AU772175B2 - Method for analysing a patient's genetic predisposition to at least a disease and amplification adapted to such a method - Google Patents
Method for analysing a patient's genetic predisposition to at least a disease and amplification adapted to such a method Download PDFInfo
- Publication number
- AU772175B2 AU772175B2 AU47660/00A AU4766000A AU772175B2 AU 772175 B2 AU772175 B2 AU 772175B2 AU 47660/00 A AU47660/00 A AU 47660/00A AU 4766000 A AU4766000 A AU 4766000A AU 772175 B2 AU772175 B2 AU 772175B2
- Authority
- AU
- Australia
- Prior art keywords
- seq
- drb1
- amplification
- primers
- hla
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000003321 amplification Effects 0.000 title claims abstract description 62
- 238000003199 nucleic acid amplification method Methods 0.000 title claims abstract description 61
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 title claims abstract description 36
- 201000010099 disease Diseases 0.000 title claims abstract description 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 32
- 238000000034 method Methods 0.000 title claims description 47
- 108700028369 Alleles Proteins 0.000 claims abstract description 133
- 239000000523 sample Substances 0.000 claims abstract description 124
- 108091093088 Amplicon Proteins 0.000 claims abstract description 14
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 50
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims description 22
- 108010058597 HLA-DR Antigens Proteins 0.000 claims description 19
- 102000006354 HLA-DR Antigens Human genes 0.000 claims description 17
- 102000006390 HLA-B Antigens Human genes 0.000 claims description 16
- 108010058607 HLA-B Antigens Proteins 0.000 claims description 16
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 229930010555 Inosine Natural products 0.000 claims description 5
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims description 5
- 229960003786 inosine Drugs 0.000 claims description 5
- 238000005497 microtitration Methods 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 abstract description 17
- 108020004707 nucleic acids Proteins 0.000 abstract description 3
- 102000039446 nucleic acids Human genes 0.000 abstract description 3
- 150000007523 nucleic acids Chemical class 0.000 abstract description 3
- 101001100327 Homo sapiens RNA-binding protein 45 Proteins 0.000 description 103
- 102100038823 RNA-binding protein 45 Human genes 0.000 description 101
- 108020004414 DNA Proteins 0.000 description 33
- 238000004458 analytical method Methods 0.000 description 32
- 241000282414 Homo sapiens Species 0.000 description 28
- 238000012360 testing method Methods 0.000 description 13
- 108010061486 HLA-B27 Antigen Proteins 0.000 description 12
- 238000009396 hybridization Methods 0.000 description 12
- 102000012153 HLA-B27 Antigen Human genes 0.000 description 11
- 238000005457 optimization Methods 0.000 description 11
- 102210012665 DRB1*03 Human genes 0.000 description 9
- 239000000427 antigen Substances 0.000 description 9
- 238000001514 detection method Methods 0.000 description 9
- 108091007433 antigens Proteins 0.000 description 8
- 102000036639 antigens Human genes 0.000 description 8
- 230000002068 genetic effect Effects 0.000 description 7
- 102100040113 Tumor necrosis factor receptor superfamily member 10A Human genes 0.000 description 6
- 239000002773 nucleotide Substances 0.000 description 6
- 125000003729 nucleotide group Chemical group 0.000 description 6
- 101150000578 HLA-B gene Proteins 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000001823 molecular biology technique Methods 0.000 description 5
- 238000003752 polymerase chain reaction Methods 0.000 description 5
- 108020004705 Codon Proteins 0.000 description 4
- 208000027932 Collagen disease Diseases 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000000405 serological effect Effects 0.000 description 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 4
- 208000023275 Autoimmune disease Diseases 0.000 description 3
- 102100040485 HLA class II histocompatibility antigen, DRB1 beta chain Human genes 0.000 description 3
- 108010046732 HLA-DR4 Antigen Proteins 0.000 description 3
- 108010039343 HLA-DRB1 Chains Proteins 0.000 description 3
