CH361279A - Verfahren zur Herstellung cyclischer Phosphorsäureesteramide - Google Patents
Verfahren zur Herstellung cyclischer PhosphorsäureesteramideInfo
- Publication number
- CH361279A CH361279A CH361279DA CH361279A CH 361279 A CH361279 A CH 361279A CH 361279D A CH361279D A CH 361279DA CH 361279 A CH361279 A CH 361279A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- phosphoric ester
- ester amides
- cyclic phosphoric
- cyclic
- Prior art date
Links
- 125000004122 cyclic group Chemical group 0.000 title 1
- -1 ester amides Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657154—Cyclic esteramides of oxyacids of phosphorus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEA26234A DE1054997B (de) | 1956-12-20 | 1956-12-20 | Verfahren zur Herstellung von cyclischen Thiophosphorsaeure-esteramiden |
DEA28444A DE1116672B (de) | 1956-12-20 | 1957-12-04 | Verfahren zur Herstellung von cyclischen Phosphorsaeure- und Thiophosphorsaeureesteramiden |
DEA24298A DE1057119B (de) | 1956-12-20 | 1957-12-04 | Verfahren zur Herstellung von cyclischen Phosphorsaeure-esteramiden |
Publications (1)
Publication Number | Publication Date |
---|---|
CH361279A true CH361279A (de) | 1962-04-15 |
Family
ID=27208860
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH361279D CH361279A (de) | 1956-12-20 | 1957-02-09 | Verfahren zur Herstellung cyclischer Phosphorsäureesteramide |
CH5317357A CH369451A (de) | 1956-12-20 | 1957-11-28 | Verfahren zur Herstellung cyclischer Thiophosphorsäureesteramide |
CH6689458A CH370406A (de) | 1956-12-20 | 1958-12-03 | Verfahren zur Herstellung von cytostatisch wirksamen Phosphorsäureesteramiden |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH5317357A CH369451A (de) | 1956-12-20 | 1957-11-28 | Verfahren zur Herstellung cyclischer Thiophosphorsäureesteramide |
CH6689458A CH370406A (de) | 1956-12-20 | 1958-12-03 | Verfahren zur Herstellung von cytostatisch wirksamen Phosphorsäureesteramiden |
Country Status (7)
Country | Link |
---|---|
US (2) | US3018302A (de) |
BE (2) | BE563332A (de) |
CH (3) | CH361279A (de) |
DE (3) | DE1054997B (de) |
FR (2) | FR1246708A (de) |
GB (2) | GB812651A (de) |
NL (3) | NL99688C (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3270093A (en) * | 1963-04-19 | 1966-08-30 | Tenneco Chem | Omicron, omicron-neopentylene-nu-diethylphosphoroamidothioate |
US3286001A (en) * | 1963-06-07 | 1966-11-15 | Continental Oil Co | Reaction products of organophosphorus monohalides with mercaptoalkylamines |
US3335129A (en) * | 1963-11-21 | 1967-08-08 | Wyandotte Chemicals Corp | Phosphoramidates |
DE2110333A1 (de) * | 1971-03-04 | 1972-09-14 | Audi Nsu Auto Union Ag | Kreiskolben-Brennkraftmaschine |
PL100390B1 (pl) | 1975-10-06 | 1978-09-30 | Sposob wytwarzania 2-tlenku-2-/bis/2-chloroetylo/-amino/-1-/okso-3-aza-2-fosfacykloheksanu/cyklofosfamidu/o czynnosci optycznej | |
DE3132221A1 (de) * | 1981-08-14 | 1983-05-19 | Behringwerke Ag, 3550 Marburg | Neue cyclophosphamid-derivate, verfahren zu ihrer herstellung und ihre verwendung |
DE3133077A1 (de) * | 1981-08-21 | 1983-03-10 | Henkel KGaA, 4000 Düsseldorf | Neue cytostatisch wirksame epoxidgruppen tragende 1,3,2-oxazaphosphorin-verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung in pharmazeutischen zubereitungen |
US5227374A (en) * | 1982-11-12 | 1993-07-13 | Mead Johnson & Company | Lyophilized cyclophosphamide |
US4537883A (en) * | 1982-11-12 | 1985-08-27 | Mead Johnson & Company | Lyophilized cyclophosphamide |
US4659699A (en) * | 1983-08-22 | 1987-04-21 | Cetus-Ben Venue Therapeutics | Process for freeze drying cyclophosphamide |
US4879286A (en) * | 1987-01-28 | 1989-11-07 | Lyphomed, Inc. | Cyclophosphamide |
IT1251472B (it) * | 1991-09-12 | 1995-05-15 | Boehringer Mannheim Italia | Ossaazafosforine utili come agenti antitumorali, un processo per la loro preparazione e composizioni farmaceutiche che le contengono |
DE19739159C1 (de) * | 1997-09-06 | 1999-01-28 | Asta Medica Ag | Verfahren zur Herstellung von Oxazaphosphorin-2-aminen |
US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
EP1060182B1 (de) | 1998-03-06 | 2012-12-19 | Metabasis Therapeutics, Inc. | Neue prodrugs für phosphorhaltige verbindungen |
