EP0418292A4 - Phosphoramides useful as antitumor agents - Google Patents

Phosphoramides useful as antitumor agents

Info

Publication number
EP0418292A4
EP0418292A4 EP19890906634 EP89906634A EP0418292A4 EP 0418292 A4 EP0418292 A4 EP 0418292A4 EP 19890906634 EP19890906634 EP 19890906634 EP 89906634 A EP89906634 A EP 89906634A EP 0418292 A4 EP0418292 A4 EP 0418292A4
Authority
EP
European Patent Office
Prior art keywords
phosphoramides
useful
antitumor agents
antitumor
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19890906634
Other versions
EP0418292A1 (en
Inventor
Richard F. Borch
Gregory W. Canute
Ronald R. Valente
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Publication of EP0418292A1 publication Critical patent/EP0418292A1/en
Publication of EP0418292A4 publication Critical patent/EP0418292A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2429—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of arylalkanols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP19890906634 1988-05-25 1989-05-25 Phosphoramides useful as antitumor agents Ceased EP0418292A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19840888A 1988-05-25 1988-05-25
US198408 1988-05-25

Publications (2)

Publication Number Publication Date
EP0418292A1 EP0418292A1 (en) 1991-03-27
EP0418292A4 true EP0418292A4 (en) 1991-09-25

Family

ID=22733260

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19890906634 Ceased EP0418292A4 (en) 1988-05-25 1989-05-25 Phosphoramides useful as antitumor agents

Country Status (3)

Country Link
EP (1) EP0418292A4 (en)
JP (1) JPH04501253A (en)
WO (1) WO1989011484A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1251472B (en) * 1991-09-12 1995-05-15 Boehringer Mannheim Italia OSSAAZAPHOSPHORINES USEFUL AS ANTI-CANCER AGENTS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
US5306727A (en) * 1993-04-30 1994-04-26 Research Corporation Technologies, Inc. Phosphoramidates useful as antitumor agents
US5659061A (en) * 1995-04-20 1997-08-19 Drug Innovation & Design, Inc. Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities
WO2001004130A1 (en) 1999-07-14 2001-01-18 Purdue Research Foundation Phosphoramide compounds
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
US11760773B2 (en) 2018-02-02 2023-09-19 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH372051A (en) * 1957-07-24 1963-09-30 Asta Werke Ag Chem Fab Process for the preparation of new cytostatically active compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826830A (en) * 1985-07-31 1989-05-02 Jui Han Topical application of glyciphosphoramide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH372051A (en) * 1957-07-24 1963-09-30 Asta Werke Ag Chem Fab Process for the preparation of new cytostatically active compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO8911484A1 *

Also Published As

Publication number Publication date
WO1989011484A1 (en) 1989-11-30
EP0418292A1 (en) 1991-03-27
JPH04501253A (en) 1992-03-05

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19901122

AK Designated contracting states

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Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: BORCH, RICHARD, F.

Inventor name: VALENTE, RONALD, R.

Inventor name: CANUTE, GREGORY, W.

A4 Supplementary search report drawn up and despatched

Effective date: 19910808

AK Designated contracting states

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Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

17Q First examination report despatched

Effective date: 19931109

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: RESEARCH CORPORATION TECHNOLOGIES, INC.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 19940916