ATE169224T1 - Peptidylderivate und inhibitoren des interleukin- 1-g(b)-konvertierenden enzyms - Google Patents

Peptidylderivate und inhibitoren des interleukin- 1-g(b)-konvertierenden enzyms

Info

Publication number
ATE169224T1
ATE169224T1 AT93905939T AT93905939T ATE169224T1 AT E169224 T1 ATE169224 T1 AT E169224T1 AT 93905939 T AT93905939 T AT 93905939T AT 93905939 T AT93905939 T AT 93905939T AT E169224 T1 ATE169224 T1 AT E169224T1
Authority
AT
Austria
Prior art keywords
formula
interleukin
converting enzyme
inhibitors
peptidyl derivatives
Prior art date
Application number
AT93905939T
Other languages
English (en)
Inventor
Kevin T Chapman
Malcolm Maccoss
Adnan Mjalli
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE169224T1 publication Critical patent/ATE169224T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AT93905939T 1992-02-21 1993-02-12 Peptidylderivate und inhibitoren des interleukin- 1-g(b)-konvertierenden enzyms ATE169224T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83959092A 1992-02-21 1992-02-21

Publications (1)

Publication Number Publication Date
ATE169224T1 true ATE169224T1 (de) 1998-08-15

Family

ID=25280154

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93905939T ATE169224T1 (de) 1992-02-21 1993-02-12 Peptidylderivate und inhibitoren des interleukin- 1-g(b)-konvertierenden enzyms

Country Status (9)

