IT1251472B - Ossaazafosforine utili come agenti antitumorali, un processo per la loro preparazione e composizioni farmaceutiche che le contengono - Google Patents

Ossaazafosforine utili come agenti antitumorali, un processo per la loro preparazione e composizioni farmaceutiche che le contengono

Info

Publication number
IT1251472B
IT1251472B ITMI912411A ITMI912411A IT1251472B IT 1251472 B IT1251472 B IT 1251472B IT MI912411 A ITMI912411 A IT MI912411A IT MI912411 A ITMI912411 A IT MI912411A IT 1251472 B IT1251472 B IT 1251472B
Authority
IT
Italy
Prior art keywords
useful
ossaazaphosphorines
contain
preparation
pharmaceutical compositions
Prior art date
Application number
ITMI912411A
Other languages
English (en)
Inventor
Silvano Spinelli
Valeria Livi
Ernesto Menta
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Priority to ITMI912411A priority Critical patent/IT1251472B/it
Publication of ITMI912411A0 publication Critical patent/ITMI912411A0/it
Priority to AU24007/92A priority patent/AU2400792A/en
Priority to PCT/EP1992/001768 priority patent/WO1993005054A1/en
Publication of ITMI912411A1 publication Critical patent/ITMI912411A1/it
Application granted granted Critical
Publication of IT1251472B publication Critical patent/IT1251472B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

I composti di formula I (FORMULA I) dove R, R1, R2, Ra e Rb hanno i significati dati nella descrizione, sono utili come farmaci antitumorali.
ITMI912411A 1991-09-12 1991-09-12 Ossaazafosforine utili come agenti antitumorali, un processo per la loro preparazione e composizioni farmaceutiche che le contengono IT1251472B (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ITMI912411A IT1251472B (it) 1991-09-12 1991-09-12 Ossaazafosforine utili come agenti antitumorali, un processo per la loro preparazione e composizioni farmaceutiche che le contengono
AU24007/92A AU2400792A (en) 1991-09-12 1992-08-04 Oxazaphosphorines useful as antitumor agents, a process for the preparation thereof and pharmaceutical compositions containing them
PCT/EP1992/001768 WO1993005054A1 (en) 1991-09-12 1992-08-04 Oxazaphosphorines useful as antitumor agents, a process for the preparation thereof and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI912411A IT1251472B (it) 1991-09-12 1991-09-12 Ossaazafosforine utili come agenti antitumorali, un processo per la loro preparazione e composizioni farmaceutiche che le contengono

Publications (3)

Publication Number Publication Date
ITMI912411A0 ITMI912411A0 (it) 1991-09-12
ITMI912411A1 ITMI912411A1 (it) 1993-03-12
IT1251472B true IT1251472B (it) 1995-05-15

Family

ID=11360646

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI912411A IT1251472B (it) 1991-09-12 1991-09-12 Ossaazafosforine utili come agenti antitumorali, un processo per la loro preparazione e composizioni farmaceutiche che le contengono

Country Status (3)

Country Link
AU (1) AU2400792A (it)
IT (1) IT1251472B (it)
WO (1) WO1993005054A1 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0988057B1 (en) 1997-02-11 2003-08-27 The Victoria University Of Manchester Bioreductive conjugates for drug targeting

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR75178E (it) * 1956-12-20 1961-09-08
EP0418292A4 (en) * 1988-05-25 1991-09-25 Research Corporation Technologies, Inc Phosphoramides useful as antitumor agents

Also Published As

Publication number Publication date
ITMI912411A0 (it) 1991-09-12
ITMI912411A1 (it) 1993-03-12
WO1993005054A1 (en) 1993-03-18
AU2400792A (en) 1993-04-05

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Legal Events

Date Code Title Description
0001 Granted