AU769304B2 - Internalizing ErbB2 antibodies - Google Patents

Internalizing ErbB2 antibodies Download PDF

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Publication number
AU769304B2
AU769304B2 AU37429/99A AU3742999A AU769304B2 AU 769304 B2 AU769304 B2 AU 769304B2 AU 37429/99 A AU37429/99 A AU 37429/99A AU 3742999 A AU3742999 A AU 3742999A AU 769304 B2 AU769304 B2 AU 769304B2
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AU
Australia
Prior art keywords
antibody
seq
antibodies
amino acid
phage
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Revoked
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AU37429/99A
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English (en)
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AU3742999A (en
Inventor
James D. Marks
Marie Alix Poul
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University of California
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University of California Berkeley
University of California San Diego UCSD
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Publication of AU3742999A publication Critical patent/AU3742999A/en
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Publication of AU769304B2 publication Critical patent/AU769304B2/en
Priority to AU2004201055A priority Critical patent/AU2004201055B2/en
Anticipated expiration legal-status Critical
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
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    • A61K47/6865Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from skin, nerves or brain cancer cell
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    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/2881Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
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    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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AU37429/99A 1998-04-24 1999-04-23 Internalizing ErbB2 antibodies Revoked AU769304B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2004201055A AU2004201055B2 (en) 1998-04-24 2004-03-12 Internalizing ErbB2 antibodies

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8295398P 1998-04-24 1998-04-24
US60/082953 1998-04-24
US09/250,056 US7244826B1 (en) 1998-04-24 1999-02-12 Internalizing ERB2 antibodies
US09/250056 1999-02-12
PCT/US1999/007395 WO1999055367A1 (en) 1998-04-24 1999-04-23 INTERNALIZING ErbB2 ANTIBODIES

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EP1071460A4 (en) 2004-09-08
CA2326377A1 (en) 1999-11-04
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WO1999055367A9 (en) 2000-03-02
US8173424B2 (en) 2012-05-08
US20110218333A1 (en) 2011-09-08
JP2002524024A (ja) 2002-08-06
US8974792B2 (en) 2015-03-10
US20160279262A1 (en) 2016-09-29
ES2316186T3 (es) 2009-04-01
WO1999055367A1 (en) 1999-11-04
ATE412432T1 (de) 2008-11-15
US20130337039A1 (en) 2013-12-19
US7244826B1 (en) 2007-07-17
EP1071460B1 (en) 2008-10-29
CA2326377C (en) 2016-12-06
US7892554B2 (en) 2011-02-22
US9388244B2 (en) 2016-07-12
AU3742999A (en) 1999-11-16
US20080108135A1 (en) 2008-05-08
DE69939820D1 (de) 2008-12-11
US20150239976A1 (en) 2015-08-27

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