK164148C true DK164148C (da) 1992-10-26

Family

ID=6198265

Family Applications (1)

Application Number Title Priority Date Filing Date
DK224184A DK164148C (da) 1983-05-06 1984-05-04 Parenteralt praeparat af nimodipin og fremgangsmaade til dets fremstilling

Country Status (19)

Country Link
US (1) US5114956A (enExample)
EP (1) EP0126315B1 (enExample)
JP (1) JPS59206305A (enExample)
KR (1) KR920000306B1 (enExample)
AT (1) ATE24835T1 (enExample)
AU (1) AU562293B2 (enExample)
BE (1) BE899564A (enExample)
CA (1) CA1220424A (enExample)
DE (2) DE3316510A1 (enExample)
DK (1) DK164148C (enExample)
ES (1) ES8505542A1 (enExample)
FR (1) FR2545354B1 (enExample)
GR (1) GR81609B (enExample)
HK (1) HK75889A (enExample)
IL (1) IL71744A (enExample)
IT (1) IT1181804B (enExample)
PT (1) PT78542B (enExample)
SG (1) SG44489G (enExample)
ZA (1) ZA843352B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60246313A (ja) * 1984-05-22 1985-12-06 Yamanouchi Pharmaceut Co Ltd 塩酸ニカルジピンの注射剤およびその製法
FR2585574B1 (fr) * 1985-07-31 1988-09-09 Corbiere Jerome Nouvelles compositions pharmaceutiques anti-glaucomateuses a base de 1,4-dihydropyridines et leur procede d'obtention
DE3544692A1 (de) * 1985-12-18 1987-06-19 Bayer Ag Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung
AT387518B (de) * 1985-12-18 1989-02-10 Bayer Ag Verfahren zur herstellung von fluessigen spruehpraeparaten von dihydropyridinen
DE3702105A1 (de) * 1987-01-24 1988-08-04 Bayer Ag Parenterale loesung
GB2228412B (en) * 1989-02-28 1993-04-14 Syntex Inc Nicardipine pharmaceutical composition for parenteral administration
RU1804845C (ru) * 1991-02-15 1993-03-30 Институт Органического Синтеза Латвийской Ан Ноотропное вещество
JPH10510540A (ja) 1994-12-12 1998-10-13 オメロス メディカル システムズ，インコーポレーテッド 灌注用溶液並びに疼痛、炎症及びけいれんの抑制法
KR100517210B1 (ko) * 1994-12-12 2006-06-07 오메로스 코포레이션 통증,염증및경련억제용관주용액
ES2377126T3 (es) * 1994-12-12 2012-03-22 Omeros Corporation Solución de irrigación y utilización de la misma para la inhibición perioperatoria del dolor, la inflamación y/o los espasmos en una estructura vascular
US6492332B1 (en) 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
US6413961B1 (en) 1995-12-12 2002-07-02 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
US6136799A (en) * 1998-04-08 2000-10-24 Abbott Laboratories Cosolvent formulations
DE10142416A1 (de) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re Verfahren zur Herstellung von Lösungen
DE10142417A1 (de) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re Arzneimittel
US8034762B2 (en) 2004-09-02 2011-10-11 Cognosci, Inc. Treatment of subarachnoid hemorrhage with Apo E analogs
WO2007047406A2 (en) * 2005-10-14 2007-04-26 Transform Pharmaceuticals, Inc. Liquid pharmaceutical compositions of nimodipine
WO2007125028A1 (de) * 2006-04-28 2007-11-08 Basf Se Verfahren zur solubilisierung von hydrophoben wirkstoffen in wässrigem medium
CN102741327B (zh) 2010-02-05 2014-11-05 巴斯夫欧洲公司 在水溶液中加溶疏水性活性成分的方法
US8728504B2 (en) 2010-02-05 2014-05-20 Basf Se Process for solubilizing hydrophobic active ingredients in aqueous medium
US9364433B2 (en) 2011-04-28 2016-06-14 Borje S. Andersson Parenteral formulations of lipophilic pharmaceutical agents and methods for preparing and using the same
PT3442586T (pt) * 2016-04-13 2022-09-28 Acasti Pharma U S Inc Formulação parentérica estável de nimodipina
US10092553B2 (en) 2016-04-13 2018-10-09 Nortic Holdings Inc. Stable nimodipine parenteral formulation
US20190255033A1 (en) 2018-02-22 2019-08-22 Nortic Holdings Inc. Stable Nimodipine Parenteral Formulation
CN119300828A (zh) 2022-05-16 2025-01-10 美国阿卡斯蒂制药股份有限公司 尼莫地平肠胃外给药

