BE563332A - - Google Patents

Info

Publication number
BE563332A
BE563332A BE563332DA BE563332A BE 563332 A BE563332 A BE 563332A BE 563332D A BE563332D A BE 563332DA BE 563332 A BE563332 A BE 563332A
Authority
BE
Belgium
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Publication of BE563332A publication Critical patent/BE563332A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657154Cyclic esteramides of oxyacids of phosphorus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
BE563332D 1956-12-20 BE563332A (xx)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEA26234A DE1054997B (de) 1956-12-20 1956-12-20 Verfahren zur Herstellung von cyclischen Thiophosphorsaeure-esteramiden
DEA28444A DE1116672B (de) 1956-12-20 1957-12-04 Verfahren zur Herstellung von cyclischen Phosphorsaeure- und Thiophosphorsaeureesteramiden
DEA24298A DE1057119B (de) 1956-12-20 1957-12-04 Verfahren zur Herstellung von cyclischen Phosphorsaeure-esteramiden

Publications (1)

Publication Number Publication Date
BE563332A true BE563332A (xx)

Family

ID=27208860

Family Applications (2)

Application Number Title Priority Date Filing Date
BE554888D BE554888A (xx) 1956-12-20
BE563332D BE563332A (xx) 1956-12-20

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BE554888D BE554888A (xx) 1956-12-20

Country Status (7)