MXPA01008937A (es) * | 1999-03-05 | 2004-04-05 | Metabasis Therapeutics Inc | Nuevos profarmacos que contienen fosforo. |
US7205404B1 (en) * | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
US6752981B1 (en) | 1999-09-08 | 2004-06-22 | Metabasis Therapeutics, Inc. | Prodrugs for liver specific drug delivery |
US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
EP1532157A4 (de) * | 2002-05-13 | 2009-02-25 | Metabasis Therapeutics Inc | Neue prodrugs von pmea auf phosphonsäurebasis und ihre analoga |
US7193081B2 (en) * | 2002-05-13 | 2007-03-20 | Metabasis Therapeutics, Inc. | Process for preparation of cyclic prodrugs of PMEA and PMPA |
BR0315806A (pt) * | 2002-10-31 | 2005-09-13 | Metabasis Therapeutics Inc | Fosfato diésteres cìclicos de 1,3-propano-1-aril diós e seu uso na preparação de pró-drogas |
US20050182252A1 (en) * | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
KR20070029196A (ko) * | 2004-06-08 | 2007-03-13 | 메타베이시스 테라퓨틱스, 인크. | 고리 에스테르의 루이스 산 매개 합성 |
JP2017512183A (ja) * | 2014-02-13 | 2017-05-18 | リガンド・ファーマシューティカルズ・インコーポレイテッド | プロドラッグ化合物およびそれらの使用 |
CN106456654A (zh) | 2014-05-09 | 2017-02-22 | 奥罗医学制药有限公司 | 环磷酰胺液体浓缩制剂 |
JP2017520545A (ja) | 2014-07-02 | 2017-07-27 | リガンド・ファーマシューティカルズ・インコーポレイテッド | プロドラッグ化合物およびそれらの使用 |
WO2016005962A2 (en) | 2014-07-11 | 2016-01-14 | Dr. Reddy’S Laboratories Limited | Stable liquid formulations of cyclophosphamide and processes |
US10849916B2 (en) | 2014-07-11 | 2020-12-01 | Dr. Reddys Laboratories Limited | Stable liquid formulations of cyclophosphamide and its impurities |
WO2016046797A1 (en) | 2014-09-26 | 2016-03-31 | Intas Pharmaceuticals Ltd. | Pharmaceutical composition having improved content uniformity |
WO2016105499A1 (en) | 2014-12-23 | 2016-06-30 | Intellectual Property Associates, Llc | Methods and formulations for transdermal administration |
WO2016156927A1 (en) | 2015-04-02 | 2016-10-06 | PRZEDSIĘBIORSTWO PRODUKCYJNO-WDROŻENIOWE IFOTAM Sp. z o.o. | Method of production of n,n-bis(2-chloroethyl)tetrahydro-2h-1,3,2-oxazaphosphorine-2-amine 2-oxide |
WO2017207719A1 (en) | 2016-06-02 | 2017-12-07 | Amneal Pharmaceuticals Company Gmbh | Cyclophosphamide composition and method for preparation thereof |
EP3681479B1 (de) | 2017-09-15 | 2024-01-31 | Dyve Biosciences, Inc. | Natriumhydrogencarbonat zur verwendung in der behandlung von gicht und verwandten erkrankungen |
EP3737676B1 (de) | 2018-01-09 | 2024-03-06 | Ligand Pharmaceuticals, Inc. | Acetalverbindungen und therapeutische verwendungen davon |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1065418B (de) * | 1953-03-21 | 1959-09-17 | Montecatini Soc. Gen. per 1'Industria Mineraria e Chimica, Mailand (Italien) | Verfahren zur Herstellung von heterocyclischen Phosphorverbindungen |
NL236264A (de) * | 1958-02-20 | 1900-01-01 |
-
0
- BE BE554888D patent/BE554888A/xx unknown
- NL NL222157D patent/NL222157A/xx unknown
- NL NL99649D patent/NL99649C/xx active
- FR FR75178D patent/FR75178E/fr not_active Expired
- BE BE563332D patent/BE563332A/xx unknown
- NL NL99688D patent/NL99688C/xx active
-
1956
- 1956-12-20 DE DEA26234A patent/DE1054997B/de active Pending
-
1957
- 1957-01-30 GB GB3283/57A patent/GB812651A/en not_active Expired
- 1957-02-04 FR FR731011A patent/FR1246708A/fr not_active Expired
- 1957-02-09 CH CH361279D patent/CH361279A/de unknown
- 1957-11-28 CH CH5317357A patent/CH369451A/de unknown
- 1957-12-04 DE DEA24298A patent/DE1057119B/de active Pending
- 1957-12-04 DE DEA28444A patent/DE1116672B/de active Pending
-
1958
- 1958-04-15 US US728568A patent/US3018302A/en not_active Expired - Lifetime
- 1958-12-03 CH CH6689458A patent/CH370406A/de unknown
- 1958-12-03 GB GB39031/58A patent/GB853044A/en not_active Expired
-
1959
- 1959-07-27 US US829528A patent/US3074992A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US3074992A (en) | 1963-01-22 |
DE1116672B (de) | 1961-11-09 |
CH370406A (de) | 1963-07-15 |
DE1054997B (de) | 1959-04-16 |
DE1057119B (de) | 1959-05-14 |
NL99688C (de) | |
BE554888A (de) | |
FR1246708A (fr) | 1960-11-25 |
CH369451A (de) | 1963-05-31 |
FR75178E (de) | 1961-09-08 |
NL222157A (de) | |
US3018302A (en) | 1962-01-23 |
NL99649C (de) | |
BE563332A (de) | |
GB853044A (en) | 1960-11-02 |
GB812651A (en) | 1959-04-29 |
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