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US4154839A (en) * 1975-11-05 1979-05-15 Bayer Aktiengesellschaft 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
DE2650013C3 (de) * 1976-10-30 1981-04-02 Bayer Ag, 5090 Leverkusen 1.4-Dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsäureisopropyl-(2-propoxy-äthyl)-ester, Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel
DE2815578C2 (de) * 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen Neue pharmazeutische Verwendung von Nimodipin
DE2841667A1 (de) * 1978-09-25 1980-04-10 Bayer Ag Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
DE3316510A1 (de) 1984-11-08
SG44489G (en) 1989-11-17
ATE24835T1 (de) 1987-01-15
KR840009031A (ko) 1984-12-24
FR2545354B1 (fr) 1986-09-26
IT1181804B (it) 1987-09-30
GR81609B (enExample) 1984-12-11
ZA843352B (en) 1984-12-24
CA1220424A (en) 1987-04-14
DE3461988D1 (en) 1987-02-19
IL71744A (en) 1988-04-29
ES531995A0 (es) 1985-06-01
US5114956A (en) 1992-05-19
JPH0422888B2 (enExample) 1992-04-20
ES8505542A1 (es) 1985-06-01
FR2545354A1 (fr) 1984-11-09
HK75889A (en) 1989-09-29
KR920000306B1 (ko) 1992-01-11
EP0126315B1 (de) 1987-01-14
IT8448139A1 (it) 1985-11-04
DK224184A (da) 1984-11-07
AU562293B2 (en) 1987-06-04
AU2758384A (en) 1984-11-08
BE899564A (fr) 1984-11-05
IL71744A0 (en) 1984-09-30
DK164148B (da) 1992-05-18
PT78542B (en) 1986-07-14
EP0126315A1 (de) 1984-11-28
IT8448139A0 (it) 1984-05-04
PT78542A (en) 1984-06-01
DK224184D0 (da) 1984-05-04
JPS59206305A (ja) 1984-11-22

Similar Documents

Publication Publication Date Title
DK164148C (da) Parenteralt praeparat af nimodipin og fremgangsmaade til dets fremstilling
BR8406642A (pt) Bismaleimida,composicao de resina"prepregavel",prepreg e composto
ES2141183T3 (es) Utilizacion de disolventes de hidrocarburos halogenados.
KR870002125A (ko) 피리딘 유도체의 제조방법
SE8503680D0 (sv) Indolderivat
ATE144498T1 (de) Herstellung von substituierten piperidinen
ES2093621T3 (es) Polialquil-1-oxa-diaza-espirodecanos polimeros.
DE69614833D1 (de) Entzündungshemmende benzoesäurederivate
ES2127191T3 (es) Derivados de diamino-s-triazinona.
DK176588A (da) Substituerede urinstofderivater, fremgangsmaade til fremstilling deraf og anvendelse af derivaterne, isaer til foraedling af cellulosefibre
IT1201481B (it) Pantotenil derivati
JPS5331638A (en) Alkylene glycol dibenzoates and fungicides containing the same
BG34903A3 (bg) Метод за получаване на 1, 1, 2- тирфенилпропанови, съответно пропенови, производни
IT1281198B1 (it) Film termoretraibili basati su composizioni poliolefiniche comprendenti un copolimero lineare dell'etilene con alfa-olefine
MX160893A (es) Procedimiento para la preparacion de polibis-triazinilimidas,utiles como estabalizadores de polimeros
ATE4166T1 (de) Langwirkende injizierbare sulfonamidzusammensetzungen.
DE3783247D1 (de) Substituierte pyrrolidinone.
JPS52139061A (en) Imidazole derivatives, their preparation and fungicides for agriculture and horticulture
JPS5371058A (en) Preparation of 1-substd.-3-substd. amino-4-substd.-thidazetidinone derivs.
KR860007876A (ko) 제초제 조성물
JPS5326850A (en) Crosslinked compositions of chlorinated polyethylene
ES8402577A1 (es) Procedimiento para la preparacion de nuevas sulfiminas.
IT7825587A0 (it) Procedimento per accrescere la stabilita' termica di composizioni polimeriche autoestinguenti.
JPS5312886A (en) 3-methylenecephalosporin derivatives and their preparation

Legal Events

Date Code Title Description
PUP Patent expired