Country Link
US (2) US3018302A (xx)
BE (2) BE563332A (xx)
CH (3) CH361279A (xx)
DE (3) DE1054997B (xx)
FR (2) FR1246708A (xx)
GB (2) GB812651A (xx)
NL (3) NL222157A (xx)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3270093A (en) * 1963-04-19 1966-08-30 Tenneco Chem Omicron, omicron-neopentylene-nu-diethylphosphoroamidothioate
US3286001A (en) * 1963-06-07 1966-11-15 Continental Oil Co Reaction products of organophosphorus monohalides with mercaptoalkylamines
US3335129A (en) * 1963-11-21 1967-08-08 Wyandotte Chemicals Corp Phosphoramidates
DE2110333A1 (de) * 1971-03-04 1972-09-14 Audi Nsu Auto Union Ag Kreiskolben-Brennkraftmaschine
PL100390B1 (pl) 1975-10-06 1978-09-30 Sposob wytwarzania 2-tlenku-2-/bis/2-chloroetylo/-amino/-1-/okso-3-aza-2-fosfacykloheksanu/cyklofosfamidu/o czynnosci optycznej
DE3132221A1 (de) * 1981-08-14 1983-05-19 Behringwerke Ag, 3550 Marburg Neue cyclophosphamid-derivate, verfahren zu ihrer herstellung und ihre verwendung
DE3133077A1 (de) * 1981-08-21 1983-03-10 Henkel KGaA, 4000 Düsseldorf Neue cytostatisch wirksame epoxidgruppen tragende 1,3,2-oxazaphosphorin-verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung in pharmazeutischen zubereitungen
US5227374A (en) * 1982-11-12 1993-07-13 Mead Johnson & Company Lyophilized cyclophosphamide
US4537883A (en) * 1982-11-12 1985-08-27 Mead Johnson & Company Lyophilized cyclophosphamide
US4659699A (en) * 1983-08-22 1987-04-21 Cetus-Ben Venue Therapeutics Process for freeze drying cyclophosphamide
US4879286A (en) * 1987-01-28 1989-11-07 Lyphomed, Inc. Cyclophosphamide
IT1251472B (it) * 1991-09-12 1995-05-15 Boehringer Mannheim Italia Ossaazafosforine utili come agenti antitumorali, un processo per la loro preparazione e composizioni farmaceutiche che le contengono
DE19739159C1 (de) * 1997-09-06 1999-01-28 Asta Medica Ag Verfahren zur Herstellung von Oxazaphosphorin-2-aminen
WO1999045016A2 (en) 1998-03-06 1999-09-10 Metabasis Therapeutics, Inc. Novel prodrugs for phosphorus-containing compounds
US6312662B1 (en) 1998-03-06 2001-11-06 Metabasis Therapeutics, Inc. Prodrugs phosphorus-containing compounds
US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
CN1321999C (zh) * 1999-03-05 2007-06-20 症变治疗公司 新的含磷前药
WO2001018013A1 (en) 1999-09-08 2001-03-15 Metabasis Therapeutics, Inc. Prodrugs for liver specific drug delivery
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
CA2485597C (en) * 2002-05-13 2013-07-02 Metabasis Therapeutics, Inc. Process for preparation of cyclic prodrugs of pmea and pmpa
JP4476811B2 (ja) * 2002-05-13 2010-06-09 メタバシス・セラピューティクス・インコーポレイテッド Pmeaおよびそのアナログの新規ホスホン酸系プロドラッグ
WO2004041837A1 (en) 2002-10-31 2004-05-21 Metabasis Therapeutics, Inc. Novel cytarabine monophosphate prodrugs
US20050182252A1 (en) * 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
CN1964967B (zh) * 2004-06-08 2014-04-16 症变治疗公司 路易斯酸介导的环状酯的合成
EP3105238A4 (en) 2014-02-13 2017-11-08 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
BR112016026140A2 (pt) 2014-05-09 2018-08-07 AuroMedics Pharma LLC formulações de concentrado líquido de ciclofosfamida.
WO2016003812A1 (en) 2014-07-02 2016-01-07 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
US10849916B2 (en) 2014-07-11 2020-12-01 Dr. Reddys Laboratories Limited Stable liquid formulations of cyclophosphamide and its impurities
WO2016005962A2 (en) 2014-07-11 2016-01-14 Dr. Reddy’S Laboratories Limited Stable liquid formulations of cyclophosphamide and processes
WO2016046797A1 (en) 2014-09-26 2016-03-31 Intas Pharmaceuticals Ltd. Pharmaceutical composition having improved content uniformity
AU2015371308A1 (en) 2014-12-23 2017-08-03 Intellectual Property Associates, Llc Methods and formulations for transdermal administration
US20180086780A1 (en) 2015-04-02 2018-03-29 Przedsiebiorstwo Produkcyjno-Wdrozeniowe Ifotam Sp. Z O.O. Method of production of n,n-bis(2-chloroethyl)tetrahydro-2h-1,3,2-oxazaphosphorine-2-amine 2-oxide
WO2017207719A1 (en) 2016-06-02 2017-12-07 Amneal Pharmaceuticals Company Gmbh Cyclophosphamide composition and method for preparation thereof
US20190083527A1 (en) 2017-09-15 2019-03-21 Ampersand Biopharmaceuticals, Inc. Method of administration and treatment
CN111788196A (zh) 2018-01-09 2020-10-16 配体药物公司 缩醛化合物及其治疗用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1065418B (de) * 1953-03-21 1959-09-17 Montecatini Soc. Gen. per 1'Industria Mineraria e Chimica, Mailand (Italien) Verfahren zur Herstellung von heterocyclischen Phosphorverbindungen
BE575869A (xx) * 1958-02-20 1900-01-01

Also Published As

Publication number Publication date
US3018302A (en) 1962-01-23
BE554888A (xx)
CH369451A (de) 1963-05-31
NL99688C (xx)
DE1054997B (de) 1959-04-16
DE1057119B (de) 1959-05-14
FR1246708A (fr) 1960-11-25
NL99649C (xx)
CH361279A (de) 1962-04-15
GB812651A (en) 1959-04-29
FR75178E (xx) 1961-09-08
US3074992A (en) 1963-01-22
CH370406A (de) 1963-07-15
GB853044A (en) 1960-11-02
DE1116672B (de) 1961-11-09
NL222157A (xx)

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