Country Link
US (1) US5430128A (de)
EP (1) EP0627926B1 (de)
JP (1) JP3386125B2 (de)
AT (1) ATE169224T1 (de)
AU (1) AU3666893A (de)
CA (1) CA2129976C (de)
DE (1) DE69320176T2 (de)
ES (1) ES2118940T3 (de)
WO (1) WO1993016710A1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US6008217A (en) * 1995-12-20 1999-12-28 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
JPH08500482A (ja) * 1992-06-12 1996-01-23 マサチューセッツ インスティテュート オブ テクノロジー Ｃｅｄ−３及び関連蛋白質のインヒビター
EP0618223A3 (de) * 1993-03-08 1996-06-12 Sandoz Ltd Peptide, die Freisetzung vom Interleukin 1-Bêta, nützlich als entzündungshemmende Wirkstoffe.
CA2122227A1 (en) * 1993-04-29 1994-10-30 Roland E. Dolle Peptide analogs as irreversible interleukin-1.beta. protease inhibitors
US5985838A (en) 1993-04-29 1999-11-16 Vertex Pharmaceuticals, Inc. Peptide analogs as irreversible interleukin-1β protease inhibitors
US5462939A (en) * 1993-05-07 1995-10-31 Sterling Winthrop Inc. Peptidic ketones as interleukin-1β-converting enzyme inhibitors
JPH0789951A (ja) * 1993-06-03 1995-04-04 Sterling Winthrop Inc インターロイキン−１β転換酵素阻害剤
IL112759A0 (en) 1994-02-25 1995-05-26 Khepri Pharmaceuticals Inc Novel cysteine protease inhibitors
US5552400A (en) * 1994-06-08 1996-09-03 Sterling Winthrop Inc. Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
US5847135A (en) * 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en) * 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5565430A (en) * 1994-08-02 1996-10-15 Sterling Winthrop Inc. Azaaspartic acid analogs as interleukin-1β converting enzyme inhibitors
GB2292149A (en) * 1994-08-09 1996-02-14 Ferring Res Ltd Peptide inhibitors of pro-interleukin-1beta converting enzyme
US5776718A (en) * 1995-03-24 1998-07-07 Arris Pharmaceutical Corporation Reversible protease inhibitors
WO1996030395A2 (en) * 1995-03-31 1996-10-03 Takeda Chemical Industries, Ltd. Cysteine protease inhibitor
US5798442A (en) * 1995-04-21 1998-08-25 Merck Frosst Canada, Inc. Peptidyl derivatives as inhibitors of pro-apoptotic cysteine proteinases
WO1997014812A2 (en) * 1995-10-16 1997-04-24 Chiron Corporation Method of screening for factors that modulate gene expression
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
US6288037B1 (en) 1996-01-29 2001-09-11 Basf Aktiengesellschaft Substrates and inhibitors for cysteine protease ICH-1
GB9621985D0 (en) 1996-10-22 1996-12-18 Peptide Therapeutics Ltd A solid-phase technology for the preparation of libraries of bi-directally functionalised drug-like molecules
US6054487A (en) * 1997-03-18 2000-04-25 Basf Aktiengesellschaft Methods and compositions for modulating responsiveness to corticosteroids
US6184210B1 (en) 1997-10-10 2001-02-06 Cytovia, Inc. Dipeptide apoptosis inhibitors and the use thereof
ES2244178T3 (es) 1998-03-09 2005-12-01 Vertex Pharmaceuticals Incorporated Derivados de 1,2-diazepan como inhibidores de la enzima convertidora de interleuquina-1 beta.
EP1076563B1 (de) * 1998-03-16 2005-05-11 Cytovia, Inc. Dipeptid kaspase inhibitoren und deren verwendung
GEP20043163B (en) 1998-03-19 2004-01-26 Vertex Pharma Inhibitors of Caspases, Pharmaceutical Composition on its Base and Method for its Production
AU757104B2 (en) 1998-06-24 2003-01-30 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
CA2367340A1 (en) * 1999-03-16 2000-09-21 Cytovia, Inc. Substituted 2-aminobenzamide caspase inhibitors and the use thereof
JP2002541237A (ja) * 1999-04-09 2002-12-03 サイトビア インコーポレイテッド カスパーゼインヒビターおよびその使用
EA200200301A1 (ru) 1999-08-27 2002-08-29 Сайтовиэ, Инк. ЗАМЕЩЕННЫЕ α-ГИДРОКСИКИСЛОТЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ИНГИБИРОВАНИЯ КЛЕТОЧНОЙ ГИБЕЛИ НА КЛЕТОЧНОМ ИЛИ ТКАНЕВОМ УРОВНЕ, СПОСОБ ЛЕЧЕНИЯ ИЛИ ОБЛЕГЧЕНИЯ СОСТОЯНИЯ ПРИ ГИБЕЛИ КЛЕТОК У ЖИВОТНОГО, СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ РАЗЛИЧНЫХ БОЛЕЗНЕЙ
US6566338B1 (en) 1999-10-12 2003-05-20 Cytovia, Inc. Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
AR026748A1 (es) 1999-12-08 2003-02-26 Vertex Pharma Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis
EP1282435A2 (de) 2000-05-12 2003-02-12 Immunex Corporation Interleukin-1 inhibitoren zur behandlung von erkrankungen
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
EP1317414A2 (de) 2000-09-08 2003-06-11 Merck Frosst Canada & Co. Gamma-ketosäure-dipeptide als inhibitoren von caspase-3
WO2003068242A1 (en) * 2002-02-11 2003-08-21 Vertex Pharmaceuticals Incorporated Phospholipids as caspase inhibitor prodrugs
PE20050159A1 (es) 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
JP4989456B2 (ja) 2004-02-26 2012-08-01 ベイラー リサーチ インスティテュート 関節炎の全身処置のための組成物および方法
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
CA2567080A1 (en) 2004-05-27 2005-12-15 Vertex Pharmaceuticals Incorporated Ice inhibitors for the treatment of autoinflammatory diseases
WO2012061785A2 (en) 2010-11-05 2012-05-10 Brandeis University Ice inhibiting compounds and uses thereof
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
JP2019525947A (ja) 2016-06-01 2019-09-12 エムスリー・バイオテクノロジー・インコーポレイテッドＭ３ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， Ｉｎｃ． 化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055451A (en) * 1986-12-22 1991-10-08 Syntex Inc. Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
AU7775991A (en) * 1990-04-04 1991-10-30 Immunex Corporation Interleukin 1beta protease
GB9123326D0 (en) * 1991-11-04 1991-12-18 Sandoz Ltd Improvements in or relating to organic compounds
EP0618223A3 (de) * 1993-03-08 1996-06-12 Sandoz Ltd Peptide, die Freisetzung vom Interleukin 1-Bêta, nützlich als entzündungshemmende Wirkstoffe.

