BE1022355B1 - Nouvelles méthodes d'induction d'une réponse immunitaire - Google Patents
Nouvelles méthodes d'induction d'une réponse immunitaire Download PDFInfo
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- BE1022355B1 BE1022355B1 BE2015/5209A BE201505209A BE1022355B1 BE 1022355 B1 BE1022355 B1 BE 1022355B1 BE 2015/5209 A BE2015/5209 A BE 2015/5209A BE 201505209 A BE201505209 A BE 201505209A BE 1022355 B1 BE1022355 B1 BE 1022355B1
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Non-Patent Citations (7)
| Title |
|---|
| ELENA MATA ET AL: "Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research", BIOMED RESEARCH INTERNATIONAL, vol. 6, no. 5, 1 January 2013 (2013-01-01), pages 599 - 19, XP055208483, ISSN: 2314-6133, DOI: 10.1016/j.ijpharm.2008.08.039 * |
| GIOVANNI GABUTTI ET AL: "Booster Vaccination: The Role of Reduced Antigen Content Vaccines as a Preschool Booster", BIOMED RESEARCH INTERNATIONAL, vol. 60, no. 1, 1 January 2014 (2014-01-01), pages 13 - 10, XP055192849, ISSN: 2314-6133, DOI: 10.4103/0974-777X.77298 * |
| HILL ADRIAN V S: "Vaccines against malaria", PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON. SERIES B: BIOLOGICAL SCIENCES, ROYAL SOCIETY OF LONDON, LONDON, GB, vol. 366, no. 1579, 12 October 2011 (2011-10-12), pages 2806 - 2814, XP002700406, ISSN: 0080-4622, DOI: 10.1098/RSTB.2011.0091 * |
| L. C. PAOLETTI ET AL: "Effects of Alum Adjuvant or a Booster Dose on Immunogenicity during Clinical Trials of Group B Streptococcal Type III Conjugate Vaccines", INFECTION AND IMMUNITY, vol. 69, no. 11, 1 November 2001 (2001-11-01), pages 6696 - 6701, XP055208551, ISSN: 0019-9567, DOI: 10.1128/IAI.69.11.6696-6701.2001 * |
| STOUTE J A ET AL: "A PRELIMINARY EVALUATION OF A RECOMBINANT CIRCUMSPOROZOITE PROTEIN VACCINE AGAINST PLASMODIUM FALCIPARUM MALARIA", NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, US, vol. 336, no. 2, 9 January 1997 (1997-01-09), pages 86 - 91, XP000990284, ISSN: 0028-4793, DOI: 10.1056/NEJM199701093360202 * |
| STOUTE J A ET AL: "LONG-TERM EFFICACY AND IMMUNE RESPONSES FOLLOWING IMMUNIZATION WITH THE RTS,S MALARIA VACCINE", JOURNAL OF INFECTIOUS DISEASES. JID, UNIVERSITY OF CHICAGO PRESS, CHICAGO, IL, vol. 178, no. 4, 1 October 1998 (1998-10-01), pages 1139 - 1144, XP008046110, ISSN: 0022-1899, DOI: 10.1086/515657 * |
| W. R. BALLOU: "The development of the RTS,S malaria vaccine candidate: challenges and lessons", PARASITE IMMUNOLOGY, vol. 31, no. 9, 1 September 2009 (2009-09-01), pages 492 - 500, XP055208451, ISSN: 0141-9838, DOI: 10.1111/j.1365-3024.2009.01143.x * |
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