BE730345A - - Google Patents

Info

Publication number
BE730345A
BE730345A BE730345DA BE730345A BE 730345 A BE730345 A BE 730345A BE 730345D A BE730345D A BE 730345DA BE 730345 A BE730345 A BE 730345A
Authority
BE
Belgium
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BE730345A publication Critical patent/BE730345A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE730345D 1968-04-03 1969-03-24 BE730345A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB06113/68A GB1218591A (en) 1968-04-03 1968-04-03 Derivatives of n-(3,4,5-trimethoxy cennamoyl) piperazine and their process of preparation

Publications (1)

Publication Number Publication Date
BE730345A true BE730345A (fr) 1969-09-21

Family

ID=10071423

Family Applications (1)

Application Number Title Priority Date Filing Date
BE730345D BE730345A (fr) 1968-04-03 1969-03-24

Country Status (17)

Country Link
US (1) US3634411A (fr)
BE (1) BE730345A (fr)
BG (1) BG15397A3 (fr)
CH (1) CH498845A (fr)
CS (1) CS163733B2 (fr)
DK (1) DK123824C (fr)
FI (1) FI51190C (fr)
FR (1) FR2007372A1 (fr)
GB (1) GB1218591A (fr)
IL (1) IL31901A (fr)
IT (1) IT1036019B (fr)
LU (1) LU58316A1 (fr)
NL (1) NL147427B (fr)
NO (1) NO124312B (fr)
RO (1) RO55704A (fr)
SE (1) SE351212B (fr)
YU (1) YU33015B (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004017964A1 (fr) 2002-08-19 2004-03-04 Pfizer Products Inc. Therapie de combinaison pour maladies hyperproliferatives
WO2007062314A2 (fr) 2005-11-23 2007-05-31 Bristol-Myers Squibb Company Inhibiteurs de cetp heterocycliques
WO2007105049A1 (fr) 2006-03-10 2007-09-20 Pfizer Products Inc. Dérivés de dibenzylamine en tant qu'inhibiteurs de cetp
WO2007105050A1 (fr) 2006-03-10 2007-09-20 Pfizer Products Inc. Dibenzylamines et leurs dérivés
WO2008070496A2 (fr) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company Inhibiteurs d'amino cetp étendus
EP2392567A1 (fr) 2005-10-21 2011-12-07 Bristol-Myers Squibb Company Derives de benzothiazine et leurs utilisation comme modulateurs de lxr
WO2014170786A1 (fr) 2013-04-17 2014-10-23 Pfizer Inc. Dérivés de n-pipéridin-3-ylbenzamide dans le traitement des maladies cardiovasculaires
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
WO2020150473A2 (fr) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Inhibiteurs de pcsk9 et leurs procédés d'utilisation

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2092703A1 (en) * 1970-06-10 1972-01-28 Delalande Sa 2-(1-pyrrolidinocarbonylmethyl-piperazin-4-yl) ethyl - 3,4,5-trimethoxy benzoate - having hypotensive and adrenolytic active
FR2092902A1 (en) * 1970-06-30 1972-01-28 Delalande Sa Substd propiophenone - beta (pyrrolidino carbonylmethyl)-1'-piperazin propiophenones, analgesics, hypotensives adrenolytics, noradrenolytic
FR2278340A1 (fr) * 1974-07-17 1976-02-13 Delalande Sa Nouveau derive de la n-(trimethoxy-3,4,5 cinnamoyl) piperazine, ses sels d'addition d'acides, son procede de preparation et son application en therapeutique
GB1473262A (en) * 1974-11-20 1977-05-11 Delalande Sa Derivatives of n-3,4,5-trimethoxy cinnamoyl-piperazine their process of preparation and their therapeutic application
US4368199A (en) * 1980-01-21 1983-01-11 Delalande S.A. Novel derivatives of 3,4,5-trimethoxy cinnamoyl piperazine, their salts, the process for preparing the same and their application in therapeutics
JPS5888370A (ja) * 1981-11-19 1983-05-26 Hokuriku Seiyaku Co Ltd １−（３，４，５−トリメトキシシンナモイル）−４−アミノカルボニルエチル置換ピペラジン及びホモピペラジン誘導体、及びその製造方法
IT1151104B (it) * 1982-02-04 1986-12-17 Delalande Sa Impiego terapeutico di derivati (1-cinnamoil oppure 1-fenetil-carbonil)piperazinici
FR2522325B1 (fr) * 1982-02-26 1985-08-09 Delalande Sa Nouveaux derives aryliques de la piperazine, de l'homopiperazine et de n,n'-dialkyl diamino-1,2 ethane, leur procede de preparation et leur application en therapeutique
FR2552762B1 (fr) * 1983-09-30 1986-07-25 Delalande Sa Nouveaux amides piperaziniques et homopiperaziniques derives de l'acide 3,4-dioxymethylene cinnamique, leur procede de preparation et leur application en therapeutique
JPS6172773A (ja) * 1984-09-17 1986-04-14 Terumo Corp ピペラジン誘導体およびこれを含有する血管拡張剤
US6011035A (en) * 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
US20060063803A1 (en) * 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
AU2008277796A1 (en) 2007-07-19 2009-01-22 F. Hoffmann-La Roche Ag Novel heterocyclyl compounds and their use as chemokine antagonists
CN101260092B (zh) * 2008-04-14 2011-07-20 罗军 马来酸桂哌齐特的制备方法
CN101723918B (zh) * 2008-10-24 2011-08-31 重庆医科大学医药研究所 马来酸桂哌齐特的制备工艺
CN101531643B (zh) * 2009-04-13 2012-11-14 上海理奥生物医药科技有限责任公司 一种改进的马来酸桂哌齐特的合成方法
CN102229583B (zh) * 2011-05-13 2013-11-27 江苏神龙药业有限公司 一种桂哌齐特的合成方法
CN103664830A (zh) * 2012-09-05 2014-03-26 凌沛学 一种马来酸桂哌齐特改进的合成方法
CN103896878B (zh) * 2012-12-26 2018-02-09 江苏万邦生化医药股份有限公司 一种桂哌齐特的纯化脱色方法
CN103245734A (zh) * 2013-01-18 2013-08-14 沈阳亿灵医药科技有限公司 一组控制马来酸桂哌齐特质量的组合物

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004017964A1 (fr) 2002-08-19 2004-03-04 Pfizer Products Inc. Therapie de combinaison pour maladies hyperproliferatives
EP2392567A1 (fr) 2005-10-21 2011-12-07 Bristol-Myers Squibb Company Derives de benzothiazine et leurs utilisation comme modulateurs de lxr
WO2007062314A2 (fr) 2005-11-23 2007-05-31 Bristol-Myers Squibb Company Inhibiteurs de cetp heterocycliques
WO2007105049A1 (fr) 2006-03-10 2007-09-20 Pfizer Products Inc. Dérivés de dibenzylamine en tant qu'inhibiteurs de cetp
WO2007105050A1 (fr) 2006-03-10 2007-09-20 Pfizer Products Inc. Dibenzylamines et leurs dérivés
WO2008070496A2 (fr) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company Inhibiteurs d'amino cetp étendus
WO2014170786A1 (fr) 2013-04-17 2014-10-23 Pfizer Inc. Dérivés de n-pipéridin-3-ylbenzamide dans le traitement des maladies cardiovasculaires
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
WO2020150473A2 (fr) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Inhibiteurs de pcsk9 et leurs procédés d'utilisation

Also Published As

Publication number Publication date
CS163733B2 (fr) 1975-11-07
FI51190C (fi) 1976-11-10
IL31901A0 (en) 1969-05-28
NL6905019A (fr) 1969-10-07
SE351212B (fr) 1972-11-20
GB1218591A (en) 1971-01-06
YU33015B (en) 1976-03-31
DK123824B (fr) 1972-08-07
IL31901A (en) 1972-03-28
DK123824C (da) 1972-12-18
LU58316A1 (fr) 1969-10-27
NL147427B (nl) 1975-10-15
BG15397A3 (bg) 1976-05-26
CH498845A (fr) 1970-11-15
IT1036019B (it) 1979-10-30
DE1915795A1 (de) 1970-09-10
DE1915795B2 (de) 1975-07-03
US3634411A (en) 1972-01-11
NO124312B (fr) 1972-04-04
RO55704A (fr) 1974-01-03
FR2007372A1 (fr) 1970-01-09
FI51190B (fr) 1976-08-02
YU83469A (en) 1975-06-30

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: DELALANDE S.A.

Effective date: 19890324