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 102000054766 genetic haplotypes Human genes 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 239000002751 oligonucleotide probe Substances 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 102000053602 DNA Human genes 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 208000026350 Inborn Genetic disease Diseases 0.000 description 2
- 108700018351 Major Histocompatibility Complex Proteins 0.000 description 2
- 241000219061 Rheum Species 0.000 description 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 208000016361 genetic disease Diseases 0.000 description 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000000873 masking effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- YFNXWBPNBVLTMB-UHFFFAOYSA-N 2-bromo-2-nitro-1,4-dioxane Chemical compound [O-][N+](=O)C1(Br)COCCO1 YFNXWBPNBVLTMB-UHFFFAOYSA-N 0.000 description 1
- 240000003291 Armoracia rusticana Species 0.000 description 1
- 235000011330 Armoracia rusticana Nutrition 0.000 description 1
- 101150076489 B gene Proteins 0.000 description 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
- 238000007400 DNA extraction Methods 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108010048896 HLA-D Antigens Proteins 0.000 description 1
- 102000009485 HLA-D Antigens Human genes 0.000 description 1
- 102210026620 HLA-DRB1*03 Human genes 0.000 description 1
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 108091054438 MHC class II family Proteins 0.000 description 1
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 108091006629 SLC13A2 Proteins 0.000 description 1
- 101150064359 SLC6A1 gene Proteins 0.000 description 1
- 206010039710 Scleroderma Diseases 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 208000006045 Spondylarthropathies Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 208000037855 acute anterior uveitis Diseases 0.000 description 1
- 229960005305 adenosine Drugs 0.000 description 1
- 230000000961 alloantigen Effects 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960001229 ciprofloxacin hydrochloride Drugs 0.000 description 1
- DIOIOSKKIYDRIQ-UHFFFAOYSA-N ciprofloxacin hydrochloride Chemical compound Cl.C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 DIOIOSKKIYDRIQ-UHFFFAOYSA-N 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 229940104302 cytosine Drugs 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000022602 disease susceptibility Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 238000012252 genetic analysis Methods 0.000 description 1
- 238000003205 genotyping method Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 208000037100 susceptibility to 1 spondyloarthropathy Diseases 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR99/06599 | 1999-05-20 | ||
| FR9906599A FR2793808B1 (fr) | 1999-05-20 | 1999-05-20 | Procede d'analyse de la predisposition genetique d'un patient a au moins une maladie |
| FR9915314A FR2793809B1 (fr) | 1999-05-20 | 1999-12-06 | Procede d'analyse de la predisposition genetique d'un patient a au moins une maladie et amplification adaptee a un tel procede |
| FR99/15314 | 1999-12-06 | ||
| PCT/FR2000/001385 WO2000071750A1 (fr) | 1999-05-20 | 2000-05-19 | Procede d'analyse de la predisposition genetique d'un patient a au moins une maladie et amplification adaptee a un tel procede |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU4766000A AU4766000A (en) | 2000-12-12 |
| AU772175B2 true AU772175B2 (en) | 2004-04-08 |
Family
ID=26234969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU47660/00A Ceased AU772175B2 (en) | 1999-05-20 | 2000-05-19 | Method for analysing a patient's genetic predisposition to at least a disease and amplification adapted to such a method |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7060438B1 (enExample) |
| EP (1) | EP1179091B2 (enExample) |
| JP (1) | JP2003500067A (enExample) |
| CN (1) | CN1351672A (enExample) |
| AT (1) | ATE279535T1 (enExample) |
| AU (1) | AU772175B2 (enExample) |
| BR (1) | BR0010739A (enExample) |
| CA (1) | CA2374440A1 (enExample) |
| DE (1) | DE60014887T3 (enExample) |
| ES (1) | ES2230109T5 (enExample) |
| FR (1) | FR2793809B1 (enExample) |