Also Published As

Publication number Publication date
EP0627926B1 (de) 1998-08-05
US5430128A (en) 1995-07-04
EP0627926A1 (de) 1994-12-14
DE69320176T2 (de) 1999-04-08
JPH07504194A (ja) 1995-05-11
AU3666893A (en) 1993-09-13
DE69320176D1 (de) 1998-09-10
CA2129976C (en) 2002-09-17
ES2118940T3 (es) 1998-10-01
EP0627926A4 (de) 1997-01-29
WO1993016710A1 (en) 1993-09-02
CA2129976A1 (en) 1993-09-02
JP3386125B2 (ja) 2003-03-17

Similar Documents

Publication Publication Date Title
DE69320176D1 (de) Peptidylderivate und inhibitoren des interleukin-1-g(b)-konvertierenden enzyms
CA2071674A1 (en) Peptidyl derivatives as inhibitors of interleukin-1.beta. converting enzyme
ES2175087T3 (es) Compuestos triciclicos utiles en el tratamiento de trastornos de proliferacion celular.
AU2787595A (en) Novel thrombin inhibitors, the preparation and use thereof
DK0932411T3 (da) Præparater indeholdende immunogene molekyler og granulocyt-makrofagkolonistimulerende faktor som en adjuvans
AU583055B2 (en) Tetralin derivatives, their preparation and their use
MX9702658A (es) Derivados novedosos de acido carboxilico, su preparacion y uso.
AU2829292A (en) Saccharin derivative proteolytic enzyme inhibitors
BG104089A (en) Dolastatine 15 derivatives
PL332640A1 (en) Sulphonamide-group substituted derivatives of aspartic acid as inhibitors of an interleukin-1beta transforming enzyme
DE59700356D1 (en) Kombinationspräparat, enthaltend 5-methylisoxazol-4-carbonsäure-(4-trifluormethyl)-anilid und n-(4-trifluormethylphenyl)-2-cyan-3-hydroxycrotonsäureamid
CA2320388A1 (en) Novel dihydroxyhexanoic acid derivatives
AU699579B2 (en) New dipeptide P-amidinobenzylamides with N-terminal sulfonyl or aminosulfonyl radicals
AU3769289A (en) Condensed pyrazole 3-oxo-propanenitrile derivatives and process for their preparation
ES2108595A1 (es) Derivados de la 3(2h)-piridacinona y procedimiento para su preparacion.
EP0354568A3 (de) Catechol-Derivate
CA2188176A1 (fr) (oxo-1 alkyl) amino-2, deoxy-2 glucopyranoside de dihydroxy - 2,3 propyl, leur procede de preparation et leurs utilisations
SG82540A1 (en) N-substituted azabicyclo [3.2.0] heptane derivatives as neuroleptics, the preparation and use thereof
ES8703456A1 (es) Procedimiento para preparar derivados de nitrofurano
HRP950437A2 (en) N-substituted azabicycloheptane derivatives, their production and use
NZ325256A (en) Imino oxyphenyl acetic acid derivatives, methods and intermediates for their preparation and use thereof
HUT58089A (en) Process for producing 3-(l-pyroglutamyl)-l-thiazolidine-4-carboxylic aci derivatives and pharmaceutical compositions comprising such compounds as active ingredient
AU2068895A (en) Dl- di- or tri-hydroxyphenylglycine alkyl esters for the treatment of inflammatory and allergic conditions
Chapman et al. Peptidyl derivatives as inhibitors of interleukin-1 beta converting enzyme
Bills et al. Gamma-pyrone-3-acetic acid as an inhibitor or interleukin-1 beta inventory enzyme

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties