AU773542B2 - Glycosulfopeptides and methods of synthesis and use thereof - Google Patents

Glycosulfopeptides and methods of synthesis and use thereof Download PDF

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Publication number
AU773542B2
AU773542B2 AU45673/99A AU4567399A AU773542B2 AU 773542 B2 AU773542 B2 AU 773542B2 AU 45673/99 A AU45673/99 A AU 45673/99A AU 4567399 A AU4567399 A AU 4567399A AU 773542 B2 AU773542 B2 AU 773542B2
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AU
Australia
Prior art keywords
linking
gal
galnac
amino acid
glcnac
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU45673/99A
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English (en)
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AU4567399A (en
Inventor
Richard D. Cummings
Rodger P Mcever
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University of Oklahoma
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University of Oklahoma
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Publication date
Application filed by University of Oklahoma filed Critical University of Oklahoma
Publication of AU4567399A publication Critical patent/AU4567399A/en
Application granted granted Critical
Publication of AU773542B2 publication Critical patent/AU773542B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU45673/99A 1998-06-16 1999-06-15 Glycosulfopeptides and methods of synthesis and use thereof Ceased AU773542B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8947298P 1998-06-16 1998-06-16
US60/089472 1998-06-16
PCT/US1999/013455 WO1999065712A2 (en) 1998-06-16 1999-06-15 Glycosulfopeptides and methods of synthesis and use thereof

Publications (2)

Publication Number Publication Date
AU4567399A AU4567399A (en) 2000-01-05
AU773542B2 true AU773542B2 (en) 2004-05-27

Family

ID=22217840

Family Applications (1)

Application Number Title Priority Date Filing Date
AU45673/99A Ceased AU773542B2 (en) 1998-06-16 1999-06-15 Glycosulfopeptides and methods of synthesis and use thereof

Country Status (8)

Country Link
US (4) US6593459B1 (https=)
EP (1) EP1087996B1 (https=)
JP (1) JP2002518354A (https=)
AU (1) AU773542B2 (https=)
CA (1) CA2332563A1 (https=)
DE (1) DE69934890D1 (https=)
MX (1) MXPA00012586A (https=)
WO (1) WO1999065712A2 (https=)