| WO (1) | WO2000071750A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2829580B1 (fr) | 2001-09-07 | 2004-02-13 | Bio Merieux | Procede de lecture, de detection ou de quantification, hybrides ou complexes utilises dans ce procede et biopuce mettant en oeuvre ledit procede |
| WO2004047007A1 (en) | 2002-11-15 | 2004-06-03 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
| EP1536021A1 (en) * | 2003-11-27 | 2005-06-01 | Consortium National de Recherche en Genomique (CNRG) | Method for HLA typing |
| US7848889B2 (en) * | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
| FR2881437B1 (fr) | 2005-01-31 | 2010-11-19 | Biomerieux Sa | Procede pour le diagnostic/pronostic d'un syndrome septique |
| FR2906537A1 (fr) | 2006-09-28 | 2008-04-04 | Biomerieux Sa | Procede de diagnostic in vitro du cancer broncho-pulmonaire par detection des transcrits majoritaires alternatifs du gene klk8 codant la kallicreine 8 et son utilisation pour le pronostic de survie |
| US20130096024A1 (en) * | 2010-04-27 | 2013-04-18 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | Method for detecting the susceptibility to develop adverse side effects related to bioimplants |
| EP2576815B1 (en) | 2010-06-04 | 2018-02-14 | Biomérieux | Method for the prognosis of colorectal cancer |
| US9110079B2 (en) | 2010-09-29 | 2015-08-18 | Biomerieux | Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS |
| WO2012129758A1 (en) | 2011-03-25 | 2012-10-04 | Biomerieux | Method and kit for determining in vitro probability for individual to suffer from colorectal cancer |
| EP3000897B1 (en) | 2013-05-21 | 2019-10-16 | Biomérieux | Colorectal cancer prognosis agent kit |
| EP3620984B1 (en) | 2018-09-06 | 2024-04-10 | Accenture Global Solutions Limited | Digital quality control using computer visioning with deep learning |
| WO2025172242A1 (en) | 2024-02-13 | 2025-08-21 | bioMérieux | Method of assessing the risk of death of a patient |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2679252A1 (fr) * | 1991-07-17 | 1993-01-22 | Bio Merieux | Systeme de sondes permettant d'effectuer le typage hla dr, et procede de typage utilisant lesdites sondes. |
| WO1998035059A1 (en) * | 1997-02-11 | 1998-08-13 | Hildebrand William H | Class i sequence based typing of hla-a, -b, and -c alleles by direct dna sequencing |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5567809A (en) * | 1986-03-13 | 1996-10-22 | Hoffmann-La Roche Inc. | Methods and reagents for HLA DRbeta DNA typing |
| US5468611A (en) * | 1990-06-27 | 1995-11-21 | The Blood Center Research Foundation, Inc. | Method for HLA typing |
| NL9002259A (nl) * | 1990-10-17 | 1992-05-18 | Eurodiagnostics B V | Werkwijze voor het bepalen van een genotype door het vergelijken van de nucleotidensequentie van leden van een genfamilie, alsmede kit voor het opsporen van genetische variaties. |
| GB9024005D0 (en) | 1990-11-05 | 1990-12-19 | British Bio Technology | Process for amplifying nucleic acid |
| US5976789A (en) * | 1991-07-17 | 1999-11-02 | Bio Merieux | System of probes enabling HLA-DR typing to be performed, and typing method using said probes |
| JPH0690757A (ja) * | 1991-08-23 | 1994-04-05 | Kitasato Inst:The | Ｈｌａ−ｄｒタイピング用塩基配列群とそれを用いた ｈｌａ−ｄｒタイピング法 |
| JPH08308596A (ja) * | 1995-03-10 | 1996-11-26 | Wakunaga Pharmaceut Co Ltd | Ｈｌａの検出 |
| US5939542A (en) | 1995-03-10 | 1999-08-17 | Wakunaga Seiyaku Kabushiki Kaisha | Detection of HLA-DR |
| WO1997020070A1 (en) * | 1995-11-29 | 1997-06-05 | The Anthony Nolan Bone Marrow Trust | Methods for separating and/or identifying dna molecules |
| FR2749308B1 (fr) * | 1996-06-03 | 1998-07-24 | Bio Merieux | Sondes nucleotidiques et procede pour determiner le typage hla dqb1 |
| EP0887423A1 (en) * | 1997-06-26 | 1998-12-30 | Biotest Ag | A method for determining the Histocompatibility locus antigen class II |
| JP2001512694A (ja) * | 1997-08-11 | 2001-08-28 | ビジブル・ジェネティクス・インコーポレーテッド | Ｄｎａのｈｌａクラスｉタイプを決定するための方法およびキット |
| US5910413A (en) * | 1997-10-10 | 1999-06-08 | Visible Genetics, Inc. | Method and kit for amplification, sequencing and typing of classical HLA class I genes |
-
1999
- 1999-12-06 FR FR9915314A patent/FR2793809B1/fr not_active Expired - Fee Related
-
2000
- 2000-05-19 AU AU47660/00A patent/AU772175B2/en not_active Ceased
- 2000-05-19 WO PCT/FR2000/001385 patent/WO2000071750A1/fr not_active Ceased
- 2000-05-19 DE DE60014887T patent/DE60014887T3/de not_active Expired - Lifetime
