AU757104B2 - Compositions and methods for inhibiting bone resorption - Google Patents

Compositions and methods for inhibiting bone resorption Download PDF

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Publication number
AU757104B2
AU757104B2 AU47025/99A AU4702599A AU757104B2 AU 757104 B2 AU757104 B2 AU 757104B2 AU 47025/99 A AU47025/99 A AU 47025/99A AU 4702599 A AU4702599 A AU 4702599A AU 757104 B2 AU757104 B2 AU 757104B2
Authority
AU
Australia
Prior art keywords
geranylgeranyl
nitrogen
isoprenoid compound
group
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU47025/99A
Other languages
English (en)
Other versions
AU4702599A (en
Inventor
Alfred A. Reszka
Edward M. Scolnick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9817172.1A external-priority patent/GB9817172D0/en
Priority claimed from GBGB9822330.8A external-priority patent/GB9822330D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU4702599A publication Critical patent/AU4702599A/en
Application granted granted Critical
Publication of AU757104B2 publication Critical patent/AU757104B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU47025/99A 1998-06-24 1999-06-21 Compositions and methods for inhibiting bone resorption Ceased AU757104B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US9040198P 1998-06-24 1998-06-24
US60/090401 1998-06-24
US9291998P 1998-07-15 1998-07-15
US60/092919 1998-07-15
GBGB9817172.1A GB9817172D0 (en) 1998-08-06 1998-08-06 Compositions and methods for inhibiting bone resorption
GB9817172 1998-08-06
GB9822330 1998-10-13
GBGB9822330.8A GB9822330D0 (en) 1998-10-13 1998-10-13 Compositions and methods for inhibiting bone resorption
PCT/US1999/013967 WO1999067809A1 (en) 1998-06-24 1999-06-21 Compositions and methods for inhibiting bone resorption

Publications (2)

Publication Number Publication Date
AU4702599A AU4702599A (en) 2000-01-10
AU757104B2 true AU757104B2 (en) 2003-01-30

Family

ID=27451815

Family Applications (1)

Application Number Title Priority Date Filing Date
AU47025/99A Ceased AU757104B2 (en) 1998-06-24 1999-06-21 Compositions and methods for inhibiting bone resorption

Country Status (6)

Country Link
US (2) US6432931B1 (enExample)
EP (1) EP1088333A4 (enExample)
JP (1) JP2002519305A (enExample)
AU (1) AU757104B2 (enExample)
CA (1) CA2336201A1 (enExample)
WO (1) WO1999067809A1 (enExample)

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CA2442692A1 (en) * 2001-03-30 2002-10-10 The Nisshin Oillio, Ltd. Bone metabolism improving agents
US20040186089A1 (en) * 2001-11-08 2004-09-23 Scolnick Edward M. Compounds useful in the treatment of anthrax
JP2005514400A (ja) * 2001-12-21 2005-05-19 ザ プロクター アンド ギャンブル カンパニー 骨疾患の治療方法
EP2172192A1 (en) * 2001-12-24 2010-04-07 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder of granular material, and process and tooling for producing it
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
PT1880744E (pt) * 2002-05-10 2015-02-13 Hoffmann La Roche Ácidos bisfosfónicos para o tratamento e a prevenção da osteoporose
PL212072B1 (pl) * 2002-12-20 2012-08-31 Hoffmann La Roche Tabletka zawierająca jako substancję czynną do 250 mg kwasu ibandronowego oraz sposób jej wytwarzania
WO2005000858A2 (en) * 2003-06-27 2005-01-06 Akira Odani Bisphosphonate complexes
JP4738007B2 (ja) * 2005-02-04 2011-08-03 久光製薬株式会社 骨粗鬆症治療用外用剤
AU2006302797B2 (en) 2005-03-02 2012-02-02 Merck Canada Inc. Composition for inhibition of cathepsin K
US7704656B2 (en) * 2005-03-23 2010-04-27 Xerox Corporation Photoconductive imaging member
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US8974801B2 (en) * 2006-12-21 2015-03-10 Amphastar Pharmaceuticals Inc. Long term sustained release pharmaceutical composition containing aqueous suspension of bisphosphonate
US20080164004A1 (en) * 2007-01-08 2008-07-10 Anastasia Kolesnichenko Method and system of electromagnetic stirring for continuous casting of medium and high carbon steels
US8882740B2 (en) * 2009-12-23 2014-11-11 Stryker Trauma Gmbh Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone
AU2012319143A1 (en) * 2011-10-04 2014-04-17 Coyote Pharmaceuticals, Inc. Geranylgeranylacetone derivatives
US20130085283A1 (en) * 2011-10-04 2013-04-04 Coyote Pharmaceuticals, Inc. Geranylgeranylacetone derivatives
WO2013130654A1 (en) * 2012-02-29 2013-09-06 Coyote Pharmaceuticals, Inc. Gga and gga derivatives, compositions thereof and methods for treating neurodegenerative diseases including paralysis including them
TW201427938A (zh) * 2012-10-01 2014-07-16 Coyote Pharmaceuticals Inc 香葉基香葉基丙酮（ｇｇａ）和其衍生物之製備方法及彼等與脲或硫脲之共結晶作用
US9119808B1 (en) 2012-10-08 2015-09-01 Coyote Pharmaceuticals, Inc. Treating neurodegenerative diseases with GGA or a derivative thereof
GB2525520B (en) 2012-12-27 2019-07-10 Kimberly Clark Co Water soluble farnesol analogs and their use
BR112015013756B1 (pt) 2012-12-27 2021-07-20 Kimberly-Clark Worldwide, Inc. Método de ajuste da solubilidade de um óleo botânico em água, óleo botânico, lenço, e, artigo absorvente
WO2014151697A1 (en) * 2013-03-15 2014-09-25 Coyote Pharmaceuticals, Inc. Therapeutic uses for geranylgeranyl acetone and derivatives thereof
WO2014151719A1 (en) * 2013-03-15 2014-09-25 Coyote Pharmaceuticals, Inc. Sublingual formulations including geranylgeranylacetone and geranylgeranylacetone derivatives
KR102363895B1 (ko) * 2020-03-02 2022-02-17 영남대학교 산학협력단 염증 질환 또는 면역 질환의 예방 또는 치료용 약학적 조성물

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Also Published As

Publication number Publication date
US6432931B1 (en) 2002-08-13
EP1088333A4 (en) 2005-08-10
WO1999067809A1 (en) 1999-12-29
EP1088333A1 (en) 2001-04-04
US20020082244A1 (en) 2002-06-27
AU4702599A (en) 2000-01-10
US6699850B2 (en) 2004-03-02
CA2336201A1 (en) 1999-12-29
JP2002519305A (ja) 2002-07-02
WO1999067809A9 (en) 2001-03-22

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FGA Letters patent sealed or granted (standard patent)