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US6492152B1 (en) 1999-06-15 2002-12-10 The Board Of Regents Of The University Of Oklahoma Core 1 β3-galactosyl transferases and methods of use thereof
WO2001044478A2 (en) * 1999-12-15 2001-06-21 The Board Of Regents Of The University Of Oklahoma CORE 1 β3-GALACTOSYL TRANSFERASES AND METHODS OF USE THEREOF
EP1325123A4 (en) * 2000-09-12 2004-07-21 Inst Genetics Llc STENOSE- OR RESEARCH INHIBITION BY P-SELECTIN ANTAGONISTS
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US20040001822A1 (en) * 2000-12-29 2004-01-01 Avigdor Levanon Y1-isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
US7132510B2 (en) * 2000-12-29 2006-11-07 Bio-Technology General (Israel) Ltd. Specific human antibodies for selective cancer therapy
EP1406930A4 (en) * 2000-12-29 2007-01-10 Savient Pharmaceuticals Inc "ISOLATED MOLECULES WITH SULFATED GROUPING CONTAINING EPITOPES, ANTIBODIES AGAINST SUCH EPITOPES AND USES THEREOF"
US20040002450A1 (en) * 2000-12-29 2004-01-01 Janette Lazarovits Y17 - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
US20040001839A1 (en) * 2000-12-29 2004-01-01 Avigdor Levanon Multimers - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
US6537780B2 (en) * 2001-03-28 2003-03-25 Applera Corporation Isolated nucleic acid molecules encoding transferase enzymes
AU2002337913A1 (en) * 2001-10-19 2003-04-28 Richard D. Cummings Glycosulfopeptide inhibitors and methods of use thereof
WO2003097658A2 (en) 2002-05-16 2003-11-27 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
US20040202665A1 (en) * 2002-07-01 2004-10-14 Janette Lazarovits Compositions and methods for therapeutic treatment
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US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
US20050069955A1 (en) * 2003-06-30 2005-03-31 Daniel Plaksin Antibodies and uses thereof
US20050152906A1 (en) * 2003-06-30 2005-07-14 Avigdor Levanon Specific human antibodies
US20050266009A1 (en) * 2003-06-30 2005-12-01 Savient Pharmaceuticals, Inc. Antibodies and uses thereof
WO2005054264A2 (en) * 2003-11-19 2005-06-16 Glycomimetics, Inc. Glycomimetic antagonists for both e- and p-selectins
EP1763533B1 (en) * 2003-11-19 2008-01-09 GlycoMimetics, Inc. Specific antagonist for both e- and p-selectins
WO2005081904A2 (en) * 2004-02-20 2005-09-09 The Burnham Institute Antimicrobial carbohydrates and methods of using same
US8201377B2 (en) * 2004-11-05 2012-06-19 Faus Group, Inc. Flooring system having multiple alignment points
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US20090036386A1 (en) * 2005-05-25 2009-02-05 Glycomimetics, Inc Heterobifunctional compounds for selectin inhibition
CN101291946B (zh) * 2005-08-09 2011-06-29 糖模拟物有限公司 对来自假单胞菌的pa-il凝集素、pa-iil凝集素或其两者的糖模拟物抑制剂
PL2264043T3 (pl) 2005-09-02 2018-04-30 Glycomimetics, Inc. Heterobifunkcyjne inhibitory pan-selektyny
US20090176717A1 (en) * 2006-06-01 2009-07-09 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
EP2074132B1 (en) 2006-10-12 2013-05-15 GlycoMimetics, Inc. Glycomimetic replacements for hexoses and n-acetyl hexosamines
AU2008216794A1 (en) * 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and N-acetyl hexosamines
US8039442B2 (en) 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
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WO2009126556A1 (en) 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
CN102088983B (zh) * 2008-06-13 2013-01-30 糖模拟物有限公司 利用选择的糖模拟化合物的血液癌症的治疗
CA2760292A1 (en) 2009-05-01 2010-11-04 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
EP2654781B1 (en) 2010-12-21 2018-01-24 Selexys Pharmaceuticals Corporation Anti-p-selectin antibodies and methods of their use and identification
KR102055958B1 (ko) 2011-12-22 2019-12-13 글리코미메틱스, 인크. E-셀렉틴 길항제 화합물, 조성물, 및 이용 방법
US9867841B2 (en) 2012-12-07 2018-01-16 Glycomimetics, Inc. Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells
US10253071B2 (en) 2013-06-03 2019-04-09 Beth Israel Deaconess Medical Center, Inc. Selectin inhibitors, composition, and uses related thereto
JP6689854B2 (ja) 2014-12-03 2020-04-28 グリコミメティクス， インコーポレイテッド Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤
JP2019502727A (ja) 2016-01-22 2019-01-31 グリコミメティクス， インコーポレイテッド Ｐａ−ｉｌおよび／またはｐａ−ｉｉｌレクチンの糖模倣体阻害剤
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
AU2017341065B2 (en) 2016-10-07 2023-04-06 Crescent Biopharma, Inc. Highly potent multimeric E-selectin antagonists
EP3596096A1 (en) 2017-03-15 2020-01-22 GlycoMimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
JP7275131B2 (ja) 2017-11-30 2023-05-17 グリコミメティクス， インコーポレイテッド 骨髄浸潤リンパ球を動員する方法、およびその使用
KR20200104889A (ko) 2017-12-29 2020-09-04 글리코미메틱스, 인크. E-셀렉틴 및 갈렉틴-3의 이종이기능성 억제제
KR20200128025A (ko) 2018-03-05 2020-11-11 글리코미메틱스, 인크. 급성 골수성 백혈병 및 관련 병태의 치료 방법
EA202092934A1 (ru) * 2018-06-11 2021-04-05 Дзе Уистар Инститьют Оф Энэтоми Энд Байолоджи Композиции и способы для посттрансляционной модификации in vivo
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
JP2022523638A (ja) 2019-01-15 2022-04-26 オプティムヴィア、エルエルシー 改変型硫酸アリール依存性酵素
JP2022540849A (ja) 2019-07-09 2022-09-20 オプティムヴィア、エルエルシー 抗凝固性多糖類の合成方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO1996006176A1 (fr) * 1994-08-25 1996-02-29 Universite Pierre Et Marie Curie (Paris Vi) Hsv1-tk modifiee fonctionnelle

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Also Published As

Publication number Publication date
US6593459B1 (en) 2003-07-15
JP2002518354A (ja) 2002-06-25
WO1999065712A2 (en) 1999-12-23
US20030144183A1 (en) 2003-07-31
US20020042102A1 (en) 2002-04-11
US20020026033A1 (en) 2002-02-28
WO1999065712A3 (en) 2000-04-20
US6569998B2 (en) 2003-05-27
EP1087996A2 (en) 2001-04-04
AU4567399A (en) 2000-01-05
US6545123B2 (en) 2003-04-08
CA2332563A1 (en) 1999-12-23
EP1087996B1 (en) 2007-01-17
MXPA00012586A (es) 2004-05-21
DE69934890D1 (de) 2007-03-08

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