- 2000-05-19 EP EP00929650A patent/EP1179091B2/fr not_active Expired - Lifetime
- 2000-05-19 CA CA002374440A patent/CA2374440A1/fr not_active Abandoned
- 2000-05-19 US US09/979,088 patent/US7060438B1/en not_active Expired - Fee Related
- 2000-05-19 ES ES00929650T patent/ES2230109T5/es not_active Expired - Lifetime
- 2000-05-19 AT AT00929650T patent/ATE279535T1/de not_active IP Right Cessation
- 2000-05-19 JP JP2000620127A patent/JP2003500067A/ja not_active Ceased
- 2000-05-19 BR BR0010739-5A patent/BR0010739A/pt not_active Application Discontinuation
- 2000-05-19 CN CN00807807A patent/CN1351672A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2679252A1 (fr) * | 1991-07-17 | 1993-01-22 | Bio Merieux | Systeme de sondes permettant d'effectuer le typage hla dr, et procede de typage utilisant lesdites sondes. |
| WO1998035059A1 (en) * | 1997-02-11 | 1998-08-13 | Hildebrand William H | Class i sequence based typing of hla-a, -b, and -c alleles by direct dna sequencing |
Non-Patent Citations (1)
| Title |
|---|
| HUMAN IMMUNOLOGY, VOL.41, PP 121-26, 1994 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1179091A1 (fr) | 2002-02-13 |
| DE60014887T3 (de) | 2009-09-24 |
| ATE279535T1 (de) | 2004-10-15 |
| EP1179091B2 (fr) | 2009-02-25 |
| ES2230109T3 (es) | 2005-05-01 |
| EP1179091B1 (fr) | 2004-10-13 |
| BR0010739A (pt) | 2002-02-19 |
| AU4766000A (en) | 2000-12-12 |
| JP2003500067A (ja) | 2003-01-07 |
| FR2793809B1 (fr) | 2006-07-28 |
| FR2793809A1 (fr) | 2000-11-24 |
| US7060438B1 (en) | 2006-06-13 |
| CA2374440A1 (fr) | 2000-11-30 |
| WO2000071750A1 (fr) | 2000-11-30 |
| CN1351672A (zh) | 2002-05-29 |
| ES2230109T5 (es) | 2009-06-05 |
| DE60014887T2 (de) | 2005-10-13 |
| DE60014887D1 (de) | 2004-11-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6670124B1 (en) | High throughput methods of HLA typing | |
| EP0553247B1 (en) | Method of determining a genotype by comparing the nucleotide sequence of members of a gene family and kit therefor | |
| AU772175B2 (en) | Method for analysing a patient's genetic predisposition to at least a disease and amplification adapted to such a method | |
| Scheltinga et al. | A generic sequencing based typing approach for the identification of HLA-A diversity | |
| US8343720B2 (en) | Methods and probes for identifying a nucleotide sequence | |
| Kawai et al. | Routine low and high resolution typing of the HLA‐DRB gene using the PCR‐MPH (microtitre plate hybridization) method | |
| US6500614B1 (en) | Method for identifying an unknown allele | |
| Moyer et al. | Human leukocyte antigen (HLA) testing in pharmacogenomics | |
| Kurz et al. | New high resolution typing strategy for HLA‐A locus alleles based on dye terminator sequencing of haplotypic group‐specific PCR‐amplicons of exon 2 and exon 3 | |
| JPH10506541A (ja) | Ｈｌａ−ｄｒ型別判定の実施を可能するプローブ系および該プローブを用いる型別判定法 | |
| US20040014101A1 (en) | Separating and/or identifying polymorphic nucleic acids using universal bases | |
| US20050266410A1 (en) | Methods of Human Leukocyte Antigen typing by neighboring single nucleotide polymorphism haplotypes | |
| TW201300528A (zh) | Ｈｌａ－ｄｑｂ１基因分型的方法及其相關引子 | |
| Moribe et al. | Complete HLA‐A DNA typing using the PCR‐RFLP method combined with allele group‐and sequence‐specific amplification | |
| US20160060696A1 (en) | Method for the identification by molecular techniques of genetic variants that encode no d antigen (d-) and altered c antigen (c+w) | |
| Middleton | HLA typing from serology to sequencing era | |
| AU2014336960A1 (en) | Major histocompatibility complex single nucleotide polymorphisms | |
| Williams et al. | Detection of HLA‐A* 24 null alleles by DNA typing methods | |
| Mougin et al. | A routine assay for the direct analysis of HLA-DR-related shared epitope and B27 alleles in chronic inflammatory arthritis | |
| Lee et al. | Development and clinical evaluation of a microarray for HLA‐A and‐DRB1 genotyping | |
| JP2002101889A (ja) | 新規遺伝子型判定方法 | |
| Paul et al. | HLA-DRB1* intron-primed sequencing for haploid genotyping | |
| Varney et al. | A novel strategy for unambiguous DPB1 typing | |
| WO2008110206A1 (en) | Method for determining a hla-dq haplotype in a subject | |
| Leffell | MHC polymorphism: Coping with the allele explosion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |