AU761363B2 - Solid phytase compositions - Google Patents
Solid phytase compositions Download PDFInfo
- Publication number
- AU761363B2 AU761363B2 AU58505/99A AU5850599A AU761363B2 AU 761363 B2 AU761363 B2 AU 761363B2 AU 58505/99 A AU58505/99 A AU 58505/99A AU 5850599 A AU5850599 A AU 5850599A AU 761363 B2 AU761363 B2 AU 761363B2
- Authority
- AU
- Australia
- Prior art keywords
- composition
- phytase
- csl
- peaks
- units
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010011619 6-Phytase Proteins 0.000 title claims abstract description 134
- 229940085127 phytase Drugs 0.000 title claims abstract description 125
- 239000000203 mixture Substances 0.000 title claims abstract description 108
- 239000007787 solid Substances 0.000 title claims abstract description 29
- 108090000790 Enzymes Proteins 0.000 claims abstract description 39
- 102000004190 Enzymes Human genes 0.000 claims abstract description 39
- 229940088598 enzyme Drugs 0.000 claims abstract description 39
- 229920002472 Starch Polymers 0.000 claims abstract description 35
- 238000000034 method Methods 0.000 claims abstract description 35
- 240000008042 Zea mays Species 0.000 claims abstract description 16
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims abstract description 16
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims abstract description 16
- 235000005822 corn Nutrition 0.000 claims abstract description 16
- 150000002016 disaccharides Chemical class 0.000 claims abstract description 13
- 235000019698 starch Nutrition 0.000 claims abstract description 11
- 239000008107 starch Substances 0.000 claims abstract description 10
- 230000000694 effects Effects 0.000 claims description 63
- 239000008187 granular material Substances 0.000 claims description 57
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 24
- 229940100445 wheat starch Drugs 0.000 claims description 23
- 241001465754 Metazoa Species 0.000 claims description 19
- 239000008247 solid mixture Substances 0.000 claims description 14
- 238000003556 assay Methods 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 9
- UHZZMRAGKVHANO-UHFFFAOYSA-M chlormequat chloride Chemical compound [Cl-].C[N+](C)(C)CCCl UHZZMRAGKVHANO-UHFFFAOYSA-M 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 239000000945 filler Substances 0.000 claims description 7
- 238000005507 spraying Methods 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 5
- 238000001694 spray drying Methods 0.000 claims description 5
- 239000012876 carrier material Substances 0.000 claims description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 3
- 239000011707 mineral Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229940088594 vitamin Drugs 0.000 claims description 3
- 229930003231 vitamin Natural products 0.000 claims description 3
- 235000013343 vitamin Nutrition 0.000 claims description 3
- 239000011782 vitamin Substances 0.000 claims description 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract description 53
- 239000004310 lactic acid Substances 0.000 abstract description 26
- 235000014655 lactic acid Nutrition 0.000 abstract description 26
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract description 9
- 239000008101 lactose Substances 0.000 abstract description 9
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 abstract description 6
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 abstract description 6
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 abstract description 6
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract description 5
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- 239000000523 sample Substances 0.000 description 30
- 238000003860 storage Methods 0.000 description 17
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 15
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 15
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 14
- 235000002949 phytic acid Nutrition 0.000 description 14
- 239000000243 solution Substances 0.000 description 14
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- 238000005469 granulation Methods 0.000 description 12
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- 239000007788 liquid Substances 0.000 description 12
- 229940068041 phytic acid Drugs 0.000 description 12
- 239000000467 phytic acid Substances 0.000 description 12
- 239000002245 particle Substances 0.000 description 11
- 239000008351 acetate buffer Substances 0.000 description 10
- 230000014509 gene expression Effects 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 235000008504 concentrate Nutrition 0.000 description 9
- 239000012141 concentrate Substances 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 8
- 229920001213 Polysorbate 20 Polymers 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 7
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 7
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 229910019142 PO4 Inorganic materials 0.000 description 6
- 229920000136 polysorbate Polymers 0.000 description 6
- 235000017281 sodium acetate Nutrition 0.000 description 6
- 239000005995 Aluminium silicate Substances 0.000 description 5
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 5
- 235000012211 aluminium silicate Nutrition 0.000 description 5
- 239000000872 buffer Substances 0.000 description 5
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 5
- 239000010452 phosphate Substances 0.000 description 5
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- 150000003839 salts Chemical class 0.000 description 5
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- 238000012360 testing method Methods 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 4
- 244000024675 Eruca sativa Species 0.000 description 4
- 235000014755 Eruca sativa Nutrition 0.000 description 4
- 235000019482 Palm oil Nutrition 0.000 description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 4
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 description 4
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- 239000011521 glass Substances 0.000 description 4
- 150000003893 lactate salts Chemical class 0.000 description 4
- 239000002540 palm oil Substances 0.000 description 4
- 229940083982 sodium phytate Drugs 0.000 description 4
- BDKLKNJTMLIAFE-UHFFFAOYSA-N 2-(3-fluorophenyl)-1,3-oxazole-4-carbaldehyde Chemical compound FC1=CC=CC(C=2OC=C(C=O)N=2)=C1 BDKLKNJTMLIAFE-UHFFFAOYSA-N 0.000 description 3
- 241000235349 Ascomycota Species 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
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- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical compound [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 description 3
- 229910017604 nitric acid Inorganic materials 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 239000001632 sodium acetate Substances 0.000 description 3
- 229940087562 sodium acetate trihydrate Drugs 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
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- -1 superabsorbents Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 239000003760 tallow Substances 0.000 description 3
- 238000000108 ultra-filtration Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 241001465318 Aspergillus terreus Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 2
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
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- 229930006000 Sucrose Natural products 0.000 description 2
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
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- 102000006029 inositol monophosphatase Human genes 0.000 description 1
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- 238000011835 investigation Methods 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
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- 239000003921 oil Substances 0.000 description 1
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- 239000011236 particulate material Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
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- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
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- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 229940076788 pyruvate Drugs 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000011091 sodium acetates Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
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- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- LSGOVYNHVSXFFJ-UHFFFAOYSA-N vanadate(3-) Chemical compound [O-][V]([O-])([O-])=O LSGOVYNHVSXFFJ-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
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- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000012711 vitamin K3 Nutrition 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- RZLVQBNCHSJZPX-UHFFFAOYSA-L zinc sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Zn+2].[O-]S([O-])(=O)=O RZLVQBNCHSJZPX-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/98—Preparation of granular or free-flowing enzyme compositions
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199801251 | 1998-10-02 | ||
| DK199801251 | 1998-10-02 | ||
| PCT/DK1999/000516 WO2000020569A1 (en) | 1998-10-02 | 1999-10-01 | Solid phytase compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU5850599A AU5850599A (en) | 2000-04-26 |
| AU761363B2 true AU761363B2 (en) | 2003-06-05 |
Family
ID=8102729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU58505/99A Expired AU761363B2 (en) | 1998-10-02 | 1999-10-01 | Solid phytase compositions |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1117771B1 (https=) |
| JP (1) | JP4455764B2 (https=) |
| CN (1) | CN1197963C (https=) |
| AT (1) | ATE238415T1 (https=) |
| AU (1) | AU761363B2 (https=) |
| BR (1) | BR9914217A (https=) |
| CA (1) | CA2341484C (https=) |
| DE (1) | DE69907240T2 (https=) |
| DK (1) | DK1117771T3 (https=) |
| WO (1) | WO2000020569A1 (https=) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003203147B2 (en) | 1998-03-23 | 2008-05-29 | Novozymes A/S | Phytase variants |
| US6451572B1 (en) | 1998-06-25 | 2002-09-17 | Cornell Research Foundation, Inc. | Overexpression of phytase genes in yeast systems |
| MXPA01009809A (es) | 1999-03-31 | 2002-07-30 | Cornell Res Foundation Inc | Fosfatasas con actividad de fitasa mejorada. |
| US6841370B1 (en) | 1999-11-18 | 2005-01-11 | Cornell Research Foundation, Inc. | Site-directed mutagenesis of Escherichia coli phytase |
| ES2597503T3 (es) | 2001-10-31 | 2017-01-19 | Huvepharma Eood | Alimento para animales que contiene fitasa y método |
| US6815486B2 (en) | 2002-04-12 | 2004-11-09 | Dow Corning Corporation | Thermally conductive phase change materials and methods for their preparation and use |
| US7309505B2 (en) | 2002-09-13 | 2007-12-18 | Cornell Research Foundation, Inc. | Using mutations to improve Aspergillus phytases |
| AR047658A1 (es) | 2004-02-03 | 2006-02-01 | Cargill Inc | Concentrado de proteinas y corriente acuosa con carbohidratos hidrosolubles |
| DE202005021810U1 (de) | 2004-09-27 | 2010-04-22 | Novozymes A/S | Körnchen mit einem Kern und einer Beschichtung |
| AR050895A1 (es) | 2004-10-04 | 2006-11-29 | Novozymes As | Polipeptidos que tienen actividad de fitasa y polinucleotidos que los codifican |
| EP1809747B1 (en) | 2004-10-04 | 2016-12-14 | Novozymes A/S | Polypeptides having phytase activity and polynucleotides encoding same |
| BRPI0617342A2 (pt) * | 2005-10-12 | 2011-07-26 | Genencor Int | grÂnulos estÁveis, durÁveis com agentes ativos |
| US7919297B2 (en) | 2006-02-21 | 2011-04-05 | Cornell Research Foundation, Inc. | Mutants of Aspergillus niger PhyA phytase and Aspergillus fumigatus phytase |
| ATE493893T1 (de) * | 2006-03-10 | 2011-01-15 | Basf Se | Feste enymformulierungen und verfahren zu deren herstellung |
| DK2365064T3 (en) | 2006-04-04 | 2015-03-30 | Novozymes As | Phytasevarianter |
| WO2008017066A2 (en) | 2006-08-03 | 2008-02-07 | Cornell Research Foundation, Inc. | Phytases with improved thermal stability |
| WO2008017659A1 (en) | 2006-08-07 | 2008-02-14 | Novozymes A/S | Enzyme granules for animal feed |
| ES2576580T3 (es) | 2006-08-07 | 2016-07-08 | Novozymes A/S | Gránulos de enzima para pienso para animales |
| JP5643083B2 (ja) | 2007-03-26 | 2014-12-17 | ノボザイムス アクティーゼルスカブ | ハフニア・フィターゼ |
| EP2933329B1 (en) | 2008-09-26 | 2017-05-17 | Novozymes A/S | Hafnia phytase variants |
| WO2011014458A1 (en) | 2009-07-28 | 2011-02-03 | Novozymes, Inc. | Polypeptides having phytase activity and polynucleotides encoding same |
| ES2758795T3 (es) | 2010-03-26 | 2020-05-06 | Novozymes As | Variantes de fitasa termoestables |
| WO2013023902A1 (en) | 2011-08-16 | 2013-02-21 | Solvay Sa | Manufacture of mixtures comprising lipo2f2 and lipf6 |
| CN102511665B (zh) * | 2011-12-29 | 2013-06-05 | 青岛玛斯特生物技术有限公司 | 一种植酸酶包衣微丸及其制备方法 |
| PL2811844T3 (pl) * | 2012-02-07 | 2020-08-24 | Danisco Us Inc. | Sposób poprawy stabilności fitazy kwasem fitynowym i kompozycje zawierające fitazę i kwas fitynowy |
| GB201308828D0 (en) | 2013-03-12 | 2013-07-03 | Verenium Corp | Phytase |
| GB201308843D0 (en) * | 2013-03-14 | 2013-07-03 | Verenium Corp | Phytase formulation |
| JP2016525354A (ja) | 2013-07-25 | 2016-08-25 | ビーエーエスエフ エンザイムズ エルエルシー | フィターゼ |
| CN109312321A (zh) | 2016-05-24 | 2019-02-05 | 诺维信公司 | 包含具有半乳聚糖酶活性的多肽和具有β-半乳糖苷酶活性的多肽的组合物 |
| DK3462904T3 (da) | 2016-05-24 | 2025-01-02 | Novozymes As | Polypeptider med alfa-galactosidaseaktivitet og polynukleotider, der koder for samme |
| BR112018073875A2 (pt) | 2016-05-24 | 2019-02-26 | Novozymes As | polipeptídeo isolado, composição, grânulo, aditivo de ração animal, formulação líquida, ração animal, métodos para liberar galactose de material à base de planta, para melhorar um ou mais parâmetros de desempenho de um animal e o valor nutricional de uma ração animal, para preparar uma ração animal e para produzir o polipeptídeo, uso, polinucleotídeo, construto de ácido nucleico ou vetor de expressão, e, célula hospedeira recombinante. |
| WO2017202997A1 (en) | 2016-05-24 | 2017-11-30 | Novozymes A/S | Compositions comprising polypeptides having galactanase activity and polypeptides having beta-galactosidase activity |
| CN109415710A (zh) | 2016-07-08 | 2019-03-01 | 诺维信公司 | 木聚糖酶变体和对其编码的多核苷酸 |
| BR112019000125A2 (pt) | 2016-07-08 | 2019-07-09 | Novozymes As | grânulo, polipeptídeo isolado, composição, aditivo de ração animal, ração animal peletizada, métodos de aprimoramento de um ou mais parâmetros de desempenho de um animal, de preparação de uma ração animal, para aprimorar o valor nutricional de uma ração animal, de solubilização de xilana a partir do material à base de planta e de produção do polipeptídeo, polinucleotídeo, construto de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, e, uso do grânulo |
| AU2017380488B2 (en) | 2016-12-21 | 2023-09-14 | Novozymes A/S | Polypeptides having lysozyme activity, polynucleotides encoding same and uses and compositions thereof |
| WO2018234465A1 (en) | 2017-06-22 | 2018-12-27 | Novozymes A/S | Xylanase variants and polynucleotides encoding same |
| AR112955A1 (es) | 2017-09-01 | 2020-01-08 | Novozymes As | Aditivos de alimento animal que comprenden polipéptidos que tienen actividad proteasa y usos de los mismos |
| CN111050565A (zh) | 2017-09-01 | 2020-04-21 | 诺维信公司 | 包含具有蛋白酶活性的多肽的动物饲料添加剂及其用途 |
| WO2019121930A1 (en) | 2017-12-20 | 2019-06-27 | Dsm Ip Assets B.V. | Animal feed compositions and uses thereof |
| BR112020012058B1 (pt) | 2017-12-20 | 2024-01-02 | Dsm Ip Assets B.V. | Composições de ração animal e usos das mesmas |
| EP3737769A1 (en) | 2018-01-11 | 2020-11-18 | Novozymes A/S | Animal feed compositions and uses thereof |
| BR112020021365A2 (pt) | 2018-04-25 | 2021-01-19 | Novozymes A/S | Ração animal, método para melhoria do fator de eficiência de produção europeu, ganho de peso corporal e/ou razão de conversão de ração de um animal monogástrico, uso de pelo menos um probiótico em combinação com um polipeptídeo tendo atividade de muramidase em uma composição de ração, e, composição de ração ou uma composição de pré-mistura, ou um aditivo de ração para animais. |
| EP4581938A3 (en) | 2018-09-17 | 2025-08-20 | DSM IP Assets B.V. | Animal feed compositions and uses thereof |
| EP3852547A1 (en) | 2018-09-17 | 2021-07-28 | DSM IP Assets B.V. | Animal feed compositions and uses thereof |
| MX2021003035A (es) | 2018-09-17 | 2021-08-11 | Dsm Ip Assets Bv | Composiciones de alimento animal y usos de las mismas. |
| MX2021003074A (es) | 2018-09-17 | 2021-06-23 | Dsm Ip Assets Bv | Composiciones de alimento animal y usos de las mismas. |
| WO2020115179A1 (en) | 2018-12-05 | 2020-06-11 | Novozymes A/S | Use of an enzyme granule |
| WO2021078839A1 (en) | 2019-10-22 | 2021-04-29 | Novozymes A/S | Animal feed composition |
| CN115605094A (zh) | 2020-05-15 | 2023-01-13 | 帝斯曼知识产权资产管理有限公司（Nl） | 用于改善动物饲料的营养价值的方法 |
| US20230180791A1 (en) | 2020-05-18 | 2023-06-15 | Dsm Ip Assets B.V. | Animal feed compositions |
| CN115666262A (zh) | 2020-05-18 | 2023-01-31 | 帝斯曼知识产权资产管理有限公司 | 动物饲料组合物 |
| CA3189083A1 (en) | 2020-08-13 | 2022-02-17 | Novozymes A/S | Phytase variants and polynucleotides encoding same |
| CA3196405A1 (en) | 2020-10-07 | 2022-04-14 | Novozymes A/S | Enzymatic feed preservation |
| EP4228424A1 (en) | 2020-10-15 | 2023-08-23 | DSM IP Assets B.V. | Methods of modulating gastrointestinal metabolites |
| CN114958803B (zh) * | 2022-05-18 | 2024-06-04 | 阳原县仁恒精细粘土有限责任公司 | 植酸酶发酵生产方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0758018A1 (en) * | 1995-07-28 | 1997-02-12 | Gist-Brocades B.V. | Salt-stabilized enzyme preparations |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1135265C (zh) * | 1996-04-12 | 2004-01-21 | 诺沃奇梅兹有限公司 | 含酶颗粒及其生产方法 |
-
1999
- 1999-10-01 EP EP99945962A patent/EP1117771B1/en not_active Expired - Lifetime
- 1999-10-01 WO PCT/DK1999/000516 patent/WO2000020569A1/en not_active Ceased
- 1999-10-01 JP JP2000574666A patent/JP4455764B2/ja not_active Expired - Fee Related
- 1999-10-01 CN CNB998114618A patent/CN1197963C/zh not_active Expired - Lifetime
- 1999-10-01 CA CA002341484A patent/CA2341484C/en not_active Expired - Lifetime
- 1999-10-01 DK DK99945962T patent/DK1117771T3/da active
- 1999-10-01 BR BR9914217-1A patent/BR9914217A/pt not_active Application Discontinuation
- 1999-10-01 AT AT99945962T patent/ATE238415T1/de not_active IP Right Cessation
- 1999-10-01 DE DE69907240T patent/DE69907240T2/de not_active Expired - Lifetime
- 1999-10-01 AU AU58505/99A patent/AU761363B2/en not_active Expired
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0758018A1 (en) * | 1995-07-28 | 1997-02-12 | Gist-Brocades B.V. | Salt-stabilized enzyme preparations |
Non-Patent Citations (1)
| Title |
|---|
| RUTGERSSON, A ET AL., 1997, CEREAL CHEMISTRY, 74:727-732 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1117771B1 (en) | 2003-04-23 |
| CN1320161A (zh) | 2001-10-31 |
| CA2341484A1 (en) | 2000-04-13 |
| BR9914217A (pt) | 2001-07-03 |
| EP1117771A1 (en) | 2001-07-25 |
| JP2002526106A (ja) | 2002-08-20 |
| DK1117771T3 (da) | 2003-06-16 |
| CA2341484C (en) | 2009-08-04 |
| AU5850599A (en) | 2000-04-26 |
| ATE238415T1 (de) | 2003-05-15 |
| CN1197963C (zh) | 2005-04-20 |
| DE69907240D1 (de) | 2003-05-28 |
| JP4455764B2 (ja) | 2010-04-21 |
| DE69907240T2 (de) | 2003-11-27 |
| WO2000020569A1 (en) | 2000-04-13 |
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